Exact Mass: 394.1416312
Exact Mass Matches: 394.1416312
Found 500 metabolites which its exact mass value is equals to given mass value 394.1416312,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Rotenone
Rotenone appears as colorless to brownish crystals or a white to brownish-white crystalline powder. Has neither odor nor taste. (NTP, 1992) Rotenone is a member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). It has a role as a phytogenic insecticide, a mitochondrial NADH:ubiquinone reductase inhibitor, a metabolite, an antineoplastic agent, a toxin and a piscicide. It is an organic heteropentacyclic compound and a member of rotenones. Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish. Rotenone is a natural product found in Pachyrhizus erosus, Millettia ferruginea, and other organisms with data available. Rotenone is a naturally occurring organic heteropentacyclic compound and member of rotenones that is found in the roots of several plant species. It is a mitochondrial NADH:ubiquinone reductase inhibitor, toxin, and metabolite, and is used as an antineoplastic agent and insecticide. It is characterized as a colorless to brownish or a white to brownish-white crystalline solid that is odorless. Exposure occurs by inhalation, ingestion, or contact. Rotenone is found in jicama. Rotenone is widely distributed in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean).Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant. In mammals, including humans, it is linked to the development of Parkinsons disease. (Wikipedia) Rotenone has been shown to exhibit apoptotic, neuroprotectant and neuroprotective functions (A7776, A7777, A7777).Rotenone belongs to the family of Rotenoids. These are phenolic compounds containing aA cis-fused tetrahydrochromeno[3,4-b]chromenenucleus. Many rotenoids contain an additional ring, e.g rotenone[1]. (Reference: [1] IUPAC. Compendium of Chemical Terminology, 2nd ed. (the Gold Book). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook. (PAC, 1995, 67, 1307 (Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)) on page 1364)). A botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is found in jicama. Rotenone is widely distributed in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean).Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant. In mammals, including humans, it is linked to the development of Parkinsons disease. A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica). Widely distrib. in the Leguminosae (Papilionoideae) e.g. Pachyrrhizus erosus (yam bean) D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Aloesin
Aloesin is a member of chromones. Aloesin is a natural product found in Aloe africana, Aloe castanea, and other organisms with data available.
Legumelin
Legumelin, also known as (-)-cis-deguelin, is a member of the class of compounds known as rotenones. Rotenones are rotenoids with a structure based on a 6a,12a-dihydrochromeno[3,4-b]chromen-12(6H)-one skeleton. Thus, legumelin is considered to be a flavonoid lipid molecule. Legumelin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Legumelin can be found in soy bean, which makes legumelin a potential biomarker for the consumption of this food product. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
Gibberellin A43
Gibberellin A43 (GA43) belongs to the class of organic compounds known as C20-gibberellin 20-carboxylic acids. These are C20-gibberellins with a carboxyl group at the 6-position. Gibberellin A43 is found in common pea. Gibberellin A43 is from Cucurbita maxim. From Cucurbita maxima. Gibberellin A43 is found in many foods, some of which are common pea, japanese pumpkin, winter squash, and fruits.
Gibberellin A39
Gibberellin A39 (GA39) belongs to the class of organic compounds known as C20-gibberellin 20-carboxylic acids. These are C20-gibberellins with a carboxyl group at the 6-position. Gibberellin A39 is found in fruits. Gibberellin A39 is a constituent of the seeds of Cucurbita pepo and Cucurbita maxima. Constituent of the seeds of Cucurbita pepo and Cucurbita maxima. Gibberellin A39 is found in winter squash, fruits, and japanese pumpkin.
6-Hydroxymusizin 8-O-b-D-glucopyranoside
6-Hydroxymusizin 8-O-b-D-glucopyranoside is found in green vegetables. 6-Hydroxymusizin 8-O-b-D-glucopyranoside is isolated from the rhubarb Rhei rhizom
Aloesone 7-O-glucoside
Aloesone 7-O-glucoside belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-fructose, and L-rhamnose. Aloesone 7-O-glucoside is found in green vegetables. Aloesone 7-O-glucoside is a constituent of Chinese rhubarb (Rheum sp.). Constituent of Chinese rhubarb (Rheum species). 2-Oxoaloesol 7-glucoside is found in green vegetables.
Garcinone B
Constituent of Garcinia mangostana (mangosteen). Garcinone B is found in fruits and purple mangosteen. Garcinone B is found in fruits. Garcinone B is a constituent of Garcinia mangostana (mangosteen)
1-(3-Methyl-2-butenoyl)-6-apiosylglucose
1-(3-Methyl-2-butenoyl)-6-apiosylglucose is found in coffee and coffee products. 1-(3-Methyl-2-butenoyl)-6-apiosylglucose is a constituent of green coffee beans (Coffea arabica). Constituent of green coffee beans (Coffea arabica). 1-(3-Methyl-2-butenoyl)-6-apiosylglucose is found in coffee and coffee products.
Loteprednol
C21H27ClO5 (394.15469220000006)
Loteprednol (as Loteprednol Etabonate) is a topical corticoid antiinflammatory. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, is used for the treatment and management of seasonal allergic rhinitis. S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D018926 - Anti-Allergic Agents
N-Acetylserotonin glucuronide
N-Acetylserotonin glucuronide is a metabolite of melatonin. Melatonin Listen/ˌmɛləˈtoʊnɪn/, also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants, and microbes. In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions. (Wikipedia)
2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
C471 - Enzyme Inhibitor Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
Aloeresin B
Deguelin
Eperezolid
Pyro(l-alpha-aminoadipyl)-L-histidyl-L-thiazolidine-4-carboxamide
C16H22N6O4S (394.14231720000004)
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
6-Chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline
4-Hydroxymethyl Ambrisentan
Varespladib methyl
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D004791 - Enzyme Inhibitors > D064801 - Phospholipase A2 Inhibitors C471 - Enzyme Inhibitor Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
6-Hydroxymusizin 8-O-glucoside
6-hydroxymusizin 8-o-glucoside is a member of the class of compounds known as phenolic glycosides. Phenolic glycosides are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose. 6-hydroxymusizin 8-o-glucoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 6-hydroxymusizin 8-o-glucoside can be found in garden rhubarb, which makes 6-hydroxymusizin 8-o-glucoside a potential biomarker for the consumption of this food product.
Gibberellin A28
Gibberellin a28 is a member of the class of compounds known as c20-gibberellin 20-carboxylic acids. C20-gibberellin 20-carboxylic acids are c20-gibberellins with a carboxyl group at the 20-position. Gibberellin a28 is slightly soluble (in water) and a weakly acidic compound (based on its pKa). Gibberellin a28 can be found in japanese pumpkin, scarlet bean, and winter squash, which makes gibberellin a28 a potential biomarker for the consumption of these food products.
Morusignin J
Deguelin
Deguelin is a rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite, an angiogenesis inhibitor, an antiviral agent, a mitochondrial NADH:ubiquinone reductase inhibitor, an anti-inflammatory agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of rotenones, an aromatic ether, an organic heteropentacyclic compound and a diether. Deguelin is a natural product found in Tephrosia vogelii, Derris montana, and other organisms with data available. A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
1,2,12,12a-Tetrahydro-2-isopropenyl-8,9-dimethoxy-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
Dehydrodihydrorotenone
2,4,5-Trimethoxy-2,2-dimethylpyrano[5,6:6,7]isoflavone
3,4-Dihydroxy-7-methoxy-8-prenyl-5-(2-hydroxyisopropyl)-[2,3:5,6]furanoflavanone
[3aS-[3aR*,4R*(Z),5R*,6R*,9S*,10E,11aS*]]-2-Methyl-, 2,3,3a,4,5,6,7,8,9,11a-decahydro-5,6,9-trihydroxy-6,10-dimethyl-3-methylene-2,7-dioxocyclodeca[b]furan-4-yl ester 2-butenoic acid
(E)-3,4-Methylenedioxy-2-methoxy-6,6-dimethylchromeno-[2,3:4,3]-9-methoxychalcone
8-C-Methylvellokaempferol 3,5-dimethyl ether
1-(4-Hydroxy-3-methoxy)-phenyl-2-[4-(2,3-dihydroxypropyl)-2-methoxy]-phenoxy-1,3-propandiol
5,7,10-trihydroxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one
Muxiangrin I
(Z)-3,4-Methylenedioxy-2-methoxy-6,6-dimethylchromeno-[2,3:4,3]-9-methoxychalcone
Purpurin
Purpurin is a naturally occurring organic compound that belongs to the anthraquinone family. It is known for its distinctive red color and is found in various plants, particularly in the bark and roots of certain trees, as well as in some soil bacteria. The compound has a long history of use as a natural dye, especially in ancient times for coloring fabrics and as a component in inks. Chemically, Purpurin is characterized by a structure consisting of three fused benzene rings forming an anthraquinone skeleton, with two carboxylic acid groups attached to two of the benzene rings. This structure is responsible for its color and chemical properties. The presence of the carboxylic acid groups makes Purpurin soluble in alkaline solutions, which is why it was historically used in dyeing processes. In addition to its historical use as a dye, Purpurin has also found applications in modern science. It has been used as a fluorescent marker in biological and medical research due to its ability to absorb light at specific wavelengths and emit fluorescence. This property makes it useful in techniques such as fluorescence microscopy and imaging. Moreover, Purpurin and its derivatives have been studied in the fields of pharmacology and materials science. The compound's unique chemical structure and properties have made it a subject of interest for developing new pharmaceuticals and advanced materials. Its natural occurrence and the potential for sustainable synthesis from plant sources also contribute to its relevance in modern chemistry and related disciplines.
Samaderine Z
A quassinoid isolated from Quassia indica and has been shown to exhibit antimalarial and antineoplastic activity.
Rotenone
Origin: Plant, Pyrans relative retention time with respect to 9-anthracene Carboxylic Acid is 1.283 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.281 Acquisition and generation of the data is financially supported by the Max-Planck-Society D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals IPB_RECORD: 2241; CONFIDENCE confident structure Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
(2E,8S,10R)-10,11-Dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl methacrylate
1,6,7-trihydroxy-6,6-dimethyl-2H-pyrano(2,3:3,2)-4-(3-methylbut-2-enyl)xanthone
A member of the class of pyranoxanthones that is 2H,6H-pyrano[3,2-b]xanthen-6-one substituted by hydroxy groups at positions 5, 8 and 9, geminal methyl groups at position 2 and a prenyl group at position 12. Isolated from Garcinia lancilimba, it exhibits inhibitory effects on human cancer cell line.
4-(6-O-trans-cinnamoyl)-(2-hydroxymethyl)-4-hydroxybutenyl-beta-D-glucopyranoside
(+)-purpurin|(+)-Purpurin 2|7a,10,10a-Triepimer -Purpurin+
8alpha-propionyloxyanthemolide C|8??-Propionyloxyanthemolide C
samaderine E
A quassinoid isolated from Quassia indica and Samadera indica and has been shown to exhibit antimalarial and cytotoxic activities.
4,5-dihydro-1,5-dihydroxy-6,6-dimethylpyrano(2,3:6,7)-4,4,5-trimethylfurano(2,3:3,4)xanthone
5,10-dihydroxy-12-((Z)-3-hydroxymethylbut-2-enyl)-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one|garcinexanthone E
2-(trans-cinnamoyloxy-methyl)-1-butene-4-O-beta-D-glucopyranoside
(2R,3R,4R,4aS,5R,5aS,7R,9R,12aR,12bS)-4,7,10-trihydroxy-5-methoxy-2,7,9-trimethyl-12-oxo-1,2,3,4,4a,5,5a,6,7,8,9,11,12a,12b-tetradecahydrobenzo[g]cycloocta[cd]pentalene-6,11-dione|abyssomicin E
5-Acetonyl-6-glucosy-7-hydroxy-2-methyl-4H-1-benzopyran-4-one
5,4,8-trihydroxy-3,3-dimethoxy-8-chloromethylene-7,9-epoxylignan
N-[1-Acetyl-2-(1,3-benzodioxole-5-ylcarbonyl)-3-phenylpyrrolidine-4-yl]acetamide
1,4,6-trihydroxy-5-(1,1-dimethyl-2-propenyl)-6,6-dimethylpyrano[2,3:3,2]xanthone|soulattrin
(+)-(7S,8S)-4-hydroxy-3,3,5-trimethoxy-7,8,9-trinor-8,4-oxyneolignan-7,9-diol-7-oic acid|4-((1S,2S)-1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yloxy)-3,5-dimethoxybenzoic acid
(7S,8R)-4,7,9,9-tetrahydroxy-3,3-dimethoxy-8-O-4-neolignan
7-[4-(4-Hydroxy-4-methyl-5-oxotetrahydrofuran-2-yl)-2,3-dihydroxy-3-methylbutoxy]-8-hydroxy-2H-1-benzopyran-2-one
4,2?,4?trihydroxy-6?-methoxy-3?(2??-hydroxybenzyl)dihydrochalcone
2-methyl-5-(2-hydroxypropy1)-7-hydroxychromone-2-O-D-glucopyranoside
(3S,4R)-4,8,2??5?-tetrahydroxy-6,7,3?,4?-tetramethoxyisoflavan|abruquinone H
2-(2,4-dihydroxyphenyl)-3-(3,5-dihydroxyphenyl)-7-hydroxy-4,4-dimethylchromane|4-[3-(3,5-dihydroxyphenyl)-3,4-dihydro-7-hydroxy-4,4-dimethyl-2H-1-benzopyran-2-yl]benzene-1,3-diol|artoxanthochromane
9,10,11,12-Tetrahydro-(7S,11Z)-Sclerotiorin
C21H27ClO5 (394.15469220000006)
8alpha-(2,3-epoxy-2-methylbutyryloxy)-4alpha,9alpha-epidioxy-9beta-hydroxy-5betaH-eudesm-1-en-6beta,12-olide
5-acetonyl-2-methylchromone-7-O-beta-O-glucopyranoside|5-acetonyl-7-beta-D-glucopyranosyloxy-2-methylchromone
10-(1,1-Dimethyl-2-propenyl)-7,9,12-trihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one|macluraxanthone
5,9,10-trihydroxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one
methyl 11,12-methylenedioxy-N(1)-decarbomethoxy-Delta14,15-chanofruticosinate|methyl 11,12-methylenedioxy-N-decarbomethoxy-Delta14,15-chanofruticosinate|Methyl 11,12-methylenedioxy-N1-decarbomethoxy-Delta14,15-chanofruticosinate|methyl 11,12-methylenedioxy-N1-decarbomethoxy-Delta14,15chanofruticosinate
(E)-3-{2,3-dihydro-2-[2-[(E)-p-coumaroyloxy]-1-methylethyl]-5-benzofuranyl}-2-propenoic acid
2alpha-tigloyloxy-3,8-dioxo-11-peroxy-4beta,5beta,7alpha,14-bis-epoxybisabol-9E-ene
1-(4-Hydroxy-3-methoxyphenyl)-2-[4-(2,3-dihydroxypropyl)-2-methoxyphenoxy]-1,3-propanediol
5-hydroxy-7-methoxy-8-methyl-3,4-methylenedioxy-5-(3-methyl-but-2-enyl)-3,4-methylenedioxyflavone
8beta-(2-methyl-2,3-epoxybutyryloxy)-5,9beta-dihydroxytrichosalviolide|8beta-<2-methyl-2,3-epoxybutyryloxy>-5,9beta-dihydroxytrichosalviolide
1,5,6-trihydroxy-6,6-dimethyl-2H-pyrano(2,3:3,4)-2-(3-methylbut-2-enyl)xanthone
A member of the class of pyranoxanthones that is 3H,7H-pyrano[2,3-c]xanthen-7-one substituted by hydroxy groups at positions 6, 10 and 11, geminal methyl groups at position 3 and a prenyl group at position 5. Isolated from Garcinia lancilimba, it exhibits inhibitory effects on human cancer cell line.
1alpha-hydroperoxy-4alpha,10alpha-dihydroxy-9alpha-angeloyloxyguaia-2,11(13)-dien-12,6alpha-olide
SB 242084
5,9,10-trihydroxy-2,2-dimethyl-12-(2-methylbut-3-en-2-yl)pyrano[3,2-b]xanthen-6-one
7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one
C21H27ClO5_6H-2-Benzopyran-6-one, 8-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-1,7,8,8a-tetrahydro-7-hydroxy-7-methyl-, (7R,8R,8aR)
C21H27ClO5 (394.15469220000006)
C20H26O8_2-Propenoic acid, 2-methyl-, (4S,6R,11E)-2,4,5,6,7,8,9,10-octahydro-6,7-dihydroxy-3-(methoxymethyl)-6,10-dimethyl-2-oxo-7,10-epoxycyclodeca[b]furan-4-yl ester
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,⁷]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate
7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one [IIN-based on: CCMSLIB00000848089]
8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one [IIN-based: Match]
8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one [IIN-based on: CCMSLIB00000848572]
7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one [IIN-based: Match]
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,⁷]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate_major
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,⁷]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate_34.9\\%
(1R,2E,8S,10R,11S)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.0³,?]tetradeca-2,6-dien-8-yl 2-methylprop-2-enoate
Ala Ala Cys Met
C14H26N4O5S2 (394.13445459999997)
Ala Ala Met Cys
C14H26N4O5S2 (394.13445459999997)
Ala Cys Ala Met
C14H26N4O5S2 (394.13445459999997)
Ala Cys Cys Val
C14H26N4O5S2 (394.13445459999997)
Ala Cys Asp Ser
Ala Cys Met Ala
C14H26N4O5S2 (394.13445459999997)
Ala Cys Ser Asp
Ala Cys Thr Thr
Ala Cys Val Cys
C14H26N4O5S2 (394.13445459999997)
Ala Asp Cys Ser
Ala Asp Ser Cys
Ala Met Ala Cys
C14H26N4O5S2 (394.13445459999997)
Ala Met Cys Ala
C14H26N4O5S2 (394.13445459999997)
Ala Met Ser Ser
Ala Ser Cys Asp
Ala Ser Asp Cys
Ala Ser Met Ser
Ala Ser Ser Met
Ala Thr Cys Thr
Ala Thr Thr Cys
Ala Val Cys Cys
C14H26N4O5S2 (394.13445459999997)
Cys Ala Ala Met
C14H26N4O5S2 (394.13445459999997)
Cys Ala Cys Val
C14H26N4O5S2 (394.13445459999997)
Cys Ala Asp Ser
Cys Ala Met Ala
C14H26N4O5S2 (394.13445459999997)
Cys Ala Ser Asp
Cys Ala Thr Thr
Cys Ala Val Cys
C14H26N4O5S2 (394.13445459999997)
Cys Cys Ala Val
C14H26N4O5S2 (394.13445459999997)
Cys Cys Gly Ile
C14H26N4O5S2 (394.13445459999997)
Cys Cys Gly Leu
C14H26N4O5S2 (394.13445459999997)
Cys Cys Ile Gly
C14H26N4O5S2 (394.13445459999997)
Cys Cys Leu Gly
C14H26N4O5S2 (394.13445459999997)
Cys Cys Val Ala
C14H26N4O5S2 (394.13445459999997)
Cys Asp Ala Ser
Cys Asp Gly Thr
Cys Asp Ser Ala
Cys Asp Thr Gly
Cys Glu Gly Ser
Cys Glu Ser Gly
Cys Gly Cys Ile
C14H26N4O5S2 (394.13445459999997)
Cys Gly Cys Leu
C14H26N4O5S2 (394.13445459999997)
Cys Gly Asp Thr
Cys Gly Glu Ser
Cys Gly Ile Cys
C14H26N4O5S2 (394.13445459999997)
Cys Gly Leu Cys
C14H26N4O5S2 (394.13445459999997)
Cys Gly Ser Glu
Cys Gly Thr Asp
Cys Ile Cys Gly
C14H26N4O5S2 (394.13445459999997)
Cys Ile Gly Cys
C14H26N4O5S2 (394.13445459999997)
Cys Leu Cys Gly
C14H26N4O5S2 (394.13445459999997)
Cys Leu Gly Cys
C14H26N4O5S2 (394.13445459999997)
Cys Met Ala Ala
C14H26N4O5S2 (394.13445459999997)
Cys Ser Ala Asp
Cys Ser Asp Ala
Cys Ser Glu Gly
Cys Ser Gly Glu
Cys Ser Ser Val
Cys Ser Val Ser
Cys Thr Ala Thr
Cys Thr Asp Gly
Cys Thr Gly Asp
Cys Thr Thr Ala
Cys Val Ala Cys
C14H26N4O5S2 (394.13445459999997)
Cys Val Cys Ala
C14H26N4O5S2 (394.13445459999997)
Cys Val Ser Ser
Asp Ala Cys Ser
Asp Ala Ser Cys
Asp Cys Ala Ser
Asp Cys Gly Thr
Asp Cys Ser Ala
Asp Cys Thr Gly
Asp Phe Gly Gly
Asp Gly Cys Thr
Asp Gly Phe Gly
Asp Gly Gly Phe
Asp Gly Thr Cys
Asp Ser Ala Cys
Asp Ser Cys Ala
Asp Ser Ser Ser
C13H22N4O10 (394.13358719999997)
Asp Thr Cys Gly
Asp Thr Gly Cys
Glu Cys Gly Ser
Glu Cys Ser Gly
Glu Gly Cys Ser
Glu Gly Ser Cys
Phe Asp Gly Gly
Phe Gly Asp Gly
Gly Cys Cys Ile
C14H26N4O5S2 (394.13445459999997)
Gly Cys Cys Leu
C14H26N4O5S2 (394.13445459999997)
Gly Cys Ile Cys
C14H26N4O5S2 (394.13445459999997)
Gly Cys Leu Cys
C14H26N4O5S2 (394.13445459999997)
Gly Asp Phe Gly
Gly Asp Gly Phe
Gly Phe Asp Gly
Gly Gly Asp Phe
Gly Gly Met Met
C14H26N4O5S2 (394.13445459999997)
Gly Ile Cys Cys
C14H26N4O5S2 (394.13445459999997)
Gly Leu Cys Cys
C14H26N4O5S2 (394.13445459999997)
Gly Met Gly Met
C14H26N4O5S2 (394.13445459999997)
Gly Met Met Gly
C14H26N4O5S2 (394.13445459999997)
Gly Met Ser Thr
Gly Met Thr Ser
Gly Ser Met Thr
Gly Ser Thr Met
Gly Thr Met Ser
Gly Thr Ser Met
Ile Cys Cys Gly
C14H26N4O5S2 (394.13445459999997)
Ile Cys Gly Cys
C14H26N4O5S2 (394.13445459999997)
Ile Gly Cys Cys
C14H26N4O5S2 (394.13445459999997)
Leu Cys Cys Gly
C14H26N4O5S2 (394.13445459999997)
Leu Cys Gly Cys
C14H26N4O5S2 (394.13445459999997)
Leu Gly Cys Cys
C14H26N4O5S2 (394.13445459999997)
Met Ala Ala Cys
C14H26N4O5S2 (394.13445459999997)
Met Ala Cys Ala
C14H26N4O5S2 (394.13445459999997)
Met Ala Ser Ser
Met Cys Ala Ala
C14H26N4O5S2 (394.13445459999997)
Met Gly Gly Met
C14H26N4O5S2 (394.13445459999997)
Met Gly Met Gly
C14H26N4O5S2 (394.13445459999997)
Met Gly Ser Thr
Met Gly Thr Ser
Met Met Gly Gly
C14H26N4O5S2 (394.13445459999997)
Met Ser Ala Ser
Met Ser Gly Thr
Met Ser Ser Ala
Met Ser Thr Gly
Met Thr Gly Ser
Met Thr Ser Gly
Ser Ala Met Ser
Ser Ala Ser Met
Ser Cys Ser Val
Ser Cys Val Ser
Ser Asp Ser Ser
C13H22N4O10 (394.13358719999997)
Ser Gly Met Thr
Ser Gly Thr Met
Ser Met Ala Ser
Ser Met Gly Thr
Ser Met Ser Ala
Ser Met Thr Gly
Ser Ser Ala Met
Ser Ser Cys Val
Ser Ser Asp Ser
C13H22N4O10 (394.13358719999997)
Ser Ser Met Ala
Ser Ser Ser Asp
C13H22N4O10 (394.13358719999997)
Ser Ser Val Cys
Ser Thr Gly Met
Ser Thr Met Gly
Ser Val Cys Ser
Ser Val Ser Cys
Thr Ala Cys Thr
Thr Ala Thr Cys
Thr Cys Ala Thr
Thr Cys Thr Ala
Thr Gly Met Ser
Thr Gly Ser Met
Thr Met Gly Ser
Thr Met Ser Gly
Thr Ser Gly Met
Thr Ser Met Gly
Thr Thr Ala Cys
Thr Thr Cys Ala
Val Ala Cys Cys
C14H26N4O5S2 (394.13445459999997)
Val Cys Ala Cys
C14H26N4O5S2 (394.13445459999997)
Val Cys Cys Ala
C14H26N4O5S2 (394.13445459999997)
Val Cys Ser Ser
Val Ser Cys Ser
Val Ser Ser Cys
(2S,7aR,10S,10aS)-9,9-Dimethyl-4-oxo-2-phenyl-3,4,7a,9,10,10a-hexahydro-2H-furo[3,2:4,5]furo[2,3-h]chromen-10-yl acetate
loteprednol
C21H27ClO5 (394.15469220000006)
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid D018926 - Anti-Allergic Agents
garcinone B
MUSIZIN GLUCOSIDE, 6-HYDROXY
Gibberellin A39
Gibberellin A43
10-Iodostearyl carnitine
1-(3-Methyl-2-butenoyl)-6-apiosylglucose
Ethyl 4-acetoxy-8-(benzyloxy)-7-methoxy-2-naphthoate
N-(4-methoxyphenyl)-N-[1-[3-(trifluoromethyl)phenyl]propan-2-yl]propanediamide
3-indol-1-ylsulfonyl-7-(4-methylpiperazin-1-yl)-1H-indole
5-fluoro-o4-(2,4,6-trimethylphenyl)-2-o-methyluridine
1-Piperidineaceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo-(9CI)
2-[4-(2-methylpropyl)phenyl]-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
3-[ethyl[3-methyl-4-[(6-nitrobenzothiazol-2-yl)azo]phenyl]amino]propiononitrile
8-[2-(1,4-BENZODIOXAN-2-YLMETHYLAMINO)ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE HYDROCHLORIDE
C20H27ClN2O4 (394.16592520000006)
[1,1,4,1',4',1'-Quaterphenyl]-4,4-dicarbonaldehyde
1-(1-(2-(4-CHLOROPHENYL)-2-OXOETHYL)PIPERIDIN-4-YL)-2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOLE-5-CARBONITRILE
SB-242084
SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage[1][2][3].
Itopride hydrochloride
C20H27ClN2O4 (394.16592520000006)
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1][2].
Eperezolid
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones C254 - Anti-Infective Agent > C258 - Antibiotic
Imanixil
C17H17F3N6O2 (394.13650179999996)
Imanixil (HOE-402 free base) is an inducer of the LDL receptor (LDLR). Imanixil (HOE-402 free base) is also a potent cholesterol-lowering compound, which inhibits very low density-lipoprotein (VLDL) production, and consequently attenuates atherosclerosis development[1].
2-(4-AMINOPHENYL)-7-(2-MORPHOLIN-4-YL-ETHOXY)IMIDAZO[2,1-B]-[1,3]BENZOTHIAZOLE
Hdac inhibitor CHR-3996
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
Aminopentamide Sulfate
C19H26N2O5S (394.15623460000006)
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
Bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether
C21H27ClO5 (394.15469220000006)
Fluacizine
C20H21F3N2OS (394.13266120000003)
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
2-[[5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-1-(4-phenyl-1-piperazinyl)ethanone
3-(4-Methoxyphenyl)-3-(4-methylphenyl)sulfonyl-1-phenyl-1-propanone
C23H22O4S (394.12387320000005)
5-[2-Furanyl-[4-(phenylmethyl)-1-piperidinyl]methyl]-6-thiazolo[3,2-b][1,2,4]triazolol
(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 12,12a-dihydro-2-isopropyl-8,9-dimethoxy-, (+)-
N-(3-Cyanophenyl)-2-Methyl-5-(5-Methyl-1,3,4-Oxadiazol-2-Yl)-4-Biphenylcarboxamide
C24H18N4O2 (394.14296879999995)
Varespladib methyl
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D004791 - Enzyme Inhibitors > D064801 - Phospholipase A2 Inhibitors C471 - Enzyme Inhibitor Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
NSC 362402
[10,11-Dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] 2-methylprop-2-enoate
5,6-Dihydroxy-4-methyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4,8-tricarboxylic acid
5,11-Dihydroxy-4-methyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4,8-tricarboxylic acid
Novobiocic acid(1-)
C22H20NO6- (394.12905600000005)
An organic anion obtained by selective deprotonation of the 4-hydroxy group on the chromene ring of novobiocic acid.
(19S)-19-ethyl-12,19-dihydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
3,4,5-trimethoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
(+)-(7S,8S)-4-hydroxy-3,3,5-trimethoxy-8,9-dinor-8,4-oxyneolignan-7,9-diol-7-oic acid
A neolignan isolated from the stems of Sinocalamus affinis.
3-[[[1,3-Dioxo-2-(2-oxolanylmethyl)-5-isoindolyl]-oxomethyl]amino]benzoic acid
methyl 4-chloro-3-[[2-[4-(2-hydroxyethyl)piperazin-1-yl]acetyl]amino]-1H-indole-2-carboxylate
C18H23ClN4O4 (394.14077480000003)
N4,N5-Bis(2-ethoxyphenyl)-1H-imidazole-4,5-dicarboxamide
N-(4-methyl-2-pyridinyl)-4-[3-(trifluoromethyl)anilino]-1-piperidinecarbothioamide
C19H21F3N4S (394.14389420000003)
2-(4-methoxyanilino)-7-oxo-N-(2-oxolanylmethyl)-1-benzopyran-3-carboxamide
N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(2-oxolanylmethyl)benzamide
2-Hydroxy-benzoic acid N-[2,4,6-trioxo-1-phenethyl-tetrahydro-pyrimidin-(5E)-ylidenemethyl]-hydrazide
2-[[5-(dimethylsulfamoyl)-1H-indol-3-yl]methylidene]propanedioic acid diethyl ester
1-Methyl-4-[[2-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]thio]-2-quinolinone
Pyridin-3-ylmethyl {4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl}carbamate
2-[[4-[(1-Methyl-2-oxo-4-quinolinyl)oxy]-1-oxobutyl]amino]benzoic acid methyl ester
N-{(E)-[1-(4-methoxybenzyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}benzohydrazide
7-benzyl-1,3-dimethyl-8-[(2E)-2-(thiophen-2-ylmethylidene)hydrazinyl]-3,7-dihydro-1H-purine-2,6-dione
3-benzyl-5-(4-hydroxyphenyl)-N-(phenylacetyl)pyrazin-2-aminide
2-(1,3-benzodioxol-5-ylmethylamino)-N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)acetamide
2-pyridin-3-yl-1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
N-[(2S,3S,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)oxan-3-yl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2S,3R,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)oxan-3-yl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2S,3S,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3S,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2S,3R,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3S,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3R,6R)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(2R,3R,6S)-6-[2-[(4-chlorophenyl)methylamino]-2-oxoethyl]-2-(hydroxymethyl)-3-oxanyl]-2-cyclopropylacetamide
C20H27ClN2O4 (394.16592520000006)
N-[(Z)-[2-(1H-imidazol-2-yl)-1-phenylethylidene]amino]-3,4,5-trimethoxybenzamide
[(2E)-10,11-dihydroxy-6-(methoxymethyl)-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] 2-methylprop-2-enoate
7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
A-674563 (hydrochloride)
A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
F-15599
C19H21ClF2N4O (394.13718700000004)
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.
Rhosin (hydrochloride)
Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3].
Z-Phe-Ala-diazomethylketone
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research[1].