Aminoacylase (BioDeep_00000177246)
human metabolite blood metabolite
代谢物信息卡片
7-[(1,3-dichloro-6,7,8,10-tetrahydro-5H-acridin-9-ylidene)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanimidic acid
化学式: C30H34Cl2N4O (536.2109534)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.92%
分子结构信息
SMILES: C1CCC2=NC3=C(C(=CC(=C3)Cl)Cl)C(=C2C1)NCCCCCCC(=O)NCCC4=CNC5=CC=CC=C54
InChI: InChI=1S/C30H34Cl2N4O/c31-21-17-24(32)29-27(18-21)36-26-12-7-5-10-23(26)30(29)34-15-8-2-1-3-13-28(37)33-16-14-20-19-35-25-11-6-4-9-22(20)25/h4,6,9,11,17-19,35H,1-3,5,7-8,10,12-16H2,(H,33,37)(H,34,36)
描述信息
同义名列表
数据库引用编号
4 个数据库交叉引用编号
- PubChem: 11706508
- HMDB: HMDB0249925
- ChEMBL: CHEMBL199585
- Wikipedia: Cellulose triacetate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gopal S Kallure, Shubhranshu Shekhar Sahoo, Rutuja S Kale, Vitthal T Barvkar, Ravindar Kontham, Ashok P Giri. Aminoacylase efficiently hydrolyses fatty acid amino acid conjugates of Helicoverpa armigera potentially to increase the pool of glutamine.
Insect biochemistry and molecular biology.
2024 Feb; 165(?):104070. doi:
10.1016/j.ibmb.2024.104070. [PMID: 38176573] - Qiong Lai, Fu-Ming Liu, Wang-Lin Rao, Guang-Ying Yuan, Zhao-Yang Fan, Lu Zhang, Fei Fu, Jun-Ping Kou, Bo-Yang Yu, Fang Li. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure.
Acta pharmacologica Sinica.
2022 Aug; 43(8):2003-2015. doi:
10.1038/s41401-021-00830-1. [PMID: 34916608] - Diğdem Göverti, Rabia Nazik Yüksel, Hasan Kaya, Nihan Büyüklüoğlu, Çiğdem Yücel, Erol Göka. Serum concentrations of aminoacylase 1 in schizophrenia as a potential biomarker: a case-sibling-control study.
Nordic journal of psychiatry.
2022 Jul; 76(5):380-385. doi:
10.1080/08039488.2021.1981435. [PMID: 35791057] - Guanbo Wang, Hai Li, Yi Hou. LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.
Cancer gene therapy.
2022 05; 29(5):585-596. doi:
10.1038/s41417-021-00339-z. [PMID: 34002044] - Corinna Krempl, Nicole Joußen, Michael Reichelt, Marco Kai, Heiko Vogel, David G Heckel. Consumption of gossypol increases fatty acid-amino acid conjugates in the cotton pests Helicoverpa armigera and Heliothis virescens.
Archives of insect biochemistry and physiology.
2021 Nov; 108(3):e21843. doi:
10.1002/arch.21843. [PMID: 34490676] - Khaloud M Alarjani, Manal F Elkhadragy, Abdulrahman H Al-Masoud, Hany M Yehia. Detection of Campylobacter jejuni and Salmonella typhimurium in chicken using PCR for virulence factor hipO and invA genes (Saudi Arabia).
Bioscience reports.
2021 09; 41(9):. doi:
10.1042/bsr20211790. [PMID: 34519329] - Marijan Posavi, Maria Diaz-Ortiz, Benjamine Liu, Christine R Swanson, R Tyler Skrinak, Pilar Hernandez-Con, Defne A Amado, Michelle Fullard, Jacqueline Rick, Andrew Siderowf, Daniel Weintraub, Leo McCluskey, John Q Trojanowski, Richard B Dewey, Xuemei Huang, Alice S Chen-Plotkin. Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis.
PLoS medicine.
2019 10; 16(10):e1002931. doi:
10.1371/journal.pmed.1002931. [PMID: 31603904] - Qian Cheng, Shaohua Gu, Zewen Liu, Chen-Zhu Wang, Xianchun Li. Expressional divergence of the fatty acid-amino acid conjugate-hydrolyzing aminoacylase 1 (L-ACY-1) in Helicoverpa armigera and Helicoverpa assulta.
Scientific reports.
2017 08; 7(1):8721. doi:
10.1038/s41598-017-09185-2. [PMID: 28821781] - Anila H A, Firoj Ali, Shilpi Kushwaha, Nandaraj Taye, Samit Chattopadhyay, Amitava Das. A Cysteine-Specific Fluorescent Switch for Monitoring Oxidative Stress and Quantification of Aminoacylase-1 in Blood Serum.
Analytical chemistry.
2016 12; 88(24):12161-12168. doi:
10.1021/acs.analchem.6b03066. [PMID: 28193016] - Xiaomin He, Yu Hong, Xiaomei Wang, Xiaohong Zhang, Jiang Long, Hai Li, Bei Zhang, Suhong Chen, Qiqi Liu, Hongyi Li, Xiaoming Wang, Xiaojuan Ou, Jian Huang. Identification and clinical significance of an elevated level of serum aminoacylase-1 autoantibody in patients with hepatitis B virus-related liver cirrhosis.
Molecular medicine reports.
2016 Nov; 14(5):4255-4262. doi:
10.3892/mmr.2016.5740. [PMID: 27633755] - Ran Zhao, Hanmin Zhang, Xiang Zou, Fenglin Yang. Effects of Inhibiting Acylated Homoserine Lactones (AHLs) on Anammox Activity and Stability of Granules'.
Current microbiology.
2016 Jul; 73(1):108-14. doi:
10.1007/s00284-016-1031-y. [PMID: 27061587] - Firoj Ali, Anila H A, Nandaraj Taye, Rajesh G Gonnade, Samit Chattopadhyay, Amitava Das. A fluorescent probe for specific detection of cysteine in the lipid dense region of cells.
Chemical communications (Cambridge, England).
2015 Dec; 51(95):16932-5. doi:
10.1039/c5cc07450a. [PMID: 26442642] - Kun Zhang, Xin Zheng, Dong-sheng Shen, Mei-zhen Wang, Hua-jun Feng, Hong-zhen He, Shuo Wang, Jue-hua Wang. Evidence for existence of quorum sensing in a bioaugmented system by acylated homoserine lactone-dependent quorum quenching.
Environmental science and pollution research international.
2015 Apr; 22(8):6050-6. doi:
10.1007/s11356-014-3795-6. [PMID: 25382500] - Masahito Nakano, Masahiro Nishihara, Hirofumi Yoshioka, Kouhei Ohnishi, Yasufumi Hikichi, Akinori Kiba. Silencing of DS2 aminoacylase-like genes confirms basal resistance to Phytophthora infestans in Nicotiana benthamiana.
Plant signaling & behavior.
2014; 9(2):e28004. doi:
10.4161/psb.28004. [PMID: 24514749] - Matthew P Welberry Smith, Alexandre Zougman, David A Cairns, Michelle Wilson, Tobias Wind, Steven L Wood, Douglas Thompson, Michael P Messenger, Andrew Mooney, Peter J Selby, Andrew J P Lewington, Rosamonde E Banks. Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation.
Kidney international.
2013 Dec; 84(6):1214-25. doi:
10.1038/ki.2013.200. [PMID: 23739232] - Simi Ali, Neil S Sheerin. Biomarkers of acute injury: predicting the long-term outcome after transplantation.
Kidney international.
2013 Dec; 84(6):1072-4. doi:
10.1038/ki.2013.305. [PMID: 24280749] - Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong, Meng-Chao Wu. A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values.
BMC cancer.
2013 Mar; 13(?):161. doi:
10.1186/1471-2407-13-161. [PMID: 23537217] - Kirill Tsirulnikov, Natalia Abuladze, Anatol Bragin, Kym Faull, Duilio Cascio, Robert Damoiseaux, Matthew J Schibler, Alexander Pushkin. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
Toxicology and applied pharmacology.
2012 Sep; 263(3):303-14. doi:
10.1016/j.taap.2012.07.002. [PMID: 22819785] - Pierre Stocker, Jean Michel Brunel, Leandro de Rezende, Antonia Tavares do Amaral, Xavier Morelli, Phillipe Roche, Nicolas Vidal, Thierry Giardina, Josette Perrier. Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides.
Biochimie.
2012 Aug; 94(8):1668-75. doi:
10.1016/j.biochi.2012.01.006. [PMID: 22349737] - Emily H Kuhns, Irmgard Seidl-Adams, James H Tumlinson. Heliothine caterpillars differ in abundance of a gut lumen aminoacylase (L-ACY-1)-Suggesting a relationship between host preference and fatty acid amino acid conjugate metabolism.
Journal of insect physiology.
2012 Mar; 58(3):408-12. doi:
10.1016/j.jinsphys.2012.01.003. [PMID: 22266147] - Emily H Kuhns, Irmgard Seidl-Adams, James H Tumlinson. A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense.
Insect biochemistry and molecular biology.
2012 Jan; 42(1):32-40. doi:
10.1016/j.ibmb.2011.10.004. [PMID: 22056272] - Patrick M Long, Holly M Stradecki, Jane E Minturn, Umadevi V Wesley, Diane M Jaworski. Differential aminoacylase expression in neuroblastoma.
International journal of cancer.
2011 Sep; 129(6):1322-30. doi:
10.1002/ijc.25798. [PMID: 21128244] - Anke Sommer, Ernst Christensen, Susanne Schwenger, Ralf Seul, Dorothea Haas, Heike Olbrich, Heymut Omran, Jörn Oliver Sass. The molecular basis of aminoacylase 1 deficiency.
Biochimica et biophysica acta.
2011 Jun; 1812(6):685-90. doi:
10.1016/j.bbadis.2011.03.005. [PMID: 21414403] - Anna Tylki-Szymanska, Wanda Gradowska, Anke Sommer, Angelina Heer, Melanie Walter, Christina Reinhard, Heymut Omran, Jörn Oliver Sass, Agnieszka Jurecka. Aminoacylase 1 deficiency associated with autistic behavior.
Journal of inherited metabolic disease.
2010 Dec; 33 Suppl 3(?):S211-4. doi:
10.1007/s10545-010-9089-3. [PMID: 20480396] - Tao Dong, Lin Zhao, Yu Huang, Xin Tan. Preparation of cross-linked aggregates of aminoacylase from Aspergillus melleus by using bovine serum albumin as an inert additive.
Bioresource technology.
2010 Aug; 101(16):6569-71. doi:
10.1016/j.biortech.2010.03.061. [PMID: 20363123] - Rainer Wardenga, Holger A Lindner, Frank Hollmann, Oliver Thum, Uwe Bornscheuer. Increasing the synthesis/hydrolysis ratio of aminoacylase 1 by site-directed mutagenesis.
Biochimie.
2010 Jan; 92(1):102-9. doi:
10.1016/j.biochi.2009.09.017. [PMID: 19818829] - Mayuko Koreishi, Yasuyuki Nakatani, Manami Ooi, Hiroyuki Imanaka, Koreyoshi Imamura, Kazuhiro Nakanishi. Purification, characterization, molecular cloning, and expression of a new aminoacylase from Streptomyces mobaraensis that can hydrolyze N-(middle/long)-chain-fatty-acyl-L-amino acids as well as N-short-chain-acyl-L-amino acids.
Bioscience, biotechnology, and biochemistry.
2009 Sep; 73(9):1940-7. doi:
10.1271/bbb.90081. [PMID: 19734688] - Yi Zhong, Janice Onuki, Toshinari Yamasaki, Osamu Ogawa, Shinya Akatsuka, Shinya Toyokuni. Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma.
Carcinogenesis.
2009 Jan; 30(1):158-64. doi:
10.1093/carcin/bgn255. [PMID: 19028700] - Rainer Wardenga, Frank Hollmann, Oliver Thum, Uwe Bornscheuer. Functional expression of porcine aminoacylase 1 in E. coli using a codon optimized synthetic gene and molecular chaperones.
Applied microbiology and biotechnology.
2008 Dec; 81(4):721-9. doi:
10.1007/s00253-008-1716-7. [PMID: 18815781] - Holger A Lindner, Margot Täfler-Naumann, Klaus-Heinrich Röhm. N-acetylamino acid utilization by kidney aminoacylase-1.
Biochimie.
2008 May; 90(5):773-80. doi:
10.1016/j.biochi.2007.12.006. [PMID: 18222180] - Udo F H Engelke, Jörn Oliver Sass, Rudy N Van Coster, Erik Gerlo, Heike Olbrich, Stefan Krywawych, Jacqui Calvin, Claire Hart, Heymut Omran, Ron A Wevers. NMR spectroscopy of aminoacylase 1 deficiency, a novel inborn error of metabolism.
NMR in biomedicine.
2008 Feb; 21(2):138-47. doi:
10.1002/nbm.1170. [PMID: 17516490] - J O Sass, H Olbrich, V Mohr, C Hart, B Woldseth, S Krywawych, B Bjurulf, P K Lakhani, R M Buchdahl, H Omran. Neurological findings in aminoacylase 1 deficiency.
Neurology.
2007 Jun; 68(24):2151-3. doi:
10.1212/01.wnl.0000264933.56204.e8. [PMID: 17562838] - Jorn Oliver Sass, Verena Mohr, Heike Olbrich, Udo Engelke, Judit Horvath, Manfred Fliegauf, Niki Tomas Loges, Susanne Schweitzer-Krantz, Ralf Moebus, Polly Weiler, Andreas Kispert, Andrea Superti-Furga, Ron A Wevers, Heymut Omran. Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism.
American journal of human genetics.
2006 Mar; 78(3):401-9. doi:
10.1086/500563. [PMID: 16465618] - R N Van Coster, E A Gerlo, T G Giardina, U F Engelke, J E Smet, C M De Praeter, V A Meersschaut, L J De Meirleir, S H Seneca, B Devreese, J G Leroy, S Herga, J P Perrier, R A Wevers, W Lissens. Aminoacylase I deficiency: a novel inborn error of metabolism.
Biochemical and biophysical research communications.
2005 Dec; 338(3):1322-6. doi:
10.1016/j.bbrc.2005.10.126. [PMID: 16274666] - Søren Persson, Katharina Ep Olsen. Multiplex PCR for identification of Campylobacter coli and Campylobacter jejuni from pure cultures and directly on stool samples.
Journal of medical microbiology.
2005 Nov; 54(Pt 11):1043-1047. doi:
10.1099/jmm.0.46203-0. [PMID: 16192435] - P Stocker, M Yousfi, C Salmi, J Perrier, J M Brunel, A Moulin. Maackiain 3-O-(6'-O-malonyl-beta-D-glucopyranoside) from Oudneya africana, a powerful inhibitor of porcine kidney acylase I.
Biochimie.
2005 Jun; 87(6):507-12. doi:
10.1016/j.biochi.2005.02.010. [PMID: 15935275] - Jeong Seok Hwa, Hyo Jin Park, Jae Hun Jung, Sung Chul Kam, Hyung Chul Park, Choong Won Kim, Kee Ryeon Kang, Jea Seog Hyun, Ky Hyun Chung. Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis.
Journal of Korean medical science.
2005 Jun; 20(3):450-5. doi:
10.3346/jkms.2005.20.3.450. [PMID: 15953868] - Anthony R Carroll, Edward Hyde, Jill Smith, Ronald J Quinn, Gordon Guymer, Paul I Forster. Actinophyllic acid, a potent indole alkaloid inhibitor of the coupled enzyme assay carboxypeptidase u/hippuricase from the leaves of Alstonia actinophylla (Apocynaceae).
The Journal of organic chemistry.
2005 Feb; 70(3):1096-9. doi:
10.1021/jo048439n. [PMID: 15675882] - Marwan Abu-Halaweh, J Bates, Bharat K C Patel. Rapid detection and differentiation of pathogenic Campylobacter jejuni and Campylobacter coli by real-time PCR.
Research in microbiology.
2005 Jan; 156(1):107-14. doi:
10.1016/j.resmic.2004.08.008. [PMID: 15636755] - Harald Groger, Harald Trauthwein, Stefan Buchholz, Karlheinz Drauz, Christiane Sacherer, Sylvie Godfrin, Helge Werner. The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids.
Organic & biomolecular chemistry.
2004 Jul; 2(14):1977-8. doi:
10.1039/b406380e. [PMID: 15254623] - Josette Perrier, Anne Durand, Thierry Giardina, Antoine Puigserver. The rat kidney acylase 1. Evidence for a new cDNA form and comparisons with the porcine intestinal enzyme.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2004 Jul; 138(3):277-83. doi:
10.1016/j.cbpc.2004.04.010. [PMID: 15253876] - Qiang Xie, Tai Guo, Jie Lu, Hai-Meng Zhou. The guanidine like effects of arginine on aminoacylase and salt-induced molten globule state.
The international journal of biochemistry & cell biology.
2004 Feb; 36(2):296-306. doi:
10.1016/s1357-2725(03)00252-8. [PMID: 14643894] - Zhen Xu, Qiang Xie, Hai-Meng Zhou. Trichloroacetic acid-induced molten globule state of aminoacylase from pig kidney.
Journal of protein chemistry.
2003 Nov; 22(7-8):669-75. doi:
10.1023/b:jopc.0000008732.38381.16. [PMID: 14714734] - Qiang Xie, Tai Guo, Tingting Wang, Jie Lu, Hai-Meng Zhou. Aspartate-induced aminoacylase folding and forming of molten globule.
The international journal of biochemistry & cell biology.
2003 Nov; 35(11):1558-72. doi:
10.1016/s1357-2725(03)00131-6. [PMID: 12824065] - Anne Durand, Thierry Giardina, Claude Villard, Alain Roussel, Antoine Puigserver, Josette Perrier. Rat kidney acylase I: further characterisation and mutation studies on the involvement of Glu 147 in the catalytic process.
Biochimie.
2003 Oct; 85(10):953-62. doi:
10.1016/j.biochi.2003.09.002. [PMID: 14644550] - Feng Xu, Tony Byun, Heinz-Josef Deussen, Kyle R Duke, Heinz-Josef Dussen. Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase.
Journal of biotechnology.
2003 Feb; 101(1):89-96. doi:
10.1016/s0168-1656(02)00305-x. [PMID: 12523973] - Magnus Stödeman, Frederick P Schwarz. Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.
Analytical biochemistry.
2002 Sep; 308(2):285-93. doi:
10.1016/s0003-2697(02)00339-1. [PMID: 12419341] - Kanthi J M Abesundara, Motonobu Higuchi, Toshiro Matsui, Kiyoshi Matsumoto. Evaluation of angiotensin I converting enzyme inhibitory activity by an FIA combined with biosensors.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2002 Apr; 18(4):467-8. doi:
10.2116/analsci.18.467. [PMID: 11999524] - Aiko Yamauchi, Nobuhiko Ueda, Sayuri Hanafusa, Eri Yamashita, Masaru Kihara, Shinsaku Naito. Tissue distribution of and species differences in deacetylation of N-acetyl-L-cysteine and immunohistochemical localization of acylase I in the primate kidney.
The Journal of pharmacy and pharmacology.
2002 Feb; 54(2):205-12. doi:
10.1211/0022357021778394. [PMID: 11848284] - X F Zheng, J Y Wang, Y Wang, L J An, H W Gai, J Hu. [Study on the direct interaction between aminoacylase and Cu(II) ions by spectroscopic analysis].
Guang pu xue yu guang pu fen xi = Guang pu.
2001 Dec; 21(6):804-6. doi:
NULL. [PMID: 12958900] - S Balabanov, U Zimmermann, C Protzel, C Scharf, K J Klebingat, R Walther. Tumour-related enzyme alterations in the clear cell type of human renal cell carcinoma identified by two-dimensional gel electrophoresis.
European journal of biochemistry.
2001 Nov; 268(22):5977-80. doi:
10.1046/j.0014-2956.2001.02546.x. [PMID: 11722587] - K A Schatteman, F J Goossens, J Leurs, Y Kasahara, S S Scharpé, D F Hendriks. Fast homogeneous assay for plasma procarboxypeptidase U.
Clinical chemistry and laboratory medicine.
2001 Sep; 39(9):806-10. doi:
10.1515/cclm.2001.133. [PMID: 11601677] - X Xing, A Fichera, K Kumar. A novel synthesis of enantiomerically pure 5,5,5,5',5',5'-hexafluoroleucine.
Organic letters.
2001 May; 3(9):1285-6. doi:
10.1021/ol015567e. [PMID: 11348215] - T Giardina, J Perrier, A Puigserver. The rat kidney acylase I, characterization and molecular cloning. Differences with other acylases I.
European journal of biochemistry.
2000 Oct; 267(20):6249-55. doi:
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Archives of biochemistry and biophysics.
2000 Jul; 379(2):261-6. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2000 Jun; 28(6):625-32. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2000 Apr; 28(4):440-5. doi:
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Biochimie.
2000 Feb; 82(2):129-37. doi:
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Applied biochemistry and biotechnology.
1999 Mar; 76(3):183-91. doi:
10.1385/abab:76:3:183. [PMID: 10390808] - J H Bai, D Xu, H R Wang, S Y Zheng, H M Zhou. Evidence for the existence of an unfolding intermediate state for aminoacylase during denaturation in guanidine solutions.
Biochimica et biophysica acta.
1999 Feb; 1430(1):39-45. doi:
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Chemical research in toxicology.
1998 Jul; 11(7):800-9. doi:
10.1021/tx980018b. [PMID: 9671543] - S Pittelkow, H Lindner, K H Röhm. Human and porcine aminoacylase I overproduced in a baculovirus expression vector system: evidence for structural and functional identity with enzymes isolated from kidney.
Protein expression and purification.
1998 Mar; 12(2):269-76. doi:
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Biochemistry and molecular biology international.
1997 Dec; 43(6):1277-83. doi:
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Journal of clinical microbiology.
1997 Oct; 35(10):2568-72. doi:
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Biochimie.
1997 May; 79(5):265-73. doi:
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International journal of peptide and protein research.
1996 Dec; 48(6):532-8. doi:
10.1111/j.1399-3011.1996.tb00872.x. [PMID: 8985786] - B Kempf, E Bremer. A novel amidohydrolase gene from Bacillus subtilis cloning: DNA-sequence analysis and map position of amhX.
FEMS microbiology letters.
1996 Aug; 141(2-3):129-37. doi:
10.1111/j.1574-6968.1996.tb08374.x. [PMID: 8768514] - Y X Zhang, W P Le, H M Zhou. Kinetics of the course of reactivation of aminoacylase reconstituted using Mn2+ ions.
Journal of protein chemistry.
1995 Nov; 14(8):695-701. doi:
10.1007/bf01886908. [PMID: 8747430] - Z Y Tang, J Y Yu, Q Zhou, B He, Z F Wang, H M Zhou. Secondary structure of holo- and apo-aminoacylase from prediction, circular dichroism, and FT-Raman spectroscopy.
Journal of biochemistry.
1995 Oct; 118(4):706-9. doi:
10.1093/oxfordjournals.jbchem.a124969. [PMID: 8576082] - B He, Y Zhang, T Zhang, H R Wang, H M Zhou. Inactivation and unfolding of aminoacylase during denaturation in sodium dodecyl sulfate solutions.
Journal of protein chemistry.
1995 Jul; 14(5):349-57. doi:
10.1007/bf01886792. [PMID: 8590603] - G J Palm, K H Röhm. Aminoacylase I from porcine kidney: identification and characterization of two major protein domains.
Journal of protein chemistry.
1995 May; 14(4):233-40. doi:
10.1007/bf01886764. [PMID: 7662111] - M Mályusz, A Hackl, P Wrigge, M Lange, T Mályusz, H Sick, G Gronow. Ammonia production from hippurate by the rat kidney in vitro.
Renal physiology and biochemistry.
1994 Nov; 17(6):307-15. doi:
10.1159/000173863. [PMID: 7533310] - M Q Huang, H M Zhou. Alkaline unfolding and salt-induced folding of aminoacylase at high pH.
Enzyme & protein.
1994 199; 48(4):229-37. doi:
10.1159/000474993. [PMID: 8821711] - M Jakob, Y E Miller, K H Röhm. Cloning and sequence analyses of cDNAs encoding aminoacylase I from porcine kidney.
Biological chemistry Hoppe-Seyler.
1992 Dec; 373(12):1227-31. doi:
10.1515/bchm3.1992.373.2.1227. [PMID: 1292507] - M Mitta, H Ohnogi, A Yamamoto, I Kato, F Sakiyama, S Tsunasawa. The primary structure of porcine aminoacylase 1 deduced from cDNA sequence.
Journal of biochemistry.
1992 Dec; 112(6):737-42. doi:
10.1093/oxfordjournals.jbchem.a123968. [PMID: 1284246] - Y B Yang, K M Hsiao, H Li, H Yano, A Tsugita, Y C Tsai. Characterization of D-aminoacylase from Alcaligenes denitrificans DA181.
Bioscience, biotechnology, and biochemistry.
1992 Sep; 56(9):1392-5. doi:
10.1271/bbb.56.1392. [PMID: 1368943] - Z X Wang, H B Wu, X C Wang, H M Zhou, C L Tsou. Kinetics of the course of inactivation of aminoacylase by 1,10-phenanthroline.
The Biochemical journal.
1992 Jan; 281 ( Pt 1)(?):285-90. doi:
10.1042/bj2810285. [PMID: 1731765] - T Huwer, H J Altmann, W Grunow, S Lenhardt, M Przybylski, G Eisenbrand. Coumarin mercapturic acid isolated from rat urine indicates metabolic formation of coumarin 3,4-epoxide.
Chemical research in toxicology.
1991 Sep; 4(5):586-90. doi:
10.1021/tx00023a016. [PMID: 1793808] - K J Greenhough, A J Turner. Aminoacylase I is not a glycolipid-anchored ectoenzyme in pig kidney.
Biochimica et biophysica acta.
1991 Feb; 1076(3):364-8. doi:
10.1016/0167-4838(91)90477-h. [PMID: 1825788] - D Heese, S Berger, K H Röhm. Nuclear magnetic relaxation studies of the role of the metal ion in Mn2(+)-substituted aminoacylase I.
European journal of biochemistry.
1990 Feb; 188(1):175-80. doi:
10.1111/j.1432-1033.1990.tb15385.x. [PMID: 2318199] - K H Röhm. Butylmalonate is a transition state analogue for aminocylase I.
FEBS letters.
1989 Jul; 250(2):191-4. doi:
10.1016/0014-5793(89)80718-5. [PMID: 2753127] - Y E Miller, J D Minna, A F Gazdar. Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p.
The Journal of clinical investigation.
1989 Jun; 83(6):2120-4. doi:
10.1172/jci114125. [PMID: 2542383] - D Heese, K H Röhm. Reactivities of sulfhydryl groups in native and metal-free aminoacylase I.
Biological chemistry Hoppe-Seyler.
1989 Jun; 370(6):607-12. doi:
10.1515/bchm3.1989.370.1.607. [PMID: 2775487] - A Hernández, E Piña. A simplified purification method of aminoacylase I.
Preparative biochemistry.
1989; 19(3):247-9. doi:
10.1080/10826068908544914. [PMID: 2616542] - S A Zhukov, Iu V Galaev. [The substrate specificity of acylase in animals from the evolutionary viewpoint].
Zhurnal evoliutsionnoi biokhimii i fiziologii.
1989 Jan; 25(1):126-8. doi:
NULL. [PMID: 2728687] - T vom Bruch, K H Röhm. Fluorescence properties of hog kidney aminoacylase I.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
1988 Sep; 43(9-10):671-8. doi:
10.1515/znc-1988-9-1008. [PMID: 3245265] - D Heese, H G Löffler, K H Röhm. Further characterization of porcine kidney aminoacylase I reveals close similarity to 'renal dipeptidase'.
Biological chemistry Hoppe-Seyler.
1988 Jul; 369(7):559-66. doi:
10.1515/bchm3.1988.369.2.559. [PMID: 3223987] - J Henseling, K H Röhm. Aminoacylase I from hog kidney: anion effects and the pH dependence of kinetic parameters.
Biochimica et biophysica acta.
1988 Apr; 959(3):370-7. doi:
10.1016/0005-2760(88)90211-1. [PMID: 3355856] - H Y Cho, K Tanizawa, H Tanaka, K Soda. A spectrophotometric rate assay of aminoacylase.
Analytical biochemistry.
1987 Aug; 165(1):142-6. doi:
10.1016/0003-2697(87)90212-0. [PMID: 3688428] - J Henseling, K H Röhm. Unusual solvent isotope effects on the aminoacylase-catalyzed hydrolysis of acetylamino acids.
FEBS letters.
1987 Jul; 219(1):27-30. doi:
10.1016/0014-5793(87)81184-5. [PMID: 3595878] - D Hendriks, S Scharpe, M van Sande, M P Lommaert, Y Kasahara. Carboxypeptidase N: colorimetric assay using a new substrate.
Analytical biochemistry.
1987 Jul; 164(1):90-5. doi:
10.1016/0003-2697(87)90372-1. [PMID: 3118736] - C Sambale, M R Kula. Studies on the enzymatic hydrolysis of amino acid carbamates.
Biotechnology and applied biochemistry.
1987 Jun; 9(3):251-7. doi:
10.1111/j.1470-8744.1987.tb00476.x. [PMID: 3111496] - H G Löffler, F Schneider. Inhibition of aminoacylase from hog kidney by 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline.
Biological chemistry Hoppe-Seyler.
1987 May; 368(5):481-5. doi:
10.1515/bchm3.1987.368.1.481. [PMID: 3620103] - J Telegdi, H Tüdös, F Kraicsovits, E Moravcsik, L Otvös. Enzymatic hydrolysis of electrically charged substrates.
Acta biochimica et biophysica Hungarica.
1987; 22(1):67-74. doi:
NULL. [PMID: 3124424] - K H Röhm, R L Van Etten. Catalysis by hog-kidney aminoacylase does not involve a covalent intermediate.
European journal of biochemistry.
1986 Oct; 160(2):327-32. doi:
10.1111/j.1432-1033.1986.tb09975.x. [PMID: 3769932] - H Saruta, Y Ashihara, M Sugiyama, M Roth, E Miyagawa, Y Kido, Y Kasahara. Colorimetric determination of carboxypeptidase A activity in serum.
Clinical chemistry.
1986 May; 32(5):748-51. doi:
. [PMID: 3698265] - F Csaikl, G Reimer, U Csaikl. Aminoacylase-1 isoenzymes: a comparative study.
Heredity.
1986 Apr; 56 ( Pt 2)(?):157-60. doi:
10.1038/hdy.1986.26. [PMID: 3700124] - M Tateishi, H Tomisawa, S Ichihara. [A novel metabolic pathway of mercapturic acids--methylthiolation].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
1985 Feb; 30(2):130-42. doi:
NULL. [PMID: 3887491] - A Szewczuk, M Kuropatwa, K Barczyk-Luczykowa, E Ziomek. Enzyme-linked immunosorbent assay (ELISA) of acylase in serum of patients with viral hepatitis.
Clinica chimica acta; international journal of clinical chemistry.
1982 Aug; 123(1-2):33-7. doi:
10.1016/0009-8981(82)90110-3. [PMID: 6749336]