Mangiferin (BioDeep_00000018968)

Main id: BioDeep_00000230176

 

human metabolite PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one

化学式: C19H18O11 (422.0849078)
中文名称: 芒果苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc1c(c2=O)cc(c(c1)O)O)O)[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
InChI: InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2

描述信息

Mangiferin is found in fruits. Mangiferin is a constituent of Mangifera indica (mango)
Constituent of Mangifera indica (mango). Mangiferin is found in mango and fruits.
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3].
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[1][2][3].

同义名列表

18 个代谢物同义名

1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one; 2-b-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, 9ci; 2-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy xanthone; 1,3,6,7-Tetrahydroxyxanthone C2-beta-D-glucoside; Mangiferin from mangifera indica bark; MLS000563058; Mannipherin; Chedisaride; Euxanthogen; Hedysaride; Alpizarine; Mangiferin; Chinoinin; Hedysarid; Chinomine; alpizarin; Chinomin; Aphloiol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

110 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dominika Zajac, Agnieszka Stasinska, Rene Delgado, Mieczyslaw Pokorski. Mangiferin and its traversal into the brain. Advances in experimental medicine and biology. 2013; 756(?):105-11. doi: 10.1007/978-94-007-4549-0_14. [PMID: 22836625]
  • Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang, Chenggang Huang. Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats. Drug metabolism and disposition: the biological fate of chemicals. 2012 Nov; 40(11):2109-18. doi: 10.1124/dmd.112.045849. [PMID: 22859782]
  • Alexandra Hudecová, Barbara Kusznierewicz, Elise Rundén-Pran, Zuzana Magdolenová, Katarína Hasplová, Alessandra Rinna, Lise Marie Fjellsbø, Marcin Kruszewski, Anna Lankoff, Wiggo Johan Sandberg, Magne Refsnes, Tonje Skuland, Per Schwarze, Gunnar Brunborg, Magnar Bjøras, Andrew Collins, Eva Miadoková, Eliska Gálová, Mária Dusinská. Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea. Mutagenesis. 2012 Nov; 27(6):759-69. doi: 10.1093/mutage/ges046. [PMID: 22940646]
  • Bosai He, Qing Li, Ying Jia, Longshan Zhao, Feng Xiao, Chunxiao Lv, Huarong Xu, Xiaohui Chen, Kaishun Bi. A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats. Journal of mass spectrometry : JMS. 2012 Oct; 47(10):1333-40. doi: 10.1002/jms.3072. [PMID: 23019165]
  • Rui Liu, Zhidong Liu, Chengui Zhang, Boli Zhang. Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: improving in vivo ocular bioavailability. Journal of pharmaceutical sciences. 2012 Oct; 101(10):3833-44. doi: 10.1002/jps.23251. [PMID: 22767401]
  • Yanfen Niu, Wei Lu, Lihui Gao, Hua Lin, Xu Liu, Ling Li. Reducing effect of mangiferin on serum uric acid levels in mice. Pharmaceutical biology. 2012 Sep; 50(9):1177-82. doi: 10.3109/13880209.2012.663763. [PMID: 22881143]
  • Lucía Márquez, Borja García-Bueno, José L M Madrigal, Juan C Leza. Mangiferin decreases inflammation and oxidative damage in rat brain after stress. European journal of nutrition. 2012 Sep; 51(6):729-39. doi: 10.1007/s00394-011-0252-x. [PMID: 21986672]
  • Alexandra Hudecová, Barbara Kusznierewicz, Katarína Hašplová, Anna Huk, Zuzana Magdolenová, Eva Miadoková, Eliška Gálová, Mária Dušinská. Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep; 50(9):3352-9. doi: 10.1016/j.fct.2012.06.017. [PMID: 22721983]
  • I Rodeiro, S Hernandez, J Morffi, J A Herrera, M J Gómez-Lechón, R Delgado, J J Espinosa-Aguirre. Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Sep; 50(9):3360-6. doi: 10.1016/j.fct.2012.06.032. [PMID: 22749943]
  • Hui-Seong Kim, Jae Hyoung Song, Ui Joung Youn, Jin Won Hyun, Woo Seok Jeong, Mi Young Lee, Hwa Jung Choi, Hyeong-Kyu Lee, Sungwook Chae. Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides. European journal of pharmacology. 2012 Aug; 689(1-3):38-44. doi: 10.1016/j.ejphar.2012.05.050. [PMID: 22683868]
  • Claudine Campa, Laurence Mondolot, Arsene Rakotondravao, Luc P R Bidel, Annick Gargadennec, Emmanuel Couturon, Philippe La Fisca, Jean-Jacques Rakotomalala, Christian Jay-Allemand, Aaron P Davis. A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses. Annals of botany. 2012 Aug; 110(3):595-613. doi: 10.1093/aob/mcs119. [PMID: 22700941]
  • Talita Cavalcante Morais, Synara Cavalcante Lopes, Karine Maria Martins Bezerra Carvalho, Bruno Rodrigues Arruda, Francisco Thiago Correia de Souza, Maria Teresa Salles Trevisan, Vietla Satyanarayana Rao, Flávia Almeida Santos. Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism. World journal of gastroenterology. 2012 Jul; 18(25):3207-14. doi: 10.3748/wjg.v18.i25.3207. [PMID: 22783044]
  • Siddaruda M Biradar, Hanumanthachar Joshi, Tarak K Chheda. Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease. European journal of pharmacology. 2012 May; 683(1-3):140-7. doi: 10.1016/j.ejphar.2012.02.042. [PMID: 22426032]
  • Rabyah B Ali, Item J Atangwho, Navneet Kaur, Omar Saad Abraika, Mariam Ahmad, Roziahanim Mahmud, Mohd Z Asmawi. Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract. Molecules (Basel, Switzerland). 2012 Apr; 17(5):4986-5002. doi: 10.3390/molecules17054986. [PMID: 22547320]
  • Joydeep Das, Jyotirmoy Ghosh, Anandita Roy, Parames C Sil. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. Toxicology and applied pharmacology. 2012 Apr; 260(1):35-47. doi: 10.1016/j.taap.2012.01.015. [PMID: 22310181]
  • Bhaskarmurthy Deepak Hiraganahalli, Velusami Chandrasekaran Chinampudur, Shekhar Dethe, Deepak Mundkinajeddu, Manoj Kumar Pandre, Jaya Balachandran, Amit Agarwal. Hepatoprotective and antioxidant activity of standardized herbal extracts. Pharmacognosy magazine. 2012 Apr; 8(30):116-23. doi: 10.4103/0973-1296.96553. [PMID: 22701284]
  • Gorawit Yusakul, Wongsathorn Kitirattrakarn, Narunat Tanwanichkul, Hiroyuki Tanaka, Waraporn Putalun. Development and application of an enzyme-linked immunosorbent assay for specific detection of mangiferin content in various cultivars of Mangifera indica leaves using anti-mangiferin polyclonal antibody. Journal of food science. 2012 Apr; 77(4):C414-9. doi: 10.1111/j.1750-3841.2011.02610.x. [PMID: 22394207]
  • Manoranjan Ghosh, Joydeep Das, Parames C Sil. D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin. Free radical research. 2012 Feb; 46(2):116-32. doi: 10.3109/10715762.2011.644240. [PMID: 22118634]
  • Jixia Li, Margarita Malakhova, Madhusoodanan Mottamal, Kanamata Reddy, Igor Kurinov, Andria Carper, Alyssa Langfald, Naomi Oi, Myoung Ok Kim, Feng Zhu, Carlos P Sosa, Keyuan Zhou, Ann M Bode, Zigang Dong. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer research. 2012 Jan; 72(1):260-70. doi: 10.1158/0008-5472.can-11-2596. [PMID: 22084399]
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  • Yucun Niu, Songtao Li, Lixin Na, Rennan Feng, Liyan Liu, Ying Li, Changhao Sun. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. PloS one. 2012; 7(1):e30782. doi: 10.1371/journal.pone.0030782. [PMID: 22292039]
  • Adam Kokotkiewicz, Maria Luczkiewicz, Anna Hering, Renata Ochocka, Krzysztof Gorynski, Adam Bucinski, Pawel Sowinski. Micropropagation of Cyclopia genistoides, an endemic South African plant of economic importance. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2012 Jan; 67(1-2):65-76. doi: 10.1515/znc-2012-1-209. [PMID: 22486043]
  • Pradeep Pratap Singh, Ambika, Shive Murat Singh Chauhan. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Natural product research. 2012; 26(18):1682-6. doi: 10.1080/14786419.2011.592836. [PMID: 21985644]
  • Jun Hou, Dezhi Zheng, Kaihua Fan, Botao Yu, Wenjing Xiao, Jie Ma, Weihua Jin, Yonghong Tan, Juan Wu. Combination of mangiferin and dipeptidyl peptidase-4 inhibitor sitagliptin improves impaired glucose tolerance in streptozotocin-diabetic rats. Pharmacology. 2012; 90(3-4):177-82. doi: 10.1159/000342128. [PMID: 22948814]
  • Fenglei Luo, Qiang Lv, Yuqin Zhao, Guibing Hu, Guodi Huang, Jiukai Zhang, Chongde Sun, Xian Li, Kunsong Chen. Quantification and purification of mangiferin from Chinese Mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H(2)O(2)-induced stress. International journal of molecular sciences. 2012; 13(9):11260-74. doi: 10.3390/ijms130911260. [PMID: 23109851]
  • Dezhi Zheng, Jun Hou, Yingbin Xiao, Zhe Zhao, Lin Chen. Cardioprotective effect of mangiferin on left ventricular remodeling in rats. Pharmacology. 2012; 90(1-2):78-87. doi: 10.1159/000339450. [PMID: 22759807]
  • Kishalay Jana, Kausik Chatterjee, Kazi Monjur Ali, Debasis De, Tushar Kanti Bera, Debidas Ghosh. Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpinia bonduc on streptozotocin-induced diabetes in male albino rats. Pharmacognosy research. 2012 Jan; 4(1):57-62. doi: 10.4103/0974-8490.91044. [PMID: 22224063]
  • Mukesh S Sikarwar, M B Patil. Antihyperlipidemic activity of Salacia chinensis root extracts in triton-induced and atherogenic diet-induced hyperlipidemic rats. Indian journal of pharmacology. 2012 Jan; 44(1):88-92. doi: 10.4103/0253-7613.91875. [PMID: 22345877]
  • Vietla S Rao, Ana C Carvalho, Maria Teresa S Trevisan, Geanne M Andrade, Helio V Nobre-Júnior, Manoel O Moraes, Hemerson I Magalhães, Talita C Morais, Flavia A Santos. Mangiferin ameliorates 6-hydroxydopamine-induced cytotoxicity and oxidative stress in ketamine model of schizophrenia. Pharmacological reports : PR. 2012; 64(4):848-56. doi: 10.1016/s1734-1140(12)70879-4. [PMID: 23087136]
  • Najla Gooda Sahib, Nazamid Saari, Amin Ismail, Alfi Khatib, Fawzi Mahomoodally, Azizah Abdul Hamid. Plants' metabolites as potential antiobesity agents. TheScientificWorldJournal. 2012; 2012(?):436039. doi: 10.1100/2012/436039. [PMID: 22666121]
  • Angela I Calderón, Johayra Simithy-Williams, Mahabir P Gupta. Antimalarial natural products drug discovery in Panama. Pharmaceutical biology. 2012 Jan; 50(1):61-71. doi: 10.3109/13880209.2011.602417. [PMID: 22196582]
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  • Fuchuan Guo, Conghui Huang, Xilu Liao, Yemei Wang, Ying He, Rennan Feng, Ying Li, Changhao Sun. Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters. Molecular nutrition & food research. 2011 Dec; 55(12):1809-18. doi: 10.1002/mnfr.201100392. [PMID: 22038976]
  • Pascale Talamond, Geneviève Conejero, Jean-Luc Verdeil, Jean-Luc Poëssel. Isolation of C-glycosyl xanthones from Coffea pseudozanguebariae and their location. Natural product communications. 2011 Dec; 6(12):1885-8. doi: ". [PMID: 22312730]
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  • Shashi Kant Singh, Saurabh K Sinha, S K Prasad, R Kumar, Bhawani S Bithu, S Sadish Kumar, P Singh. Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic. Asian Pacific journal of tropical medicine. 2011 Nov; 4(11):866-9. doi: 10.1016/s1995-7645(11)60210-1. [PMID: 22078948]
  • Min Xu, Ming Zhang, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang. Phenolic compounds from the whole plants of Gentiana rhodantha (Gentianaceae). Chemistry & biodiversity. 2011 Oct; 8(10):1891-900. doi: 10.1002/cbdv.201000220. [PMID: 22006717]
  • Dagmar García Rivera, Ivones Hernández, Nelson Merino, Yilian Luque, Alina Álvarez, Yanet Martín, Aylin Amador, Lauro Nuevas, René Delgado. Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma. The Journal of pharmacy and pharmacology. 2011 Oct; 63(10):1336-45. doi: 10.1111/j.2042-7158.2011.01328.x. [PMID: 21899550]
  • A Upaganlawar, R Balaraman. Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study. Journal of young pharmacists : JYP. 2011 Oct; 3(4):297-303. doi: 10.4103/0975-1483.90241. [PMID: 22224036]
  • Fouad Abdulrahman Hassan, Amin Ismail, Azizah Abdulhamid, Azrina Azlan. Identification and quantification of phenolic compounds in bambangan (Mangifera pajang Kort.) peels and their free radical scavenging activity. Journal of agricultural and food chemistry. 2011 Sep; 59(17):9102-11. doi: 10.1021/jf201270n. [PMID: 21800901]
  • Yuan-Yuan Zhang, Qi Wang, Lian-Wen Qi, Xiao-Ying Qin, Min-Jian Qin. Characterization and determination of the major constituents in Belamcandae Rhizoma by HPLC-DAD-ESI-MS(n). Journal of pharmaceutical and biomedical analysis. 2011 Sep; 56(2):304-14. doi: 10.1016/j.jpba.2011.05.040. [PMID: 21715119]
  • Shubhankar Das, B Nageshwar Rao, B S Satish Rao. Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential. Chemico-biological interactions. 2011 Sep; 193(2):129-40. doi: 10.1016/j.cbi.2011.06.002. [PMID: 21703249]
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