3-Oxalomalic acid (BioDeep_00000004815)

 

Secondary id: BioDeep_00001869920

human metabolite blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


3-carboxy-3-deoxy-2-pentulosaric acid, trisodium salt

化学式: C6H6O8 (206.0063)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 52.77%

分子结构信息

SMILES: C(C(C(=O)O)O)(C(=O)C(=O)O)C(=O)O
InChI: InChI=1S/C6H6O8/c7-2(5(11)12)1(4(9)10)3(8)6(13)14/h1-2,7H,(H,9,10)(H,11,12)(H,13,14)



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Asfaw Degu, Bayissa Hatew, Adriano Nunes-Nesi, Ludmila Shlizerman, Naftali Zur, Ehud Katz, Alisdair R Fernie, Eduardo Blumwald, Avi Sadka. Inhibition of aconitase in citrus fruit callus results in a metabolic shift towards amino acid biosynthesis. Planta. 2011 Sep; 234(3):501-13. doi: 10.1007/s00425-011-1411-2. [PMID: 21528417]
  • Hyuntae Yoo, Maciek R Antoniewicz, Gregory Stephanopoulos, Joanne K Kelleher. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. The Journal of biological chemistry. 2008 Jul; 283(30):20621-7. doi: 10.1074/jbc.m706494200. [PMID: 18364355]
  • Eun Sun Yang, Jeen-Woo Park. Antioxidant enzyme inhibitors enhance peroxynitrite-induced cell death in U937 cells. Molecular and cellular biochemistry. 2007 Jul; 301(1-2):61-8. doi: 10.1007/s11010-006-9397-y. [PMID: 17206381]
  • Jin Hyup Lee, Jeen-Woo Park. Oxalomalate regulates ionizing radiation-induced apoptosis in mice. Free radical biology & medicine. 2007 Jan; 42(1):44-51. doi: 10.1016/j.freeradbiomed.2006.09.016. [PMID: 17157192]
  • In Sup Kil, Seoung Woo Shin, Hyun Seok Yeo, Young Sup Lee, Jeen-Woo Park. Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis. Molecular pharmacology. 2006 Sep; 70(3):1053-61. doi: 10.1124/mol.106.023515. [PMID: 16785314]
  • E S Yang, J-W Park. Antioxidant enzyme inhibitors enhance nitric oxide-induced cell death in U937 cells. Biochimie. 2006 Jul; 88(7):869-78. doi: 10.1016/j.biochi.2006.02.001. [PMID: 16540229]
  • Eun Sun Yang, Joon-Hyuck Yang, Ji Eun Park, Jeen-Woo Park. Oxalomalate, a competitive inhibitor of NADP+ -dependent isocitrate dehydrogenase, regulates lipid peroxidation-mediated apoptosis in U937 cells. Free radical research. 2005 Jan; 39(1):89-94. doi: 10.1080/10715760400022996. [PMID: 15875816]
  • Rita Santamaria, Carlo Irace, Michela Festa, Carmen Maffettone, Alfredo Colonna. Induction of ferritin expression by oxalomalate. Biochimica et biophysica acta. 2004 May; 1691(2-3):151-9. doi: 10.1016/j.bbamcr.2004.01.004. [PMID: 15110995]
  • In Youl Choi, Jeen-Woo Park. Sensitization of U937 cells to heat shock by oxalomalate, a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase. Free radical research. 2003 Oct; 37(10):1099-105. doi: 10.1080/10715760310001601047. [PMID: 14703799]
  • Joon-Hyuck Yang, Jeen-Woo Park. Oxalomalate, a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase, enhances lipid peroxidation-mediated oxidative damage in U937 cells. Archives of biochemistry and biophysics. 2003 Aug; 416(1):31-7. doi: 10.1016/s0003-9861(03)00291-1. [PMID: 12859979]
  • Un Ju Jung, Oh-Shin Kwon, Yong Bok Park, Tae-Lin Huh, Mi-Kyung Lee, Myung-Sook Choi. Effect of oxalomalate on lipid metabolism and antioxidant defense system in rats. Journal of biochemical and molecular toxicology. 2003; 17(5):295-302. doi: 10.1002/jbt.10092. [PMID: 14595852]