7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine (BioDeep_00000175111)

   

human metabolite blood metabolite


代谢物信息卡片


9-Amino-7-methoxy-1,2,3,4-tetrahydroacridine

化学式: C14H16N2O (228.1263)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1)N=C1CCCCC1=C2N
InChI: InChI=1S/C14H16N2O/c1-17-9-6-7-13-11(8-9)14(15)10-4-2-3-5-12(10)16-13/h6-8H,2-5H2,1H3,(H2,15,16)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Michele Rossi, Michela Freschi, Luciana de Camargo Nascente, Alessandra Salerno, Sarah de Melo Viana Teixeira, Florian Nachon, Fabien Chantegreil, Ondrej Soukup, Lukáš Prchal, Marco Malaguti, Christian Bergamini, Manuela Bartolini, Cristina Angeloni, Silvana Hrelia, Luiz Antonio Soares Romeiro, Maria Laura Bolognesi. Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. Journal of medicinal chemistry. 2021 04; 64(8):4972-4990. doi: 10.1021/acs.jmedchem.1c00048. [PMID: 33829779]
  • Jana Zdarova Karasova, Ondrej Soukup, Jan Korabecny, Milos Hroch, Marketa Krejciova, Martina Hrabinova, Jan Misik, Ladislav Novotny, Vendula Hepnarova, Kamil Kuca. Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats. Drug and chemical toxicology. 2021 Mar; 44(2):207-214. doi: 10.1080/01480545.2019.1566350. [PMID: 31257938]
  • Zdenka Kristofikova, Jan Ricny, Ondrej Soukup, Jan Korabecny, Eugenie Nepovimova, Kamil Kuca, Daniela Ripova. Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1. Dementia and geriatric cognitive disorders. 2017; 43(1-2):45-58. doi: 10.1159/000453256. [PMID: 27988521]
  • Martin Mzik, Jan Korabecny, Eugenie Nepovimova, Viktor Voříšek, Vladimir Palička, Kamil Kuca, Jana Zdarova Karasova. An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 May; 1020(?):85-9. doi: 10.1016/j.jchromb.2016.02.038. [PMID: 27030895]
  • M G Vargas, J Havel, J Patocka. Determination of the anti-Alzheimer's disease drugs tacrine, 7-methoxytacrine, and its metabolites by capillary zone electrophoresis. American clinical laboratory. 1998 Jun; 17(5):22-3. doi: NULL. [PMID: 10181004]
  • V Filip, J Vachek, V Albrecht, I Dvorák, J Dvoráková, J Fusek, J Havlůj. Pharmacokinetics and tolerance of 7-methoxytacrine following the single dose administration in healthy volunteers. International journal of clinical pharmacology, therapy, and toxicology. 1991 Nov; 29(11):431-6. doi: NULL. [PMID: 1800389]
  • J Patocka, J Bielavský. [Biotransformation of the anticholinesterase agent, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine]. Ceskoslovenska farmacie. 1991 May; 40(3):130-2. doi: NULL. [PMID: 2070431]
  • R J Srám, B Binková, J Topinka, I Fojtíková. Inhibition of DNA repair synthesis in the rat by in vivo exposure to psychotropic drugs and reversal of the effect by co-administration with alpha-tocopherol. Mutation research. 1990 Aug; 244(4):331-5. doi: 10.1016/0165-7992(90)90081-t. [PMID: 2385247]