Diphacinone (BioDeep_00000002761)

 

Secondary id: BioDeep_00001867938

human metabolite blood metabolite


代谢物信息卡片


2-(2,2-diphenylacetyl)-2,3-dihydro-1H-indene-1,3-dione

化学式: C23H16O3 (340.10993859999996)
中文名称: 敌鼠
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)C3C(=O)C4=CC=CC=C4C3=O
InChI: InChI=1S/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AA - Vitamin k antagonists
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent

同义名列表

9 个代谢物同义名

2-(2,2-diphenylacetyl)-2,3-dihydro-1H-indene-1,3-dione; Diphenadione, sodium salt; Diphenylacetylindandione; Diphenadione; Diphacinone; Difenadion; Diphenacin; Diphacine; didion



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Megan C Romano, Kyle A Francis, Jennifer G Janes, Robert H Poppenga, Michael S Filigenzi, Darko Stefanovski, Cynthia L Gaskill. Determining an approximate minimum toxic dosage of diphacinone in horses and corresponding serum, blood, and liver diphacinone concentrations: a pilot study. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2022 May; 34(3):489-495. doi: 10.1177/10406387221086923. [PMID: 35369800]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Hongfang Li, Shuang Liu, Baolei Dong, Chenglong Li, Huijuan Yang, Xiya Zhang, Kai Wen, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Jiancheng Li, Zhanhui Wang. Production of a specific monoclonal antibody and a sensitive immunoassay for the detection of diphacinone in biological samples. Analytical and bioanalytical chemistry. 2019 Oct; 411(25):6755-6765. doi: 10.1007/s00216-019-02051-2. [PMID: 31388716]
  • Xijuan Tan, Zhenghua Song, Donghua Chen, Airu Lv. Ultrasensitive determination of diphacinone by flow injection chemiluminescence: application to quantification in biofluids and photodegradation monitoring in water samples. Journal of AOAC International. 2014 Nov; 97(6):1725-9. doi: 10.5740/jaoacint.12-123. [PMID: 25632450]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Barnett A Rattner, Katherine E Horak, Rebecca S Lazarus, David A Goldade, John J Johnston. Toxicokinetics and coagulopathy threshold of the rodenticide diphacinone in eastern screech-owls (Megascops asio). Environmental toxicology and chemistry. 2014 Jan; 33(1):74-81. doi: 10.1002/etc.2390. [PMID: 24014246]
  • Robert A Middleberg, Joseph Homan. Qualitative identification of rodenticide anticoagulants by LC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2012; 902(?):139-48. doi: 10.1007/978-1-61779-934-1_12. [PMID: 22767114]
  • David G Harrison, Paul J Marvar, Jens M Titze. Vascular inflammatory cells in hypertension. Frontiers in physiology. 2012; 3(?):128. doi: 10.3389/fphys.2012.00128. [PMID: 22586409]
  • Meiqiang Cai, Xiaohong Chen, Micong Jin. An enhancement of europium-/gadolinium- diphacinone -DL-histidine- cetylpyridine bromide system for the determination of diphacinone in serum. Journal of fluorescence. 2011 Jul; 21(4):1349-56. doi: 10.1007/s10895-011-0863-x. [PMID: 21340617]
  • Xiaohong Chen, Meiqiang Cai, Micong Jin. [Study on the enhancement diphacinone-europium fluorescence system and application for determination of the residue in urine]. Wei sheng yan jiu = Journal of hygiene research. 2011 Jul; 40(4):523-6. doi: . [PMID: 21861363]
  • Barnett A Rattner, Katherine E Horak, Sarah E Warner, Daniel D Day, Carol U Meteyer, Steven F Volker, John D Eisemann, John J Johnston. Acute toxicity, histopathology, and coagulopathy in American kestrels (Falco sparverius) following administration of the rodenticide diphacinone. Environmental toxicology and chemistry. 2011 May; 30(5):1213-22. doi: 10.1002/etc.490. [PMID: 21337606]
  • Micong Jin, Xiaohong Chen. [Simultaneous determination of trace diphacinone and chlorophacinone in biological samples by high performance liquid chromatography coupled with ion trap mass spectrometry]. Se pu = Chinese journal of chromatography. 2010 Feb; 28(2):197-203. doi: 10.3724/sp.j.1123.2012.00197. [PMID: 20556961]
  • Mi-cong Jin, Mei-qiang Cai, Xiao-hong Chen. Simultaneous measurement of indandione-type rodenticides in human serum by liquid chromatography-electrospray ionization- tandem mass spectrometry. Journal of analytical toxicology. 2009 Jul; 33(6):294-300. doi: 10.1093/jat/33.6.294. [PMID: 19653932]
  • John J Johnston, William C Pitt, Robert T Sugihara, John D Eisemann, Thomas M Primus, Melvin J Holmes, Joe Crocker, Andy Hart. Probabilistic risk assessment for snails, slugs, and endangered honeycreepers in diphacinone rodenticide baited areas on Hawaii, USA. Environmental toxicology and chemistry. 2005 Jun; 24(6):1557-67. doi: 10.1897/04-255r.1. [PMID: 16117137]
  • Barbara E Watt, Alex T Proudfoot, Sally M Bradberry, J Allister Vale. Anticoagulant rodenticides. Toxicological reviews. 2005; 24(4):259-69. doi: 10.2165/00139709-200524040-00005. [PMID: 16499407]
  • Henry A Spiller, G Leroy Gallenstein, Michael J Murphy. Dermal absorption of a liquid diphacinone rodenticide causing coagulaopathy. Veterinary and human toxicology. 2003 Dec; 45(6):313-4. doi: . [PMID: 14640483]
  • S Y Yang, G M Pan, G F Meng, D M Zhang. [Study of diphacinone in biological samples by high performance liquid chromatography/diode array detector]. Se pu = Chinese journal of chromatography. 2001 May; 19(3):245-7. doi: . [PMID: 12541808]
  • M E Mount, P H Kass. Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide. American journal of veterinary research. 1989 Oct; 50(10):1704-9. doi: . [PMID: 2802299]
  • C C Yu, Y H Atallah, D M Whitacre. Metabolism and disposition of diphacinone in rats and mice. Drug metabolism and disposition: the biological fate of chemicals. 1982 Nov; 10(6):645-8. doi: . [PMID: 6130915]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]