L-Aspartate-semialdehyde (BioDeep_00000004429)

Main id: BioDeep_00000739943

Secondary id: BioDeep_00001869080

human metabolite Endogenous


代谢物信息卡片


L-Aspartic acid beta-semialdehyde

化学式: C4H7NO3 (117.0425912)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C=O)C(C(=O)O)N
InChI: InChI=1S/C4H7NO3/c5-3(1-2-6)4(7)8/h2-3H,1,5H2,(H,7,8)/t3-/m0/s1

描述信息

L-Aspartate-semialdehyde (CAS: 15106-57-7) is involved in both the lysine biosynthesis I and homoserine biosynthesis pathways. In the lysine biosynthesis I pathway, L-aspartate-semialdehyde is produced from a reaction between L-aspartyl-4-phosphate and NADPH, with phosphate and NADP+ as byproducts. The reaction is catalyzed by aspartate-semialdehyde dehydrogenase. L-Aspartate-semialdehyde reacts with pyruvate to produce L-2,3-dihydrodipicolinate and water. Dihydrodipicolinate synthase catalyzes this reaction. In the homoserine biosynthesis pathway, L-aspartate-semialdehyde is produced from a reaction between L-aspartyl-4-phosphate and NADPH, with phosphate and NADP+ as byproducts. The reaction is catalyzed by aspartate-semialdehyde dehydrogenase. L-Aspartate-semialdehyde reacts with NAD(P)H and H+ to form homoserine and NAD(P)+.
L-Aspartate-semialdehyde is involved in both the lysine biosynthesis I and homoserine biosynthesis pathways.

同义名列表

34 个代谢物同义名

L-Aspartic acid beta-semialdehyde; Aspartic acid beta-semialdehyde; (2S)-2-Amino-4-oxobutanoic acid; (S)-2-Amino-4-oxobutanoic acid; L-Aspartic acid b-semialdehyde; L-Aspartic acid β-semialdehyde; L-Aspartate beta-semialdehyde; Aspartic acid β-semialdehyde; Aspartic acid b-semialdehyde; L-Aspartic beta-semialdehyde; L-Aspartic acid-semialdehyde; 2-Amino-adipic semialdehyde; Aspartate beta-semialdehyde; Aspartic-beta-semialdehyde; L-Aspartate-4-semialdehyde; beta-Aspartic semialdehyde; 2-amino-4-oxobutanoic acid; Aspartic beta-semialdehyde; L-Aspartate β-semialdehyde; (S)-2-Amino-4-oxobutanoate; L-Aspartate b-semialdehyde; L-Aspartic b-semialdehyde; L-Aspartic 4-semialdehyde; beta-Aspartaldehydic acid; L-Aspartic β-semialdehyde; L-Aspartate-semialdehyde; Aspartate β-semialdehyde; Aspartate b-semialdehyde; Aspartic-β-semialdehyde; β-Aspartic semialdehyde; Aspartic β-semialdehyde; Aspartic b-semialdehyde; β-Aspartaldehydic acid; 3-Formylalanine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(0)

代谢反应

593 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(9)

WikiPathways(1)

Plant Reactome(570)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(13)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Piliang Hao, Jingru Qian, Bamaprasad Dutta, Esther Sok Hwee Cheow, Kae Hwan Sim, Wei Meng, Sunil S Adav, Andrew Alpert, Siu Kwan Sze. Enhanced separation and characterization of deamidated peptides with RP-ERLIC-based multidimensional chromatography coupled with tandem mass spectrometry. Journal of proteome research. 2012 Mar; 11(3):1804-11. doi: 10.1021/pr201048c. [PMID: 22239700]
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  • Hongqian Yang, Yaroslav Lyutvinskiy, Hilkka Soininen, Roman A Zubarev. Alzheimer's disease and mild cognitive impairment are associated with elevated levels of isoaspartyl residues in blood plasma proteins. Journal of Alzheimer's disease : JAD. 2011; 27(1):113-8. doi: 10.3233/jad-2011-110626. [PMID: 21765210]
  • Tingsu Chen, Nihar Nayak, Susmita Maitra Majee, Jonathan Lowenson, Kim R Schäfermeyer, Alyssa C Eliopoulos, Taylor D Lloyd, Randy Dinkins, Sharyn E Perry, Nancy R Forsthoefel, Steven G Clarke, Daniel M Vernon, Zhaohui Sunny Zhou, Tomas Rejtar, A Bruce Downie. Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning. The Journal of biological chemistry. 2010 Nov; 285(48):37281-92. doi: 10.1074/jbc.m110.157008. [PMID: 20870712]
  • Andrés R Schwember, Kent J Bradford. Quantitative trait loci associated with longevity of lettuce seeds under conventional and controlled deterioration storage conditions. Journal of experimental botany. 2010 Oct; 61(15):4423-36. doi: 10.1093/jxb/erq248. [PMID: 20693410]
  • Hong Hua Piao, Vo Thi Minh Tam, Hee Sam Na, Hyun Ju Kim, Phil Youl Ryu, Soo Young Kim, Joon Haeng Rhee, Hyon E Choy, Suhng Wook Kim, Yeongjin Hong. Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice. Journal of microbiology (Seoul, Korea). 2010 Aug; 48(4):486-95. doi: 10.1007/s12275-010-0023-z. [PMID: 20799091]
  • Gregor Füser, Alexander Steinbüchel. Analysis of genome sequences for genes of cyanophycin metabolism: identifying putative cyanophycin metabolizing prokaryotes. Macromolecular bioscience. 2007 Mar; 7(3):278-96. doi: 10.1002/mabi.200600207. [PMID: 17390395]
  • Subramanian Shankar, David J Hosking. Biochemical assessment of Paget's disease of bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2006 Dec; 21 Suppl 2(?):P22-7. doi: 10.1359/jbmr.06s204. [PMID: 17229003]
  • Mei-Ling Yang, Hester A Doyle, Renelle J Gee, Jonathan D Lowenson, Steven Clarke, Brian R Lawson, Dana W Aswad, Mark J Mamula. Intracellular protein modification associated with altered T cell functions in autoimmunity. Journal of immunology (Baltimore, Md. : 1950). 2006 Oct; 177(7):4541-9. doi: 10.4049/jimmunol.177.7.4541. [PMID: 16982891]
  • Karolina Michalska, Grzegorz Bujacz, Mariusz Jaskolski. Crystal structure of plant asparaginase. Journal of molecular biology. 2006 Jun; 360(1):105-16. doi: 10.1016/j.jmb.2006.04.066. [PMID: 16725155]
  • Karolina Michalska, Mariusz Jaskolski. Structural aspects of L-asparaginases, their friends and relations. Acta biochimica Polonica. 2006; 53(4):627-40. doi: 10.18388/abp.2006_3291. [PMID: 17143335]
  • Christine Farrar, Carolyn R Houser, Steven Clarke. Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice. Aging cell. 2005 Feb; 4(1):1-12. doi: 10.1111/j.1474-9728.2004.00136.x. [PMID: 15659208]
  • Alessandra F Perna, Rosanna Capasso, Cinzia Lombardi, Filomena Acanfora, Ersilia Satta, Diego Ingrosso. Hyperhomocysteinemia and macromolecule modifications in uremic patients. Clinical chemistry and laboratory medicine. 2005; 43(10):1032-8. doi: 10.1515/cclm.2005.181. [PMID: 16197294]
  • Dominika Borek, Karolina Michalska, Krzysztof Brzezinski, Agnieszka Kisiel, Jan Podkowinski, David T Bonthron, Daniel Krowarsch, Jacek Otlewski, Mariusz Jaskolski. Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog. European journal of biochemistry. 2004 Aug; 271(15):3215-26. doi: 10.1111/j.1432-1033.2004.04254.x. [PMID: 15265041]
  • Adam Prahl, Marzena Pazgier, Mahdi Hejazi, Wolfgang Lockau, Jacek Lubkowski. Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli. Acta crystallographica. Section D, Biological crystallography. 2004 Jun; 60(Pt 6):1173-6. doi: 10.1107/s0907444904003403. [PMID: 15159592]
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  • Hester A Doyle, Renelle J Gee, Mark J Mamula. A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production. Journal of immunology (Baltimore, Md. : 1950). 2003 Sep; 171(6):2840-7. doi: 10.4049/jimmunol.171.6.2840. [PMID: 12960305]
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  • Mahdi Hejazi, Kirill Piotukh, Jens Mattow, Rainer Deutzmann, Rudolf Volkmer-Engert, Wolfgang Lockau. Isoaspartyl dipeptidase activity of plant-type asparaginases. The Biochemical journal. 2002 May; 364(Pt 1):129-36. doi: 10.1042/bj3640129. [PMID: 11988085]
  • A F Perna, D Ingrosso, E Satta, M Romano, A Cimmino, P Galletti, V Zappia, N G De Santo. Metabolic consequences of hyperhomocysteinemia in uremia. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2001 Oct; 38(4 Suppl 1):S85-90. doi: 10.1053/ajkd.2001.27411. [PMID: 11576929]
  • S D'Angelo, D Ingrosso, B Perfetto, A Baroni, M Zappia, L L Lobianco, M A Tufano, P Galletti. UVA irradiation induces L-isoaspartyl formation in melanoma cell proteins. Free radical biology & medicine. 2001 Jul; 31(1):1-9. doi: 10.1016/s0891-5849(01)00518-4. [PMID: 11425484]
  • M C Ronchel, J L Ramos. Dual system to reinforce biological containment of recombinant bacteria designed for rhizoremediation. Applied and environmental microbiology. 2001 Jun; 67(6):2649-56. doi: 10.1128/aem.67.6.2649-2656.2001. [PMID: 11375176]
  • A F Perna, P Castaldo, N G De Santo, E di Carlo, A Cimmino, P Galletti, V Zappia, D Ingrosso. Plasma proteins containing damaged L-isoaspartyl residues are increased in uremia: implications for mechanism. Kidney international. 2001 Jun; 59(6):2299-308. doi: 10.1046/j.1523-1755.2001.00747.x. [PMID: 11380834]
  • A Craciun, M Jacobs, M Vauterin. Arabidopsis loss-of-function mutant in the lysine pathway points out complex regulation mechanisms. FEBS letters. 2000 Dec; 487(2):234-8. doi: 10.1016/s0014-5793(00)02303-6. [PMID: 11150516]
  • B L Asselin, M Y Lorenson, J C Whitin, D J Coppola, A S Kende, R L Blakley, H J Cohen. Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor. Cancer research. 1991 Dec; 51(24):6568-73. doi: . [PMID: 1742729]
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