Exact Mass: 394.16592520000006
Exact Mass Matches: 394.16592520000006
Found 500 metabolites which its exact mass value is equals to given mass value 394.16592520000006
,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Rotenone
Rotenone appears as colorless to brownish crystals or a white to brownish-white crystalline powder. Has neither odor nor taste. (NTP, 1992) Rotenone is a member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). It has a role as a phytogenic insecticide, a mitochondrial NADH:ubiquinone reductase inhibitor, a metabolite, an antineoplastic agent, a toxin and a piscicide. It is an organic heteropentacyclic compound and a member of rotenones. Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish. Rotenone is a natural product found in Pachyrhizus erosus, Millettia ferruginea, and other organisms with data available. Rotenone is a naturally occurring organic heteropentacyclic compound and member of rotenones that is found in the roots of several plant species. It is a mitochondrial NADH:ubiquinone reductase inhibitor, toxin, and metabolite, and is used as an antineoplastic agent and insecticide. It is characterized as a colorless to brownish or a white to brownish-white crystalline solid that is odorless. Exposure occurs by inhalation, ingestion, or contact. Rotenone is found in jicama. Rotenone is widely distributed in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean).Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant. In mammals, including humans, it is linked to the development of Parkinsons disease. (Wikipedia) Rotenone has been shown to exhibit apoptotic, neuroprotectant and neuroprotective functions (A7776, A7777, A7777).Rotenone belongs to the family of Rotenoids. These are phenolic compounds containing aA cis-fused tetrahydrochromeno[3,4-b]chromenenucleus. Many rotenoids contain an additional ring, e.g rotenone[1]. (Reference: [1] IUPAC. Compendium of Chemical Terminology, 2nd ed. (the Gold Book). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook. (PAC, 1995, 67, 1307 (Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)) on page 1364)). A botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is found in jicama. Rotenone is widely distributed in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean).Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant. In mammals, including humans, it is linked to the development of Parkinsons disease. A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). Widely distrib. in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean) D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Legumelin
Legumelin, also known as (-)-cis-deguelin, is a member of the class of compounds known as rotenones. Rotenones are rotenoids with a structure based on a 6a,12a-dihydrochromeno[3,4-b]chromen-12(6H)-one skeleton. Thus, legumelin is considered to be a flavonoid lipid molecule. Legumelin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Legumelin can be found in soy bean, which makes legumelin a potential biomarker for the consumption of this food product. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
Brucine
C23H26N2O4 (394.18924760000004)
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents D002491 - Central Nervous System Agents > D000700 - Analgesics D007155 - Immunologic Factors CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2329 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.545 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.540 ORIGINAL_ACQUISITION_NO 5860; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; ORIGINAL_PRECURSOR_SCAN_NO 5859 CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5850; ORIGINAL_PRECURSOR_SCAN_NO 5847 CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5870; ORIGINAL_PRECURSOR_SCAN_NO 5868 CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5860; ORIGINAL_PRECURSOR_SCAN_NO 5859 CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5841; ORIGINAL_PRECURSOR_SCAN_NO 5839 CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5876; ORIGINAL_PRECURSOR_SCAN_NO 5873 CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5855; ORIGINAL_PRECURSOR_SCAN_NO 5853 [Raw Data] CBA35_Brucine_pos_40eV_1-3_01_1629.txt [Raw Data] CBA35_Brucine_pos_10eV_1-3_01_1618.txt [Raw Data] CBA35_Brucine_pos_30eV_1-3_01_1628.txt [Raw Data] CBA35_Brucine_pos_20eV_1-3_01_1627.txt [Raw Data] CBA35_Brucine_pos_50eV_1-3_01_1630.txt
Triamcinolone
CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3715; ORIGINAL_PRECURSOR_SCAN_NO 3712 H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XB - Corticosteroids, moderately potent, other combinations D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii) A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AC - Corticosteroids for local oral treatment R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D000893 - Anti-Inflammatory Agents CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3708; ORIGINAL_PRECURSOR_SCAN_NO 3707 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3717; ORIGINAL_PRECURSOR_SCAN_NO 3716 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3711; ORIGINAL_PRECURSOR_SCAN_NO 3706 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3783; ORIGINAL_PRECURSOR_SCAN_NO 3781 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3714; ORIGINAL_PRECURSOR_SCAN_NO 3712 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7651; ORIGINAL_PRECURSOR_SCAN_NO 7649 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7679; ORIGINAL_PRECURSOR_SCAN_NO 7677 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7697; ORIGINAL_PRECURSOR_SCAN_NO 7693 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7704; ORIGINAL_PRECURSOR_SCAN_NO 7701 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7689; ORIGINAL_PRECURSOR_SCAN_NO 7684 CONFIDENCE standard compound; INTERNAL_ID 239; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7706; ORIGINAL_PRECURSOR_SCAN_NO 7702 CONFIDENCE standard compound; INTERNAL_ID 2400 CONFIDENCE standard compound; INTERNAL_ID 8735 Triamcinolone is a long-acting glucocorticoid, a corticosteroid receptor (corticosteroid hormone receptor) agonist, and has anti-inflammatory effects.
N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide
Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
Triamcinolone
Triamcinolone is a C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections. It has a role as an anti-allergic agent and an anti-inflammatory drug. It is a fluorinated steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a glucocorticoid, a 17alpha-hydroxy steroid, a 16alpha-hydroxy steroid, a C21-steroid hormone, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It derives from a hydride of a pregnane. Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermatoses. Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate. Triamcinolone was granted FDA approval on 3 December 1957. In October 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection - the first suprachoroidal injection to receive FDA approval - for the treatment of patients with macular edema associated with uveitis. Triamcinolone is a Corticosteroid. The mechanism of action of triamcinolone is as a Corticosteroid Hormone Receptor Agonist. Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B. A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) See also: Triamcinolone Acetonide (active moiety of); Triamcinolone Diacetate (is active moiety of). Triamcinolone is only found in individuals that have used or taken this drug. It is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XB - Corticosteroids, moderately potent, other combinations D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii) A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AC - Corticosteroids for local oral treatment R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D000893 - Anti-Inflammatory Agents Triamcinolone is a long-acting glucocorticoid, a corticosteroid receptor (corticosteroid hormone receptor) agonist, and has anti-inflammatory effects.
Gibberellin A43
Gibberellin A43 (GA43) belongs to the class of organic compounds known as C20-gibberellin 20-carboxylic acids. These are C20-gibberellins with a carboxyl group at the 6-position. Gibberellin A43 is found in common pea. Gibberellin A43 is from Cucurbita maxim. From Cucurbita maxima. Gibberellin A43 is found in many foods, some of which are common pea, japanese pumpkin, winter squash, and fruits.
Gibberellin A39
Gibberellin A39 (GA39) belongs to the class of organic compounds known as C20-gibberellin 20-carboxylic acids. These are C20-gibberellins with a carboxyl group at the 6-position. Gibberellin A39 is found in fruits. Gibberellin A39 is a constituent of the seeds of Cucurbita pepo and Cucurbita maxima. Constituent of the seeds of Cucurbita pepo and Cucurbita maxima. Gibberellin A39 is found in winter squash, fruits, and japanese pumpkin.
cis-3-Hexenyl b-primeveroside
cis-3-Hexenyl b-primeveroside is found in tea. cis-3-Hexenyl b-primeveroside is a constituent of Camellia sinensis
Garcinone B
Constituent of Garcinia mangostana (mangosteen). Garcinone B is found in fruits and purple mangosteen. Garcinone B is found in fruits. Garcinone B is a constituent of Garcinia mangostana (mangosteen)
1-(3-Methyl-2-butenoyl)-6-apiosylglucose
1-(3-Methyl-2-butenoyl)-6-apiosylglucose is found in coffee and coffee products. 1-(3-Methyl-2-butenoyl)-6-apiosylglucose is a constituent of green coffee beans (Coffea arabica). Constituent of green coffee beans (Coffea arabica). 1-(3-Methyl-2-butenoyl)-6-apiosylglucose is found in coffee and coffee products.
Loteprednol
C21H27ClO5 (394.15469220000006)
Loteprednol (as Loteprednol Etabonate) is a topical corticoid antiinflammatory. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, is used for the treatment and management of seasonal allergic rhinitis. S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D018926 - Anti-Allergic Agents
1,3,8-Trihydroxy-4-methyl-2,7-diprenylxanthone
1,3,8-Trihydroxy-4-methyl-2,7-diprenylxanthone is found in fruits. 1,3,8-Trihydroxy-4-methyl-2,7-diprenylxanthone is a constituent of the fruit hulls of Garcinia mangostana (mangosteen). Constituent of the fruit hulls of Garcinia mangostana (mangosteen). 1,3,8-Trihydroxy-4-methyl-2,7-diprenylxanthone is found in fruits.
16-DHPS
C21H30O5S (394.18138500000003)
Brucine
C23H26N2O4 (394.18924760000004)
Deguelin
Eperezolid
Pyro(l-alpha-aminoadipyl)-L-histidyl-L-thiazolidine-4-carboxamide
C16H22N6O4S (394.14231720000004)
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
Sirtinol
Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively[1][2][3][4].
4-Hydroxymethyl Ambrisentan
Varespladib methyl
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D004791 - Enzyme Inhibitors > D064801 - Phospholipase A2 Inhibitors C471 - Enzyme Inhibitor Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
Gibberellin A28
Gibberellin a28 is a member of the class of compounds known as c20-gibberellin 20-carboxylic acids. C20-gibberellin 20-carboxylic acids are c20-gibberellins with a carboxyl group at the 20-position. Gibberellin a28 is slightly soluble (in water) and a weakly acidic compound (based on its pKa). Gibberellin a28 can be found in japanese pumpkin, scarlet bean, and winter squash, which makes gibberellin a28 a potential biomarker for the consumption of these food products.
Morusignin J
Deguelin
Deguelin is a rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite, an angiogenesis inhibitor, an antiviral agent, a mitochondrial NADH:ubiquinone reductase inhibitor, an anti-inflammatory agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of rotenones, an aromatic ether, an organic heteropentacyclic compound and a diether. Deguelin is a natural product found in Tephrosia vogelii, Derris montana, and other organisms with data available. A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
1,2,12,12a-Tetrahydro-2-isopropenyl-8,9-dimethoxy-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Dehydrodihydrorotenone
2,4,5-Trimethoxy-2,2-dimethylpyrano[5,6:6,7]isoflavone
Akuammiline
C23H26N2O4 (394.18924760000004)
Akuammiline is a monoterpenoid indole alkaloid.
3,4-Dihydroxy-7-methoxy-8-prenyl-5-(2-hydroxyisopropyl)-[2,3:5,6]furanoflavanone
[3aS-[3aR*,4R*(Z),5R*,6R*,9S*,10E,11aS*]]-2-Methyl-, 2,3,3a,4,5,6,7,8,9,11a-decahydro-5,6,9-trihydroxy-6,10-dimethyl-3-methylene-2,7-dioxocyclodeca[b]furan-4-yl ester 2-butenoic acid
(E)-3,4-Methylenedioxy-2-methoxy-6,6-dimethylchromeno-[2,3:4,3]-9-methoxychalcone
8-C-Methylvellokaempferol 3,5-dimethyl ether
1-(4-Hydroxy-3-methoxy)-phenyl-2-[4-(2,3-dihydroxypropyl)-2-methoxy]-phenoxy-1,3-propandiol
5,7,10-trihydroxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one
Muxiangrin I
(Z)-3,4-Methylenedioxy-2-methoxy-6,6-dimethylchromeno-[2,3:4,3]-9-methoxychalcone
Purpurin
Purpurin is a naturally occurring organic compound that belongs to the anthraquinone family. It is known for its distinctive red color and is found in various plants, particularly in the bark and roots of certain trees, as well as in some soil bacteria. The compound has a long history of use as a natural dye, especially in ancient times for coloring fabrics and as a component in inks. Chemically, Purpurin is characterized by a structure consisting of three fused benzene rings forming an anthraquinone skeleton, with two carboxylic acid groups attached to two of the benzene rings. This structure is responsible for its color and chemical properties. The presence of the carboxylic acid groups makes Purpurin soluble in alkaline solutions, which is why it was historically used in dyeing processes. In addition to its historical use as a dye, Purpurin has also found applications in modern science. It has been used as a fluorescent marker in biological and medical research due to its ability to absorb light at specific wavelengths and emit fluorescence. This property makes it useful in techniques such as fluorescence microscopy and imaging. Moreover, Purpurin and its derivatives have been studied in the fields of pharmacology and materials science. The compound's unique chemical structure and properties have made it a subject of interest for developing new pharmaceuticals and advanced materials. Its natural occurrence and the potential for sustainable synthesis from plant sources also contribute to its relevance in modern chemistry and related disciplines.
Samaderine Z
A quassinoid isolated from Quassia indica and has been shown to exhibit antimalarial and antineoplastic activity.
Rotenone
Origin: Plant, Pyrans relative retention time with respect to 9-anthracene Carboxylic Acid is 1.283 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.281 Acquisition and generation of the data is financially supported by the Max-Planck-Society D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals IPB_RECORD: 2241; CONFIDENCE confident structure Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
(2E,8S,10R)-10,11-Dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl methacrylate
1,6,7-trihydroxy-6,6-dimethyl-2H-pyrano(2,3:3,2)-4-(3-methylbut-2-enyl)xanthone
A member of the class of pyranoxanthones that is 2H,6H-pyrano[3,2-b]xanthen-6-one substituted by hydroxy groups at positions 5, 8 and 9, geminal methyl groups at position 2 and a prenyl group at position 12. Isolated from Garcinia lancilimba, it exhibits inhibitory effects on human cancer cell line.
4-(6-O-trans-cinnamoyl)-(2-hydroxymethyl)-4-hydroxybutenyl-beta-D-glucopyranoside
(+)-purpurin|(+)-Purpurin 2|7a,10,10a-Triepimer -Purpurin+
Brucin
C23H26N2O4 (394.18924760000004)
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents D002491 - Central Nervous System Agents > D000700 - Analgesics D007155 - Immunologic Factors
8alpha-propionyloxyanthemolide C|8??-Propionyloxyanthemolide C
2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin
samaderine E
A quassinoid isolated from Quassia indica and Samadera indica and has been shown to exhibit antimalarial and cytotoxic activities.
(E)-2-Hexenyl-??-L-arabinopyranosyl-(1鈥樏傗垎2)-??-D-glucopyranoside
4,5-dihydro-1,5-dihydroxy-6,6-dimethylpyrano(2,3:6,7)-4,4,5-trimethylfurano(2,3:3,4)xanthone
5,10-dihydroxy-12-((Z)-3-hydroxymethylbut-2-enyl)-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one|garcinexanthone E
2-(trans-cinnamoyloxy-methyl)-1-butene-4-O-beta-D-glucopyranoside
(2R,3R,4R,4aS,5R,5aS,7R,9R,12aR,12bS)-4,7,10-trihydroxy-5-methoxy-2,7,9-trimethyl-12-oxo-1,2,3,4,4a,5,5a,6,7,8,9,11,12a,12b-tetradecahydrobenzo[g]cycloocta[cd]pentalene-6,11-dione|abyssomicin E
2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E),7-pentenyl]-furo[2,3-b]chromone
Z-hex-3-en-1-ol O-alpha-L-arabinopyransyl (1-2)-beta-D-glucopyranoside
N-[1-Acetyl-2-(1,3-benzodioxole-5-ylcarbonyl)-3-phenylpyrrolidine-4-yl]acetamide
1,4,6-trihydroxy-5-(1,1-dimethyl-2-propenyl)-6,6-dimethylpyrano[2,3:3,2]xanthone|soulattrin
(7S,8R)-4,7,9,9-tetrahydroxy-3,3-dimethoxy-8-O-4-neolignan
isobrucine
C23H26N2O4 (394.18924760000004)
A monoterpenoid indole alkaloid with formula C23H26N2O4, originally isolated from the seeds of Strychnos nux-vomica.
1,3-dihydroxy-6-methoxy-2,4-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one|1,3-dihydroxy-6-methoxy-2,4-bis(3-methylbut-2-enyl)-9H-xanthen-9-one
4,2?,4?trihydroxy-6?-methoxy-3?(2??-hydroxybenzyl)dihydrochalcone
2-methyl-5-(2-hydroxypropy1)-7-hydroxychromone-2-O-D-glucopyranoside
2-(2,4-dihydroxyphenyl)-3-(3,5-dihydroxyphenyl)-7-hydroxy-4,4-dimethylchromane|4-[3-(3,5-dihydroxyphenyl)-3,4-dihydro-7-hydroxy-4,4-dimethyl-2H-1-benzopyran-2-yl]benzene-1,3-diol|artoxanthochromane
9,10,11,12-Tetrahydro-(7S,11Z)-Sclerotiorin
C21H27ClO5 (394.15469220000006)
8alpha-(2,3-epoxy-2-methylbutyryloxy)-4alpha,9alpha-epidioxy-9beta-hydroxy-5betaH-eudesm-1-en-6beta,12-olide
methyl 11,12-methylenedioxy-N(1)-decarbomethoxy-Delta14,15-chanofruticosinate|methyl 11,12-methylenedioxy-N-decarbomethoxy-Delta14,15-chanofruticosinate|Methyl 11,12-methylenedioxy-N1-decarbomethoxy-Delta14,15-chanofruticosinate|methyl 11,12-methylenedioxy-N1-decarbomethoxy-Delta14,15chanofruticosinate
2alpha-tigloyloxy-3,8-dioxo-11-peroxy-4beta,5beta,7alpha,14-bis-epoxybisabol-9E-ene
2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-3-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin
(16S)-17-Acetoxy-sarpagan-16-carbonsaeure-methylester|(16S)-17-acetoxy-sarpagane-16-carboxylic acid methyl ester|Acetylakuammidin|Monoacetylrhazin|O-Acetyl-rhazin|Polyneuridinacetat
C23H26N2O4 (394.18924760000004)
1-(4-Hydroxy-3-methoxyphenyl)-2-[4-(2,3-dihydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol
(E)-2-hexenyl alpha-L-arabinopyranosyl-(1->6)-beta-D-glucopyranoside
8beta-(2-methyl-2,3-epoxybutyryloxy)-5,9beta-dihydroxytrichosalviolide|8beta-<2-methyl-2,3-epoxybutyryloxy>-5,9beta-dihydroxytrichosalviolide
(-)-2beta-(3-methyl-1-oxobut-2-enyl)-2-deoxybruceol
1alpha-hydroperoxy-4alpha,10alpha-dihydroxy-9alpha-angeloyloxyguaia-2,11(13)-dien-12,6alpha-olide
11-Methoxyicajine|3-methoxy-19-methyl-16,19-seco-strychnidine-10,16-dione|3-Methoxy-icajin|3-methoxy-icajine|3-methoxyicajine|N-methyl-sec-pseudo-alpha-colubrine
C23H26N2O4 (394.18924760000004)
Salermide
Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
N, N-p-Cinnamoyl, caffeoylcadaverine
C23H26N2O4 (394.18924760000004)
Brucine - CASMI2016 Category 1 - Challenge 9
C23H26N2O4 (394.18924760000004)
C21H27ClO5_6H-2-Benzopyran-6-one, 8-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-1,7,8,8a-tetrahydro-7-hydroxy-7-methyl-, (7R,8R,8aR)
C21H27ClO5 (394.15469220000006)
C20H26O8_2-Propenoic acid, 2-methyl-, (4S,6R,11E)-2,4,5,6,7,8,9,10-octahydro-6,7-dihydroxy-3-(methoxymethyl)-6,10-dimethyl-2-oxo-7,10-epoxycyclodeca[b]furan-4-yl ester
C17H30O10_(3Z)-3-Hexen-1-yl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside
C23H26N2O4_2,3-Dimethoxystrychnidin-10-one
C23H26N2O4 (394.18924760000004)
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,⁷]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,⁷]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate_major
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,⁷]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate_34.9\\%
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,?]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate
Ala Ala Ala Tyr
Ala Ala Phe Ser
Ala Ala Ser Phe
Ala Ala Tyr Ala
Ala Cys Thr Thr
Ala Phe Ala Ser
Ala Phe Gly Thr
Ala Phe Ser Ala
Ala Phe Thr Gly
Ala Gly Phe Thr
Ala Gly Thr Phe
Ala Met Ser Ser
Ala Ser Ala Phe
Ala Ser Phe Ala
Ala Ser Met Ser
Ala Ser Ser Met
Ala Thr Cys Thr
Ala Thr Phe Gly
Ala Thr Gly Phe
Ala Thr Thr Cys
Ala Tyr Ala Ala
Cys Ala Thr Thr
Cys Ser Ser Val
Cys Ser Val Ser
Cys Thr Ala Thr
Cys Thr Thr Ala
Cys Val Ser Ser
Asp Phe Gly Gly
Asp Gly Phe Gly
Asp Gly Gly Phe
Phe Ala Ala Ser
Phe Ala Gly Thr
Phe Ala Ser Ala
Phe Ala Thr Gly
Phe Asp Gly Gly
Phe Gly Ala Thr
Phe Gly Asp Gly
Phe Gly Thr Ala
Phe Ser Ala Ala
Phe Thr Ala Gly
Phe Thr Gly Ala
Gly Ala Phe Thr
Gly Ala Thr Phe
Gly Asp Phe Gly
Gly Asp Gly Phe
Gly Phe Ala Thr
Gly Phe Asp Gly
Gly Phe Thr Ala
Gly Gly Asp Phe
Gly Gly Val Tyr
Gly Gly Tyr Val
Gly Met Ser Thr
Gly Met Thr Ser
Gly Ser Met Thr
Gly Ser Thr Met
Gly Thr Ala Phe
Gly Thr Phe Ala
Gly Thr Met Ser
Gly Thr Ser Met
Gly Val Gly Tyr
Gly Val Tyr Gly
Gly Tyr Gly Val
Gly Tyr Val Gly
Met Ala Ser Ser
Met Gly Ser Thr
Met Gly Thr Ser
Met Ser Ala Ser
Met Ser Gly Thr
Met Ser Ser Ala
Met Ser Thr Gly
Met Thr Gly Ser
Met Thr Ser Gly
Ser Ala Ala Phe
Ser Ala Phe Ala
Ser Ala Met Ser
Ser Ala Ser Met
Ser Cys Ser Val
Ser Cys Val Ser
Ser Phe Ala Ala
Ser Gly Met Thr
Ser Gly Thr Met
Ser Met Ala Ser
Ser Met Gly Thr
Ser Met Ser Ala
Ser Met Thr Gly
Ser Ser Ala Met
Ser Ser Cys Val
Ser Ser Met Ala
Ser Ser Thr Thr
Ser Ser Val Cys
Ser Thr Gly Met
Ser Thr Met Gly
Ser Thr Ser Thr
Ser Thr Thr Ser
Ser Val Cys Ser
Ser Val Ser Cys
Thr Ala Cys Thr
Thr Ala Phe Gly
Thr Ala Gly Phe
Thr Ala Thr Cys
Thr Cys Ala Thr
Thr Cys Thr Ala
Thr Phe Ala Gly
Thr Phe Gly Ala
Thr Gly Ala Phe
Thr Gly Phe Ala
Thr Gly Met Ser
Thr Gly Ser Met
Thr Met Gly Ser
Thr Met Ser Gly
Thr Ser Gly Met
Thr Ser Met Gly
Thr Ser Ser Thr
Thr Ser Thr Ser
Thr Thr Ala Cys
Thr Thr Cys Ala
Thr Thr Ser Ser
Val Cys Ser Ser
Val Gly Gly Tyr
Val Gly Tyr Gly
Val Ser Cys Ser
Val Ser Ser Cys
Val Tyr Gly Gly
Tyr Ala Ala Ala
Tyr Gly Gly Val
Tyr Gly Val Gly
Tyr Val Gly Gly
loteprednol
C21H27ClO5 (394.15469220000006)
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D018926 - Anti-Allergic Agents
cis-3-Hexenyl b-primeveroside
Gibberellin A39
Gibberellin A43
1,3,8-Trihydroxy-4-methyl-2,7-diprenylxanthone
A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1,3 and 8, prenyl groups at positions 2 and 7, and a methyl group at position 4.
1-(3-Methyl-2-butenoyl)-6-apiosylglucose
N-(4-methoxyphenyl)-N-[1-[3-(trifluoromethyl)phenyl]propan-2-yl]propanediamide
3-indol-1-ylsulfonyl-7-(4-methylpiperazin-1-yl)-1H-indole
(1R,2R)-N-(2,4,6-TRIMETHYLPHENYLSULFONYL)-1,2-DIPHENYLETHANE-1,2-DIAMINE
C23H26N2O2S (394.17148960000003)
(1S,2S)-(-)-N-(2,4,6-TRIMETHYLPHENYLSULFONYL)-1,2-DIPHENYLETHANE-1,2-DIAMINE
C23H26N2O2S (394.17148960000003)
Urea, N-[2-(1H-benzimidazol-2-yl)ethyl]-N-cyclopentyl-N-[4-(methylthio)phenyl]- (9CI)
C22H26N4OS (394.18272260000003)
5-fluoro-o4-(2,4,6-trimethylphenyl)-2-o-methyluridine
1-Piperidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo-(9CI)
2-[4-(2-methylpropyl)phenyl]-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Thiourea, N-[2-(1H-benzimidazol-2-yl)ethyl]-N-cyclopentyl-N-(4-methoxyphenyl)- (9CI)
C22H26N4OS (394.18272260000003)
8-[2-(1,4-BENZODIOXAN-2-YLMETHYLAMINO)ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE HYDROCHLORIDE
C20H27ClN2O4 (394.16592520000006)
Thiourea, N-[2-(1H-benzimidazol-2-yl)ethyl]-N-cyclopentyl-N-(3-methoxyphenyl)- (9CI)
C22H26N4OS (394.18272260000003)
4-[(Z)-1-hydroxy-3-(3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-3-oxoprop-1-enyl]benzoic acid
(2-{4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL}PHENYL)METHANOL
(4-{4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL}PHENYL)METHANOL
Itopride hydrochloride
C20H27ClN2O4 (394.16592520000006)
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1][2].
Eperezolid
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones C254 - Anti-Infective Agent > C258 - Antibiotic
2-(4-AMINOPHENYL)-7-(2-MORPHOLIN-4-YL-ETHOXY)IMIDAZO[2,1-B]-[1,3]BENZOTHIAZOLE
Rimacalib
C22H23FN4O2 (394.18049499999995)
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
Hdac inhibitor CHR-3996
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
Aminopentamide Sulfate
C19H26N2O5S (394.15623460000006)
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether
C21H27ClO5 (394.15469220000006)
N-{1-[(naphthalen-2-yl)amino]-1-oxo-3-phenylpropan-2-yl}benzamide
2-[[5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-1-(4-phenyl-1-piperazinyl)ethanone
5-[2-Furanyl-[4-(phenylmethyl)-1-piperidinyl]methyl]-6-thiazolo[3,2-b][1,2,4]triazolol
N-Allyl-5-amidinoaminooxy-propyloxy-3-chloro-N-cyclopentylbenzamide
N-(3-Cyanophenyl)-2-Methyl-5-(5-Methyl-1,3,4-Oxadiazol-2-Yl)-4-Biphenylcarboxamide
C24H18N4O2 (394.14296879999995)
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
Varespladib methyl
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D004791 - Enzyme Inhibitors > D064801 - Phospholipase A2 Inhibitors C471 - Enzyme Inhibitor Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
Volon
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XB - Corticosteroids, moderately potent, other combinations D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii) A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AC - Corticosteroids for local oral treatment R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D000893 - Anti-Inflammatory Agents Triamcinolone is a long-acting glucocorticoid, a corticosteroid receptor (corticosteroid hormone receptor) agonist, and has anti-inflammatory effects.
[10,11-Dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] 2-methylprop-2-enoate
5,6-Dihydroxy-4-methyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4,8-tricarboxylic acid
5,11-Dihydroxy-4-methyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4,8-tricarboxylic acid
(4aR,5aS,8aR,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one
C23H26N2O4 (394.18924760000004)
(17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl) hydrogen sulfate
C21H30O5S (394.18138500000003)
N4,N5-Bis(2-ethoxyphenyl)-1H-imidazole-4,5-dicarboxamide
N-(4-methyl-2-pyridinyl)-4-[3-(trifluoromethyl)anilino]-1-piperidinecarbothioamide
C19H21F3N4S (394.14389420000003)
2-(4-methoxyanilino)-7-oxo-N-(2-oxolanylmethyl)-1-benzopyran-3-carboxamide
1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[4-(difluoromethoxy)-3-methoxyphenyl]methyl-methylamino]ethanone
C20H24F2N2O4 (394.17040480000003)
N-[3-(1-naphthalenylamino)-3-oxo-1-phenylpropyl]benzamide
1-Methyl-4-[[2-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]thio]-2-quinolinone
3-hydroxy-5-nitro-2-phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-4-triazolimine
C20H22N6O3 (394.17533019999996)
Pyridin-3-ylmethyl {4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl}carbamate
2-[Oxo-[2-[oxo-(2-phenylethylamino)methyl]anilino]methyl]-1-cyclohexanecarboxylic acid
C23H26N2O4 (394.18924760000004)
2-[[4-[(1-Methyl-2-oxo-4-quinolinyl)oxy]-1-oxobutyl]amino]benzoic acid methyl ester
3-benzyl-5-(4-hydroxyphenyl)-N-(phenylacetyl)pyrazin-2-aminide
2-(1,3-benzodioxol-5-ylmethylamino)-N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)acetamide
2-[[1-[[3-(2-Hydroxyethoxy)phenyl]methyl]-4-piperidinyl]methyl]isoindole-1,3-dione
C23H26N2O4 (394.18924760000004)
2-pyridin-3-yl-1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
N-[(2S,3S,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)oxan-3-yl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2S,3R,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)oxan-3-yl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2S,3S,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3S,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2S,3R,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3S,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3R,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3R,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
1-[(3aR,4R,9bR)-8-[2-(4-fluorophenyl)ethynyl]-4-(hydroxymethyl)-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-1-yl]-2-methoxyethanone
1-[(3aS,4S,9bS)-8-[2-(4-fluorophenyl)ethynyl]-4-(hydroxymethyl)-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-1-yl]-2-methoxyethanone
N-[(Z)-[2-(1H-imidazol-2-yl)-1-phenylethylidene]amino]-3,4,5-trimethoxybenzamide
[2-Butanoyloxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] butanoate
[1-Propanoyloxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropan-2-yl] pentanoate
[1-Acetyloxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropan-2-yl] hexanoate
[(2E)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] 2-methylprop-2-enoate
Sirtinol
Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively[1][2][3][4].
A-674563 (hydrochloride)
A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
Z-Phe-Ala-diazomethylketone
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research[1].
methyl (13z)-18-[(acetyloxy)methyl]-13-ethylidene-8,15-diazapentacyclo[10.5.1.0¹,⁹.0²,⁷.0¹⁰,¹⁵]octadeca-2,4,6,8-tetraene-18-carboxylate
C23H26N2O4 (394.18924760000004)
(1r,13s,14z,19s,21s)-14-(2-hydroxyethylidene)-4,5-dimethoxy-8,16-diazahexacyclo[11.5.2.1¹,⁸.0²,⁷.0¹⁶,¹⁹.0¹²,²¹]henicosa-2(7),3,5,11-tetraen-9-one
C23H26N2O4 (394.18924760000004)
(1s,2r,7r,9r,13r,14s,15r,16s,17r)-14,15,16-trihydroxy-4-methoxy-2,14,17-trimethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-4-ene-3,6,11-trione
1,12-dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.0⁴,⁸]tetradec-2-en-9-yl 2-methylbut-2-enoate
(1s,2z,4s,8r,9r,11s,12r)-1,12-dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.0⁴,⁸]tetradec-2-en-9-yl (2z)-2-methylbut-2-enoate
(2s,3r,4s,5s,6r)-2-{[(1r,4r,5r,6s,7r,8s,9s)-4,5-dihydroxy-6-methoxy-2,10-dioxatricyclo[5.3.1.0⁴,⁸]undecan-9-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
8-hydroxy-4,9-dimethyl-14-methylidene-13-oxo-5,12-dioxatricyclo[9.3.0.0⁴,⁶]tetradec-9-en-2-yl 4-hydroxy-2-(hydroxymethyl)but-2-enoate
3,4a,8,8-tetramethyl-4-{[(2-oxochromen-7-yl)oxy]methyl}-4,5,6,8a-tetrahydronaphthalene-1,7-dione
(3s,8s,9s,11e)-8,9,16-trihydroxy-13,14-dimethoxy-3-methyl-4,5,6,8,9,10-hexahydro-3h-2-benzoxacyclotetradecine-1,7-dione
7-hydroxy-2,3-dimethyl-2-[4-methyl-5-(4-methylfuran-2-yl)pent-3-en-1-yl]-3h-furo[2,3-b]chromen-4-one
(1s,2r)-1-(4-hydroxy-3-methoxyphenyl)-2-[2-hydroxy-4-(3-hydroxypropyl)-6-methoxyphenoxy]propane-1,3-diol
(2s,3r,4s,5r)-2-{[(2r,3r,4s,5s,6r)-2-[(3z)-hex-3-en-1-yloxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}oxane-3,4,5-triol
5,10,13,14,15-pentahydroxy-4,12,16-trimethyl-3,8-dioxapentacyclo[9.8.0.0¹,⁵.0⁴,⁹.0¹²,¹⁷]nonadeca-16,18-dien-7-one
5-(6-hydroxy-1-benzofuran-2-yl)-4-(6-hydroxy-3,7-dimethylocta-2,7-dien-1-yl)benzene-1,3-diol
(1r,3s,4as,5s,8r,8as)-7,8-diformyl-5-hydroxy-3,8a-dimethyl-4-methylidene-1,2,3,4a,5,8-hexahydronaphthalen-1-yl (2e)-3-phenylprop-2-enoate
(2s,3s)-7-hydroxy-2,3-dimethyl-2-[(3e)-4-methyl-5-(4-methylfuran-2-yl)pent-3-en-1-yl]-3h-furo[2,3-b]chromen-4-one
(3as,4r,5r,6s,6ar,8r,9bs)-5-(acetyloxy)-6,8-dihydroxy-6,9-dimethyl-3-methylidene-2-oxo-3ah,4h,5h,6ah,7h,8h,9bh-azuleno[4,5-b]furan-4-yl propanoate
methyl (1s,10s,12s,13e,18r)-18-[(acetyloxy)methyl]-13-ethylidene-8,15-diazapentacyclo[10.5.1.0¹,⁹.0²,⁷.0¹⁰,¹⁵]octadeca-2,4,6,8-tetraene-18-carboxylate
C23H26N2O4 (394.18924760000004)
2-(7-hydroxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-5-yl)-7-(3-methylbut-3-en-2-yl)-1-benzofuran-4,6-diol
methyl (1r,2r,4r,5r,7r,12s,15s,23r)-4-hydroxy-3-oxo-6-oxa-8,16-diazaoctacyclo[10.10.1.0¹,¹⁵.0²,⁷.0⁴,¹⁵.0⁵,¹².0⁸,²³.0¹⁷,²²]tricosa-17,19,21-triene-16-carboxylate
(3s,8s,9r,11e)-8,9,16-trihydroxy-13,14-dimethoxy-3-methyl-4,5,6,8,9,10-hexahydro-3h-2-benzoxacyclotetradecine-1,7-dione
2-(7-hydroxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-5-yl)-7-[(2r)-3-methylbut-3-en-2-yl]-1-benzofuran-4,6-diol
3-[(1r,7s,8s,9r)-7-(acetyloxy)-4-(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0¹,⁷]tridec-3-en-9-yl]propanoic acid
5-chloro-3-[(1e,3e)-3,5-dimethylhepta-1,3-dien-1-yl]-7-hydroxy-7-methyl-6-oxo-8,8a-dihydro-1h-isochromen-8-yl acetate
C21H27ClO5 (394.15469220000006)
(2s,3r,4s,5s,6r)-6-({[(2r,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 3-methylbut-2-enoate
(3as,4r,6ar)-6a-[2-(2,5-dihydroxyphenyl)-2-oxoethyl]-3a-(dimethoxymethyl)-4-ethoxy-tetrahydrocyclopenta[c]furan-1-one
2-({[3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-6-(hex-3-en-1-yloxy)oxane-3,4,5-triol
(7r,8r,8ar)-5-chloro-3-[(1e,3e,5s)-3,5-dimethylhepta-1,3-dien-1-yl]-7-hydroxy-7-methyl-6-oxo-8,8a-dihydro-1h-isochromen-8-yl acetate
C21H27ClO5 (394.15469220000006)