6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (BioDeep_00000175793)

   

human metabolite blood metabolite


代谢物信息卡片


9-oxo-6-(propan-2-yloxy)-9H-xanthene-2-carboxylic acid

化学式: C17H14O5 (298.0841194)
中文名称: AH 6809
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)OC1=CC2=C(C=C1)C(=O)C1=C(O2)C=CC(=C1)C(O)=O
InChI: InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists

同义名列表

4 个代谢物同义名

9-oxo-6-(propan-2-yloxy)-9H-xanthene-2-carboxylic acid; 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid; 6-Isopropoxy-9-oxoxanthene-2-carboxylate; AH 6809



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lin Miao, Chanyuan Jiao, Rui Shao, Yaxin Qi, Guanwei Fan, Xiaojiang Li, Yuefei Wang, Yan Zhu, Ju Zhang, Xiumei Gao. Bakuchiol suppresses oestrogen/testosterone-induced Benign Prostatic Hyperplasia development through up-regulation of epithelial estrogen receptor β and down-regulation of stromal aromatase. Toxicology and applied pharmacology. 2019 10; 381(?):114637. doi: 10.1016/j.taap.2019.114637. [PMID: 31238046]
  • Xiaoyan Li, Tingting Xie, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang. Prostaglandin E2 facilitates Hepatitis B virus replication by impairing CTL function. Molecular immunology. 2018 11; 103(?):243-250. doi: 10.1016/j.molimm.2018.08.009. [PMID: 30321734]
  • Jing Liu, Yi-de Zhang, Xiao-Lan Chen, Xue-Ling Zhu, Xu Chen, Jian-Hua Wu, Nai-Feng Guo. The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway. PloS one. 2018; 13(5):e0197158. doi: 10.1371/journal.pone.0197158. [PMID: 29746568]
  • Patrizia Amadio, Damiano Baldassarre, Eva Tarantino, Elena Zacchi, Sara Gianellini, Isabella Squellerio, Mauro Amato, Babette B Weksler, Elena Tremoli, Silvia S Barbieri. Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Sep; 29(9):4001-10. doi: 10.1096/fj.14-268383. [PMID: 26065856]
  • Shancheng Li, Xiaoya Xu, Man Jiang, Yuli Bi, Jiying Xu, Mingyong Han. Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway. Molecular medicine reports. 2015 Jun; 11(6):4454-62. doi: 10.3892/mmr.2015.3258. [PMID: 25625500]
  • Seon Min Woo, Kyoung-Jin Min, In Gyeong Chae, Kyung-Soo Chun, Taeg Kyu Kwon. Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways. Molecular carcinogenesis. 2015 Mar; 54(3):216-28. doi: 10.1002/mc.22092. [PMID: 24127286]
  • Manigandan Lejeune, France Moreau, Kris Chadee. Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4. PloS one. 2014; 9(11):e113270. doi: 10.1371/journal.pone.0113270. [PMID: 25396731]
  • Hyun-Seok Yeo, Adeeb Shehzad, Young Sup Lee. Prostaglandin E2 blocks menadione-induced apoptosis through the Ras/Raf/Erk signaling pathway in promonocytic leukemia cell lines. Molecules and cells. 2012 Apr; 33(4):371-8. doi: 10.1007/s10059-012-2293-2. [PMID: 22450688]
  • Zbigniew Zaslona, Carlos H Serezani, Katsuhide Okunishi, David M Aronoff, Marc Peters-Golden. Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood. 2012 Mar; 119(10):2358-67. doi: 10.1182/blood-2011-08-374207. [PMID: 22234697]
  • Neil Martin, Andrew Ruddick, Greer K Arthur, Heidi Wan, Lucy Woodman, Christopher E Brightling, Don J L Jones, Ian D Pavord, Peter Bradding. Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. PloS one. 2012; 7(8):e43545. doi: 10.1371/journal.pone.0043545. [PMID: 22970103]
  • Xuesong Qian, Jidong Zhang, Jianguo Liu. Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. The Journal of biological chemistry. 2011 Jan; 286(3):2111-20. doi: 10.1074/jbc.m110.154971. [PMID: 21097507]
  • F Stanisçuaski, V Te Brugge, C R Carlini, I Orchard. Jack bean urease alters serotonin-induced effects on Rhodnius prolixus anterior midgut. Journal of insect physiology. 2010 Sep; 56(9):1078-86. doi: 10.1016/j.jinsphys.2010.03.002. [PMID: 20223243]
  • Xiaosong Zhang, Ming Zhao, Michelle A Rudek, Ping He, Bert Vogelstein. Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of DMXAA in human and mouse plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 852(1-2):217-22. doi: 10.1016/j.jchromb.2007.01.018. [PMID: 17307035]
  • Sawsan Ibrahim Kreydiyyeh, Sarah Riman, Maya Serhan, Ari Kassardjian. TNF-alpha modulates hepatic Na+-K+ ATPase activity via PGE2 and EP2 receptors. Prostaglandins & other lipid mediators. 2007 Jun; 83(4):295-303. doi: 10.1016/j.prostaglandins.2007.02.003. [PMID: 17499749]
  • Lamine Aoudjit, Anna Potapov, Tomoko Takano. Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor. American journal of physiology. Renal physiology. 2006 Jun; 290(6):F1534-42. doi: 10.1152/ajprenal.00267.2005. [PMID: 16396944]
  • Rongsong Li, Kevin P Mouillesseaux, Dennis Montoya, Daniel Cruz, Navid Gharavi, Martin Dun, Lukasz Koroniak, Judith A Berliner. Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC. Circulation research. 2006 Mar; 98(5):642-50. doi: 10.1161/01.res.0000207394.39249.fc. [PMID: 16456101]
  • Keikantse Matlhagela, Mary Taub. Involvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells. Prostaglandins & other lipid mediators. 2006 Mar; 79(1-2):101-13. doi: 10.1016/j.prostaglandins.2005.12.002. [PMID: 16516814]
  • Micaela Zonta, Annalisa Sebelin, Sara Gobbo, Tommaso Fellin, Tullio Pozzan, Giorgio Carmignoto. Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. The Journal of physiology. 2003 Dec; 553(Pt 2):407-14. doi: 10.1113/jphysiol.2003.046706. [PMID: 14500777]
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  • Teresa Sanchez, Juan Jose Moreno. Role of EP(1) and EP(4) PGE(2) subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation. American journal of physiology. Cell physiology. 2002 Feb; 282(2):C280-8. doi: 10.1152/ajpcell.00128.2001. [PMID: 11788339]
  • M T Walsh, B T Kinsella. Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. British journal of pharmacology. 2000 Oct; 131(3):601-9. doi: 10.1038/sj.bjp.0703624. [PMID: 11015313]
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  • C S Venugopalan, R E Beadle, T L Seahorn, E P Holmes. Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. Veterinary research communications. 1998 Nov; 22(7):493-503. doi: 10.1023/a:1006131217140. [PMID: 9868763]
  • Y Boie, R Stocco, N Sawyer, D M Slipetz, M D Ungrin, F Neuschäfer-Rube, G P Püschel, K M Metters, M Abramovitz. Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. European journal of pharmacology. 1997 Dec; 340(2-3):227-41. doi: 10.1016/s0014-2999(97)01383-6. [PMID: 9537820]
  • S M Hutchinson, T G Hammond, R Coleman, A A Horton. Effects of eicosanoids on parameters in isolated rat hepatocytes and isolated rat hepatocyte couplets: protective effects of eicosanoid receptor antagonists. Journal of lipid mediators and cell signalling. 1997 Mar; 15(3):249-54. doi: 10.1016/s0929-7855(96)00560-3. [PMID: 9041475]
  • J S Matthews, R L Jones. Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues. British journal of pharmacology. 1993 Feb; 108(2):363-9. doi: 10.1111/j.1476-5381.1993.tb12810.x. [PMID: 8448586]
  • D M Biddulph, A A Capehart, T C Beasley. Comparative effects of cytosine arabinoside and a prostaglandin E2 antagonist, AH6809, on chondrogenesis in serum-free cultures of chick limb mesenchyme. Experimental cell research. 1991 Sep; 196(1):131-3. doi: 10.1016/0014-4827(91)90465-7. [PMID: 1879468]
  • A A Capehart, D M Biddulph. Effects of a putative prostaglandin E2 antagonist, AH6809, on chondrogenesis in serum-free cultures of chick limb mesenchyme. Journal of cellular physiology. 1991 Jun; 147(3):403-11. doi: 10.1002/jcp.1041470304. [PMID: 1648563]
  • R J Keery, P Lumley. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. British journal of pharmacology. 1988 Jul; 94(3):745-54. doi: 10.1111/j.1476-5381.1988.tb11584.x. [PMID: 2460179]