1-Deoxynojirimycin (BioDeep_00000014725)

Main id: BioDeep_00000229773

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, hydrochloride

化学式: C6H13NO4 (163.0844538)
中文名称: (2R,3R,4R,5S)-2-羟甲基哌啶-3,4,5-三醇, 1-脱氧野尻霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(C(N1)CO)O)O)O
InChI: InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2

描述信息

1-Deoxynojirimycin is found in fruits. 1-Deoxynojirimycin is an alkaloid from Morus specie
Alkaloid from Morus subspecies 1-Deoxynojirimycin is found in fruits.
Same as: D09605
1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].
1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

同义名列表

24 个代谢物同义名

2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, hydrochloride; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-imino-D-glucitol, 9ci; 1-Deoxynojirimycin Hydrochloride; 1,5-Dideoxy-1,5-imino-D-mannitol; 1 Deoxynojirimycin Hydrochloride; 1,5-Deoxy-1,5-imino-D-mannitol; 1-deoxynojirimycin (DNJ); 1-Deoxymannojirimycin; 1 Deoxymannojirimycin; 1-Deoxy-Nojirimycin; 1-Deoxynojirimycin; 1 Deoxynojirimycin; deoxynojirimycin; Antibiotic S-GI; Moranoline; Bay N 5595; Moranolin; 1oim; S-GI; 1HXK; NOJ; Duvoglustat



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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118 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Nuraniye Eruygur, Emrah Dural. Determination of 1-Deoxynojirimycin by a developed and validated HPLC-FLD method and assessment of In-vitro antioxidant, α-Amylase and α-Glucosidase inhibitory activity in mulberry varieties from Turkey. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 53(?):234-242. doi: 10.1016/j.phymed.2018.09.016. [PMID: 30668403]
  • C Ferrari, G Testori, A Scanni, S Frezzati, A Bertazzoni, M Romussi. Letter: Reduction of serum alkaline phosphatase and gamma-glutamyl transpeptidase activities by short-term clofibrate. The New England journal of medicine. 1976 Aug; 295(8):449. doi: 10.1056/nejm197608192950817. [PMID: 6912]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]