4-Trimethylammoniobutanal (BioDeep_00000004594)
Secondary id: BioDeep_00001869284
human metabolite Endogenous
代谢物信息卡片
化学式: C7H16NO+ (130.1231826)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 0.63%
分子结构信息
SMILES: C[N+](C)(C)CCCC=O
InChI: InChI=1S/C7H16NO/c1-8(2,3)6-4-5-7-9/h7H,4-6H2,1-3H3/q+1
描述信息
4-Trimethylammoniobutanal is a substrate for Serine hydroxymethyltransferase (cytosolic), Serine hydroxymethyltransferase (mitochondrial), Aldehyde dehydrogenase (mitochondrial), Fatty aldehyde dehydrogenase, 4-trimethylaminobutyraldehyde dehydrogenase, Aldehyde dehydrogenase (dimeric NADP-preferring), Aldehyde dehydrogenase family 7 member A1, Aldehyde dehydrogenase 1A3 and Aldehyde dehydrogenase X (mitochondrial). [HMDB]
4-Trimethylammoniobutanal is a substrate for Serine hydroxymethyltransferase (cytosolic), Serine hydroxymethyltransferase (mitochondrial), Aldehyde dehydrogenase (mitochondrial), Fatty aldehyde dehydrogenase, 4-trimethylaminobutyraldehyde dehydrogenase, Aldehyde dehydrogenase (dimeric NADP-preferring), Aldehyde dehydrogenase family 7 member A1, Aldehyde dehydrogenase 1A3 and Aldehyde dehydrogenase X (mitochondrial).
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:18020
- KEGG: C01149
- PubChem: 133
- HMDB: HMDB0001345
- MetaCyc: 4-TRIMETHYLAMMONIOBUTANAL
- foodb: FDB022567
- chemspider: 130
- CAS: 64595-66-0
- PMhub: MS000017123
- PubChem: 4378
- PDB-CCD: 2ZO
- 3DMET: B00247
- NIKKAJI: J2.362.000F
分类词条
相关代谢途径
PlantCyc(0)
代谢反应
66 个相关的代谢反应过程信息。
Reactome(52)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
H2O + NAD + TEABL ⟶ H+ + NADH + TEABT - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
HTMLYS ⟶ Gly + TEABL - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
H2O + NAD + TEABL ⟶ H+ + NADH + TEABT - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
HTMLYS ⟶ Gly + TEABL - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Carnitine synthesis:
HTMLYS ⟶ Gly + TEABL - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
BioCyc(4)
- L-carnitine biosynthesis:
γ-butyrobetaine + 2-oxoglutarate + O2 ⟶ CO2 + L-carnitine + succinate - L-carnitine biosynthesis:
3-hydroxy-N6,N6,N6-trimethyl-L-lysine ⟶ 4-trimethylammoniobutanal + gly - L-carnitine biosynthesis:
γ-butyrobetaine + 2-oxoglutarate + O2 ⟶ CO2 + L-carnitine + succinate - L-carnitine biosynthesis:
γ-butyrobetaine + 2-oxoglutarate + O2 ⟶ CO2 + L-carnitine + succinate
WikiPathways(0)
Plant Reactome(0)
INOH(3)
- Lysine degradation ( Lysine degradation ):
2-Oxo-glutaric acid + L-Lysine + NADH ⟶ H2O + L-Saccharopine + NAD+ - NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid ( Lysine degradation ):
4-Trimethyl-ammonio-butanal + H2O + NAD+ ⟶ 4-Trimethyl-ammonio-butanoic acid + NADH - NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid ( Lysine degradation ):
4-Trimethyl-ammonio-butanal + H2O + NAD+ ⟶ 4-Trimethyl-ammonio-butanoic acid + NADH
PlantCyc(3)
- L-carnitine biosynthesis:
γ-butyrobetaine + 2-oxoglutarate + O2 ⟶ CO2 + L-carnitine + succinate - L-carnitine biosynthesis:
γ-butyrobetaine + 2-oxoglutarate + O2 ⟶ CO2 + L-carnitine + succinate - L-carnitine biosynthesis:
γ-butyrobetaine + 2-oxoglutarate + O2 ⟶ CO2 + L-carnitine + succinate
COVID-19 Disease Map(0)
PathBank(4)
- Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid - Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid - Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid - Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Martina Tylichová, David Kopecný, Solange Moréra, Pierre Briozzo, René Lenobel, Jacques Snégaroff, Marek Sebela. Structural and functional characterization of plant aminoaldehyde dehydrogenase from Pisum sativum with a broad specificity for natural and synthetic aminoaldehydes.
Journal of molecular biology.
2010 Mar; 396(4):870-82. doi:
10.1016/j.jmb.2009.12.015. [PMID: 20026072]