alpha-Fluoro-beta-ureidopropionic acid (BioDeep_00000011318)

 

Secondary id: BioDeep_00001876925

human metabolite Endogenous blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


2-Fluoro-3-[(C-hydroxycarbonimidoyl)amino]propanoate

化学式: C4H7FN2O3 (150.04406840000001)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.33%

分子结构信息

SMILES: C(C(C(=O)O)F)NC(=O)N
InChI: InChI=1S/C4H7FN2O3/c5-2(3(8)9)1-7-4(6)10/h2H,1H2,(H,8,9)(H3,6,7,10)

描述信息

alpha-Fluoro-beta-ureidopropionic acid is a metabolite of fluorouracil. Fluorouracil (5-FU or f5U) (sold under the brand names Adrucil, Carac, Efudix, Efudex and Fluoroplex) is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin. (Wikipedia)

同义名列表

13 个代谢物同义名

2-Fluoro-3-[(C-hydroxycarbonimidoyl)amino]propanoate; 3-(carbamoylamino)-2-fluoropropanoic acid; alpha-Fluoro-beta-ureidopropionic acid; alpha-Fluoro-beta-ureidopropionate; a-Fluoro-b-ureidopropionic acid; 2-Fluoro-3-ureidopropionic acid; Α-fluoro-β-ureidopropionic acid; Α-fluoro-β-ureidopropionate; a-Fluoro-b-ureidopropionate; 2-Fluoro-3-ureidopropionate; Fluoroureidopropionic acid; FUPA; alpha-Fluoro-beta-ureidopropionic acid



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

1 个相关的代谢反应过程信息。

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WikiPathways(1)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Ottiniel Chavani, Berit Packert Jensen, R Matthew Strother, Christopher M Florkowski, Peter M George. Development, validation and application of a novel liquid chromatography tandem mass spectrometry assay measuring uracil, 5,6-dihydrouracil, 5-fluorouracil, 5,6-dihydro-5-fluorouracil, α-fluoro-β-ureidopropionic acid and α-fluoro-β-alanine in human plasma. Journal of pharmaceutical and biomedical analysis. 2017 Aug; 142(?):125-135. doi: 10.1016/j.jpba.2017.04.055. [PMID: 28501750]
  • Franck Desmoulin, Véronique Gilard, Myriam Malet-Martino, Robert Martino. Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine. Drug metabolism and disposition: the biological fate of chemicals. 2002 Nov; 30(11):1221-9. doi: 10.1124/dmd.30.11.1221. [PMID: 12386128]
  • M C Malet-Martino, J P Armand, A Lopez, J Bernadou, J P Béteille, M Bon, R Martino. Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry. Cancer research. 1986 Apr; 46(4 Pt 2):2105-12. doi: . [PMID: 2936452]
  • J Bernadou, J P Armand, A Lopez, M C Malet-Martino, R Martino. Complete urinary excretion profile of 5-fluorouracil during a six-day chemotherapeutic schedule, as resolved by 19F nuclear magnetic resonance. Clinical chemistry. 1985 Jun; 31(6):846-8. doi: 10.1093/clinchem/31.6.846. [PMID: 3922650]