Amlexanox (BioDeep_00000018448)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid

化学式: C16H14N2O4 (298.0954)
中文名称: 氨来呫诺
谱图信息: 最多检出来源 Homo sapiens(blood) 21.52%

分子结构信息

SMILES: CC(C)C1=CC2=C(C=C1)OC3=NC(=C(C=C3C2=O)C(=O)O)N
InChI: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)

描述信息

Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5\\% and 50\\% of the general population.
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
R - Respiratory system > R03 - Drugs for obstructive airway diseases
D018926 - Anti-Allergic Agents

同义名列表

11 个代谢物同义名

2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid; 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid; 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid; 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylate; GlaxoSmithKline brand OF amlexanox; Amlexanoxum; Amlexanoxo; amlexanox; Aphthasol; Amoxanox; Solfa



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yong-Ping Chen. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro. BMC medicine. 2024 Mar; 22(1):96. doi: 10.1186/s12916-024-03314-1. [PMID: 38443977]
  • Dan Chen, Kaixin Du, Xiaochen Niu, Hongwei Zhang, Xue Zhang, Yu Tang, Jianchun Zhao. Development and validation of LC-MS/MS method for amlexanox in rat plasma and its application in preclinical pharmacokinetics. Biomedical chromatography : BMC. 2022 Mar; 36(3):e5288. doi: 10.1002/bmc.5288. [PMID: 34842293]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Shouma Ishikawa, Atsushi Sawamoto, Satoshi Okuyama, Mitsunari Nakajima. T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning. Biological & pharmaceutical bulletin. 2021; 44(4):550-556. doi: 10.1248/bpb.b20-00889. [PMID: 33790105]
  • Qian He, Jun Zeng, Kecheng Yao, Wei Wang, Qiong Wu, Renmin Tang, Xuan Xia, Xiulan Zou. Long-term subcutaneous injection of lipopolysaccharides and high-fat diet induced non-alcoholic fatty liver disease through IKKε/ NF-κB signaling. Biochemical and biophysical research communications. 2020 11; 532(3):362-369. doi: 10.1016/j.bbrc.2020.08.036. [PMID: 32883523]
  • Zixiong Zhou, Jing Qi, Chae Woong Lim, Jong-Won Kim, Bumseok Kim. Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro. Toxicology. 2020 11; 444(?):152579. doi: 10.1016/j.tox.2020.152579. [PMID: 32905826]
  • Yixin Han, Rui Hou, Xiaoyu Zhang, Haibo Liu, Yuan Gao, Ximeng Li, Ruijuan Qi, Runlan Cai, Yun Qi. Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages. Biochimica et biophysica acta. Molecular cell research. 2020 10; 1867(10):118766. doi: 10.1016/j.bbamcr.2020.118766. [PMID: 32504661]
  • Ewa Wilcz-Villega, Edward Carter, Alastair Ironside, Ruoyan Xu, Isabella Mataloni, Julie Holdsworth, William Jones, Rocío Moreno Béjar, Lukas Uhlik, Robert B Bentham, Susana A Godinho, Jesmond Dalli, Richard Grose, Gyorgy Szabadkai, Louise Jones, Kairbaan Hodivala-Dilke, Katiuscia Bianchi. Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. EMBO molecular medicine. 2020 02; 12(2):e10491. doi: 10.15252/emmm.201910491. [PMID: 31930708]
  • Qian He, Xuan Xia, Kecheng Yao, Jun Zeng, Wei Wang, Qiong Wu, Renmin Tang, Xiulan Zou. Amlexanox reversed non-alcoholic fatty liver disease through IKKε inhibition of hepatic stellate cell. Life sciences. 2019 Dec; 239(?):117010. doi: 10.1016/j.lfs.2019.117010. [PMID: 31672578]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Koji Ozasa, Burcu Temizoz, Takato Kusakabe, Shingo Kobari, Masatoshi Momota, Cevayir Coban, Shuichi Ito, Kouji Kobiyama, Etsushi Kuroda, Ken J Ishii. Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor. Frontiers in immunology. 2019; 10(?):2212. doi: 10.3389/fimmu.2019.02212. [PMID: 31616416]
  • L-F Zhou, W Zeng, L-C Sun, Y Wang, F Jiang, X Li, Y Zheng, G-M Wu. IKKε aggravates inflammatory response via activation of NF-κB in rheumatoid arthritis. European review for medical and pharmacological sciences. 2018 04; 22(7):2126-2133. doi: 10.26355/eurrev_201804_14746. [PMID: 29687872]
  • Justin Bailey, Claire McCarthy, Rita F Smith. Clinical inquiry. What is the most effective way to treat recurrent canker sores?. The Journal of family practice. 2011 Oct; 60(10):621-32. doi: ". [PMID: 21977491]
  • Samia Yazid, Egle Solito, Helen Christian, Simon McArthur, Nicolas Goulding, Roderick Flower. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochemical pharmacology. 2009 Jun; 77(12):1814-26. doi: 10.1016/j.bcp.2009.03.010. [PMID: 19428336]
  • Jeffrey A Burgess, Peter F van der Ven, Michael Martin, Jeffrey Sherman, Jeff Haley. Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract. The journal of contemporary dental practice. 2008 Mar; 9(3):88-98. doi: 10.5005/jcdp-9-3-88. [PMID: 18335124]
  • Hayato Matsunaga, Hiroshi Ueda. Evidence for serum-deprivation-induced co-release of FGF-1 and S100A13 from astrocytes. Neurochemistry international. 2006 Aug; 49(3):294-303. doi: 10.1016/j.neuint.2006.01.017. [PMID: 16519964]
  • Juliette Bell. Amlexanox for the treatment of recurrent aphthous ulcers. Clinical drug investigation. 2005; 25(9):555-66. doi: 10.2165/00044011-200525090-00001. [PMID: 17532700]
  • A Khandwala, R G Van Inwegen, M R Charney, M C Alfano. 5\% amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers: II. Pharmacokinetics and demonstration of clinical safety. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 1997 Feb; 83(2):231-8. doi: 10.1016/s1079-2104(97)90010-x. [PMID: 9117755]
  • E Makino, T Ohashi, H Takahashi, H Kato, Y Ito, H Nagai, A Koda, H Azuma. Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs. The Journal of pharmacy and pharmacology. 1990 Apr; 42(4):236-41. doi: 10.1111/j.2042-7158.1990.tb05399.x. [PMID: 1974289]
  • A Puigvert, D Ruano. [Etiopathogenesis of so-called congenital hydronephrosis]. Journal d'urologie et de nephrologie. 1979 Jan; 85(1-2):1-12. doi: NULL. [PMID: 439196]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]