2-CMP (BioDeep_00001868977)

Main id: BioDeep_00000005096

 


代谢物信息卡片


2-Cytidylic acid

化学式: C9H14N3O8P (323.0518)
中文名称: 胞苷 2ˊ-一磷酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)OP(=O)(O)O
InChI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(20-21(16,17)18)6(14)4(3-13)19-8/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

描述信息

同义名列表

3 个代谢物同义名

2-Cytidylic acid; 2-CMP; Cytidine 2'-phosphate



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhiwei Han, Yuanqiang Zhu, Jingji Xu, Didi Wen, Yuwei Xia, Minwen Zheng, Tao Yan, Mengqi Wei. Predictive Value of CT-Based Radiomics in Distinguishing Renal Angiomyolipomas with Minimal Fat from Other Renal Tumors. Disease markers. 2022; 2022(?):9108129. doi: 10.1155/2022/9108129. [PMID: 35669501]
  • Farasat Kazmi, Shibani Nicum, Rene L Roux, Laura Spiers, Chat Gnanaranjan, Ajithkumar Sukumaran, Hani Gabra, Essam Ghazaly, Nigel W McCracken, David J Harrison, Sarah P Blagden. A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 06; 27(11):3028-3038. doi: 10.1158/1078-0432.ccr-20-4403. [PMID: 33741651]
  • Mairéad G McNamara, John Bridgewater, Daniel H Palmer, Olusola Faluyi, Harpreet Wasan, Alkesh Patel, William D Ryder, Safia Barber, Chathunissa Gnanaranjan, Essam Ghazaly, T R Jeff Evans, Juan W Valle. A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patients with Advanced Biliary Tract Cancer (ABC-08). The oncologist. 2021 04; 26(4):e669-e678. doi: 10.1002/onco.13598. [PMID: 33210382]
  • Sandrine Bonneton, Isabelle Maillard, Frédéric Denis, Jean-Luc Roelandt. Title Not Available. Sante publique (Vandoeuvre-les-Nancy, France). 2021; 32(5):531-535. doi: 10.3917/spub.205.0531. [PMID: 35724169]
  • Wufan Pan, Dongdong Yu, Yazhou Qin, Wanghua Wu, Yuxiang Lu, Zhen Yuan, Jianguang Zhou. Aligner mediated cleavage of nucleic acids for site-specific detection of single base mismatch. Talanta. 2019 Aug; 201(?):358-363. doi: 10.1016/j.talanta.2019.03.106. [PMID: 31122435]
  • Ben A Wagstaff, Martin Rejzek, Robert A Field. Identification of a Kdn biosynthesis pathway in the haptophyte Prymnesium parvum suggests widespread sialic acid biosynthesis among microalgae. The Journal of biological chemistry. 2018 10; 293(42):16277-16290. doi: 10.1074/jbc.ra118.004921. [PMID: 30171074]
  • Sunita Gulati, Ian C Schoenhofen, Dennis M Whitfield, Andrew D Cox, Jianjun Li, Frank St Michael, Evgeny V Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A Lewis, Rachel E Taylor, Corinna S Landig, Sandra Diaz, George W Reed, Ajit Varki, Peter A Rice, Sanjay Ram. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics. PLoS pathogens. 2015 Dec; 11(12):e1005290. doi: 10.1371/journal.ppat.1005290. [PMID: 26630657]
  • Sathnur Pushpakumar, Sourav Kundu, Nithya Narayanan, Utpal Sen. DNA hypermethylation in hyperhomocysteinemia contributes to abnormal extracellular matrix metabolism in the kidney. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Nov; 29(11):4713-25. doi: 10.1096/fj.15-272443. [PMID: 26224753]
  • Paola Rota, Federica Cirillo, Marco Piccoli, Antonio Gregorio, Guido Tettamanti, Pietro Allevi, Luigi Anastasia. Synthesis and biological evaluation of several dephosphonated analogues of CMP-Neu5Ac as inhibitors of GM3-synthase. Chemistry (Weinheim an der Bergstrasse, Germany). 2015 Oct; 21(41):14614-29. doi: 10.1002/chem.201501770. [PMID: 26397189]
  • Zi Li, Soyoun Hwang, Jaime Ericson, Kyle Bowler, Maor Bar-Peled. Pen and Pal are nucleotide-sugar dehydratases that convert UDP-GlcNAc to UDP-6-deoxy-D-GlcNAc-5,6-ene and then to UDP-4-keto-6-deoxy-L-AltNAc for CMP-pseudaminic acid synthesis in Bacillus thuringiensis. The Journal of biological chemistry. 2015 Jan; 290(2):691-704. doi: 10.1074/jbc.m114.612747. [PMID: 25414257]
  • Ai-hua Zhang, Hui Sun, Shi Qiu, Xi-jun Wang. Metabolomics in noninvasive breast cancer. Clinica chimica acta; international journal of clinical chemistry. 2013 Sep; 424(?):3-7. doi: 10.1016/j.cca.2013.05.003. [PMID: 23669185]
  • Carmen Eicher, Alexander Dewerth, Verena Ellerkamp, Joerg Fuchs, Sarah Schott, Sorin Armeanu-Ebinger. Effect of duplex drugs linking 2'-deoxy-5-fluorouridine (5-FdU) with 3'-C-ethynylcytidine (ECyd) on hepatoblastoma cell lines. Pediatric surgery international. 2013 Feb; 29(2):121-7. doi: 10.1007/s00383-012-3192-5. [PMID: 23187893]
  • Sarah Schott, Heike Niessner, Tobias Sinnberg, Sascha Venturelli, Alexander Berger, Kristian Ikenberg, Jessie Villanueva, Friedegund Meier, Claus Garbe, Christian Busch. Cytotoxicity of new duplex drugs linking 3'-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human melanoma cells. International journal of cancer. 2012 Nov; 131(9):2165-74. doi: 10.1002/ijc.27476. [PMID: 22323315]
  • Jae Suk Kim, James R Beadle, William R Freeman, Karl Y Hostetler, Kathrin Hartmann, Nadejda Valiaeva, Igor Kozak, Laura Conner, Julissa Trahan, Kathy A Aldern, Lingyun Cheng. A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy. Molecular vision. 2012; 18(?):1907-17. doi: . [PMID: 22876115]
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  • Akira Horikoshi, Kazuhiro Takei, Yoshifumi Hosokawa, Shigemasa Sawada. The value of oral cytarabine ocfosfate and etoposide in the treatment of refractory and elderly AML patients. International journal of hematology. 2008 Mar; 87(2):118-125. doi: 10.1007/s12185-007-0019-6. [PMID: 18228114]
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  • Mads Gabrielsen, Johannes Kaiser, Felix Rohdich, Wolfgang Eisenreich, Ralf Laupitz, Adelbert Bacher, Charles S Bond, William N Hunter. The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate. The FEBS journal. 2006 Mar; 273(5):1065-73. doi: 10.1111/j.1742-4658.2006.05133.x. [PMID: 16478479]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • Mohammad Alamgir Hossain, Osamu Yamato, Masahiro Yamasaki, Yoshimitsu Maede. Inhibitory effect of pyrimidine and purine nucleotides on the multiplication of Babesia gibsoni: possible cause of low parasitemia and simultaneous reticulocytosis in canine babesiosis. The Journal of veterinary medical science. 2004 Apr; 66(4):389-95. doi: 10.1292/jvms.66.389. [PMID: 15133268]
  • A T Pearman, H C Castro-Faria-Neto, T M McIntyre, S M Prescott, D M Stafforini. Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. Life sciences. 2001 Oct; 69(20):2361-70. doi: 10.1016/s0024-3205(01)01322-4. [PMID: 11681623]
  • C Kirsch, E Logemann, B Lippok, E Schmelzer, K Hahlbrock. A highly specific pathogen-responsive promoter element from the immediate-early activated CMPG1 gene in Petroselinum crispum. The Plant journal : for cell and molecular biology. 2001 Apr; 26(2):217-27. doi: 10.1046/j.1365-313x.2001.01015.x. [PMID: 11389762]
  • S M Lawrence, K A Huddleston, N Tomiya, N Nguyen, Y C Lee, W F Vann, T A Coleman, M J Betenbaugh. Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. Glycoconjugate journal. 2001 Mar; 18(3):205-13. doi: 10.1023/a:1012452705349. [PMID: 11602804]
  • J Royo, E Gímez, G Hueros. CMP-KDO synthetase: a plant gene borrowed from gram-negative eubacteria. Trends in genetics : TIG. 2000 Oct; 16(10):432-3. doi: 10.1016/s0168-9525(00)02102-8. [PMID: 11050325]
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  • K E de Rudder, C Sohlenkamp, O Geiger. Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase. The Journal of biological chemistry. 1999 Jul; 274(28):20011-6. doi: 10.1074/jbc.274.28.20011. [PMID: 10391951]
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  • E Schleyer, J Braess, B Ramsauer, M Unterhalt, C Kaufmann, S Wilde, M Schüssler, W Hiddemann. Pharmacokinetics of Ara-CMP-Stearate (YNK01): phase I study of the oral Ara-C derivative. Leukemia. 1995 Jun; 9(6):1085-90. doi: . [PMID: 7596174]
  • B Ramsauer, J Braess, M Unterhalt, C C Kaufmann, W Hiddemann, E Schleyer. Highly sensitive high-performance liquid chromatographic assay for 1-beta-D-arabinofuranosylcytosine-5'-stearyl phosphate (cytarabine-ocfosfate). Journal of chromatography. B, Biomedical applications. 1995 Mar; 665(1):183-92. doi: 10.1016/0378-4347(94)00523-8. [PMID: 7795790]
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