Epigalanthamin (BioDeep_00001874892)
代谢物信息卡片
Epigalanthamin
化学式: C17H21NO3 (287.1521356)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 4668 - Amaryllidaceae:
- 205937 - Crinum asiaticum:
- 223245 - Crinum asiaticum var. sinicum:
- 1157045 - Galanthus alpinus var. alpinus:
- 82232 - Galanthus elwesii: 10.1007/BF00567346
- 4670 - Galanthus nivalis:
- 197699 - Galanthus woronowii:
- 54835 - Leucojum aestivum: 10.1248/CPB.43.318
- 108053 - Lycoris sanguinea: 10.1016/S0031-9422(00)89030-5
- 1695117 - Narcissus confusus:
- 54860 - Narcissus tazetta: 10.1016/0031-9422(94)00827-G
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gabriela Haist, Boriana Sidjimova, Elina Yankova-Tsvetkova, Milena Nikolova, Rumen Denev, Ivanka Semerdjieva, Jaume Bastida, Strahil Berkov. Metabolite profiling and histochemical localization of alkaloids in Hippeastrum papilio (Ravena) van Scheepen.
Journal of plant physiology.
2024 May; 296(?):154223. doi:
10.1016/j.jplph.2024.154223. [PMID: 38507926] - M A Aldubayan, A S Alsharidah, S K Alenezi, A H Alhowail. Galantamine mitigates neurotoxicity caused by doxorubicin via reduced neuroinflammation, oxidative stress, and apoptosis in rat model.
European review for medical and pharmacological sciences.
2024 Jan; 28(2):805-813. doi:
10.26355/eurrev_202401_35081. [PMID: 38305623] - Ayca Cimen, Yavuz Baba, Arzu Birinci Yildirim, Arzu Ucar Turker. Do Vermicompost Applications Improve Growth Performance, Pharmaceutically Important Alkaloids, Phenolic Content, Free Radical Scavenging Potency and Defense Enzyme Activities in Summer Snowflake (Leucojum aestivum L.)?.
Chemistry & biodiversity.
2023 Oct; ?(?):e202301074. doi:
10.1002/cbdv.202301074. [PMID: 37779102] - Wenli Shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang. Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 Sep; 305(?):123452. doi:
10.1016/j.saa.2023.123452. [PMID: 37769468] - Kouadio Kra Norbert Bini, Koffi Christophe Kobenan, Malanno Kouakou, Ibrahime Sinan Kouadio, Gokhan Zengin, József Jekő, Zoltán Cziáky, Mathias Danho, Ochou Germain Ochou. Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast.
Archives of insect biochemistry and physiology.
2023 Apr; ?(?):e22017. doi:
10.1002/arch.22017. [PMID: 37185885] - Rupa Sanyal, Manokari M, Sharmila Pandey, Saheli Nandi, Protha Biswas, Saikat Dewanjee, Abilash Valsala Gopalakrishnan, Niraj Kumar Jha, Saurabh Kumar Jha, Nirmal Joshee, Devendra Kumar Pandey, Abhijit Dey, Mahipal S Shekhawat. Biotechnological interventions and production of galanthamine in Crinum spp.
Applied microbiology and biotechnology.
2023 Apr; 107(7-8):2155-2167. doi:
10.1007/s00253-023-12444-0. [PMID: 36922438] - Meng Tang, Chaohan Li, Cheng Zhang, Youming Cai, Yongchun Zhang, Liuyan Yang, Moxian Chen, Fuyuan Zhu, Qingzhu Li, Kehu Li. SWATH-MS-Based Proteomics Reveals the Regulatory Metabolism of Amaryllidaceae Alkaloids in Three Lycoris Species.
International journal of molecular sciences.
2023 Feb; 24(5):. doi:
10.3390/ijms24054495. [PMID: 36901927] - Gabriela Haist, Boriana Sidjimova, Vladimir Vladimirov, Liliya Georgieva, Milena Nikolova, Jaume Bastida, Strahil Berkov. Morphological, cariological, and phytochemical studies of diploid and autotetraploid Hippeastrum papilio plants.
Planta.
2023 Feb; 257(3):51. doi:
10.1007/s00425-023-04084-5. [PMID: 36757512] - Meenakshee Shrivas, Dignesh Khunt, Meera Shrivas, Manju Misra. Studies on pomegranate seed oil enriched galantamine hydrobromide microemulsion: formulation, in vitro antioxidant and neuroprotective potential.
Pharmaceutical development and technology.
2023 Feb; 28(2):153-163. doi:
10.1080/10837450.2023.2171433. [PMID: 36662596] - Luciane B Silva, Elenilze F B Ferreira, Maryam, José M Espejo-Román, Glauber V Costa, Josiane V Cruz, Njogu M Kimani, Josivan S Costa, José A H M Bittencourt, Jorddy N Cruz, Joaquín M Campos, Cleydson B R Santos. Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28031035. [PMID: 36770702] - Rumyana Simeonova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Irini Doytchinova. Ex Vivo Antioxidant and Cholinesterase Inhibiting Effects of a Novel Galantamine-Curcumin Hybrid on Scopolamine-Induced Neurotoxicity in Mice.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314843. [PMID: 36499171] - María Pilar de Torre, Rita Yolanda Cavero, María Isabel Calvo. Anticholinesterase Activity of Selected Medicinal Plants from Navarra Region of Spain and a Detailed Phytochemical Investigation of Origanum vulgare L. ssp. vulgare.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27207100. [PMID: 36296692] - Cheng Liu, Li-Ning Wang, Yu-Ming Liu. Novel Morpholine-Bearing Quinoline Derivatives as Potential Cholinesterase Inhibitors: The Influence of Amine, Carbon Linkers and Phenylamino Groups.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911231. [PMID: 36232533] - Ion Brinza, Mohamed A El Raey, Walaa El-Kashak, Omayma A Eldahshan, Lucian Hritcu. Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185901. [PMID: 36144637] - Agata Ptak, Emilia Morańska, Marzena Warchoł, Artur Gurgul, Edyta Skrzypek, Michał Dziurka, Dominique Laurain-Mattar, Rosella Spina, Anita Jaglarz, Magdalena Simlat. Endophytic bacteria from in vitro culture of Leucojum aestivum L. a new source of galanthamine and elicitor of alkaloid biosynthesis.
Scientific reports.
2022 08; 12(1):13700. doi:
10.1038/s41598-022-17992-5. [PMID: 35953692] - Thitipon Yaowaluk, Vorapun Senanarong, Chanin Limwongse, Rasda Boonprasert, Duangkamon Bunditvorapoom, Supannee Kaewsutthi, Pornpimol Kijsanayotin. Association study identifies genetic determinants and non-genetic factors on steady-state plasma and therapeutic outcome of galantamine in mixed dementia.
European journal of clinical pharmacology.
2022 Aug; 78(8):1249-1259. doi:
10.1007/s00228-022-03322-1. [PMID: 35633386] - Manoj Koirala, Vahid Karimzadegan, Nuwan Sameera Liyanage, Natacha Mérindol, Isabel Desgagné-Penix. Biotechnological Approaches to Optimize the Production of Amaryllidaceae Alkaloids.
Biomolecules.
2022 06; 12(7):. doi:
10.3390/biom12070893. [PMID: 35883449] - Dena Parsa, Luul A Aden, Ashley Pitzer, Tan Ding, Chang Yu, Andre Diedrich, Ginger L Milne, Annet Kirabo, Cyndya A Shibao. Enhanced parasympathetic cholinergic activity with galantamine inhibited lipid-induced oxidative stress in obese African Americans.
Molecular medicine (Cambridge, Mass.).
2022 06; 28(1):60. doi:
10.1186/s10020-022-00486-5. [PMID: 35659521] - Lyubomir T Vezenkov, Dancho L Danalev, Iwan Iwanov, Valentin Lozanov, Atanas Atanasov, Rumyana Todorova, Nikolay Vassilev, Veronika Karadjova. Synthesis and biological study of new galanthamine-peptide derivatives designed for prevention and treatment of Alzheimer's disease.
Amino acids.
2022 Jun; 54(6):897-910. doi:
10.1007/s00726-022-03167-z. [PMID: 35562605] - Mariyana Atanasova, Ivan Dimitrov, Stefan Ivanov, Borislav Georgiev, Strahil Berkov, Dimitrina Zheleva-Dimitrova, Irini Doytchinova. Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103139. [PMID: 35630613] - Chien-Ting Liu, Chuan-Chi Yang, Wu-Chien Chien, Chi-Hsiang Chung, Chien-Sung Tsai, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Chang Lin, Yi-Shi Chen, Nian-Sheng Tzeng. Association between long-term usage of acetylcholinesterase inhibitors and lung cancer in the elderly: a nationwide cohort study.
Scientific reports.
2022 03; 12(1):3531. doi:
10.1038/s41598-022-06377-3. [PMID: 35241672] - Fangcheng Fan, Hua Liu, Xiaojie Shi, Yangwen Ai, Qingshan Liu, Yong Cheng. The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review.
Journal of Alzheimer's disease : JAD.
2022; 85(3):1195-1204. doi:
10.3233/jad-215423. [PMID: 34924395] - Rong Wang, Yantong Liu, Sheng Xu, Jie Li, Jiayu Zhou, Ren Wang. An ATP-Binding Cassette Transporter, LaABCB11, Contributes to Alkaloid Transport in Lycoris aurea.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111458. [PMID: 34768889] - Mahmoud Agami, Rasha A Shaalan, Saied F Belal, Marwa A A Ragab. LC-MS bioanalysis of targeted nasal galantamine bound chitosan nanoparticles in rats' brain homogenate and plasma.
Analytical and bioanalytical chemistry.
2021 Aug; 413(20):5181-5191. doi:
10.1007/s00216-021-03487-1. [PMID: 34173038] - Ari Dienel, Remya A Veettil, Kanako Matsumura, Jude P J Savarraj, H Alex Choi, Peeyush Kumar T, Jaroslaw Aronowski, Pramod Dash, Spiros L Blackburn, Devin W McBride. α7-Acetylcholine Receptor Signaling Reduces Neuroinflammation After Subarachnoid Hemorrhage in Mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2021 07; 18(3):1891-1904. doi:
10.1007/s13311-021-01052-3. [PMID: 33970466] - Shikha Lohan, Teenu Sharma, Sumant Saini, Rajan Swami, Dinesh Dhull, Sarwar Beg, Kaisar Raza, Anil Kumar, Bhupinder Singh. QbD-steered development of mixed nanomicelles of galantamine: Demonstration of enhanced brain uptake, prolonged systemic retention and improved biopharmaceutical attributes.
International journal of pharmaceutics.
2021 May; 600(?):120482. doi:
10.1016/j.ijpharm.2021.120482. [PMID: 33737096] - Lamia Said Kandil, Ragwa M Farid, Safaa S ElGamal, Amira Sayed Hanafy. Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect.
Drug development and industrial pharmacy.
2021 May; 47(5):735-740. doi:
10.1080/03639045.2021.1934861. [PMID: 34032549] - Ferdausi Aleya, Chang Xianmin, Hall Anthony, Jones Meriel. Relative expression of putative genes involved in galanthamine and other Amaryllidaceae alkaloids biosynthesis in Narcissus field and in vitro tissues.
Gene.
2021 Mar; 774(?):145424. doi:
10.1016/j.gene.2021.145424. [PMID: 33434626] - Rumyana Simeonova, Dimitrina Zheleva, Iva Valkova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Irini Doytchinova. A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders.
Molecules (Basel, Switzerland).
2021 Mar; 26(7):. doi:
10.3390/molecules26071865. [PMID: 33806197] - Eman Shawky, Samah M El Sohafy, Jean Paulo de Andrade, Warley de Souza Borges. Profiling of acetylcholinesterase inhibitory alkaloids from some Crinum, Habranthus and Zephyranthes species by GC-MS combined with multivariate analyses and in silico studies.
Natural product research.
2021 Mar; 35(5):807-814. doi:
10.1080/14786419.2019.1598989. [PMID: 30990078] - M D Fraser, H E Vallin, J R T Davies, G E Rowlands, X Chang. Integrating Narcissus-derived galanthamine production into traditional upland farming systems.
Scientific reports.
2021 01; 11(1):1389. doi:
10.1038/s41598-021-81042-9. [PMID: 33446764] - Maria Lazarova, Lyubka Tancheva, Albena Alexandrova, Elina Tsvetanova, Almira Georgieva, Miroslava Stefanova, Daniela Tsekova, Lyubomir Vezenkov, Reni Kalfin, Diamara Uzunova, Polina Petkova-Kirova. Effects of New Galantamine Derivatives in a Scopolamine Model of Dementia in Mice.
Journal of Alzheimer's disease : JAD.
2021; 84(2):671-690. doi:
10.3233/jad-215165. [PMID: 34569967] - Carine Teles Sangaleti, Keyla Yukari Katayama, Kátia De Angelis, Tércio Lemos de Moraes, Amanda Aparecida Araújo, Heno F Lopes, Cleber Camacho, Luiz Aparecido Bortolotto, Lisete Compagno Michelini, Maria Cláudia Irigoyen, Peder S Olofsson, Douglas P Barnaby, Kevin J Tracey, Valentin A Pavlov, Fernanda Marciano Consolim Colombo. The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial.
Frontiers in immunology.
2021; 12(?):613979. doi:
10.3389/fimmu.2021.613979. [PMID: 33776997] - Maria I Lazarova, Daniela S Tsekova, Lyubka P Tancheva, Kiril T Kirilov, Diamara N Uzunova, Lyubomir T Vezenkov, Elina R Tsvetanova, Albena V Alexandrova, Almira P Georgieva, Petja T Gavrilova, Stela T Dragomanova, Maria G Papazova, Yordan S Handzhiyski, Reni E Kalfin. New Galantamine Derivatives with Inhibitory Effect on Acetylcholinesterase Activity.
Journal of Alzheimer's disease : JAD.
2021; 83(3):1211-1220. doi:
10.3233/jad-210577. [PMID: 34420968] - Farrukh Ahmad. COVID-19 induced ARDS, and the use of galantamine to activate the cholinergic anti-inflammatory pathway.
Medical hypotheses.
2020 12; 145(?):110331. doi:
10.1016/j.mehy.2020.110331. [PMID: 33038588] - Aakash Katdare, Dignesh Khunt, Shreya Thakkar, Surya Narayana Polaka, Manju Misra. Comparative evaluation of fish oil and butter oil in modulating delivery of galantamine hydrobromide to brain via intranasal route: pharmacokinetic and oxidative stress studies.
Drug delivery and translational research.
2020 08; 10(4):1136-1146. doi:
10.1007/s13346-020-00739-y. [PMID: 32219727] - Darja Koutová, Negar Maafi, Radim Havelek, Lubomír Opletal, Gerald Blunden, Martina Řezáčová, Lucie Cahlíková. Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family.
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102337. [PMID: 32429491] - Md Tanvir Kabir, Md Sahab Uddin, Abdullah Al Mamun, Philippe Jeandet, Lotfi Aleya, Rasha A Mansouri, Ghulam Md Ashraf, Bijo Mathew, May N Bin-Jumah, Mohamed M Abdel-Daim. Combination Drug Therapy for the Management of Alzheimer's Disease.
International journal of molecular sciences.
2020 May; 21(9):. doi:
10.3390/ijms21093272. [PMID: 32380758] - Nan Wu, Xuan Xu, Biao Wang, Xian-Mei Li, Ying-Yin Cheng, Ming Li, Xiao-Qin Xia, Yong-An Zhang. Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish.
Fish & shellfish immunology.
2020 Feb; 97(?):204-215. doi:
10.1016/j.fsi.2019.12.028. [PMID: 31843701] - Ye Yuan, Minjie Zhao, Ludivine Riffault-Valois, Saïd Ennahar, Martine Bergaentzlé, Eric Marchioni. Online acetylcholinesterase inhibition evaluation by high-performance liquid chromatography-mass spectrometry hyphenated with an immobilized enzyme reactor.
Journal of chromatography. A.
2020 Jan; 1609(?):460506. doi:
10.1016/j.chroma.2019.460506. [PMID: 31526637] - Roma Ghai, Kandasamy Nagarajan, Meenakshi Arora, Parul Grover, Nazakat Ali, Garima Kapoor. Current Strategies and Novel Drug Approaches for Alzheimer Disease.
CNS & neurological disorders drug targets.
2020; 19(9):676-690. doi:
10.2174/1871527319666200717091513. [PMID: 32679025] - Soyeon Yoo, Min Su Han. A fluorescent probe for butyrylcholinesterase activity in human serum based on a fluorophore with specific binding affinity for human serum albumin.
Chemical communications (Cambridge, England).
2019 Dec; 55(97):14574-14577. doi:
10.1039/c9cc07737e. [PMID: 31663530] - Deepali Katoch, Upendra Sharma. Simultaneous quantification and identification of Amaryllidaceae alkaloids in Narcissus tazetta by ultra performance liquid chromatography-diode array detector-electrospray ionisation tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2019 Oct; 175(?):112750. doi:
10.1016/j.jpba.2019.06.047. [PMID: 31330284] - Ameneh Tarakemeh, Majid Azizi, Vahid Rowshan, Hassan Salehi, Rosella Spina, François Dupire, Hossein Arouie, Dominique Laurain-Mattar. Screening of Amaryllidaceae alkaloids in bulbs and tissue cultures of Narcissus papyraceus and four varieties of N. tazetta.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):230-237. doi:
10.1016/j.jpba.2019.04.043. [PMID: 31060036] - Kathleen M Carroll, Elise E DeVito, Sarah W Yip, Charla Nich, Mehmet Sofuoglu. Double-Blind Placebo-Controlled Trial of Galantamine for Methadone-Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use.
The American journal on addictions.
2019 07; 28(4):238-245. doi:
10.1111/ajad.12904. [PMID: 31165574] - Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Lee. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease.
International journal of molecular sciences.
2019 Feb; 20(4):. doi:
10.3390/ijms20041000. [PMID: 30823604] - Sarah W Yip, Dustin Scheinost, Marc N Potenza, Kathleen M Carroll. Connectome-Based Prediction of Cocaine Abstinence.
The American journal of psychiatry.
2019 02; 176(2):156-164. doi:
10.1176/appi.ajp.2018.17101147. [PMID: 30606049] - Kurt R Lehner, Harold A Silverman, Meghan E Addorisio, Ashbeel Roy, Mohammed A Al-Onaizi, Yaakov Levine, Peder S Olofsson, Sangeeta S Chavan, Robert Gros, Neil M Nathanson, Yousef Al-Abed, Christine N Metz, Vania F Prado, Marco A M Prado, Kevin J Tracey, Valentin A Pavlov. Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation.
Frontiers in immunology.
2019; 10(?):585. doi:
10.3389/fimmu.2019.00585. [PMID: 31024522] - Grace S Pham, Lei A Wang, Keisa W Mathis. Pharmacological potentiation of the efferent vagus nerve attenuates blood pressure and renal injury in a murine model of systemic lupus erythematosus.
American journal of physiology. Regulatory, integrative and comparative physiology.
2018 12; 315(6):R1261-R1271. doi:
10.1152/ajpregu.00362.2017. [PMID: 30332305] - Sherehan M Ibrahim, Muhammad Y Al-Shorbagy, Dalaal M Abdallah, Hanan S El-Abhar. Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.
Scientific reports.
2018 11; 8(1):16814. doi:
10.1038/s41598-018-35254-1. [PMID: 30429582] - Wei Li, Yun Yang, Chong Qiao, Guolin Zhang, Yinggang Luo. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encoding genes from Lycoris radiata, a galanthamine-producing plant.
International journal of biological macromolecules.
2018 Oct; 117(?):1264-1279. doi:
10.1016/j.ijbiomac.2018.06.046. [PMID: 29894786] - Milen G Bogdanov, Ivan Svinyarov. Analysis of acetylcholinesterase inhibitors by extraction in choline saccharinate aqueous biphasic systems.
Journal of chromatography. A.
2018 Jul; 1559(?):62-68. doi:
10.1016/j.chroma.2018.01.007. [PMID: 29307532] - Robert Ross MacLean, Andrew J Waters, Emily Brede, Mehmet Sofuoglu. Effects of galantamine on smoking behavior and cognitive performance in treatment-seeking smokers prior to a quit attempt.
Human psychopharmacology.
2018 07; 33(4):e2665. doi:
10.1002/hup.2665. [PMID: 29926988] - Edoardo Fabini, Anna Tramarin, Manuela Bartolini. Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening.
Journal of pharmaceutical and biomedical analysis.
2018 Jun; 155(?):177-184. doi:
10.1016/j.jpba.2018.03.060. [PMID: 29635172] - Worranan Rangsimawong, Yasuko Obata, Praneet Opanasopit, Tanasait Ngawhirunpat, Kozo Takayama. Enhancement of Galantamine HBr Skin Permeation Using Sonophoresis and Limonene-Containing PEGylated Liposomes.
AAPS PharmSciTech.
2018 Apr; 19(3):1093-1104. doi:
10.1208/s12249-017-0921-z. [PMID: 29168128] - Brian H May, Mei Feng, Anna J Hyde, Helmut Hügel, Su-Yueh Chang, Lin Dong, Xinfeng Guo, Anthony L Zhang, Chuanjian Lu, Charlie C Xue. Comparisons between traditional medicines and pharmacotherapies for Alzheimer disease: A systematic review and meta-analysis of cognitive outcomes.
International journal of geriatric psychiatry.
2018 03; 33(3):449-458. doi:
10.1002/gps.4830. [PMID: 29239495] - Kathleen M Carroll, Charla Nich, Elise E DeVito, Julia M Shi, Mehmet Sofuoglu. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
The Journal of clinical psychiatry.
2018 Jan; 79(1):. doi:
10.4088/jcp.17m11669. [PMID: 29286595] - Elif Özdemir, Sevgi Tatar Ulu. Highly sensitive HPLC method for the determination of galantamine in human plasma and urine through derivatization with dansyl chloride using fluorescence detector.
Luminescence : the journal of biological and chemical luminescence.
2017 Nov; 32(7):1145-1149. doi:
10.1002/bio.3301. [PMID: 28430400] - M Rejwan Ali, Mostafa Sadoqi, Simon G Møller, Allal Boutajangout, Mihaly Mezei. Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies.
Journal of molecular graphics & modelling.
2017 09; 76(?):36-42. doi:
10.1016/j.jmgm.2017.06.027. [PMID: 28711758] - Yan Zhang, Lingling Zhao, Zhaoxuan Wu, Xinxin Chen, Tong Ma. Galantamine alleviates senescence of U87 cells induced by beta-amyloid through decreasing ROS production.
Neuroscience letters.
2017 Jul; 653(?):183-188. doi:
10.1016/j.neulet.2017.05.055. [PMID: 28554861] - Shuangjiao Sun, Yanfen Wei, Yupin Cao, Biyang Deng. Simultaneous electrochemiluminescence determination of galanthamine, homolycorine, lycorenine, and tazettine in Lycoris radiata by capillary electrophoresis with ultrasonic-assisted extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jun; 1055-1056(?):15-19. doi:
10.1016/j.jchromb.2017.04.020. [PMID: 28441543] - Emma L Wightman. Potential benefits of phytochemicals against Alzheimer's disease.
The Proceedings of the Nutrition Society.
2017 05; 76(2):106-112. doi:
10.1017/s0029665116002962. [PMID: 28143625] - Mariecia D Fraser, John R T Davies, Xianmin Chang. New Gold in Them Thar Hills: Testing a Novel Supply Route for Plant-Derived Galanthamine.
Journal of Alzheimer's disease : JAD.
2017; 55(4):1321-1325. doi:
10.3233/jad-160791. [PMID: 27834779] - M Pohanka, J Zakova, J Fusek. Galantamine has impact on immunity in mice exposed to keyhole limpet hemocyanin.
Bratislavske lekarske listy.
2017; 118(1):9-12. doi:
10.4149/bll_2017_002. [PMID: 28127976] - Donatella Ferri, Carla Ubaldi, Giordana Marcozzi, Paolo Fasciani, Loretta Bacchetta, Loretta Pace. Chemical Characterization of Narcissus poeticus from Sirente -Velino (Apennines - Italy): Galantamine Accumulation and Distribution of Allergenic Compounds in the Flower.
Natural product communications.
2017 Jan; 12(1):15-18. doi:
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Journal of pharmaceutical and biomedical analysis.
2016 Nov; 131(?):188-194. doi:
10.1016/j.jpba.2016.08.026. [PMID: 27596831] - Shubham Misra, Kanwaljit Chopra, Uma Nahar Saikia, Vivek Ranjan Sinha, Rakesh Sehgal, Manish Modi, Bikash Medhi. Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer's disease.
Regenerative medicine.
2016 10; 11(7):629-46. doi:
10.2217/rme-2016-0032. [PMID: 27582416] - Shubham Misra, Kanwaljit Chopra, V R Sinha, Bikash Medhi. Galantamine-loaded solid-lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations.
Drug delivery.
2016 May; 23(4):1434-43. doi:
10.3109/10717544.2015.1089956. [PMID: 26405825] - Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao. Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities.
Journal of natural products.
2016 Apr; 79(4):760-6. doi:
10.1021/acs.jnatprod.5b00681. [PMID: 26913788] - G Li, C L Zhou, Q S Zhou, H D Zou. Galantamine protects against lipopolysaccharide-induced acute lung injury in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2016 Feb; 49(2):e5008. doi:
10.1590/1414-431x20155008. [PMID: 26648090] - Mennatallah A Gowayed, Rowaida Refaat, Walid M Ahmed, Hanan S El-Abhar. Effect of galantamine on adjuvant-induced arthritis in rats.
European journal of pharmacology.
2015 Oct; 764(?):547-553. doi:
10.1016/j.ejphar.2015.07.038. [PMID: 26189022] - Mennatallah A Ali, Hanan S El-Abhar, Maher A Kamel, Ahmed S Attia. Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug.
PloS one.
2015; 10(8):e0134648. doi:
10.1371/journal.pone.0134648. [PMID: 26262991] - Arif Nisha Syad, Kasi Pandima Devi. Assessment of anti-amyloidogenic activity of marine red alga G. acerosa against Alzheimer's beta-amyloid peptide 25-35.
Neurological research.
2015 Jan; 37(1):14-22. doi:
10.1179/1743132814y.0000000422. [PMID: 25016970] - Soumee Bhattacharya, Alfred Maelicke, Dirk Montag. Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice.
Journal of Alzheimer's disease : JAD.
2015; 46(1):123-36. doi:
10.3233/jad-142421. [PMID: 25720404] - P S Suresh, Ramesh Mullangi, Sathesh Kumar Sukumaran. Highly sensitive LC-MS/MS method for determination of galantamine in rat plasma: application to pharmacokinetic studies in rats.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1633-40. doi:
10.1002/bmc.3191. [PMID: 24801995] - Xin Zhou, Yue-Bin Liu, Shan Huang, Ying Liu. An LC-MS/MS method for the simultaneous determination of lycorine and galanthamine in rat plasma and its application to pharmacokinetic study of Lycoris radiata extract in rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2014 Dec; 34(6):861-868. doi:
10.1007/s11596-014-1365-2. [PMID: 25480582] - Dhas Jebasingh, Dhas Devavaram Jackson, S Venkataraman, Ernest Adeghate, Bright Starling Emerald. The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury.
Pharmaceutical biology.
2014 Dec; 52(12):1558-69. doi:
10.3109/13880209.2014.908395. [PMID: 25026346] - Gulen Irem Kaya, Derya Cicek Polat, Buket Sarikaya, Mustafa Ali Onur, Nehir Unver Somer. Quantititative determination of lycorine and galanthamine in Galanthus trojanus and G. cilicicus by HPLC-DAD.
Natural product communications.
2014 Aug; 9(8):1157-8. doi:
". [PMID: 25233596] - ". Holy Moly: Hermes' anticholinesterase antidote.
Anesthesiology.
2014 Aug; 121(2):371. doi:
10.1097/01.anes.0000451816.76346.cd. [PMID: 25050493] - Yuqiong Zhang, Yong Li, Jianhui Zhou, Na Chen, Meifang Wang, Zhaorong Dong, Cuiyun Gao, Yanlong Zhong. [Effect of precursor on growth and accumulation of alkaloids of Lycoris radiata suspension cells].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2014 Feb; 30(2):247-54. doi:
". [PMID: 24945053] - Christina E Turi, Katarina E Axwik, Anderson Smith, A Maxwell P Jones, Praveen K Saxena, Susan J Murch. Galanthamine, an anticholinesterase drug, effects plant growth and development in Artemisia tridentate Nutt. via modulation of auxin and neutrotransmitter signaling.
Plant signaling & behavior.
2014; 9(4):e28645. doi:
10.4161/psb.28645. [PMID: 24690897] - Soumee Bhattacharya, Christin Haertel, Alfred Maelicke, Dirk Montag. Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease.
PloS one.
2014; 9(2):e89454. doi:
10.1371/journal.pone.0089454. [PMID: 24586789] - Mohamed G Hassan, Rie Ikeda, Mitsuhiro Wada, Naotaka Kuroda, Hanaa M Abdel-Wadood, Horria A Mohamed, Kenichiro Nakashima. Interaction study of acetylcholinestrase inhibitors on pharmacokinetics of memantine in rat plasma by HPLC-fluorescence method.
Biomedical chromatography : BMC.
2013 Dec; 27(12):1685-9. doi:
10.1002/bmc.2980. [PMID: 23861199] - Dae Young Yoo, Jung Hoon Choi, Woosuk Kim, Sung Min Nam, Hyo Young Jung, Jong Hwi Kim, Moo-Ho Won, Yeo Sung Yoon, In Koo Hwang. Effects of luteolin on spatial memory, cell proliferation, and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia model.
Neurological research.
2013 Oct; 35(8):813-20. doi:
10.1179/1743132813y.0000000217. [PMID: 23651687] - Ivan Ivanov, Vasil Georgiev, Atanas Pavlov. Elicitation of galanthamine biosynthesis by Leucojum aestivum liquid shoot cultures.
Journal of plant physiology.
2013 Aug; 170(12):1122-9. doi:
10.1016/j.jplph.2013.03.017. [PMID: 23648110] - María Cuartero, María Soledad García, Francisco García-Cánovas, Joaquín Ángel Ortuño. New approach for the potentiometric-enzymatic assay of reversible-competitive enzyme inhibitors. Application to acetylcholinesterase inhibitor galantamine and its determination in pharmaceuticals and human urine.
Talanta.
2013 Jun; 110(?):8-14. doi:
10.1016/j.talanta.2013.03.022. [PMID: 23618168] - Ahmet Turan Isik, Ergun Bozoglu, Kursat Kaptan, Turgay Celik. Effect of galantamine on platelet functions in healthy elderly people.
The Indian journal of medical research.
2013 May; 137(5):977-80. doi:
NULL. [PMID: 23760386] - Muriel Noetzli, Monia Guidi, Karsten Ebbing, Stephan Eyer, Serge Zumbach, Panteleimon Giannakopoulos, Armin von Gunten, Chantal Csajka, Chin B Eap. Relationship of CYP2D6, CYP3A, POR, and ABCB1 genotypes with galantamine plasma concentrations.
Therapeutic drug monitoring.
2013 Apr; 35(2):270-5. doi:
10.1097/ftd.0b013e318282ff02. [PMID: 23503455] - Andrea Lubbe, Henk Gude, Robert Verpoorte, Young Hae Choi. Seasonal accumulation of major alkaloids in organs of pharmaceutical crop Narcissus Carlton.
Phytochemistry.
2013 Apr; 88(?):43-53. doi:
10.1016/j.phytochem.2012.12.008. [PMID: 23318143] - Anika Schumann, Laura Torras-Claveria, Strahil Berkov, Diana Claus, André Gerth, Jaume Bastida, Carles Codina. Elicitation of galanthamine production by Leucojum aestivum shoots grown in temporary immersion system.
Biotechnology progress.
2013 Mar; 29(2):311-8. doi:
10.1002/btpr.1677. [PMID: 23225790] - Lijuan Xin, Ritupriya Yamujala, Yuehu Wang, Huan Wang, Wen-Hsuan Wu, Michael A Lawton, Chunlin Long, Rong Di. Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176.
PloS one.
2013; 8(5):e63874. doi:
10.1371/journal.pone.0063874. [PMID: 23675513] - P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesario. Multitarget drugs of plants origin acting on Alzheimer's disease.
Current medicinal chemistry.
2013; 20(13):1686-93. doi:
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Analytica chimica acta.
2012 Dec; 756(?):60-72. doi:
10.1016/j.aca.2012.10.042. [PMID: 23176740] - Deepali Katoch, Shiv Kumar, Neeraj Kumar, Bikram Singh. Simultaneous quantification of Amaryllidaceae alkaloids from Zephyranthes grandiflora by UPLC-DAD/ESI-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2012 Dec; 71(?):187-92. doi:
10.1016/j.jpba.2012.08.001. [PMID: 22939505] - Javier E Ortiz, Strahil Berkov, Natalia B Pigni, Cristina Theoduloz, German Roitman, Alejandro Tapia, Jaume Bastida, Gabriela E Feresin. Wild Argentinian Amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids.
Molecules (Basel, Switzerland).
2012 Nov; 17(11):13473-82. doi:
10.3390/molecules171113473. [PMID: 23149565] - Xue-jia Zhai, Yong-ning Lu. Food-drug interactions: effect of capsaicin on the pharmacokinetics of galantamine in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2012 Nov; 42(11):1151-5. doi:
10.3109/00498254.2012.693220. [PMID: 22668071] - Chun-Woong Park, Dao-Danh Son, Ju-Young Kim, Tack-Oon Oh, Jung-Myung Ha, Yun-Seok Rhee, Eun-Seok Park. Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.
International journal of pharmaceutics.
2012 Oct; 436(1-2):32-40. doi:
10.1016/j.ijpharm.2012.06.057. [PMID: 22771734] - Yoo-Sin Park, Shin-Hee Kim, Sang-Yeon Kim, Youn-Hee Kim, Min-Ho Lee, Seok-Chul Yang, Leslie M Shaw, Ju-Seop Kang. Quantification of galantamine in human plasma by validated liquid chromatography-tandem mass spectrometry using glimepride as an internal standard: application to bioavailability studies in 32 healthy Korean subjects.
Journal of chromatographic science.
2012 Oct; 50(9):803-9. doi:
10.1093/chromsci/bms074. [PMID: 22744744] - Weize Li, Yongqiang Zhou, Ning Zhao, Baohua Hao, Xiaoning Wang, Peng Kong. Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes.
Environmental toxicology and pharmacology.
2012 Sep; 34(2):272-279. doi:
10.1016/j.etap.2012.04.012. [PMID: 22613079]