Exact Mass: 298.0904624
Exact Mass Matches: 298.0904624
Found 320 metabolites which its exact mass value is equals to given mass value 298.0904624,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Coumafuryl
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins
Apigenin 7,4'-dimethyl ether
Apigenin 7,4-dimethyl ether, also known as apigenin dimethylether or 4,7-dimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, apigenin 7,4-dimethyl ether is considered to be a flavonoid lipid molecule. Apigenin 7,4-dimethyl ether is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, apigenin 7,4-dimethyl ether has been detected, but not quantified in, common sages and sweet basils. This could make apigenin 7,4-dimethyl ether a potential biomarker for the consumption of these foods. BioTransformer predicts that apigenin 7,4-dimethyl ether is a product of 4,5,7-trimethoxyflavone metabolism via an O-dealkylation reaction and catalyzed by CYP2C9 and CYP2C19 enzymes (PMID: 30612223). 4-methylgenkwanin, also known as apigenin dimethylether or 4,7-dimethylapigenin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4-methylgenkwanin is considered to be a flavonoid lipid molecule. 4-methylgenkwanin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 4-methylgenkwanin can be found in common sage and sweet basil, which makes 4-methylgenkwanin a potential biomarker for the consumption of these food products. The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Sayanedin
Isolated from pods of Pisum sativum (pea). Sayanedin is found in pulses and common pea. Sayanedin is found in common pea. Sayanedin is isolated from pods of Pisum sativum (pea
Spirolaurenone
A spirocyclic sesquiterpenoid that is isolated from the red alga Laurencia glandulifera.
Antibiotic PS 5
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
castanin
A 4-methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 6 and 4 and a hydroxy group at position 7.
Amlexanox
Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5\\% and 50\\% of the general population. A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist R - Respiratory system > R03 - Drugs for obstructive airway diseases D018926 - Anti-Allergic Agents
3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one
2-(3-hydroxy-4,5-dimethoxyphenyl)-4H-chromen-4-one
3-(3,4-dimethoxyphenyl)-7-hydroxy-4H-chromen-4-one
Alfalone
Alfalone is found in alfalfa. Alfalone is isolated from alfalfa callus tissue. Isolated from alfalfa callus tissue. Alfalone is found in alfalfa and pulses.
8-Deoxy-11-hydroxy-13-chlorogrosheimin
8-Deoxy-11-hydroxy-13-chlorogrosheimin is found in green vegetables. 8-Deoxy-11-hydroxy-13-chlorogrosheimin is a constituent of Cynara scolymus (artichoke). Constituent of Cynara scolymus (artichoke). 8-Deoxy-11-hydroxy-13-chlorogrosheimin is found in green vegetables.
4',5-Dihydroxy-7-methoxy-6-methylflavone
4,5-Dihydroxy-7-methoxy-6-methylflavone is found in beverages. 4,5-Dihydroxy-7-methoxy-6-methylflavone is isolated from Gaultheria procumbens (wintergreen
2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylic acid
1H-Pyrrole-2,5-dione, 1-[7-(dimethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl]-
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents D004396 - Coloring Agents > D005456 - Fluorescent Dyes
6-Isopropoxy-9-oxoxanthene-2-carboxylic acid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists
Ciclazindol
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
2,3,4,5-Tetrahydroxy-6-(1,2,3,4-tetrahydroxybutyl)oxane-2-carbaldehyde
(5R,6R)-3-(2-Acetamidoethylsulfanyl)-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Moslosooflavone
5-Hydroxy-7,8-dimethoxyflavone is a natural product found in Uvaria rufa, Andrographis paniculata, and other organisms with data available. Moslosooflavone is a flavonoid isolated from Andrographis paniculata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities[1]. Moslosooflavone is a flavonoid isolated from Andrographis paniculata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities[1].
Apigenin 7,4'-dimethyl ether
Apigenin 7,4-dimethyl ether, also known as apigenin dimethylether or 4,7-dimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, apigenin 7,4-dimethyl ether is considered to be a flavonoid lipid molecule. Apigenin 7,4-dimethyl ether is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, apigenin 7,4-dimethyl ether has been detected, but not quantified in, common sages and sweet basils. This could make apigenin 7,4-dimethyl ether a potential biomarker for the consumption of these foods. BioTransformer predicts that apigenin 7,4-dimethyl ether is a product of 4,5,7-trimethoxyflavone metabolism via an O-dealkylation reaction and catalyzed by CYP2C9 and CYP2C19 enzymes (PMID: 30612223). 4-methylgenkwanin, also known as apigenin dimethylether or 4,7-dimethylapigenin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4-methylgenkwanin is considered to be a flavonoid lipid molecule. 4-methylgenkwanin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 4-methylgenkwanin can be found in common sage and sweet basil, which makes 4-methylgenkwanin a potential biomarker for the consumption of these food products. Apigenin 7,4-dimethyl ether is a dimethoxyflavone that is the 7,4-dimethyl ether derivative of apigenin. It has a role as a plant metabolite. It is a dimethoxyflavone and a monohydroxyflavone. It is functionally related to an apigenin. Apigenin 7,4-dimethyl ether is a natural product found in Teucrium polium, Calea jamaicensis, and other organisms with data available. A dimethoxyflavone that is the 7,4-dimethyl ether derivative of apigenin. The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Mosloflavone
Mosloflavone is a member of flavonoids and an ether. Mosloflavone is a natural product found in Desmos dumosus, Phonus arborescens, and other organisms with data available. Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation. Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
2,8-Dimethoxy-7-hydroxy-3,4,-methylenedioxyphenanthrene
1-hydroxy-2,3-dimethoxy-7-methyl-9,10-anthraquinone
6-HYDROXY-1,3-DIMETHOXY-7-METHYLANTHRACENE-9,10-DIONE
Syzalterin
Syzalterin is a natural product found in Pancratium maritimum with data available.
4-Methoxytectochrysin
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
3-HYDROXY-3,4-DIMETHOXYFLAVONE
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.219 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.221 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.218 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.224
(-)-alpinone|(2S,3S)-3,5-dihydroxy-7-methoxyflavanone
5,7-dihydroxy-6-methyl-3-(4-hydroxybenzyl) chromone
7-hydroxy-2,6-dimethoxy-5H-phenanthro[4,5-bcd]pyran-5-ol|agrostophyllanthrol|isoagrostophyllantrol
2-(Methylamino)-3-oxo-3H-phenoxazine-8-carboxylic acid ethyl ester
5,7-dihydroxy-3-(4-hydroxybenzyl)-8-methylchromone
4H-1-benzopyran-4-one, 3-(2-hydroxy-4-methoxyphenyl)-7-methoxy-
(+-)-1,1-Binaphthyl-carbonsaeure-8|(+-)-Binaphthyl-(1.1)-carbonsaeure-(8)|1,1-Binaphthyl-8-carbonsaeure|<1,1>Binaphthyl-8-carbonsaeure|Binaphthyl-(1.1)-carbonsaeure-(8)|[1,1]Binaphthyl-carbonsaeure-(8)|[1,1]binaphthyl-carboxylic acid-(8)
5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one
2H-1-Benzopyran-8-carboxaldehyde, 3,4-dihydro-5,7-dihydroxy-6-methyl-4-oxo-2-phenyl-
Eutypoid D
A butenolide that is furan-2(5H)-one substituted by a 3,5-dihydroxyphenyl group at position 3 and a 4-hydroxybenzyl group at position 4. It has been isolated from Penicillium species.
(4S,6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undec-2-en-4-ol
6-Hydroxy-5-methoxy-2-(4-methoxy-phenyl)-chromen-7-on|6-hydroxy-5-methoxy-2-(4-methoxy-phenyl)-chromen-7-one
ibericin
Lucidin ethyl ether is a natural product found in Rubia alata, Rubia lanceolata, and other organisms with data available.
1-Hydroxy-3,8-dimethoxy-2-methyl-anthrachinon|3,8-Di-Me ether-1,3,8-Trihydroxy-2-methylanthraquinone
(3E)-2,3-dihydro-7-hydroxy-3-[(3-hydroxy-4-methoxyphenyl)-methylene]-4H-1-benzopyran-4-one|E-7-hydroxy-3-(3-hydroxy-4-methoxybenzylidene)-chroman-4-one
2,6-Dimethoxy-1-phenazinecarboxylic acid methyl ester
8-hydroxy-1,2-dimethoxy-3-methylanthracene-9,10-dione
1,5-dihydroxy-8-methoxy-2,3-dimethyl-9,10-anthraquinone
4h-1-benzopyran-4-one,5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-
(E)-4-demethyl-6-methyleucomin|(E)-5,7-dihydroxy-3-(4-hydroxybenzylidene)-6-methylchroman-4-one|Eucomnalin
1-Methoxy-2-hydroxy-3-methyl-6-methoxy-9,10-anthraquinone
2(S)-7,4-dihydroxy-3-formylflavanone|erythribyssin K
6-Desmethylsideroxylin
A monomethoxyflavone that is sideroxylin in which the methyl group at position 6 has been replaced by a hydrogen. It has been isolated from Hydrastis canadensis and Dracaena cochinchinensis.
6,8-dimethylisogenistein
A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 2 and methyl group at positions 6 and 8. It has been isolated from Pisonia aculeata.
3-Hydroxy-2,4-dimethoxy-7,8-methylenedioxyphenanthrene
(2S)-8-formyl-7-hydroxy-5-methoxyflavanone|5-methoxy-7-hydroxy-8-formylflavanone
10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol
(S)-2-(8-hydroxy-4-oxo-2-phenylchroman-5-yl)acetic acid|cryptogione C
methyl 1-(propionic acid)-beta-carboline-3-carboxylate
5,2-dihydroxy-7-methoxy-3-benzylidenechroman-4-one|portulacanone D
2,4-Dihydroxy-4-methoxy-5-formylchalkon|Neobavachalcon|Neobavachalcone
6-(2,4-dimethoxyphenyl)furo[2,3-f][1,3]benzodioxole
2,9-Dimethoxy-1-phenazinecarboxylic acid methyl ester
2-(2-hydroxy-4-methoxyphenyl)-3-methyl-5,6-dioxymethylene-benzofuran|2-(2-hydroxy-4-methoxyphenyl)-3-methyl-5,6-dioxymethylene-benzo[b]furan|2-(2-Hydroxy-4-methoxyphenyl)-3-methyl-5,6-methylenedioxybenzofuran
(2E,4Z)-1,5-Bis(3,4-dihydroxyphenyl)penta-2,4-dien-1-one|sinensigenin B
(S)-4-methoxy-7-phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]isochromen-5-one
Eutypoid C
A butenolide that is furan-2(5H)-one substituted by a 3,4-dihydroxybenzyl group at position 4 and a 4-hydroxyphenyl group at position 3. It has been isolated from Penicillium species.
6-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
4-(4-Methoxyphenyl)-5-hydroxy-7-methoxy-2H-1-benzopyran-2-one
Tri-Me ether-1,3,4-Trihydroxy-2,7-phenanthraquinone
1-hydroxy-3,8-dimethoxy-6-methylanthracene-9,10-dione
AH 6809
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists
KBio2_007587
7,4-Dimethoxy-5-hydroxyisoflavone is a natural product found in Peperomia humilis, Peperomia leptostachya, and other organisms with data available.
COUMAFURYL
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins CONFIDENCE standard compound; EAWAG_UCHEM_ID 3091
4,7-Dimethoxy-3-hydroxyflavone
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.311 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.307
3,7-Dimethoxy-3-hydroxyflavone
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.301 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.294
5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one
amlexanox
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist R - Respiratory system > R03 - Drugs for obstructive airway diseases D018926 - Anti-Allergic Agents
8-Deoxy-11-hydroxy-13-chlorogrosheimin
2-tert-Butoxycarbonylamino-4,5,6,7-tetrahydro-benzothiazole-4-carboxylic acid
methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride
2-(4-METHYL-6-OXO-6H-BENZO[C]CHROMEN-3-YLOXY)-PROPIONIC ACID
3-AMINO-3-[5-(2-TRIFLUOROMETHYLPHENYL)-FURAN-2-YL]-PROPIONIC ACID AMIDE
2,5-DIOXOPYRROLIDIN-1-YL 2,6-DIMETHYLQUINOLINE-4-CARBOXYLATE
5-[(4-Methylphenyl)sulfonyl]-3-oxopentanoic acid ethyl ester
3-(3,4-dichlorophenyl)-3,9-diazaspiro[5.5]undecane
3-(2,3-dichlorophenyl)-3,9-diazaspiro[5.5]undecane
[3-[(2-oxido-4-phenyl-1,2,5-oxadiazol-2-ium-3-yl)methoxy]phenyl]methanol
[4-[(2-oxido-4-phenyl-1,2,5-oxadiazol-2-ium-3-yl)methoxy]phenyl]methanol
3-(4-METHYLPIPERAZIN-1-YL)-4-(METHYLSULFONYL)BENZOIC ACID
3-[(3-nitrophenyl)methyl]-1,6,7,8-tetrahydroquinoline-2,5-dione
4-methyl-1-(4-methyl-3-nitrophenyl)sulfonylpiperidine
4-METHYL-2-[3-(1H-PYRROL-1-YL)PHENYL]-1,3-THIAZOLE-5-CARBOHYDRAZIDE
2-(CHLOROMETHYL)-5-METHYL-3-(O-TOLYL)QUINAZOLIN-4(3H)-ONE
(Z)-2-(2-tert-Butoxycarbonylaminothiazol-4-yl)-2-pentenoic acid
2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLICACID3,6-DIETHYLESTER
6-tert-butoxycarbonyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepine-2- carboxylic acid
3-[(1S)-1-Aminoethyl]-8-chloro-2-phenyl-1(2H)-isoquinolinone
5-Methyl-n-(4-methyl-5-oxodithiolo(3,4-d)pyrrol-6-yl)hexanamide
2-(6-(4-Chlorophenoxy)hexyl)oxirane-2-carboxylic acid
8-Hydroxy-7-methoxy-3-(4-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 7-hydroxy-5-methoxy-2-(4-methoxyphenyl)-
N-(2-furanylmethyl)-5-(3-methoxyphenyl)-3-isoxazolecarboxamide
dihydro-5,5-dimethyl-3-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2(3H)-furanone
(2S)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid
3-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-ylamino]-phenol
Cyclohexylmethyl 2-formylphenyl hydrogen phosphate
AIDS-071717
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
2-(3,4-Dimethoxyphenyl)-7-hydroxy-4H-chromen-4-one
(3e,3ar,8bs)-3-({[(2r)-4-Methyl-5-Oxo-2,5-Dihydrofuran-2-Yl]oxy}methylidene)-3,3a,4,8b-Tetrahydro-2h-Indeno[1,2-B]furan-2-One
3-[5-[(E)-(1H-tetrazol-5-ylhydrazono)methyl]-2-furyl]benzoic acid
C13H10N6O3 (298.08143500000006)
2-[[5-[2-(1H-benzimidazol-2-yl)ethyl]-4-methyl-1,2,4-triazol-3-yl]thio]acetonitrile
(3E,3aS,8bR)-3-({[(2S)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methylidene)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one
(2E)-N-(3-methoxyphenyl)-3-(4-nitrophenyl)prop-2-enamide
4-(4-Methylphenyl)sulfonyl-4-oxanecarboxylic acid methyl ester
3-[2-(phenylsulfonyloxy)ethyl]-5,5-dimethyldihydro-2(3H)-furanone
(3E)-3-{[(4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy]methylidene}-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one
(2R,3R,4R)-2,3,5-trihydroxy-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxypentanoic acid
Thiosalicylic acid, S-trimethylsilyl-, trimethylsilyl ester
C13H22O2SSi2 (298.08789920000004)
(1-Phosphonooxy-3-propanoyloxypropan-2-yl) butanoate
C10H19O8P (298.08175040000003)
(1-Acetyloxy-3-phosphonooxypropan-2-yl) pentanoate
C10H19O8P (298.08175040000003)
PS-5
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
1-[(2R,5S,9R)-9-Bromo-6,10,10-trimethylspiro[4.5]dec-6-en-2-yl]ethan-1-one
8-Desmethylsideroxylin
A monomethoxyflavone that is sideroxylin in which the methyl group at position 8 is replaced by a hydrogen. It has been found in Hydrastis canadensis and Eucalyptus species.