zolpidem (BioDeep_00000406066)
Main id: BioDeep_00000001912
代谢物信息卡片
zolpidem
化学式: C19H21N3O (307.1684536)
中文名称: 唑吡坦
谱图信息:
最多检出来源 Viridiplantae(plant) 83.33%
分子结构信息
SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C
InChI: InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CF - Benzodiazepine related drugs
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
同义名列表
1 个代谢物同义名
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:10125
- KEGG: C07219
- KEGGdrug: D08690
- PubChem: 5732
- DrugBank: DB00425
- ChEMBL: CHEMBL911
- MeSH: Zolpidem
- CAS: 82626-48-0
- MoNA: WA000328
- MoNA: WA000327
- MoNA: WA000326
- MoNA: WA000325
- MoNA: WA000324
- MoNA: WA000323
- MoNA: FiehnHILIC002428
- MoNA: FiehnHILIC000870
- PubChem: 9428
- PDB-CCD: R5R
- NIKKAJI: J33.161I
- RefMet: Zolpidem
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Q Zhang, M Zhang, Y Liu, Y Wang, F Lv, Y Wang. [Exploring the therapeutic mechanism of Liuwei Suanzao decoction for perimenopausal insomnia based on network pharmacology and animal experiments].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2023 Sep; 43(9):1536-1547. doi:
10.12122/j.issn.1673-4254.2023.09.11. [PMID: 37814868] - Jumpei Saito, Yoshiyuki Tachibana, Yuka Sano Wada, Hiroyo Kawasaki, Yoriko Miura, Motoko Oho, Kaori Aoyagi, Naho Yakuwa, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Presence of Hypnotics in the Cord Blood and Breast Milk, with No Adverse Effects in the Infant: A Case Report.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2022 04; 17(4):349-352. doi:
10.1089/bfm.2021.0321. [PMID: 34935466] - Anna Carfora, Carlo Pietro Campobasso, Paola Cassandro, Raffaella Petrella, Renata Borriello. Long-Term Detection in Hair of Zolpidem, Oxazepam and Flunitrazepam in a Case of Drug-Facilitated Sexual Assault.
Journal of analytical toxicology.
2022 Feb; 46(1):e16-e20. doi:
10.1093/jat/bkaa174. [PMID: 33180140] - O V Kotova, E V Tsareva, V E Medvedev, A A Belyaev, E V Gushanskaya, V I Frolova, I G Kotelnikova. [Clinical aspects of the use of imidazopyridine derivatives in the treatment of sleep disorders associated with post-COVID syndrome].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2022; 122(12):39-44. doi:
10.17116/jnevro202212212139. [PMID: 36537629] - Zhennan Xiao, Bo Long, Zeji Zhao. The Effect of Improving Preoperative Sleep Quality on Perioperative Pain by Zolpidem in Patients Undergoing Laparoscopic Colorectal Surgery: A Prospective, Randomized Study.
Pain research & management.
2022; 2022(?):3154780. doi:
10.1155/2022/3154780. [PMID: 35069955] - Donata Favretto, Sindi Visentin, Alan W Jones. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret.
Forensic science international.
2022 Jan; 330(?):111097. doi:
10.1016/j.forsciint.2021.111097. [PMID: 34814082] - Seonghae Yoon, Seongmee Jeong, Eben Jung, Ki Soon Kim, Inseung Jeon, Yujin Lee, Joo-Youn Cho, Woo-Yong Oh, Jae-Yong Chung. Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem.
Scientific reports.
2021 09; 11(1):19150. doi:
10.1038/s41598-021-98689-z. [PMID: 34580385] - Hubert Bland, Xiaodong Li, Eric Mangin, Ka Lai Yee, Christopher Lines, W Joseph Herring, Gillian Gillespie. Effects of Bedtime Dosing With Suvorexant and Zolpidem on Balance and Psychomotor Performance in Healthy Elderly Participants During the Night and in the Morning.
Journal of clinical psychopharmacology.
2021 Jul; 41(4):414-420. doi:
10.1097/jcp.0000000000001439. [PMID: 34181362] - Seon Yeong Kim, Nam Hee Kwon, Jae Chul Cheong, Jin Young Kim. LC-MS/MS method for determining picogram-level of zolpidem and its main metabolites in hair using a zirconia-based sorbent.
Talanta.
2021 Jun; 228(?):122041. doi:
10.1016/j.talanta.2020.122041. [PMID: 33773721] - Xiaomei I Liu, John N van den Anker, Gilbert J Burckart, André Dallmann. Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups.
Journal of clinical pharmacology.
2021 06; 61 Suppl 1(?):S94-S107. doi:
10.1002/jcph.1845. [PMID: 34185902] - Inayat Ur Rehman, Raheel Ahmed, Aziz Ur Rahman, David Bin Chia Wu, Syed Munib, Yasar Shah, Nisar Ahmad Khan, Ateeq Ur Rehman, Learn Han Lee, Kok Gan Chan, Tahir Mehmood Khan. Effectiveness and safety profiling of zolpidem and acupressure in CKD associated pruritus: An interventional study.
Medicine.
2021 05; 100(21):e25995. doi:
10.1097/md.0000000000025995. [PMID: 34032717] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Liu Jinlei, Amin Wurita, Wei Xuejun, Yang Hongkun, Gu Jie, Chen Liqin. Supramolecular solvent (SUPRASs) extraction method for detecting benzodiazepines and zolpidem in human urine and blood using gas chromatography tandem mass spectrometry.
Legal medicine (Tokyo, Japan).
2021 Feb; 48(?):101822. doi:
10.1016/j.legalmed.2020.101822. [PMID: 33285339] - Magdalene M Assimon, Jennifer E Flythe. Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis.
Clinical journal of the American Society of Nephrology : CJASN.
2020 12; 16(1):88-97. doi:
10.2215/cjn.10070620. [PMID: 33355192] - Rafael L M Paraiso, Rachel H Rose, Nikoletta Fotaki, Mark McAllister, Jennifer B Dressman. The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Dec; 155(?):105534. doi:
10.1016/j.ejps.2020.105534. [PMID: 32871212] - Szabolcs Sofalvi, Eric S Lavins, Claire K Kaspar, Haley M Michel, Christie L Mitchell-Mata, Marilyn A Huestis, Luigino G Apollonio. Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction.
Journal of analytical toxicology.
2020 Oct; 44(7):708-717. doi:
10.1093/jat/bkaa072. [PMID: 32808043] - Eui Hyun Jung, Choong-Min Lee, Ji-Yeong Byeon, Hyo-Bin Shin, Kyung-Yul Oh, Chang-Keun Cho, Chang Woo Lim, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee. Relationship between plasma exposure of zolpidem and CYP2D6 genotype in healthy Korean subjects.
Archives of pharmacal research.
2020 Sep; 43(9):976-981. doi:
10.1007/s12272-020-01250-1. [PMID: 32661920] - Xijun Zheng, Yingchun He, Fang Yin, Hongxia Liu, Yunfei Li, Qingshan Zheng, Lujin Li. Pharmacological interventions for the treatment of insomnia: quantitative comparison of drug efficacy.
Sleep medicine.
2020 08; 72(?):41-49. doi:
10.1016/j.sleep.2020.03.022. [PMID: 32544795] - Hong Joon Ahn, Won Joon Jeong, Kwan Jae Kim, Sun Cheun Kim, Dong Woo Kim, Hye Jin Chang, Chang Shin Kang, Se Kwang Oh, Sung Uk Cho, Jin Hong Min, Yong Chul Cho, Jung Soo Park, Seung Ryu, Yeon Ho You, Jing Woong Lee, Min Su Kim. Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia.
Clinical toxicology (Philadelphia, Pa.).
2020 06; 58(6):501-503. doi:
10.1080/15563650.2019.1663206. [PMID: 31512527] - Gustavo D Mendes, Thais da Silva Pereira, Júlio César Rodrigues, Elaine Marcílio Santos, Mariani Rafaela Souza, Rodrigo Alvaro Brandão Lopes-Martins, Natalícia de Jesus Antunes, Ronilson Agnaldo Moreno, Gilberto De Nucci. Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high-performance liquid chromatography coupled to tandem mass spectrometry.
Biomedical chromatography : BMC.
2020 Apr; 34(4):e4731. doi:
10.1002/bmc.4731. [PMID: 31652344] - Choong-Min Lee, Eui Hyun Jung, Ji-Yeong Byeon, Se-Hyung Kim, Choon-Gon Jang, Yun Jeong Lee, Seok-Yong Lee. Effects of steady-state clarithromycin on the pharmacokinetics of zolpidem in healthy subjects.
Archives of pharmacal research.
2019 Dec; 42(12):1101-1106. doi:
10.1007/s12272-019-01201-5. [PMID: 31820397] - Thomas Dahl, Lan Bo Chen, Mika Scheinin, Jaana Suopanki-Lalowski, Marju Valge, Antti Puhakka, Hannu Mikola, Zsófia Lovró, Axel Meierjohann, Lauri Vuorilehto, Thomas Roth. Pharmacodynamic and pharmacokinetic profile of SM-1, a triple-drug combination to increase total sleep time.
Human psychopharmacology.
2019 11; 34(6):e2716. doi:
10.1002/hup.2716. [PMID: 31794072] - Rafael Leal Monteiro Paraiso, Ayahisa Watanabe, Cord J Andreas, David Turner, Patricia Zane, Jennifer Dressman. In-vitro-in-silico investigation of the negative food effect of zolpidem when administered as immediate-release tablets.
The Journal of pharmacy and pharmacology.
2019 Nov; 71(11):1663-1676. doi:
10.1111/jphp.13161. [PMID: 31566757] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Timothy Roehrs, Thomas Roth. Hyperarousal in insomnia: pre-sleep and diurnal cortisol levels in response to chronic zolpidem treatment.
Sleep medicine.
2019 09; 61(?):52-56. doi:
10.1016/j.sleep.2019.04.010. [PMID: 31255482] - Xueyi Feng, Hang Chen, Ping Xiang, Min Shen. Zolpidem and zolpidem phenyl-4-carboxylic acid pharmacokinetics in oral fluid after a single dose.
Drug testing and analysis.
2019 Jul; 11(7):1076-1082. doi:
10.1002/dta.2594. [PMID: 30912258] - Carsten Theodor Beuckmann, Takashi Ueno, Makoto Nakagawa, Michiyuki Suzuki, Shigeru Akasofu. Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation.
Sleep.
2019 06; 42(6):. doi:
10.1093/sleep/zsz076. [PMID: 30923834] - Sangoh Kwon, Minseok Yoon, Jaekwang Lee, Kwang-Deog Moon, Dohyeon Kim, Seon-Bong Kim, Suengmok Cho. A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice.
Nutrients.
2019 Mar; 11(3):. doi:
10.3390/nu11030556. [PMID: 30845636] - Koutaro Hasegawa, Amin Wurita, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki. Fatal zolpidem poisoning due to its intravenous self-injection: Postmortem distribution/redistribution of zolpidem and its predominant metabolite zolpidem phenyl-4-carboxylic acid in body fluids and solid tissues in an autopsy case.
Forensic science international.
2018 Sep; 290(?):111-120. doi:
10.1016/j.forsciint.2018.06.044. [PMID: 30015275] - Ji-Yeong Byeon, Young-Hoon Kim, Se-Hyung Kim, Choong-Min Lee, Eui-Hyun Jung, Won-Ki Chae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee. The influences of CYP2C9*1/*3 genotype on the pharmacokinetics of zolpidem.
Archives of pharmacal research.
2018 Sep; 41(9):931-936. doi:
10.1007/s12272-018-1070-y. [PMID: 30178440] - Sheng Feng, Oneka T Cummings, Gregory McIntire. Zolpidem and Zolpidem Carboxylic Acid Results from Medication Monitoring.
Journal of analytical toxicology.
2018 Sep; 42(7):491-495. doi:
10.1093/jat/bky033. [PMID: 29750249] - Inayat Ur Rehman, David Bin-Chia Wu, Raheel Ahmed, Nisar Ahmad Khan, Aziz Ur Rahman, Syed Munib, Learn Han Lee, Kok Gan Chan, Tahir Mehmood Khan. A randomized controlled trial for effectiveness of zolpidem versus acupressure on sleep in hemodialysis patients having chronic kidney disease-associated pruritus.
Medicine.
2018 08; 97(31):e10764. doi:
10.1097/md.0000000000010764. [PMID: 30075491] - Ji-Yeong Byeon, Young-Hoon Kim, Se-Hyung Kim, Choong-Min Lee, Eui-Hyun Jung, Won-Ki Chae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee. Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem.
Archives of pharmacal research.
2018 Aug; 41(8):861-866. doi:
10.1007/s12272-018-1065-8. [PMID: 30117082] - Kai Zhao, Xiaoqian Luan, Yuntao Liu, Xinjie Tu, Huijun Chen, Huiping Shen, Huihua Qiu, Zhuoying Zhu, Jincai He. Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months.
Clinica chimica acta; international journal of clinical chemistry.
2017 Dec; 475(?):147-151. doi:
10.1016/j.cca.2017.10.024. [PMID: 29080688] - NULL. Good Night's Sleep Gone Wrong.
AORN journal.
2017 10; 106(4):360-331. doi:
10.1016/j.aorn.2017.07.001. [PMID: 28958323] - Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, Matthias Gabler, Pascal Heitel, Jan Kramer, Astrid Kaiser, Markus Hartmann, Mara Lindner, Kerstin Lüddens-Dämgen, Jan Heering, Christina Lamers, Hartmut Lüddens, Mario Wurglics, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk. Nonacidic Farnesoid X Receptor Modulators.
Journal of medicinal chemistry.
2017 08; 60(16):7199-7205. doi:
10.1021/acs.jmedchem.7b00903. [PMID: 28749691] - Christopher L Drake, Heith Durrence, Philip Cheng, Thomas Roth, Vivek Pillai, Edward L Peterson, Meeta Singh, Kieulinh Michelle Tran. Arousability and Fall Risk During Forced Awakenings From Nocturnal Sleep Among Healthy Males Following Administration of Zolpidem 10 mg and Doxepin 6 mg: A Randomized, Placebo-Controlled, Four-Way Crossover Trial.
Sleep.
2017 07; 40(7):. doi:
10.1093/sleep/zsx086. [PMID: 28575467] - Cord J Andreas, Xavier Pepin, Constantinos Markopoulos, Maria Vertzoni, Christos Reppas, Jennifer B Dressman. Mechanistic investigation of the negative food effect of modified release zolpidem.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 May; 102(?):284-298. doi:
10.1016/j.ejps.2017.03.011. [PMID: 28286289] - Jaime M Monti, David Warren Spence, Kenneth Buttoo, Seithikurippu R Pandi-Perumal. Zolpidem's use for insomnia.
Asian journal of psychiatry.
2017 Feb; 25(?):79-90. doi:
10.1016/j.ajp.2016.10.006. [PMID: 28262178] - Bandar Essa Al-Dhubiab. In vitro and in vivo evaluation of nano-based films for buccal delivery of zolpidem.
Brazilian oral research.
2016 Nov; 30(1):e126. doi:
10.1590/1807-3107bor-2016.vol30.0126. [PMID: 27901207] - Cheng-Tai Li, Tung-Ping Su, Yanfeng Wang, Benjamin Lee, Melvin Toh, Tony Ho. Pharmacokinetics of a Novel Zolpidem Nasal Spray for Rapid Management of Insomnia: First Trial in Humans.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
2016 11; 12(11):1453-1459. doi:
10.5664/jcsm.6264. [PMID: 27568900] - Hyejin Yang, Junsung Woo, Ae Nim Pae, Min Young Um, Nam-Chul Cho, Ki Duk Park, Minseok Yoon, Jiyoung Kim, C Justin Lee, Suengmok Cho. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors.
Molecular pharmacology.
2016 Nov; 90(5):530-539. doi:
10.1124/mol.116.105080. [PMID: 27573669] - Andrea E Steuer, Michael Poetzsch, Thomas Kraemer. MALDI-MS drug analysis in biological samples: opportunities and challenges.
Bioanalysis.
2016 Sep; 8(17):1859-78. doi:
10.4155/bio-2016-0158. [PMID: 27524467] - Yanfeng Wang, Mi Li, Shuai Qian, Qizhi Zhang, Limin Zhou, Zhong Zuo, Benjamin Lee, Melvin Toh, Tony Ho. Zolpidem Mucoadhesive Formulations for Intranasal Delivery: Characterization, In Vitro Permeability, Pharmacokinetics, and Nasal Ciliotoxicity in Rats.
Journal of pharmaceutical sciences.
2016 09; 105(9):2840-2847. doi:
10.1016/j.xphs.2016.03.035. [PMID: 27189774] - T A Roehrs, T Roth. Hyperarousal in insomnia and hypnotic dose escalation.
Sleep medicine.
2016 07; 23(?):16-20. doi:
10.1016/j.sleep.2016.06.008. [PMID: 27692272] - Beril Anilanmert, Fatma Çavuş, Ibrahim Narin, Salih Cengiz, Şefika Sertler, Ali Acar Özdemir, Münevver Açikkol. Simultaneous analysis method for GHB, ketamine, norketamine, phenobarbital, thiopental, zolpidem, zopiclone and phenytoin in urine, using C18 poroshell column.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):230-241. doi:
10.1016/j.jchromb.2016.03.040. [PMID: 27107852] - Yu-Dong Jeong, Min Kyung Kim, Sung Ill Suh, Moon Kyo In, Jin Young Kim, Ki-Jung Paeng. Rapid determination of benzodiazepines, zolpidem and their metabolites in urine using direct injection liquid chromatography-tandem mass spectrometry.
Forensic science international.
2015 Dec; 257(?):84-92. doi:
10.1016/j.forsciint.2015.07.043. [PMID: 26282513] - Anna Fuhl, Florian Müller-Dahlhaus, Caroline Lücke, Stefan W Toennes, Ulf Ziemann. Low Doses of Ethanol Enhance LTD-like Plasticity in Human Motor Cortex.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Dec; 40(13):2969-80. doi:
10.1038/npp.2015.151. [PMID: 26038159] - Yong-zhi Zhang, Hong-yuan He, Cai-meng She, Jie Lian. [Research Progress on Forensic Toxicology of Z-drugs].
Fa yi xue za zhi.
2015 Aug; 31(4):293-7. doi:
. [PMID: 26665884] - ". Drugs for Insomnia.
The Medical letter on drugs and therapeutics.
2015 Jul; 57(1472):95-8. doi:
". [PMID: 26147892] - Binfeng Xia, Zhen Yang, Haiying Zhou, Viera Lukacova, Wei Zhu, Mikolaj Milewski, Filippos Kesisoglou. Development of a Novel Oral Cavity Compartmental Absorption and Transit Model for Sublingual Administration: Illustration with Zolpidem.
The AAPS journal.
2015 May; 17(3):631-42. doi:
10.1208/s12248-015-9727-7. [PMID: 25716146] - Ji-Yeong Byeon, Hye-In Lee, Yun-Jeong Lee, Jung-Eun Lee, Se-Hyung Kim, Young-Hoon Kim, Han-Sung Na, Choon-Gon Jang, Seok-Yong Lee. Determination of zolpidem in human plasma by liquid chromatography-tandem mass spectrometry for clinical application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Apr; 986-987(?):129-34. doi:
10.1016/j.jchromb.2015.02.004. [PMID: 25728370] - Ralph Francis Mangusan, Vallire Hooper, Sheri A Denslow, Lucille Travis. Outcomes associated with postoperative delirium after cardiac surgery.
American journal of critical care : an official publication, American Association of Critical-Care Nurses.
2015 Mar; 24(2):156-63. doi:
10.4037/ajcc2015137. [PMID: 25727276] - Lawrence A Galitz, Shyamalie Jayawardena, Sandy A Furey. Pharmacokinetic effects of simultaneous administration of single-dose gabapentin 500 mg and zolpidem tartrate 10 mg in healthy volunteers: a randomized, open-label, crossover trial.
Drugs in R&D.
2015 Mar; 15(1):71-7. doi:
10.1007/s40268-014-0079-z. [PMID: 25567214] - Chris Stockmann, Michele M Gottschlich, Daniel Healy, Jane C Khoury, Theresa Mayes, Catherine M T Sherwin, Michael G Spigarelli, Richard J Kagan. Relationship between zolpidem concentrations and sleep parameters in pediatric burn patients.
Journal of burn care & research : official publication of the American Burn Association.
2015 Jan; 36(1):137-44. doi:
10.1097/bcr.0000000000000164. [PMID: 25185933] - Janne Nurminen, Juha Puustinen, Ritva Lähteenmäki, Tero Vahlberg, Alan Lyles, Markku Partinen, Ismo Räihä, Pertti J Neuvonen, Sirkka-Liisa Kivelä. Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics.
BMC geriatrics.
2014 Nov; 14(?):121. doi:
10.1186/1471-2318-14-121. [PMID: 25416480] - Kristi S Thompson, Russell J Lewis, Roxane M Ritter. Analysis of zolpidem in postmortem fluids and tissues using ultra-performance liquid chromatography-mass spectrometry.
Journal of analytical toxicology.
2014 Oct; 38(8):507-12. doi:
10.1093/jat/bku062. [PMID: 25217538] - David J Greenblatt, Jerold S Harmatz, Nikhilesh N Singh, Frank Steinberg, Thomas Roth, Stephen C Harris, Ram P Kapil. Pharmacokinetics of zolpidem from sublingual zolpidem tartrate tablets in healthy elderly versus non-elderly subjects.
Drugs & aging.
2014 Oct; 31(10):731-6. doi:
10.1007/s40266-014-0211-3. [PMID: 25246162] - David M Schwope, Anne DePriest, David L Black, Yale H Caplan, Edward J Cone, Rebecca Heltsley. Determining zolpidem compliance: urinary metabolite detection and prevalence in chronic pain patients.
Journal of analytical toxicology.
2014 Oct; 38(8):513-8. doi:
10.1093/jat/bku068. [PMID: 25217539] - Lindsey M Mann, Rabia S Atayee, Brookie M Best, Candis M Morello, Joseph D Ma. Urine specimen detection of zolpidem use in patients with pain.
Journal of analytical toxicology.
2014 Jul; 38(6):322-6. doi:
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Therapeutic drug monitoring.
2014 Jun; 36(3):295-301. doi:
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Acta pharmaceutica Sinica. B.
2014 Apr; 4(2):146-50. doi:
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Drug testing and analysis.
2014 Mar; 6(3):226-33. doi:
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Journal of clinical pharmacology.
2014 Mar; 54(3):282-90. doi:
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European journal of clinical pharmacology.
2014 Mar; 70(3):319-29. doi:
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Analytical and bioanalytical chemistry.
2014 Jan; 406(3):803-18. doi:
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Pediatric emergency care.
2013 Nov; 29(11):1204-6. doi:
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Journal of clinical pharmacology.
2013 Nov; 53(11):1194-8. doi:
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Planta medica.
2013 Oct; 79(15):1408-12. doi:
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Journal of analytical toxicology.
2013 Jul; 37(6):369-75. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2013 Jun; 9(2):155-62. doi:
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Revista espanola de salud publica.
2013 May; 87(3):247-55. doi:
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Clinical therapeutics.
2013 May; 35(5):604-11. doi:
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Forensic science international.
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Indian journal of pharmacology.
2013 Jan; 45(1):34-9. doi:
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PloS one.
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2012 Dec; 911(?):140-6. doi:
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2012 Nov; 50(10):893-901. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2012 Oct; 109(40):16330-5. doi:
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American journal of veterinary research.
2012 Oct; 73(10):1650-6. doi:
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2012 Sep; 36(7):472-6. doi:
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Bioorganic & medicinal chemistry.
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International journal of legal medicine.
2012 May; 126(3):451-9. doi:
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Mayo Clinic proceedings.
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Clinical and experimental pharmacology & physiology.
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Analytical and bioanalytical chemistry.
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