Nitracrine (BioDeep_00000181696)
human metabolite blood metabolite
代谢物信息卡片
化学式: C18H20N4O2 (324.1586)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 5.5%
分子结构信息
SMILES: CN(C)CCCNC1=C2C(=NC3=CC=CC=C31)C=CC=C2[N+](=O)[O-]
InChI: InChI=1S/C18H20N4O2/c1-21(2)12-6-11-19-18-13-7-3-4-8-14(13)20-15-9-5-10-16(17(15)18)22(23)24/h3-5,7-10H,6,11-12H2,1-2H3,(H,19,20)
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135384
- PubChem: 20628
- HMDB: HMDB0255631
- ChEMBL: CHEMBL26291
- MeSH: Nitracrine
- chemspider: 19425
- CAS: 6514-85-8
- CAS: 4533-39-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Noelia Negreira, Juliet Kinyua, Nik De Brabanter, Kristof Maudens, Alexander L N van Nuijs. Identification of in vitro and in vivo human metabolites of the new psychoactive substance nitracaine by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
Analytical and bioanalytical chemistry.
2016 Jul; 408(19):5221-9. doi:
10.1007/s00216-016-9616-7
. [PMID: 27185541] - Badithe T Ashok, Kiranmayi Tadi, Venkata P S Garikapaty, Yuangen Chen, Qiang Huang, Debabrata Banerjee, Jerzy Konopa, Raj K Tiwari. Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents.
Anti-cancer drugs.
2007 Jan; 18(1):87-94. doi:
10.1097/01.cad.0000236316.04199.20
. [PMID: 17159506] - B T Ashok, K Tadi, D Banerjee, J Konopa, M Iatropoulos, R K Tiwari. Pre-clinical toxicology and pathology of 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs.
Life sciences.
2006 Aug; 79(14):1334-42. doi:
10.1016/j.lfs.2006.03.043
. [PMID: 16712873] - K O Hicks, F B Pruijn, B C Baguley, W R Wilson. Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells.
The Journal of pharmacology and experimental therapeutics.
2001 Jun; 297(3):1088-98. doi:
NULL
. [PMID: 11356933] - I G Robertson, T J Bland, B D Palmer. Effect of substituents on the metabolism of nitracrine in rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1996 May; 26(5):559-69. doi:
10.3109/00498259609046732
. [PMID: 8736066] - D Antosiewicz. Analysis of the cell cycle in the root meristem of Allium cepa under the influence of ledakrin.
Folia histochemica et cytobiologica.
1990; 28(1-2):79-95. doi:
"
. [PMID: 2097185] - W R Wilson, W A Denny, G M Stewart, A Fenn, J C Probert. Reductive metabolism and hypoxia-selective toxicity of nitracrine.
International journal of radiation oncology, biology, physics.
1986 Jul; 12(7):1235-8. doi:
10.1016/0360-3016(86)90266-x
. [PMID: 3744944] - U Popowicz, A Preisler, J Paluszak. Ledacrine effect on free fatty acids and glycerol mobilization from rat adipose tissue in vivo.
Acta physiologica Polonica.
1981 May; 32(3):277-81. doi:
NULL
. [PMID: 7304198] - B Błaszczyk, J Giełdanowski, J Patkowski, S H Kowalczyk-Bronisz. Pharmacological studies on new oncostatic acridine derivatives. II. Chronic action.
Archivum immunologiae et therapiae experimentalis.
1979; 27(6):765-76. doi:
NULL
. [PMID: 549531] - T Kedryna, M Gumińska. The effect of the cytostatic preparation C283 (Ledacrine) on platelet aggregation in human and rabbit plasma in vitro and in vivo.
Materia medica Polona. Polish journal of medicine and pharmacy.
1977 Oct; 9(4):290-4. doi:
NULL
. [PMID: 599958] - M Warwas, B Narczeuska, W Dobryszycka. Blood serum peptidases in patients with ovarian carcinoma treated with Ledakrin.
Archivum immunologiae et therapiae experimentalis.
1977; 25(2):235-42. doi:
NULL
. [PMID: 17375] - B Bratkowska-Seniów, T Kaniak, A Stumpf, M Wahl-Mugeńska, J Wojnarska. The effect of Ledakrin on renal and hepatic functions.
Materia medica Polona. Polish journal of medicine and pharmacy.
1976 Jul; 8(3):316-22. doi:
NULL
. [PMID: 1011874] - T Jerzykowski, M Szalsza-Kuśnierczyk, G Chalupka, M Chorazy. Excretion and organ distribution of the cytostatic preparation Ledakrin (preparation C-283) in rat.
Acta medica Polona.
1976; 17(3):169-74. doi:
NULL
. [PMID: 998329]