Loteprednol (BioDeep_00000033271)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H27ClO5 (394.1547)
中文名称: 氯替泼诺
谱图信息:
最多检出来源 Mus musculus(urine) 8.95%
分子结构信息
SMILES: CC12CC(C3C(C1CCC2(C(=O)OCCl)O)CCC4=CC(=O)C=CC34C)O
InChI: InChI=1S/C21H27ClO5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,18(25)27-11-22)20(15,2)10-16(24)17(14)19/h5,7,9,14-17,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,17+,19-,20-,21-/m0/s1
描述信息
Loteprednol (as Loteprednol Etabonate) is a topical corticoid antiinflammatory. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, is used for the treatment and management of seasonal allergic rhinitis.
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D018926 - Anti-Allergic Agents
同义名列表
10 个代谢物同义名
chloromethyl (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-14-carboxylate; 17-Ethoxycarbonyloxy-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate, chloromethyl; Chloromethyl 17 ethoxycarbonyloxy 11 hydroxy 3 oxoandrosta 1,4 diene 17 carboxylate; Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate; Etabonate, loteprednol; Loteprednol etabonate; loteprednol; Lotemax; CEHOAC; Alrex
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:50848
- PubChem: 9865442
- HMDB: HMDB0015011
- DrugBank: DB00873
- Wikipedia: Loteprednol
- MeSH: Loteprednol Etabonate
- chemspider: 8041134
- CAS: 129260-79-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Burcu Uner, Samet Ozdemir, Cetin Tas, Melike Uner, Yildiz Ozsoy. Loteprednol-Loaded Nanoformulations for Corneal Delivery by Quality-by-Design Concepts: Optimization, Characterization, and Anti-inflammatory Activity.
AAPS PharmSciTech.
2023 Mar; 24(4):92. doi:
10.1208/s12249-023-02551-6. [PMID: 36977841] - Burcu Üner, Samet Özdemir, Çetin Taş, Yıldız Özsoy, Melike Üner. Development of lipid nanoparticles for transdermal loteprednol etabonate delivery.
Journal of microencapsulation.
2022 Jun; 39(4):327-340. doi:
10.1080/02652048.2022.2079744. [PMID: 35583383] - Ahmed Samir, Ayano Kage, Kayoko Ohura, Teruko Imai. Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 May; 49(5):569-576. doi:
10.1080/00498254.2018.1479803. [PMID: 29781759] - Ahmed Samir, Nicholas Bodor, Teruko Imai. Identification of esterase involved in the metabolism of two corticosteroid soft drugs.
Biochemical pharmacology.
2017 03; 127(?):82-89. doi:
10.1016/j.bcp.2016.12.010. [PMID: 28017774] - Aileen Sy, Kieran S O'Brien, Margaret P Liu, Puja A Cuddapah, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer. Expert opinion in the management of aqueous Deficient Dry Eye Disease (DED).
BMC ophthalmology.
2015 Oct; 15(?):133. doi:
10.1186/s12886-015-0122-z. [PMID: 26462481] - Shellise Glogowski, Ezra Lowe, Raphaele Siou-Mermet, Tuyen Ong, Mary Richardson. Prolonged exposure to loteprednol etabonate in human tear fluid and rabbit ocular tissues following topical ocular administration of Lotemax gel, 0.5\%.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2014 Feb; 30(1):66-73. doi:
10.1089/jop.2013.0142. [PMID: 24325539] - Ramon C Ghanem, Vinícius C Ghanem, Gustavo Victor, Milton Ruiz Alves. Bilateral progressive idiopathic annular lipid keratopathy.
Case reports in ophthalmological medicine.
2012; 2012(?):731413. doi:
10.1155/2012/731413. [PMID: 22649744] - W M Wu, Y Tang, P Buchwald, N Bodor. Pharmacokinetics and delta1-cortienic acid excretion after intravenous administration of prednisolone and loteprednol etabonate in rats.
Die Pharmazie.
2010 Jun; 65(6):412-6. doi:
NULL. [PMID: 20614688] - Whei-Mei Wu, Fenglei Huang, Yangsuk Lee, Peter Buchwald, Nicholas Bodor. Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats.
The Journal of pharmacy and pharmacology.
2008 Mar; 60(3):291-7. doi:
10.1211/jpp.60.3.0003. [PMID: 18284808] - Robert Hermann, Mathias Locher, Marianne Siebert-Weigel, Nicole LaVallee, Hartmut Derendorf, Günther Hochhaus. Intranasal loteprednol etabonate in healthy male subjects: pharmacokinetics and effects on endogenous cortisol.
Journal of clinical pharmacology.
2004 May; 44(5):510-9. doi:
10.1177/0091270004264163. [PMID: 15102872] - L F Buris, N Bodor, L Buris. Loteprednol etabonate, a new soft steroid is effective in a rabbit acute experimental model for arthritis.
Die Pharmazie.
1999 Jan; 54(1):58-61. doi:
NULL. [PMID: 9987798] - J Howes, G D Novack. Failure to detect systemic levels, and effects of loteprednol etabonate and its metabolite, PJ-91, following chronic ocular administration.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
1998 Apr; 14(2):153-8. doi:
10.1089/jop.1998.14.153. [PMID: 9572541] - N Bodor, T Murakami, W M Wu. Soft drugs. 18. Oral and rectal delivery of loteprednol etabonate, a novel soft corticosteroid, in rats--for safer treatment of gastrointestinal inflammation.
Pharmaceutical research.
1995 Jun; 12(6):869-74. doi:
10.1023/a:1016213121069. [PMID: 7667192] - N Bodor, W M Wu, T Murakami, S Engel. Soft drugs. 19. Pharmacokinetics, metabolism and excretion of a novel soft corticosteroid, loteprednol etabonate, in rats.
Pharmaceutical research.
1995 Jun; 12(6):875-9. doi:
10.1023/a:1016265105139. [PMID: 7667193] - G Hochhaus, L S Chen, A Ratka, P Druzgala, J Howes, N Bodor, H Derendorf. Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs.
Journal of pharmaceutical sciences.
1992 Dec; 81(12):1210-5. doi:
10.1002/jps.2600811217. [PMID: 1491342]
