Ulifloxacin (BioDeep_00000009933)
Secondary id: BioDeep_00001876703
human metabolite blood metabolite
代谢物信息卡片
6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
化学式: C16H16FN3O3S (349.0896358)
中文名称: 6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸
谱图信息:
最多检出来源 Homo sapiens(blood) 51.85%
分子结构信息
SMILES: CC1N2C3=CC(=C(C=C3C(=O)C(=C2S1)C(=O)O)F)N4CCNCC4
InChI: InChI=1S/C16H16FN3O3S/c1-8-20-11-7-12(19-4-2-18-3-5-19)10(17)6-9(11)14(21)13(16(22)23)15(20)24-8/h6-8,18H,2-5H2,1H3,(H,22,23)
描述信息
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
7 个代谢物同义名
6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid; 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate; 6-fluoro-1-Methyl-7-(1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid; 6-fluoro-1-Methyl-4-oxo-7-piperazin-1-yl-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate; UNII:C38638H76Y; Ulifloxacin; NM 394
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:35044
- KEGG: C14492
- PubChem: 124225
- HMDB: HMDB0259395
- Metlin: METLIN70101
- ChEMBL: CHEMBL345937
- chemspider: 110680
- CAS: 112984-60-8
- PMhub: MS000023755
- PubChem: 17395492
- NIKKAJI: J462.718K
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Valeria Tellone, Paola Coppola, Marco Ammendola, Giorgio Di Loreto, Rossella Picollo, Alessandra Del Vecchio, Alessandro Comandini, Fabio Garofolo, Serena Tongiani. New Insights on the Pharmacokinetics of Ulifloxacin After Administration of Prulifloxacin in Patients with Mild, Moderate and Severe Renal Impairment.
Drugs in R&D.
2018 Sep; 18(3):237-245. doi:
10.1007/s40268-018-0245-9. [PMID: 30151791] - Vincenzo Ferrone, Roberto Cotellese, Maura Carlucci, Lorenzo Di Marco, Giuseppe Carlucci. Air assisted dispersive liquid-liquid microextraction with solidification of the floating organic droplets (AA-DLLME-SFO) and UHPLC-PDA method: Application to antibiotics analysis in human plasma of hospital acquired pneumonia patients.
Journal of pharmaceutical and biomedical analysis.
2018 Mar; 151(?):266-273. doi:
10.1016/j.jpba.2017.12.039. [PMID: 29413974] - Vincenzo Ferrone, Maura Carlucci, Paola Palumbo, Giuseppe Carlucci. Development and validation of a MEPS-UHPLC-PDA method for determination of ulifloxacin in human plasma and urine of patients with peripheral arterial disease.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):313-321. doi:
10.1016/j.jpba.2016.06.001. [PMID: 27318081] - Vincenzo Ferrone, Maura Carlucci, Paola Palumbo, Giuseppe Carlucci. Bioanalytical method development for quantification of ulifloxacin, fenbufen and felbinac in rat plasma by solid-phase extraction (SPE) and HPLC with PDA detection.
Journal of pharmaceutical and biomedical analysis.
2016 May; 123(?):205-12. doi:
10.1016/j.jpba.2016.01.062. [PMID: 26898973] - Marcello Locatelli, Roberta Cifelli, Giuseppe Carlucci, Annalisa Romagnoli. Stability study of Prulifloxacin and Ulifloxacin in human plasma by HPLC-DAD.
Journal of enzyme inhibition and medicinal chemistry.
2016; 31(1):106-11. doi:
10.3109/14756366.2015.1004062. [PMID: 25683081] - Utpal Nandi, Bikash Roy, Anjan Kumar Das, Tapan Kumar Pal. Correlation among the toxicity profiling (28-days repeated oral dose toxicity), toxicokinetics and tissue distribution data of ulifloxacin, the active metabolite of prulifloxacin in Wistar albino rats.
Environmental toxicology and pharmacology.
2012 Sep; 34(2):588-607. doi:
10.1016/j.etap.2012.07.001. [PMID: 22885677] - Michele De Benedetto, Desiderio Passali, Giovanni Tomacelli, Alessandro Ruggieri, Maria Teresa Rosignoli, Rossella Picollo, Luisa Bellussi, Paolo Dionisio. Penetration of prulifloxacin into sinus mucosa of patients undergoing paranasal sinus elective endoscopic surgery.
Journal of chemotherapy (Florence, Italy).
2012 Feb; 24(1):26-31. doi:
10.1179/1120009x12z.0000000009. [PMID: 22546721] - Bikash Roy, Hira Choudhury, Ayan Das, Anjan Kumar Das, Tapan Kumar Pal. Development and validation of a liquid chromatography-tandem mass spectrometry method to determine ulifloxacin, the active metabolite of prulifloxacin in rat and rabbit plasma: application to toxicokinetic study.
Biomedical chromatography : BMC.
2011 Aug; 25(8):890-901. doi:
10.1002/bmc.1539. [PMID: 21154639] - Maria Teresa Rosignoli, Giorgio Di Loreto, Paolo Dionisio. Effects of prulifloxacin on cardiac repolarization in healthy subjects: a randomized, crossover, double-blind versus placebo, moxifloxacin-controlled study.
Clinical drug investigation.
2010; 30(1):5-14. doi:
10.2165/11319400-000000000-00000. [PMID: 19995094] - Makoto Aoki, Maki Iguchi, Hiroyuki Hayashi, Shigeki Shibasaki, Tohru Kurosawa, Masahiro Hayashi. Active uptake of ulifloxacin from plasma to lung that controls its concentration in epithelial lining fluid.
Biological & pharmaceutical bulletin.
2009 Jun; 32(6):1095-100. doi:
10.1248/bpb.32.1095. [PMID: 19483322] - Claudio Giberti, Fabrizio Gallo, Maria T Rosignoli, Alessandro Ruggieri, Simona Barattè, Rossella Picollo, Paolo Dionisio. Penetration of orally administered prulifloxacin into human prostate tissue.
Clinical drug investigation.
2009; 29(1):27-34. doi:
10.2165/0044011-200929010-00003. [PMID: 19067472] - Lingli Zhang, Jun Wen, Yaju Pan, Zhen Li, Guorong Fan, Yutian Wu. Determination of ulifloxacin, the active metabolite of prulifloxacin, in human plasma by a 96-well format solid-phase extraction and capillary zone electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 872(1-2):172-6. doi:
10.1016/j.jchromb.2008.07.033. [PMID: 18706872] - Makoto Aoki, Maki Iguchi, Hiroyuki Hayashi, Hisashi Suzuki, Shigeki Shibasaki, Tohru Kurosawa, Masahiro Hayashi. Proposal of membrane transport mechanism of protein-unbound ulifloxacin into epithelial lining fluid determined by improved microdialysis.
Biological & pharmaceutical bulletin.
2008 Sep; 31(9):1773-7. doi:
10.1248/bpb.31.1773. [PMID: 18758075] - Xiaoli Wang, Bo Shen, Huichun Zhao, Linpei Jin. Determination of ulifloxacin by terbium-sensitized fluorescence with second-order scattering and its applications.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2007 Dec; 23(12):1373-6. doi:
10.2116/analsci.23.1373. [PMID: 18071221] - Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I Alvarez, Alfred H Schinkel, Yuichi Sugiyama. Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Oct; 35(10):1873-9. doi:
10.1124/dmd.107.014969. [PMID: 17639028] - Franco Gorlero, Paola Lorenzi, Maria Teresa Rosignoli, Rossella Picollo, Alessandro Ruggieri, Simona Barattè, Paolo Dionisio. Penetration of prulifloxacin into gynaecological tissues after single and repeated oral administrations.
Drugs in R&D.
2007; 8(6):373-81. doi:
10.2165/00126839-200708060-00005. [PMID: 17963428] - Lixia Guo, Meiling Qi, Xin Jin, Peng Wang, Huaiqing Zhao. Determination of the active metabolite of prulifloxacin in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Mar; 832(2):280-5. doi:
10.1016/j.jchromb.2006.01.026. [PMID: 16490405] - Takeshi Mikuniya, Yoshihisa Kato, Reiko Kariyama, Koichi Monden, Muneo Hikida, Hiromi Kumon. Synergistic effect of fosfomycin and fluoroquinolones against Pseudomonas aeruginosa growing in a biofilm.
Acta medica Okayama.
2005 Oct; 59(5):209-16. doi:
10.18926/amo/31977. [PMID: 16286954] - Ercole Concia, Benedetta Allegranzi, Giovanni B Ciottoli, Giovanna Orticelli, Marcello Marchetti, Paolo Dionisio. Penetration of orally administered prulifloxacin into human lung tissue.
Clinical pharmacokinetics.
2005; 44(12):1287-94. doi:
10.2165/00003088-200544120-00007. [PMID: 16372826] - Y Tomii, M Ozaki, M Matsuda, T Honmura, I Nishimura, R Yamaguchi, T Adachi, Y Okawa, T Nishino. Therapeutic effect of the quinolone prodrug prulifloxacin against experimental urinary tract infections in mice.
Arzneimittel-Forschung.
1996 Dec; 46(12):1169-73. doi:
. [PMID: 9006794] - S Ishida, M Iketani, S Yamazaki, K Tamura, Y Shindo, K Iwakura, N Sumi. [A 4-week intravenous toxicity study of the active metabolite (NM394) of prulifloxacin (NM441) in rats followed by a 4-week recovery test].
The Journal of toxicological sciences.
1996 Jun; 21 Suppl 1(?):131-48. doi:
10.2131/jts.21.supplementi_131. [PMID: 8709157] - H Shimazu, Y Ishikawa, Y Nishiguchi, M Yoshida, K Iwakura, N Sumi, Y Shindo. [Single-dose toxicity studies of prulifloxacin (NM441) in mice, rats and dogs and the active metabolite (NM394) in rats].
The Journal of toxicological sciences.
1996 Jun; 21 Suppl 1(?):33-44. doi:
10.2131/jts.21.supplementi_33. [PMID: 8709168] - N Nishimura, K Fukuda, S Yamazaki, K Tamura, Y Shindo, K Iwakura, N Sumi. [A 4-week oral toxicity study of prulifloxacin (NM441) in rats followed by a 4-week recovery test].
The Journal of toxicological sciences.
1996 Jun; 21 Suppl 1(?):45-70. doi:
10.2131/jts.21.supplementi_45. [PMID: 8709169] - S Oda, M Ide, K Tamura, M Nagatani, Y Shindo, K Iwakura, N Sumi. [A 4-week oral toxicity study of prulifloxacin (NM441) in dogs followed by a 4-week recovery test].
The Journal of toxicological sciences.
1996 Jun; 21 Suppl 1(?):71-88. doi:
10.2131/jts.21.supplementi_71. [PMID: 8709170] - C Tateda, K Sakai, S Yamakawa, T Nakasuji, T Nakamura, N Sumi, Y Shindo. [Antigenicity studies of prulifloxacin (NM441)].
The Journal of toxicological sciences.
1996 Jun; 21 Suppl 1(?):231-9. doi:
10.2131/jts.21.supplementi_231. [PMID: 8709164] - A Kawaminami, T Tawaratani, S Ishibashi, T Oka, S Matsuyama, K Kakemi, K Iwakura, N Sumi, Y Shindo. [Renal toxicity of prulifloxacin (NM441) in rats].
The Journal of toxicological sciences.
1996 Jun; 21 Suppl 1(?):267-76. doi:
10.2131/jts.21.supplementi_267. [PMID: 8709167] - M Ozaki, M Matsuda, Y Tomii, K Kimura, J Segawa, M Kitano, M Kise, K Shibata, M Otsuki, T Nishino. In vivo evaluation of NM441, a new thiazeto-quinoline derivative.
Antimicrobial agents and chemotherapy.
1991 Dec; 35(12):2496-9. doi:
10.1128/aac.35.12.2496. [PMID: 1667252] - M Ozaki, M Matsuda, Y Tomii, K Kimura, K Kazuno, M Kitano, M Kise, K Shibata, M Otsuki, T Nishino. In vitro antibacterial activity of a new quinolone, NM394.
Antimicrobial agents and chemotherapy.
1991 Dec; 35(12):2490-5. doi:
10.1128/aac.35.12.2490. [PMID: 1667251]