Exact Mass: 298.0728
Exact Mass Matches: 298.0728
Found 500 metabolites which its exact mass value is equals to given mass value 298.0728,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Ekalux
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals
Coumafuryl
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins
Phoxim
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D010575 - Pesticides > D007306 - Insecticides D004791 - Enzyme Inhibitors D016573 - Agrochemicals
Apigenin 7,4'-dimethyl ether
Apigenin 7,4-dimethyl ether, also known as apigenin dimethylether or 4,7-dimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, apigenin 7,4-dimethyl ether is considered to be a flavonoid lipid molecule. Apigenin 7,4-dimethyl ether is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, apigenin 7,4-dimethyl ether has been detected, but not quantified in, common sages and sweet basils. This could make apigenin 7,4-dimethyl ether a potential biomarker for the consumption of these foods. BioTransformer predicts that apigenin 7,4-dimethyl ether is a product of 4,5,7-trimethoxyflavone metabolism via an O-dealkylation reaction and catalyzed by CYP2C9 and CYP2C19 enzymes (PMID: 30612223). 4-methylgenkwanin, also known as apigenin dimethylether or 4,7-dimethylapigenin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4-methylgenkwanin is considered to be a flavonoid lipid molecule. 4-methylgenkwanin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 4-methylgenkwanin can be found in common sage and sweet basil, which makes 4-methylgenkwanin a potential biomarker for the consumption of these food products. The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Spirolaurenone
A spirocyclic sesquiterpenoid that is isolated from the red alga Laurencia glandulifera.
3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one
Benzoyl glucuronide (Benzoic acid)
Benzoyl glucuronide (Benzoic acid) is a natural human metabolite of Benzoic acid generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys. Benzoyl glucuronide (Benzoic acid) is a natural human metabolite of Benzoic acid generated in the liver by UDP glucuonyltransferase.
2-(3-hydroxy-4,5-dimethoxyphenyl)-4H-chromen-4-one
3-(3,4-dimethoxyphenyl)-7-hydroxy-4H-chromen-4-one
4',5-Dihydroxy-7-methoxy-6-methylflavone
4,5-Dihydroxy-7-methoxy-6-methylflavone is found in beverages. 4,5-Dihydroxy-7-methoxy-6-methylflavone is isolated from Gaultheria procumbens (wintergreen
N-Acetylserotonin sulfate
N-Acetylserotonin sulfate is a metabolite of melatonin. Melatonin Listen/ˌmɛləˈtoʊnɪn/, also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants, and microbes. In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions. (Wikipedia)
6-Isopropoxy-9-oxoxanthene-2-carboxylic acid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists
Ciclazindol
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
2,3,4,5-Tetrahydroxy-6-(1,2,3,4-tetrahydroxybutyl)oxane-2-carbaldehyde
Ethyl (E)-3-diethoxyphosphanylsulfinyloxybut-2-enoate
zaltoprofen
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
Nicotinamide ascorbate
It is used as a food additive
3'-deamino-3'-oxonicotianamine
3-deamino-3-oxonicotianamine is practically insoluble (in water) and a moderately acidic compound (based on its pKa). 3-deamino-3-oxonicotianamine can be found in a number of food items such as daikon radish, nutmeg, greenthread tea, and small-leaf linden, which makes 3-deamino-3-oxonicotianamine a potential biomarker for the consumption of these food products.
Sitostanol-beta
Moslosooflavone
5-Hydroxy-7,8-dimethoxyflavone is a natural product found in Uvaria rufa, Andrographis paniculata, and other organisms with data available. Moslosooflavone is a flavonoid isolated from Andrographis paniculata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities[1]. Moslosooflavone is a flavonoid isolated from Andrographis paniculata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities[1].
Apigenin 7,4'-dimethyl ether
Apigenin 7,4-dimethyl ether, also known as apigenin dimethylether or 4,7-dimethylapigenin, belongs to the class of organic compounds known as 7-O-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, apigenin 7,4-dimethyl ether is considered to be a flavonoid lipid molecule. Apigenin 7,4-dimethyl ether is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Outside of the human body, apigenin 7,4-dimethyl ether has been detected, but not quantified in, common sages and sweet basils. This could make apigenin 7,4-dimethyl ether a potential biomarker for the consumption of these foods. BioTransformer predicts that apigenin 7,4-dimethyl ether is a product of 4,5,7-trimethoxyflavone metabolism via an O-dealkylation reaction and catalyzed by CYP2C9 and CYP2C19 enzymes (PMID: 30612223). 4-methylgenkwanin, also known as apigenin dimethylether or 4,7-dimethylapigenin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, 4-methylgenkwanin is considered to be a flavonoid lipid molecule. 4-methylgenkwanin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 4-methylgenkwanin can be found in common sage and sweet basil, which makes 4-methylgenkwanin a potential biomarker for the consumption of these food products. Apigenin 7,4-dimethyl ether is a dimethoxyflavone that is the 7,4-dimethyl ether derivative of apigenin. It has a role as a plant metabolite. It is a dimethoxyflavone and a monohydroxyflavone. It is functionally related to an apigenin. Apigenin 7,4-dimethyl ether is a natural product found in Teucrium polium, Calea jamaicensis, and other organisms with data available. A dimethoxyflavone that is the 7,4-dimethyl ether derivative of apigenin. The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Mosloflavone
Mosloflavone is a member of flavonoids and an ether. Mosloflavone is a natural product found in Desmos dumosus, Phonus arborescens, and other organisms with data available. Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation. Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
2,8-Dimethoxy-7-hydroxy-3,4,-methylenedioxyphenanthrene
1-hydroxy-2,3-dimethoxy-7-methyl-9,10-anthraquinone
6-HYDROXY-1,3-DIMETHOXY-7-METHYLANTHRACENE-9,10-DIONE
4-[2-[(1-Carboxy-2-hydroxyethyl)imino]ethylidene]-1,2,3,4-tetrahydro-2,6-pyridinedicarboxylic acid
Syzalterin
Syzalterin is a natural product found in Pancratium maritimum with data available.
4-Methoxytectochrysin
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
3-HYDROXY-3,4-DIMETHOXYFLAVONE
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.219 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.221 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.218 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.224
2-O-caffeoylthreonic acid|E-2-(3-(3,4-dihydroxyphenyl)prop-2-enoyloxy)-3,4-dihydroxybutanoic acid
(-)-alpinone|(2S,3S)-3,5-dihydroxy-7-methoxyflavanone
5,7-dihydroxy-6-methyl-3-(4-hydroxybenzyl) chromone
7-hydroxy-2,6-dimethoxy-5H-phenanthro[4,5-bcd]pyran-5-ol|agrostophyllanthrol|isoagrostophyllantrol
5,7-dihydroxy-3-(4-hydroxybenzyl)-8-methylchromone
4H-1-benzopyran-4-one, 3-(2-hydroxy-4-methoxyphenyl)-7-methoxy-
5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one
2H-1-Benzopyran-8-carboxaldehyde, 3,4-dihydro-5,7-dihydroxy-6-methyl-4-oxo-2-phenyl-
Eutypoid D
A butenolide that is furan-2(5H)-one substituted by a 3,5-dihydroxyphenyl group at position 3 and a 4-hydroxybenzyl group at position 4. It has been isolated from Penicillium species.
(4S,6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undec-2-en-4-ol
6-Hydroxy-5-methoxy-2-(4-methoxy-phenyl)-chromen-7-on|6-hydroxy-5-methoxy-2-(4-methoxy-phenyl)-chromen-7-one
1-Hydroxy-3,8-dimethoxy-2-methyl-anthrachinon|3,8-Di-Me ether-1,3,8-Trihydroxy-2-methylanthraquinone
(3E)-2,3-dihydro-7-hydroxy-3-[(3-hydroxy-4-methoxyphenyl)-methylene]-4H-1-benzopyran-4-one|E-7-hydroxy-3-(3-hydroxy-4-methoxybenzylidene)-chroman-4-one
8-hydroxy-1,2-dimethoxy-3-methylanthracene-9,10-dione
1,5-dihydroxy-8-methoxy-2,3-dimethyl-9,10-anthraquinone
4h-1-benzopyran-4-one,5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-
(E)-4-demethyl-6-methyleucomin|(E)-5,7-dihydroxy-3-(4-hydroxybenzylidene)-6-methylchroman-4-one|Eucomnalin
1-Methoxy-2-hydroxy-3-methyl-6-methoxy-9,10-anthraquinone
8-bromo-9-hydroxy-7,7-dimethyl-11-methylenespiro[5.5]undec-1-en-3-one|mailione|mailione
2(S)-7,4-dihydroxy-3-formylflavanone|erythribyssin K
6-Desmethylsideroxylin
A monomethoxyflavone that is sideroxylin in which the methyl group at position 6 has been replaced by a hydrogen. It has been isolated from Hydrastis canadensis and Dracaena cochinchinensis.
6,8-dimethylisogenistein
A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 2 and methyl group at positions 6 and 8. It has been isolated from Pisonia aculeata.
3-Hydroxy-2,4-dimethoxy-7,8-methylenedioxyphenanthrene
(2S)-8-formyl-7-hydroxy-5-methoxyflavanone|5-methoxy-7-hydroxy-8-formylflavanone
10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol
(S)-2-(8-hydroxy-4-oxo-2-phenylchroman-5-yl)acetic acid|cryptogione C
5,2-dihydroxy-7-methoxy-3-benzylidenechroman-4-one|portulacanone D
2beta,3beta-dihydroxy-3alpha-vanilloylmethyl-gamma-lactone|phellolactone
2,4-Dihydroxy-4-methoxy-5-formylchalkon|Neobavachalcon|Neobavachalcone
6-(2,4-dimethoxyphenyl)furo[2,3-f][1,3]benzodioxole
2-(2-hydroxy-4-methoxyphenyl)-3-methyl-5,6-dioxymethylene-benzofuran|2-(2-hydroxy-4-methoxyphenyl)-3-methyl-5,6-dioxymethylene-benzo[b]furan|2-(2-Hydroxy-4-methoxyphenyl)-3-methyl-5,6-methylenedioxybenzofuran
(2E,4Z)-1,5-Bis(3,4-dihydroxyphenyl)penta-2,4-dien-1-one|sinensigenin B
(S)-4-methoxy-7-phenyl-7,8-dihydro[1,3]dioxolo[4,5-g]isochromen-5-one
Eutypoid C
A butenolide that is furan-2(5H)-one substituted by a 3,4-dihydroxybenzyl group at position 4 and a 4-hydroxyphenyl group at position 3. It has been isolated from Penicillium species.
6-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one
4-(4-Methoxyphenyl)-5-hydroxy-7-methoxy-2H-1-benzopyran-2-one
Tri-Me ether-1,3,4-Trihydroxy-2,7-phenanthraquinone
1-hydroxy-3,8-dimethoxy-6-methylanthracene-9,10-dione
KBio2_007587
7,4-Dimethoxy-5-hydroxyisoflavone is a natural product found in Peperomia humilis, Peperomia leptostachya, and other organisms with data available.
COUMAFURYL
D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins CONFIDENCE standard compound; EAWAG_UCHEM_ID 3091
4,7-Dimethoxy-3-hydroxyflavone
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.311 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.307
3,7-Dimethoxy-3-hydroxyflavone
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.301 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.294
5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one
C11H14N4O4S_6H-Purin-6-one, 1,9-dihydro-9-(5-S-methyl-5-thiopentofuranosyl)
methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride
2-(4-METHYL-6-OXO-6H-BENZO[C]CHROMEN-3-YLOXY)-PROPIONIC ACID
7-Chloro-8-methyl-2-pyridin-4-ylquinoline-4-carboxylic acid
7-Chloro-8-methyl-2-pyridin-3-ylquinoline-4-carboxylic acid
7-Chloro-8-methyl-2-pyridin-2-ylquinoline-4-carboxylic acid
3-AMINO-3-[5-(2-TRIFLUOROMETHYLPHENYL)-FURAN-2-YL]-PROPIONIC ACID AMIDE
2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one
Unifiram (DM232) is acts as a potent cognition enhancer?through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research[1][2].
METHYL 2-FLUORO-3-(TRIFLUOROMETHYL)-[1,1-BIPHENYL]-4-CARBOXYLATE
METHYL 4-FLUORO-3-(TRIFLUOROMETHYL)-[1,1-BIPHENYL]-4-CARBOXYLATE
5-[(4-Methylphenyl)sulfonyl]-3-oxopentanoic acid ethyl ester
5-allyl-5-(1-methylbutyl)-2-thiobarbituric acid, sodium derivative
6-Methylmercaptopurine riboside
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite 6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
3-(4-ETHOXYPHENYL)-2-THIOXO-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE
1-[(4-Methylphenyl)sulfonyl]-5-vinyl-1H-pyrrolo[2,3-b]pyridine
2-Naphthalenol,1-[2-(5-chloro-2-hydroxyphenyl)diazenyl]-
N-(4-CHLOROBENZYL)-N-(4-METHOXYPHENYL)HYDRAZINE HYDROCHLORIDE
METHYL 3-(ETHYLTHIO)-6,6-DIMETHYL-4-OXO-4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE-1-CARBOXYLATE
DIETHYL 2-(((5-CHLOROPYRIDIN-2-YL)AMINO)METHYLENE)MALONATE
4-METHYL-2-[3-(1H-PYRROL-1-YL)PHENYL]-1,3-THIAZOLE-5-CARBOHYDRAZIDE
2-(CHLOROMETHYL)-5-METHYL-3-(O-TOLYL)QUINAZOLIN-4(3H)-ONE
5-(4-CHLORO-PHENYL)-2-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
methyl 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoate
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
3-(4-CHLORO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
N-carbamoyl-5-cyano-6-phenylsulfanylpyridine-3-carboxamide
2-(4-CHLORO-PHENYL)-5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
2-(5-phenyltetrazol-1-yl)-3-thiophen-2-ylprop-2-enoic acid
3-[(1S)-1-Aminoethyl]-8-chloro-2-phenyl-1(2H)-isoquinolinone
(1-AMINOMETHYL-CYCLOHEXYL)-CARBAMICACIDTERT-BUTYLESTER
trans-4-[[(2-Amino-5-bromophenyl)Methyl]amino]-cyclohexanol
3-b-D-Ribofuranosyl-6-hydroxyMethyl-furano[2,3-d]-pyriMidin-2-one
(4-(4-(TRIFLUOROMETHOXY)PHENOXY)PHENYL)BORONIC ACID
3-(2-ethoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one
ethyl (2Z,4Z)-5-chloro-2-(chloromethyl)-5-(4-methylphenyl)penta-2,4-dienoate
Glyprothiazol
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent
5-Methyl-n-(4-methyl-5-oxodithiolo(3,4-d)pyrrol-6-yl)hexanamide
8-Hydroxy-7-methoxy-3-(4-methoxyphenyl)chromen-4-one
N-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]furan-2-carboxamide
4H-1-Benzopyran-4-one, 7-hydroxy-5-methoxy-2-(4-methoxyphenyl)-
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzamide
dihydro-5,5-dimethyl-3-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2(3H)-furanone
3-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-ylamino]-phenol
Zaltoprofen
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
AIDS-071717
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1] The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
N-(2-fluorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide
2-(3,4-Dimethoxyphenyl)-7-hydroxy-4H-chromen-4-one
6-Benzoyloxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Nicotinamide ascorbate
It is used as a food additive
7-[(2S)-2-amino-2-carboxyethyl]-5-hydroxy-3,4-dihydro-2H-1,4-benzothiazine-3-carboxylic acid
Ethyl (E)-3-diethoxyphosphanylsulfinyloxybut-2-enoate
(3e,3ar,8bs)-3-({[(2r)-4-Methyl-5-Oxo-2,5-Dihydrofuran-2-Yl]oxy}methylidene)-3,3a,4,8b-Tetrahydro-2h-Indeno[1,2-B]furan-2-One
3-[5-[(E)-(1H-tetrazol-5-ylhydrazono)methyl]-2-furyl]benzoic acid
Ethyl 3-cyano-6-methyl-2-(phenylthio)isonicotinate
(3E,3aS,8bR)-3-({[(2S)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methylidene)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one
3-[(3-Methylphenyl)methylthio]-6-thiophen-2-ylpyridazine
N-(4-methylphenyl)-2-(3-oxo-1,2-benzothiazol-2-yl)acetamide
2-{[(E)-thiophen-2-ylmethylidene]amino}hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
N-(5-methyl-3-isoxazolyl)-2-(2-naphthalenylthio)acetamide
5-nitro-2-spiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3-1H-indole]one
4-(4-Methylphenyl)sulfonyl-4-oxanecarboxylic acid methyl ester
3-[2-(phenylsulfonyloxy)ethyl]-5,5-dimethyldihydro-2(3H)-furanone
(3E)-3-{[(4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy]methylidene}-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one
(2R,3R,4R)-2,3,5-trihydroxy-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxypentanoic acid
Thiosalicylic acid, S-trimethylsilyl-, trimethylsilyl ester
(1-Phosphonooxy-3-propanoyloxypropan-2-yl) butanoate
(1-Acetyloxy-3-phosphonooxypropan-2-yl) pentanoate
1-[(2R,5S,9R)-9-Bromo-6,10,10-trimethylspiro[4.5]dec-6-en-2-yl]ethan-1-one
QUINALPHOS
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals
8-Desmethylsideroxylin
A monomethoxyflavone that is sideroxylin in which the methyl group at position 8 is replaced by a hydrogen. It has been found in Hydrastis canadensis and Eucalyptus species.
8-methoxy-12-phenyl-4,6,11-trioxatricyclo[7.4.0.0³,⁷]trideca-1(9),2,7-trien-10-one
8-[(1-hydroxyethylidene)amino]-7-oxophenoxazine-2-carboxylic acid
5-hydroxy-3-[(4-hydroxyphenyl)methyl]-7-methoxychromen-4-one
(2r,3s,4s,4ar,6s,7r,8r,8as)-2,6-bis(hydroxymethyl)-hexahydropyrano[3,2-b]pyran-3,4,4a,7,8,8a-hexol
6-hydroxy-7-methoxy-4-(4-methoxyphenyl)chromen-2-one
5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-6-methylchromen-4-one
3,5-dihydroxy-7-methoxy-2-phenyl-2,3-dihydronaphthalene-1,4-dione
(2s,3s)-2-{[(2e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-3,4-dihydroxybutanoic acid
1-(ethylsulfanyl)-1-{[1-(ethylsulfanyl)butyl]disulfanyl}butane
2-bromo-1,1,9-trimethyl-5-methylidenespiro[5.5]undec-8-en-3-ol
(2s,6s,8s)-8-bromo-3,7,7-trimethyl-11-methylidenespiro[5.5]undec-3-en-2-ol
6,8-dihydroxy-3-(2-hydroxy-6-methylphenyl)-7-methylisochromen-1-one
(2e)-1,5-bis(3,4-dihydroxyphenyl)penta-2,4-dien-1-one
3-hydroxy-1-methoxy-2-(methoxymethyl)anthracene-9,10-dione
(6as)-9-acetyl-6a-methyl-3-[(1e)-prop-1-en-1-yl]furo[2,3-h]isochromene-6,8-dione
2-{[3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-3,4-dihydroxybutanoic acid
(2s,3r,6s)-2-bromo-1,1,9-trimethyl-5-methylidenespiro[5.5]undec-8-en-3-ol
(1s,5s,6r,8r,9s)-9-bromo-2,5,6,8-tetramethyl-7-oxatricyclo[6.2.2.0¹,⁶]dodec-2-ene
2-hydroxy-1,6-dimethoxy-3-methylanthracene-9,10-dione
(2s,4r,5s,6s,7r)-5,6,12,14-tetrahydroxy-4-(hydroxymethyl)-3,8-dioxatricyclo[8.4.0.0²,⁷]tetradeca-1(14),10,12-trien-9-one
(2r,3r,6r)-2-bromo-1,1,9-trimethyl-5-methylidenespiro[5.5]undec-8-en-3-ol
(2s,3s)-3,5-dihydroxy-7-methoxy-2-phenyl-2,3-dihydronaphthalene-1,4-dione
3-[(3,4-dihydroxyphenyl)methylidene]-7-methoxy-2h-1-benzopyran-4-one
[2-(1,2-dihydroxypropan-2-yl)-4-hydroxy-6-methyl-2,3-dihydro-1-benzofuran-5-yl](methylsulfanyl)methanone
(3e)-1-bromo-5-(2,2-dimethyl-6-methylidenecyclohex-3-en-1-yl)-3-methylpent-3-en-2-ol
3-hydroxy-1,2-dimethoxy-6-methylanthracene-9,10-dione
6-hydroxy-3-[(4-hydroxyphenyl)methyl]-7-methoxychromen-2-one
4-hydroxy-5-[3-(4-hydroxyphenyl)prop-2-enoyl]-2-methoxybenzaldehyde
(1r,3s,5'r,6s)-5'-bromo-2',6,6',6'-tetramethyl-7-oxaspiro[bicyclo[4.1.0]heptane-3,1'-cyclohexan]-2'-ene
1-methoxy-2-methoxymethyl-3-hydroxyanthraquinion
{"Ingredient_id": "HBIN002694","Ingredient_name": "1-methoxy-2-methoxymethyl-3-hydroxyanthraquinion","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "COCC1=C(C=C2C(=C1OC)C(=O)C3=CC=CC=C3C2=O)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "31561","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
1-methoxy-2-methoxymethyl-3-hydroxy-anthraquinone
{"Ingredient_id": "HBIN002695","Ingredient_name": "1-methoxy-2-methoxymethyl-3-hydroxy-anthraquinone","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "COCC1=C(C=C2C(=C1OC)C(=O)C3=CC=CC=C3C2=O)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "13991","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
1-methylxanthosine
{"Ingredient_id": "HBIN002817","Ingredient_name": "1-methylxanthosine","Alias": "NA","Ingredient_formula": "C11H14N4O6","Ingredient_Smile": "CN1C(=O)C2=C(NC1=O)N(C=N2)C3C(C(C(O3)CO)O)O","Ingredient_weight": "298.25 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "14808","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "5319815","DrugBank_id": "NA"}
2,4,7-trihydroxyphenanthraquinone; tri-me ether
{"Ingredient_id": "HBIN004266","Ingredient_name": "2,4,7-trihydroxyphenanthraquinone; tri-me ether","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "NA","Ingredient_weight": "298.29","OB_score": "NA","CAS_id": "263761-53-1","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "8903","PubChem_id": "NA","DrugBank_id": "NA"}
2′-o-methylabronisoflavone
{"Ingredient_id": "HBIN006250","Ingredient_name": "2\u2032-o-methylabronisoflavone","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "CC1=C(C=C2C(=C1O)C(=O)C(=CO2)C3=CC=CC=C3OC)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "14102","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
(?)-4-(e)-caffeoyl-l-threonicacid
{"Ingredient_id": "HBIN010346","Ingredient_name": "(?)-4-(e)-caffeoyl-l-threonicacid","Alias": "NA","Ingredient_formula": "C13H14O8","Ingredient_Smile": "C1=CC(=C(C=C1C=CC(=O)OCC(C(C(=O)O)O)O)O)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "2928","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
5-hydroxy-4′,7-dimethoxyflavone
{"Ingredient_id": "HBIN011613","Ingredient_name": "5-hydroxy-4\u2032,7-dimethoxyflavone","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "40929","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
5-hydroxy-7, 4′-dimethoxyflavone
{"Ingredient_id": "HBIN011642","Ingredient_name": "5-hydroxy-7, 4\u2032-dimethoxyflavone","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "40928","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
(6r,9r,10s)-10-bromo-9-hydroxy-chamigra-2,7(14)-diene
{"Ingredient_id": "HBIN012785","Ingredient_name": "(6r,9r,10s)-10-bromo-9-hydroxy-chamigra-2,7(14)-diene","Alias": "NA","Ingredient_formula": "C15H23BrO","Ingredient_Smile": "CC1=CCC2(CC1)C(=C)CC(C(C2(C)C)Br)O","Ingredient_weight": "299.25 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "2624","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "12016530","DrugBank_id": "NA"}
7,4'-dimethoxy-3'-hydroxyflavone
{"Ingredient_id": "HBIN012930","Ingredient_name": "7,4'-dimethoxy-3'-hydroxyflavone","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)OC)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "6239","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
7-o-methylnaringenin
{"Ingredient_id": "HBIN013417","Ingredient_name": "7-o-methylnaringenin","Alias": "NA","Ingredient_formula": "C17H14O5","Ingredient_Smile": "CC(=O)C1=CC(=C2C(=O)CC(OC2=C1)C3=CC=C(C=C3)O)O","Ingredient_weight": "298.29 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "21437;21438","PubChem_id": "49798152","DrugBank_id": "NA"}
