Quinacrine (BioDeep_00000003331)
Secondary id: BioDeep_00000397940, BioDeep_00001867737
human metabolite blood metabolite
代谢物信息卡片
N(4)-(6-Chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine
化学式: C23H30ClN3O (399.20772800000003)
中文名称: 疟涤平
谱图信息:
最多检出来源 Homo sapiens(blood) 11.86%
分子结构信息
SMILES: CCN(CC)CCCC(C)N=c1c2ccc(Cl)cc2[nH]c2ccc(OC)cc12
InChI: InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
描述信息
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [PubChem]
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
30 个代谢物同义名
N(4)-(6-Chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine; 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine; 6-chloro-N-[5-(diethylamino)pentan-2-yl]-2-methoxyacridin-9-amine; 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine; 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine; Quinacrine dihyrochloride, (R)-isomer; Quinacrine dihyrochloride, (S)-isomer; Quinacrine dihydrochloride, dihydrate; Quinacrine Dihydrochloride Dihydrate; Monohydrochloride, quinacrine; Quinacrine monohydrochloride; Dihydrochloride, quinacrine; Quinacrine dihydrochloride; Hydrochloride, quinacrine; Monomesylate, quinacrine; Quinacrine hydrochloride; Quinacrine, (+-)-isomer; Monoacetate, quinacrine; Quinacrine monomesylate; Quinacrine, (R)-isomer; Quinacrine monoacetate; Quinacrine, (S)-isomer; Dimesylate, quinacrine; Quinacrine dimesylate; quinacrine; Mepacrine; Quinacrin; Acrichine; Atabrine; Atebrin
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:8711
- KEGG: C07339
- KEGGdrug: D08179
- PubChem: 237
- HMDB: HMDB0015235
- Metlin: METLIN24079
- DrugBank: DB01103
- ChEMBL: CHEMBL7568
- Wikipedia: Quinacrine
- MeSH: Quinacrine
- MetaCyc: ATABRINE
- chemspider: 232
- CAS: 65960-39-6
- CAS: 83-89-6
- PMhub: MS000009369
- PubChem: 9546
- NIKKAJI: J3.877F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Biswajit Das, Somya Ranjan Dash, Harun Patel, Saptarshi Sinha, Subhasmita Bhal, Subarno Paul, Chinmay Das, Rajalaxmi Pradhan, Iqrar Ahmed, Kunal Goutam, Chanakya Nath Kundu. Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Aug; 117(?):154914. doi:
10.1016/j.phymed.2023.154914. [PMID: 37321076] - Xiangxiang Li, Jing Zhou, Zhuozhou Hu, Liang Han, Wenyang Zhao, Tongyu Wu, Chun Li, Jingjing Liu, Jia Kang, Xinping Chen. Quinacrine attenuates diet-induced obesity by inhibiting adipogenesis via activation of AMPK signaling.
European journal of pharmacology.
2023 Jan; 938(?):175432. doi:
10.1016/j.ejphar.2022.175432. [PMID: 36460132] - Nirod Kumar Sarangi, Amrutha Prabhakaran, Tia E Keyes. Multimodal Investigation into the Interaction of Quinacrine with Microcavity-Supported Lipid Bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2022 05; 38(20):6411-6424. doi:
10.1021/acs.langmuir.2c00524. [PMID: 35561255] - Benjamin Pineda. Quinacrine, an Old Drug with Potentially usefull in the Treatment for COVID-19.
Archives of medical research.
2021 11; 52(8):858-859. doi:
10.1016/j.arcmed.2021.06.002. [PMID: 34154830] - Nada F Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H Eisa. Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910660. [PMID: 34639002] - Lucy Martinez-Guerrero, Xiaohong Zhang, Kimberley M Zorn, Sean Ekins, Stephen H Wright. Cationic Compounds with SARS-CoV-2 Antiviral Activity and Their Interaction with Organic Cation Transporter/Multidrug and Toxin Extruder Secretory Transporters.
The Journal of pharmacology and experimental therapeutics.
2021 10; 379(1):96-107. doi:
10.1124/jpet.121.000619. [PMID: 34253645] - M F Ara-Montojo, J Bustamante, T Sainz, S Pérez, B Jiménez-Moreno, G Ruiz-Carrascoso, P Rodríguez-Molino, J Villota, M García-López-Hortenano, M J Mellado-Peña. Intestinal giardiasis in children: Five years' experience in a reference unit.
Travel medicine and infectious disease.
2021 Jul; 42(?):102082. doi:
10.1016/j.tmaid.2021.102082. [PMID: 34020030] - Raphael J Eberle, Danilo S Olivier, Marcos S Amaral, Ian Gering, Dieter Willbold, Raghuvir K Arni, Monika A Coronado. The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CLpro In Vitro.
Viruses.
2021 05; 13(5):. doi:
10.3390/v13050873. [PMID: 34068686] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tomohisa Kitagawa, Atsushi Matsumoto, Ichiro Terashima, Yukifumi Uesono. Antimalarial Quinacrine and Chloroquine Lose Their Activity by Decreasing Cationic Amphiphilic Structure with a Slight Decrease in pH.
Journal of medicinal chemistry.
2021 04; 64(7):3885-3896. doi:
10.1021/acs.jmedchem.0c02056. [PMID: 33775096] - Mónica Salas Rojas, Raúl Silva Garcia, Estela Bini, Verónica Pérez de la Cruz, Juan Carlos León Contreras, Rogelio Hernández Pando, Fernando Bastida Gonzalez, Eduardo Davila-Gonzalez, Mario Orozco Morales, Armando Gamboa Domínguez, Julio Sotelo, Benjamín Pineda. Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro.
Viruses.
2021 Jan; 13(1):. doi:
10.3390/v13010121. [PMID: 33477376] - B Pineda, V Pérez de la Cruz, R Hernández Pando, J Sotelo. Quinacrine as a potential treatment for COVID-19 virus infection.
European review for medical and pharmacological sciences.
2021 01; 25(1):556-566. doi:
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Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Aug; 26(8):1092.e1-1092.e6. doi:
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Molecular pharmaceutics.
2020 07; 17(7):2463-2472. doi:
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International journal of pharmaceutics.
2020 Mar; 577(?):118995. doi:
10.1016/j.ijpharm.2019.118995. [PMID: 31935471] - Silvia Biggi, Michael Pancher, Claudia Stincardini, Silvia Luotti, Tania Massignan, Andrea Dalle Vedove, Andrea Astolfi, Pamela Gatto, Graziano Lolli, Maria Letizia Barreca, Valentina Bonetto, Valentina Adami, Emiliano Biasini. Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface.
Journal of neurochemistry.
2020 01; 152(1):136-150. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Sabrina Forveille, Juliette Humeau, Allan Sauvat, Lucillia Bezu, Guido Kroemer, Oliver Kepp. Quinacrine-mediated detection of intracellular ATP.
Methods in enzymology.
2019; 629(?):103-113. doi:
10.1016/bs.mie.2019.05.050. [PMID: 31727236] - Mariachiara Buccarelli, Matteo Marconi, Simone Pacioni, Ivana De Pascalis, Quintino Giorgio D'Alessandris, Maurizio Martini, Barbara Ascione, Walter Malorni, Luigi Maria Larocca, Roberto Pallini, Lucia Ricci-Vitiani, Paola Matarrese. Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis.
Cell death & disease.
2018 08; 9(8):841. doi:
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The Journal of infectious diseases.
2017 03; 215(6):946-953. doi:
10.1093/infdis/jix066. [PMID: 28453841] - Anna-Maria Kreidler, Roland Benz, Holger Barth. Chloroquine derivatives block the translocation pores and inhibit cellular entry of Clostridium botulinum C2 toxin and Bacillus anthracis lethal toxin.
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2017 Mar; 91(3):1431-1445. doi:
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BMC nephrology.
2017 01; 18(1):41. doi:
10.1186/s12882-017-0450-8. [PMID: 28129740] - Wenlin Huang, Zhongsheng Zhang, Ximena Barros-Álvarez, Cho Yeow Koh, Ranae M Ranade, J Robert Gillespie, Sharon A Creason, Sayaka Shibata, Christophe L M J Verlinde, Wim G J Hol, Frederick S Buckner, Erkang Fan. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
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Eukaryotic cell.
2015 Dec; 14(12):1203-16. doi:
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Journal of drug targeting.
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Journal of medicinal chemistry.
2014 Feb; 57(3):828-35. doi:
10.1021/jm401178t. [PMID: 24354316] - Muhammad Usman, Mohammad Siddiq. Probing the micellar properties of Quinacrine 2HCl and its binding with surfactants and human serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2013 Sep; 113(?):182-90. doi:
10.1016/j.saa.2013.04.089. [PMID: 23727671] - Caroline Roy, Valérie Gagné, Maria J G Fernandes, François Marceau. High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs.
Toxicology and applied pharmacology.
2013 Jul; 270(2):77-86. doi:
10.1016/j.taap.2013.04.004. [PMID: 23603060] - Annaliese K Franz, Megan A Danielewicz, Diana M Wong, Lisa A Anderson, Jordan R Boothe. Phenotypic screening with oleaginous microalgae reveals modulators of lipid productivity.
ACS chemical biology.
2013 May; 8(5):1053-62. doi:
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2013 Feb; 52(?):129-36. doi:
10.1016/j.fct.2012.11.015. [PMID: 23168241] - Ranjan Preet, Purusottam Mohapatra, Dipon Das, Shakti R Satapathy, Tathagata Choudhuri, Michael D Wyatt, Chanakya N Kundu. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.
Carcinogenesis.
2013 Feb; 34(2):277-86. doi:
10.1093/carcin/bgs351. [PMID: 23129580] - Andrzej Woznica, Agnieszka Nowak, Przemyslaw Ziemski, Mirosław Kwasniewski, Tytus Bernas. Stimulatory effect of xenobiotics on oxidative electron transport of chemolithotrophic nitrifying bacteria used as biosensing element.
PloS one.
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10.1155/2013/938047. [PMID: 24367790] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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European journal of pharmacology.
2012 Sep; 691(1-3):93-102. doi:
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PloS one.
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2011 Jul; 46(7):2917-29. doi:
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2011 Jul; 55(7):3363-9. doi:
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2011 May; 25(3):158-68. doi:
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2010 Dec; 8(?):128. doi:
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The journal of the Royal College of Physicians of Edinburgh.
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Biochemistry. Biokhimiia.
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Cryobiology.
2009 Dec; 59(3):297-301. doi:
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PloS one.
2009 Oct; 4(10):e7376. doi:
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Prostaglandins & other lipid mediators.
2009 Jan; 88(1-2):51-61. doi:
10.1016/j.prostaglandins.2008.09.004. [PMID: 18984060] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Jung J Kang, Ildikó Toma, Arnold Sipos, Elliott J Meer, Sarah L Vargas, János Peti-Peterdi. The collecting duct is the major source of prorenin in diabetes.
Hypertension (Dallas, Tex. : 1979).
2008 Jun; 51(6):1597-604. doi:
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The Journal of infection.
2008 Apr; 56(4):268-73. doi:
10.1016/j.jinf.2008.01.013. [PMID: 18328567] - Ferenc Zsila, Júlia Visy, György Mády, Ilona Fitos. Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein.
Bioorganic & medicinal chemistry.
2008 Apr; 16(7):3759-72. doi:
10.1016/j.bmc.2008.01.053. [PMID: 18289858] - Yuji Moriyasu, Yuko Inoue. Use of protease inhibitors for detecting autophagy in plants.
Methods in enzymology.
2008; 451(?):557-80. doi:
10.1016/s0076-6879(08)03232-1. [PMID: 19185740] - Evgeny Pryazhnikov, Leonard Khiroug. Sub-micromolar increase in [Ca(2+)](i) triggers delayed exocytosis of ATP in cultured astrocytes.
Glia.
2008 Jan; 56(1):38-49. doi:
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International journal of toxicology.
2007 Nov; 26(6):553-69. doi:
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European journal of pharmacology.
2007 Oct; 571(2-3):138-44. doi:
10.1016/j.ejphar.2007.05.061. [PMID: 17628524] - E M Shapovalova, A J Rudzevich. Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.
Bulletin of experimental biology and medicine.
2007 Oct; 144(4):527-8. doi:
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The Journal of biological chemistry.
2007 Sep; 282(39):28749-28758. doi:
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Blood.
2007 Aug; 110(4):1334-42. doi:
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Toxicology.
2007 Jul; 236(3):149-57. doi:
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Bioinformation.
2007 May; 2(1):12-6. doi:
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Biochemistry. Biokhimiia.
2007 May; 72(5):572-82. doi:
10.1134/s000629790705015x. [PMID: 17573713] - Ho Jae Han, Min Jin Lim, Yun Jung Lee, Jang Hern Lee, Il Suk Yang, Mary Taub. Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-kappaB.
American journal of physiology. Renal physiology.
2007 Jan; 292(1):F373-81. doi:
10.1152/ajprenal.00104.2006. [PMID: 16985215] - W Kozak, S Wrotek, K Walentynowicz. Hypoxia-induced sickness behaviour.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2006 Nov; 57 Suppl 8(?):35-50. doi:
NULL. [PMID: 17242471] - Roberto Canete, Angel A Escobedo, Maria E Gonzalez, Pedro Almirall. Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children.
World journal of gastroenterology.
2006 Oct; 12(39):6366-70. doi:
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Thrombosis journal.
2006 Oct; 4(?):19. doi:
10.1186/1477-9560-4-19. [PMID: 17040572] - Dan Zhu, Ming-Yi Jiang, Ming-Pu Tan. [The mechanism of ABA-induced apoplastic H2O2 accumulation in maize leaves].
Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology.
2006 Oct; 32(5):519-26. doi:
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Journal of neurochemistry.
2006 Aug; 98(3):748-59. doi:
10.1111/j.1471-4159.2006.03889.x. [PMID: 16749906] - Yong Huang, Hideaki Okochi, Barnaby C H May, Giuseppe Legname, Stanley B Prusiner, Leslie Z Benet, B Joseph Guglielmo, Emil T Lin. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jul; 34(7):1136-44. doi:
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Journal of toxicology and environmental health. Part A.
2006 Jun; 69(11):1083-95. doi:
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Kidney international.
2006 May; 69(10):1823-32. doi:
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Scandinavian journal of immunology.
2006 Apr; 63(4):299-303. doi:
10.1111/j.1365-3083.2006.01737.x. [PMID: 16623930] - Tze-Wen Chung, Min-Chia Yang, Wei-Jean Tsai. A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs. Influences of the surface properties of liposomes and the crosslinked fibrin network.
International journal of pharmaceutics.
2006 Mar; 311(1-2):122-9. doi:
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The Journal of cell biology.
2006 Mar; 172(7):1057-68. doi:
10.1083/jcb.200508058. [PMID: 16567503] - Warren Thomas, Natasha Coen, Sheila Faherty, Cathal O Flatharta, Brian J Harvey. Estrogen induces phospholipase A2 activation through ERK1/2 to mobilize intracellular calcium in MCF-7 cells.
Steroids.
2006 Mar; 71(3):256-65. doi:
10.1016/j.steroids.2005.10.010. [PMID: 16375935] - Yu-Jen Chen. Phospholipase A(2) activity of beta-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons.
Journal of neurobiology.
2005 Aug; 64(2):213-23. doi:
10.1002/neu.20137. [PMID: 15849737] - Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi, Junichi Arai, Hiroshi Wakiguchi, Kunihiko Yokotani. Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
European journal of pharmacology.
2005 May; 514(2-3):151-8. doi:
10.1016/j.ejphar.2005.03.033. [PMID: 15910801] - Frank Orlik, Bettina Schiffler, Roland Benz. Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis.
Biophysical journal.
2005 Mar; 88(3):1715-24. doi:
10.1529/biophysj.104.050336. [PMID: 15596516] - Kenji Yamada, Kentaro Fuji, Tomoo Shimada, Mikio Nishimura, Ikuko Hara-Nishimura. Endosomal proteases facilitate the fusion of endosomes with vacuoles at the final step of the endocytotic pathway.
The Plant journal : for cell and molecular biology.
2005 Mar; 41(6):888-98. doi:
10.1111/j.1365-313x.2005.02349.x. [PMID: 15743452] - Gabriele Jedlitschky, Konstanze Tirschmann, Lena E Lubenow, Hendrik K Nieuwenhuis, Jan W N Akkerman, Andreas Greinacher, Heyo K Kroemer. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.
Blood.
2004 Dec; 104(12):3603-10. doi:
10.1182/blood-2003-12-4330. [PMID: 15297306] - Lotus Yung, Yong Huang, Pierre Lessard, Giuseppe Legname, Emil T Lin, Michael Baldwin, Stanley B Prusiner, Chongsuk Ryou, B Joseph Guglielmo. Pharmacokinetics of quinacrine in the treatment of prion disease.
BMC infectious diseases.
2004 Nov; 4(?):53. doi:
10.1186/1471-2334-4-53. [PMID: 15569390] - Park Yoon-yub, Brooks Hybertson, Richard Wright, Mehdi Fini, Nancy Elkins, John Repine. Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment.
Experimental lung research.
2004 Oct; 30(7):571-84. doi:
10.1080/01902140490489207. [PMID: 15371093] - Ho Jae Han, Min Jin Lim, Yun Jung Lee. Oxalate inhibits renal proximal tubule cell proliferation via oxidative stress, p38 MAPK/JNK, and cPLA2 signaling pathways.
American journal of physiology. Cell physiology.
2004 Oct; 287(4):C1058-66. doi:
10.1152/ajpcell.00063.2004. [PMID: 15229103] - Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi-Shima, Kunihiko Yokotani. Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.
European journal of pharmacology.
2004 Sep; 499(1-2):99-105. doi:
10.1016/j.ejphar.2004.07.087. [PMID: 15363956] - Su Hyung Park, Yun Jung Lee, Min Jin Lim, Eun Jung Kim, Jang Hern Lee, Ho Jae Han. High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2.
Journal of cellular physiology.
2004 Sep; 200(3):407-16. doi:
10.1002/jcp.20023. [PMID: 15254969] - Parvaiz A Koul. Species identification after treatment for taeniasis.
Lancet (London, England).
2004 Jun; 363(9425):1999; author reply 1999. doi:
10.1016/s0140-6736(04)16420-9. [PMID: 15194265] - Walter Oleschko Arruda, Kelly C Bordignon, Jerônimo B Milano, Ricardo Ramina. [Creutzfeldt-Jakob disease, Heidenhain variant: case report with MRI (DWI) findings].
Arquivos de neuro-psiquiatria.
2004 Jun; 62(2A):347-52. doi:
10.1590/s0004-282x2004000200029. [PMID: 15235744] - Ho Jae Han, Soo Hyun Park, Yun Jung Lee. Signaling cascade of ANG II-induced inhibition of alpha-MG uptake in renal proximal tubule cells.
American journal of physiology. Renal physiology.
2004 Apr; 286(4):F634-42. doi:
10.1152/ajprenal.00217.2003. [PMID: 14644748] - Gian Gaetano Aloisi, Arianna Barbafina, Marcella Canton, Francesco Dall'Acqua, Fausto Elisei, Laura Facciolo, Loredana Latterini, Giampietro Viola. Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions.
Photochemistry and photobiology.
2004 Mar; 79(3):248-58. doi:
10.1562/sa-03-29.1. [PMID: 15115297] - Changbin Chen, Martin B Dickman. Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signalling pathways.
Molecular microbiology.
2004 Mar; 51(5):1493-507. doi:
10.1111/j.1365-2958.2003.03932.x. [PMID: 14982641] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - Larry D Alexander, Suganthi Alagarsamy, Janice G Douglas. Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells.
Kidney international.
2004 Feb; 65(2):551-63. doi:
10.1111/j.1523-1755.2004.00405.x. [PMID: 14717925] - A G Lopes, A C Soares, D P A Santos, M S Fernandes, L R Leão-Ferreira, E Quintana-Gomes, C Caruso-Neves. PLA2/PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin-(1-7)-stimulated Na(+)-ATPase activity of the proximal tubule.
Regulatory peptides.
2004 Jan; 117(1):37-41. doi:
10.1016/j.regpep.2003.10.001. [PMID: 14687699]