Exact Mass: 295.0046
Exact Mass Matches: 295.0046
Found 159 metabolites which its exact mass value is equals to given mass value 295.0046,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Diclofenac
Diclofenac is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. [PubChem]The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation. CONFIDENCE standard compound; INTERNAL_ID 186; ORIGINAL_ACQUISITION_NO 4640; ORIGINAL_PRECURSOR_SCAN_NO 4636; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9659; ORIGINAL_PRECURSOR_SCAN_NO 9657 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9639; ORIGINAL_PRECURSOR_SCAN_NO 9636 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4656; ORIGINAL_PRECURSOR_SCAN_NO 4654 CONFIDENCE standard compound; INTERNAL_ID 186; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4640; ORIGINAL_PRECURSOR_SCAN_NO 4636 M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor CONFIDENCE standard compound; EAWAG_UCHEM_ID 201 CONFIDENCE standard compound; INTERNAL_ID 4093 CONFIDENCE standard compound; INTERNAL_ID 2346 CONFIDENCE standard compound; INTERNAL_ID 8569 CONFIDENCE standard compound; INTERNAL_ID 1147 D000893 - Anti-Inflammatory Agents KEIO_ID D128; [MS2] KO008928 D004791 - Enzyme Inhibitors D - Dermatologicals KEIO_ID D128
Meclofenamic acid
Meclofenamic acid is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease. M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor CONFIDENCE standard compound; EAWAG_UCHEM_ID 3690 D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors
2-(4-Chlorophenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
3-(2-Chlorophenyl)-2-(1,3-dithian-2-yliden)-3-oxopropanenitrile
5-hydroxy-2-methyl-pyrano[2,3:5,6]chromeno[3,4-c]pyridine-4,8-dione|Schumanniophytin|Schumanniophytine
diclofenac
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors D - Dermatologicals
meclofenamic acid
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors
METHYL 2-[BENZENESULFONYLIMINO]-3,3,3-TRIFLUOROPROPIONATE
3-AMINO-4-(ISOPROPYLSULFONYL)-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID
Ethyl 2-(2-bromo-1-methyl-1H-indol-3-yl)acetate
(BENZENESULFONYL-FURAN-2-YLMETHYL-AMINO)-ACETIC ACID
3-[5-(4-bromophenyl)-1,2-oxazol-3-yl]propanoic acid
ethyl 6-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate
ethyl 1-(5-bromopyridin-2-yl)pyrazole-4-carboxylate
N-(2-NITROBENZENESULFONYL)-1,3-DIAMINOPROPANE HYDROCHLORIDE
3-[5-(4-bromophenyl)-1,3-oxazol-2-yl]propanoic acid
4-((4-Chlorophenyl)sulfonyl)piperidine hydrochloride
2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE
2-(3-BROMO-2,2-DIMETHYLPROPYL)ISOINDOLINE-1,3-DIONE
methyl 5-chloro-7-(trifluoromethyl)thieno[3,2-b]pyridine-3-carboxylate
3-(2-BROMO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
(4-(N-(4-Fluorophenyl)sulfamoyl)phenyl)boronic acid
N-[2-(3-BROMO-PHENYL)-ETHYL]-2,2,2-TRIFLUORO-ACETAMIDE
Methyl 5-bromo-8-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate
3-(4-CHLOROPHENYL)-3-(2,2,2-TRIFLUOROACETAMIDO)PROPANOIC ACID
4-Diazo-3,4-dihydro-7-nitro-3-oxo-1-naphthalenesulfonic acid
2-BROMO-1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)-1-ETHANONE
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine
3-(TRIFLUOROMETHYL)-1-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-5-AMINE
3-Quinolinecarboxylic acid, 7-bromo-3,4-dihydro-4-oxo-, ethyl ester
ETHYL5-CHLORO-1-(2-NITROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
ETHYL5-CHLORO-1-(4-NITROPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
dimethyl 7-chloro-4-oxo-1H-quinoline-2,3-dicarboxylate
4-(N-Acetylacetamido)benzenesulfonate potassium salt
ETHYL5-BROMO-1-(PYRIDIN-2-YL)-1H-PYRAZOLE-4-CARBOXYLATE
Cyclopropanamine, 1-(3-iodophenyl)-, hydrochloride (1:1)Cyclopropanamine, 1-(3-iodophenyl)-, hydrochloride (1:1)
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-nitrophenyl carbonate
4-(4,6-DICHLORO-5-(2-CHLOROETHYL)PYRIMIDIN-2-YL)MORPHOLINE
4-ALLYL-5-(4-BROMOPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL
1-(4-bromo-2-fluorophenyl)-2,5-dimethylpyrrole-3-carbaldehyde
Methyl 1-(5-chloro-3-fluoropyridin-2-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylate
7-iodo-1,2,3,4-tetrahydro-isoquinoline hydrochloride
(S)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide
ETHYL 6-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
methyl (E)-3-(2-chloro-6-fluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)prop-2-enoate
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol
Methyl 4-chloro-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate
5-(5,6-dichloro-1H-indol-2-yl)furan-2-carboxylic acid
ETHYL 7-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
6-bromospiro[1,3-dihydroquinazoline-2,4-piperidine]-4-one
1-(4-BROMOBENZYL)-5-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
8-nitronaphth[1,2-d][1,2,3]oxadiazole-5-sulphonic acid
ethyl 3-(2-chloro-4-nitrophenylaMino)-2-cyanoacrylate
2,4-dichloro-N-(2,6-dimethylphenyl)pyrimidine-5-carboxamide
5-[(2-chlorophenyl)methyl]thieno[3,2-c]pyridin-5-ium,chloride
5-(3-BROMO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
2-AMINO-4-(3-CHLORO-PHENYL)-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
ETHYL 7-BROMO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
4-amino-N-(4-methoxyphenyl)-2-(methylthio)-5-thiazolecarboxamide
N-[2-[(4-chlorophenyl)methylsulfanyl]ethyl]furan-2-carboxamide
7-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate
8-[(2S)-2-amino-2-carboxylatoethyl]-5-hydroxy-2H-1,4-benzothiazine-3-carboxylate
5-Cyclopropyl-4-[(3,4-dichlorophenyl)hydrazinylidene]-3-pyrazolamine
4-Tert-butyl-2-[(5-nitro-2-pyridinyl)thio]thiazole
N-[(4-chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazide
5-[(3-nitro-2-pyridinyl)thio]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
3-[1-(3,5-Dichlorophenyl)-5-tetrazolyl]-5-methylisoxazole
2-Phenyl-5-(trifluoromethyl)-1,2-benzothiazol-3-one
1-(2,6-Dichlorophenyl)-3-(6-methyl-3-pyridinyl)urea
2-(2-methoxyethylthio)-N-(1,3,4-thiadiazol-2-yl)benzamide
4-(3,4-dimethoxybenzylidene)-2-(methylthio)-1,3-thiazol-5(4H)-one
5-HT2B antagonist-1
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].
