Arabinofuranosyluracil (BioDeep_00000406343)

Secondary id: BioDeep_00000174130, BioDeep_00001028445

natural product PANOMIX_OTCML-2023

代谢物信息卡片

1-β-D-Arabinofuranosyluracil

化学式: C9H12N2O6 (244.0695332)
中文名称: 阿糖尿苷
谱图信息: 最多检出来源 Homo sapiens(blood) 2.44%

分子结构信息

SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)

描述信息

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties[1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells[2].
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties[1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells[2].
1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties[1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells[2].

同义名列表

4 个代谢物同义名

1-β-D-Arabinofuranosyluracil; Arabinofuranosyluracil; Uracil 1-β-D-arabinofuranoside; 1-beta-D-Arabinofuranosyluracil

数据库引用编号

20 个数据库交叉引用编号

分类词条

其他

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

40674 - Animals: -
4072 - Capsicum annuum: 10.1021/JF061404Z
42017 - Gloiopeltis furcata: 10.1248/CPB.58.1236
9606 - Homo sapiens: 10.1016/J.PHYTOCHEM.2007.09.006
153348 - Lepidium meyenii: 10.1021/JF020280X
699669 - Lepisorus contortus: 10.1021/NP100373F
49563 - Peucedanum japonicum: 10.1021/JF0262458
158314 - Polyporus umbellatus: 10.3184/030823409X12562954717147
3755 - Prunus dulcis: 10.1021/JF020262F

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Melanie Donnette, Caroline Solas, Madeleine Giocanti, Geoffroy Venton, Laure Farnault, Yael Berda-Haddad, Le Thi Thu Hau, Régis Costello, L'Houcine Ouafik, Bruno Lacarelle, Joseph Ciccolini, Raphaëlle Fanciullino. Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics-pharmacogenetics pilot study in AML patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Sep; 1126-1127(?):121770. doi: 10.1016/j.jchromb.2019.121770. [PMID: 31454720]
Ulka N Vaishampayan, Omid S Tehrani, Jawana M Lawhorn-Crews, Lance K Heilbrun, Kimberlee Dobson, Daryn Smith, Brenda Dickow, Anthony F Shields. A Pilot Trial Evaluating Zoledronic Acid Induced Changes in [18F]FMAU-Positron Emission Tomography Imaging of Bone Metastases in Prostate Cancer. Molecular imaging and biology. 2017 12; 19(6):810-816. doi: 10.1007/s11307-017-1057-y. [PMID: 28289967]
Jing Li, Seongho Kim, Anthony F Shields, Kirk A Douglas, Christopher I McHugh, Jawana M Lawhorn-Crews, Jianmei Wu, Thomas J Mangner, Patricia M LoRusso. Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase. Journal of clinical pharmacology. 2016 11; 56(11):1433-1447. doi: 10.1002/jcph.751. [PMID: 27095537]
Xiaoyan M Zhang, Halle H Zhang, Patrick McLeroth, Richard D Berkowitz, Michael A Mont, Michael G Stabin, Barry A Siegel, Abass Alavi, T Marc Barnett, Jeffrey Gelb, Chantal Petit, John Spaltro, Steve Y Cho, Martin G Pomper, James J Conklin, Chetan Bettegowda, Saurabh Saha. [(124)I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection. Nuclear medicine and biology. 2016 May; 43(5):273-9. doi: 10.1016/j.nucmedbio.2016.01.004. [PMID: 27150029]
Dan Wang, Qingqing Xiao, Wanqiu Yang, Wei Qian, Jin Yang. HPLC-MS/MS method for the simultaneous determination of MB07133 and its metabolites, cytarabine and arabinofuranosyluracil, in rat plasma. Journal of pharmaceutical and biomedical analysis. 2016 Feb; 120(?):228-34. doi: 10.1016/j.jpba.2015.12.049. [PMID: 26760240]
Maxim A Moroz, Hanwen Zhang, Jason Lee, Ekaterina Moroz, Juan Zurita, Larissa Shenker, Inna Serganova, Ronald Blasberg, Vladimir Ponomarev. Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Jul; 56(7):1055-60. doi: 10.2967/jnumed.115.159855. [PMID: 26025962]
David Tung, Gary DeCrescenzo, Dean Welsch, Peter H Cheung, Chetan Bettegowda, Saurabh Saha. Evaluation of 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) as an ex vivo bacterial detection agent. World journal of microbiology & biotechnology. 2014 Nov; 30(11):3003-10. doi: 10.1007/s11274-014-1709-x. [PMID: 25085723]
Dan Xu, Toshi Nishimura, Sachiko Nishimura, Haili Zhang, Ming Zheng, Ying-Ying Guo, Marylin Masek, Sara A Michie, Jeffrey Glenn, Gary Peltz. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PLoS medicine. 2014 Apr; 11(4):e1001628. doi: 10.1371/journal.pmed.1001628. [PMID: 24736310]
James Fung, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen. Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment. Journal of gastroenterology and hepatology. 2014 Mar; 29(3):428-34. doi: 10.1111/jgh.12499. [PMID: 24372662]
Chuanrong Liao, Sheng Chang, Shuhua Hu, Zhen Tang, Guoqiang Fu. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of 1-β-d-arabinofuranosyluracil in human plasma and application to therapeutic drug monitoring in patient with leukemia. Journal of pharmaceutical and biomedical analysis. 2013 Nov; 85(?):118-22. doi: 10.1016/j.jpba.2013.07.015. [PMID: 23933564]
Masanobu Uchiyama, Yasushi Takamatsu, Kentaro Ogata, Taichi Matsumoto, Shiro Jimi, Kazuo Tamura, Shuuji Hara. Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection. Biomedical chromatography : BMC. 2013 Jul; 27(7):818-20. doi: 10.1002/bmc.2876. [PMID: 23420764]
Ugir Hossain Sk, Siva P Kambhampati, Manoj K Mishra, Wojciech G Lesniak, Fan Zhang, Rangaramanujam M Kannan. Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study. Biomacromolecules. 2013 Mar; 14(3):801-10. doi: 10.1021/bm3018615. [PMID: 23373724]
Suk Bae Kim, Il Han Song, Young Min Kim, Ran Noh, Ha Yan Kang, Hyang Ie Lee, Hyeon Yoong Yang, An Na Kim, Hee Bok Chae, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee, Heon Young Lee. Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B. World journal of gastroenterology. 2012 Dec; 18(47):6943-50. doi: 10.3748/wjg.v18.i47.6943. [PMID: 23322992]
Richard Wiegand, Jianmei Wu, Anthony F Shields, Patricia Lorusso, Jing Li. Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 891-892(?):64-70. doi: 10.1016/j.jchromb.2012.02.030. [PMID: 22410089]
Cungang Ding, Qinghua Ge, Yemu Wang, Zhen Zhou, Xiaojin Zhi, Xiaofen Liu, Zhou Li. Normal-phase liquid chromatography coupled with electrospray ionization mass spectrometry for chiral separation and quantification of clevudine and its enantiomer in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Feb; 885-886(?):97-102. doi: 10.1016/j.jchromb.2011.12.020. [PMID: 22265667]
Yoon-Ok Jang, Xianglan Quan, Ranjan Das, Shanhua Xu, Choon-Hee Chung, Chan Mug Ahn, Soon-Koo Baik, In Deok Kong, Kyu-Sang Park, Moon Young Kim. High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells. BMC gastroenterology. 2012 Jan; 12(?):4. doi: 10.1186/1471-230x-12-4. [PMID: 22230186]
Dejan Radeski, Gavin M Cull, Michael Cain, L Peter Hackett, Kenneth F Ilett. Effective clearance of Ara-U the major metabolite of cytosine arabinoside (Ara-C) by hemodialysis in a patient with lymphoma and end-stage renal failure. Cancer chemotherapy and pharmacology. 2011 Apr; 67(4):765-8. doi: 10.1007/s00280-010-1373-2. [PMID: 20532508]
Suk Hyang Bae, Yang Hyun Baek, Sung Wook Lee, Sang Young Han. [Treatment efficacy of clevudine, entecavir and lamivudine in treatment-naive patients with HBeAg-positive chronic hepatitis B]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2010 Dec; 56(6):365-72. doi: 10.4166/kjg.2010.56.6.365. [PMID: 21173560]
George K K Lau, Nancy Leung. Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized study. The Korean journal of hepatology. 2010 Sep; 16(3):315-20. doi: 10.3350/kjhep.2010.16.3.315. [PMID: 20924215]
Won Young Tak, Soo Young Park, Chang Min Cho, Min Kyu Jung, Seong Woo Jeon, Young Oh Kweon, Ji Young Park, Yoon Kyung Sohn. Clinical, biochemical, and pathological characteristics of clevudine-associated myopathy. Journal of hepatology. 2010 Aug; 53(2):261-6. doi: 10.1016/j.jhep.2010.03.006. [PMID: 20466447]
In Hee Kim, Seok Lee, Seong Hun Kim, Sang Wook Kim, Seung Ok Lee, Soo Teik Lee, Dae Ghon Kim, Chang Soo Choi, Haak Cheoul Kim. Treatment outcomes of clevudine versus lamivudine at week 48 in naïve patients with HBeAg positive chronic hepatitis B. Journal of Korean medical science. 2010 May; 25(5):738-45. doi: 10.3346/jkms.2010.25.5.738. [PMID: 20436711]
June Sung Lee, Eun Taek Park, Seung Sik Kang, Eun Sil Gu, Jong Sun Kim, Dong Seob Jang, Kyoung Seog Lee, Jae-Su Lee, Nung Hwa Park, Chang Hwang Bae, Soon Koo Baik, Byeong Jeon Yu, Soon Hyung Lee, Eun Jong Lee, Sung Il Park, Myoung Bae, Jung Woo Shin, Jae Hong Choi, Chul Gu, Sin Kil Moon, Gab Jin Chun, Ju Hyun Kim, Hong Soo Kim, Sung-Kyu Choi. Clevudine demonstrates potent antiviral activity in naïve chronic hepatitis B patients. Intervirology. 2010; 53(2):83-6. doi: 10.1159/000264197. [PMID: 19955812]
Min Hwan Kim, Kyung Ah Kim, June Sung Lee, Hyun Woong Lee, Hyung Joon Kim, Sang Gu Yun, Nam Hoon Kim, Won Ki Bae, Young Soo Moon. [Efficacy of 48-week clevudine therapy for chronic hepatitis B]. The Korean journal of hepatology. 2009 Sep; 15(3):331-7. doi: 10.3350/kjhep.2009.15.3.331. [PMID: 19783882]
Heon Ju Lee, Jong Ryul Eun, Chang Hyeong Lee, Jae Seok Hwang, Jeong Ill Suh, Byung Seok Kim, Byoung Kuk Jang. [Long-term clevudine therapy in nucleos(t)ide-naïve and lamivudine-experienced patients with hepatitis B virus-related chronic liver diseases]. The Korean journal of hepatology. 2009 Jun; 15(2):179-92. doi: 10.3350/kjhep.2009.15.2.179. [PMID: 19581770]
Soon Young Ko, So Young Kwon, Won Hyeok Choe, Byung Kook Kim, Kyun-Hwan Kim, Chang Hong Lee. Clinical and virological responses to clevudine therapy in chronic hepatitis B patients: results at 1 year of an open-labelled prospective study. Antiviral therapy. 2009; 14(4):585-90. doi: NULL. [PMID: 19578244]
L H Lindner, H Ostermann, W Hiddemann, A Kiani, M Würfel, T Illmer, C Karsch, U Platzbecker, G Ehninger, E Schleyer. AraU accumulation in patients with renal insufficiency as a potential mechanism for cytarabine neurotoxicity. International journal of hematology. 2008 Nov; 88(4):381-386. doi: 10.1007/s12185-008-0171-7. [PMID: 18836794]
S G Lim, N Leung, H W L Hann, G K K Lau, C Trepo, H Mommeja-Marin, C Moxham, J Sorbel, A Snow, M R Blum, F Rousseau, P Marcellin. Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti-viral activity of clevudine for 12 weeks in patients with chronic hepatitis B. Alimentary pharmacology & therapeutics. 2008 Jun; 27(12):1282-92. doi: 10.1111/j.1365-2036.2008.03686.x. [PMID: 18363895]
Joo Ho Tai, Binh Nguyen, R Glenn Wells, Michael S Kovacs, Rebecca McGirr, Frank S Prato, Timothy G Morgan, Savita Dhanvantari. Imaging of gene expression in live pancreatic islet cell lines using dual-isotope SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Jan; 49(1):94-102. doi: 10.2967/jnumed.107.043430. [PMID: 18077534]
Peter S Conti, James R Bading, Peter P Mouton, Jonathan M Links, Mian M Alauddin, John D Fissekis, Hayden T Ravert, John Hilton, Dean F Wong, James H Anderson. In vivo measurement of cell proliferation in canine brain tumor using C-11-labeled FMAU and PET. Nuclear medicine and biology. 2008 Jan; 35(1):131-41. doi: 10.1016/j.nucmedbio.2007.09.003. [PMID: 18158952]
Congrong Niu, Eisuke Murakami, Phillip A Furman. Clevudine is efficiently phosphorylated to the active triphosphate form in primary human hepatocytes. Antiviral therapy. 2008; 13(2):263-9. doi: NULL. [PMID: 18505177]
Byung Chul Yoo, Ju Hyun Kim, Young-Hwa Chung, Kwan Sik Lee, Seung Woon Paik, Soo Hyung Ryu, Byung Hoon Han, Joon-Yeol Han, Kwan Soo Byun, Mong Cho, Heon-Ju Lee, Tae-Hun Kim, Se-Hyun Cho, Joong-Won Park, Soon-Ho Um, Seong Gyu Hwang, Young Soo Kim, Youn-Jae Lee, Chae Yoon Chon, Byung-Ik Kim, Young-Suk Lee, Jin-Mo Yang, Haak Cheoul Kim, Jae Seok Hwang, Sung-Kyu Choi, Young-Oh Kweon, Sook-Hyang Jeong, Myung-Seok Lee, Jong-Young Choi, Dae-Ghon Kim, Yun Soo Kim, Heon Young Lee, Kwon Yoo, Hee-Won Yoo, Hyo-Suk Lee. Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B. Hepatology (Baltimore, Md.). 2007 May; 45(5):1172-8. doi: 10.1002/hep.21629. [PMID: 17464992]
Sridhar Nimmagadda, Thomas J Mangner, Kirk A Douglas, Otto Muzik, Anthony F Shields. Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2007 Apr; 48(4):655-60. doi: 10.2967/jnumed.106.036830. [PMID: 17401105]
Ersin Karatayli, Selim Karayalçin, Hayri Karaaslan, Handan Kayhan, A Resat Türkyilmaz, Fikret Sahin, Cihan Yurdaydin, A Mithat Bozdayi. A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment. Antiviral therapy. 2007; 12(5):761-8. doi: . [PMID: 17713159]
Kwan Sik Lee, Kwan Soo Byun, Young-Hwa Chung, Seung Woon Paik, Joon-Yeol Han, Kwon Yoo, Hee-Won Yoo, Byung Chul Yoo, Hyo-Suk Lee. Clevudine therapy for 24 weeks further reduced serum hepatitis B virus DNA levels and increased ALT normalization rates without emergence of viral breakthrough than 12 weeks of clevudine therapy. Intervirology. 2007; 50(4):296-302. doi: 10.1159/000105442. [PMID: 17622789]
Eun-Woo Lee, Yurong Lai, Huixia Zhang, Jashvant D Unadkat. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. The Journal of biological chemistry. 2006 Jun; 281(24):16700-6. doi: 10.1074/jbc.m513825200. [PMID: 16595656]
Seng Gee Lim, Zahary Krastev, Tay Meng Ng, Grigor Mechkov, Iskren Andreev Kotzev, Sing Chan, Elsa Mondou, Andrea Snow, Jeff Sorbel, Franck Rousseau. Randomized, double-blind study of emtricitabine (FTC) plus clevudine versus FTC alone in treatment of chronic hepatitis B. Antimicrobial agents and chemotherapy. 2006 May; 50(5):1642-8. doi: 10.1128/aac.50.5.1642-1648.2006. [PMID: 16641430]
Hyo-Suk Lee, Young-Hwa Chung, Kwansik Lee, Kwan Soo Byun, Seung Woon Paik, Joon-Yeol Han, Kwon Yoo, Hee-Won Yoo, Jin Heon Lee, Byung Chul Yoo. A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B. Hepatology (Baltimore, Md.). 2006 May; 43(5):982-8. doi: 10.1002/hep.21166. [PMID: 16628625]
Haihao Sun, Jerry M Collins, Thomas J Mangner, Otto Muzik, Anthony F Shields. Imaging the pharmacokinetics of [F-18]FAU in patients with tumors: PET studies. Cancer chemotherapy and pharmacology. 2006 Feb; 57(3):343-8. doi: 10.1007/s00280-005-0037-0. [PMID: 16001172]
Haihao Sun, Thomas J Mangner, Jerry M Collins, Otto Muzik, Kirk Douglas, Anthony F Shields. Imaging DNA synthesis in vivo with 18F-FMAU and PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Feb; 46(2):292-6. doi: NULL. [PMID: 15695789]
Haihao Sun, Andrew Sloan, Thomas J Mangner, Ulka Vaishampayan, Otto Muzik, Jerry M Collins, Kirk Douglas, Anthony F Shields. Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer. European journal of nuclear medicine and molecular imaging. 2005 Jan; 32(1):15-22. doi: 10.1007/s00259-004-1713-8. [PMID: 15586282]
A C Jacquard, M Nassal, C Pichoud, S Ren, U Schultz, S Guerret, M Chevallier, B Werle, S Peyrol, C Jamard, L T Rimsky, C Trepo, F Zoulim. Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection. Antimicrobial agents and chemotherapy. 2004 Jul; 48(7):2683-92. doi: 10.1128/aac.48.7.2683-2692.2004. [PMID: 15215126]
Patrick Marcellin, Herve Mommeja-Marin, Stephen L Sacks, George K K Lau, Daniel Sereni, Jean-Pierre Bronowicki, Brian Conway, Christian Trepo, M Robert Blum, Byung Chul Yoo, Elsa Mondou, Jeff Sorbel, Andrea Snow, Franck Rousseau, Hyo-Suk Lee. A phase II dose-escalating trial of clevudine in patients with chronic hepatitis B. Hepatology (Baltimore, Md.). 2004 Jul; 40(1):140-8. doi: 10.1002/hep.20257. [PMID: 15239097]
Yurong Lai, Chung-Ming Tse, Jashvant D Unadkat. Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. The Journal of biological chemistry. 2004 Feb; 279(6):4490-7. doi: 10.1074/jbc.m307938200. [PMID: 14607828]
Haihao Sun, Jerry M Collins, Thomas J Mangner, Otto Muzik, Anthony F Shields. Imaging [18F]FAU [1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) uracil] in dogs. Nuclear medicine and biology. 2003 Jan; 30(1):25-30. doi: 10.1016/s0969-8051(02)00376-1. [PMID: 12493539]
Li Lu, Linda Samuelsson, Mats Bergström, Kengo Sato, Karl-Johan Fasth, Bengt Långström. Rat studies comparing 11C-FMAU, 18F-FLT, and 76Br-BFU as proliferation markers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2002 Dec; 43(12):1688-98. doi: NULL. [PMID: 12468521]
Juri Gelovani Tjuvajev, Mikhail Doubrovin, Timothy Akhurst, Shangde Cai, Julius Balatoni, Mian M Alauddin, Ronald Finn, William Bornmann, Howard Thaler, Peter S Conti, Ronald G Blasberg. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2002 Aug; 43(8):1072-83. doi: NULL. [PMID: 12163634]
Ayman M Abdelhamed, Colleen M Kelley, Thomas G Miller, Phillip A Furman, Harriet C Isom. Rebound of hepatitis B virus replication in HepG2 cells after cessation of antiviral treatment. Journal of virology. 2002 Aug; 76(16):8148-60. doi: 10.1128/jvi.76.16.8148-8160.2002. [PMID: 12134020]
Stephan Menne, Carol A Roneker, Brent E Korba, John L Gerin, Bud C Tennant, Paul J Cote. Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. Journal of virology. 2002 Jun; 76(11):5305-14. doi: 10.1128/jvi.76.11.5305-5314.2002. [PMID: 11991959]
Toshiki Yamamoto, Samuel Litwin, Tianlun Zhou, Yuao Zhu, Lynn Condreay, Phillip Furman, William S Mason. Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil. Journal of virology. 2002 Feb; 76(3):1213-23. doi: 10.1128/jvi.76.3.1213-1223.2002. [PMID: 11773397]
Stephan Menne, Carol A Roneker, Bud C Tennant, Brent E Korba, John L Gerin, Paul J Cote. Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection. Intervirology. 2002; 45(4-6):237-50. doi: 10.1159/000067914. [PMID: 12566706]
J Tjuvajev, R Blasberg, X Luo, L M Zheng, I King, D Bermudes. Salmonella-based tumor-targeted cancer therapy: tumor amplified protein expression therapy (TAPET) for diagnostic imaging. Journal of controlled release : official journal of the Controlled Release Society. 2001 Jul; 74(1-3):313-5. doi: 10.1016/s0168-3659(01)00340-6. [PMID: 11489512]
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