Isoquercitroside (BioDeep_00000894603)
Main id: BioDeep_00000000179
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
3-{[5-(1,2-dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]oxy}-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
化学式: C21H20O12 (464.09547200000003)
中文名称: 异槲皮苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(O4)C(CO)O)O)O)O)O
InChI: InChI=1S/C21H20O12/c22-6-12(27)19-16(29)17(30)21(32-19)33-20-15(28)14-11(26)4-8(23)5-13(14)31-18(20)7-1-2-9(24)10(25)3-7/h1-5,12,16-17,19,21-27,29-30H,6H2
描述信息
Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor.
Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor.
同义名列表
5 个代谢物同义名
3-{[5-(1,2-dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]oxy}-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; 3-{[5-(1,2-dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]oxy}-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one; 3-[5-(1,2-Dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one; isoquercitroside; Isoquercitrin
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 13179952
- HMDB: HMDB0253683
- chemspider: 10752062
- CAS: 21637-25-2
- medchemexpress: HY-N0768
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qi-Yang Wang, Hao-Yu Wang, Wei-Guo Zhang, Jian-Zhong Xu. Economical one-pot synthesis of isoquercetin and D-allulose from quercetin and sucrose using whole-cell biocatalyst.
Enzyme and microbial technology.
2024 May; 176(?):110412. doi:
10.1016/j.enzmictec.2024.110412. [PMID: 38402828] - Tengfei Niu, Chaokang Huang, Rufeng Wang, Li Yang, Shujuan Zhao, Zhengtao Wang. Combinatorial metabolic engineering of Bacillus subtilis enables the efficient biosynthesis of isoquercitrin from quercetin.
Microbial cell factories.
2024 Apr; 23(1):114. doi:
10.1186/s12934-024-02390-5. [PMID: 38641799] - Hong-Liu Jin, Xiao-Ying Feng, Sen-Ling Feng, Ling Dai, Wen-Ting Zhu, Zhong-Wen Yuan. Isoquercitrin attenuates the progression of non-alcoholic steatohepatitis in mice by modulating galectin-3-mediated insulin resistance and lipid metabolism.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155188. doi:
10.1016/j.phymed.2023.155188. [PMID: 38056146] - Meijuan Yi, Opeyemi B Fasina, Yajing Li, Lan Xiang, Jianhua Qi. Mixture of Peanut Skin Extract, Geniposide, and Isoquercitrin Improves the Hepatic Lipid Accumulation of Mice via Modification of Gut Microbiota Homeostasis and the TLR4 and AMPK Signaling Pathways.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316684. [PMID: 38069009] - Xinggu Luo, Yongqian Gong, Qingshan Jiang, Qin Wang, Songtao Li, Lijun Liu. Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway.
Journal of biochemical and molecular toxicology.
2023 Sep; ?(?):e23542. doi:
10.1002/jbt.23542. [PMID: 37712196] - Muxin Zheng, Shenghao Chen, Yi Liu, Yang He. α-Glucosidase inhibitory activities of constituents from Psidium guajava leaves.
Natural product research.
2023 Jul; ?(?):1-4. doi:
10.1080/14786419.2023.2238113. [PMID: 37506309] - Ye-Jin Moon, Hee-Seong Kim, Min-Ji Kim, Hyeon-Yeong Im, Yun-Hee Lee. Synergistic Effects of Heat-Treated Green Tea Extract and Enzymatically-Modified Isoquercitrin in Preventing Obesity.
Nutrients.
2023 Jun; 15(13):. doi:
10.3390/nu15132931. [PMID: 37447257] - Mohamad Fawzi Mahomoodally, Gokhan Zengin, Seebaluck-Sandoram Roumita, Giovanni Caprioli, Ahmed M Mustafa, Diletta Piatti, Evren Yıldıztugay, Gunes Ak, Ayşe Esra Karadağ, Asaad Khalid, Ashraf N Abdalla, Abdullahi Ibrahim Uba, Fatih Demirci. Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches.
Chemistry & biodiversity.
2023 Mar; ?(?):e202201181. doi:
10.1002/cbdv.202201181. [PMID: 36891864] - Sou Hyun Kim, Chawon Yun, Doyoung Kwon, Yun-Hee Lee, Jae-Hwan Kwak, Young-Suk Jung. Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells.
Molecules (Basel, Switzerland).
2023 Feb; 28(3):. doi:
10.3390/molecules28031476. [PMID: 36771140] - Jiang Liu, LiJun Ren, HaoWen Wang, Zuowei Li. Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells.
Biochemical genetics.
2022 Dec; ?(?):. doi:
10.1007/s10528-022-10309-1. [PMID: 36480095] - Majid Manzoor, Makoto Muroi, Naoko Ogawa, Hiroki Kobayashi, Haruna Nishimura, Danni Chen, Opeyemi B Fasina, Jianyu Wang, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi. Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo.
Food & function.
2022 Oct; 13(21):10923-10936. doi:
10.1039/d2fo02438a. [PMID: 36205648] - Xue Li, Dongyue Zhou, Di Yang, Yunhua Fu, Xingyu Tao, Xuan Hu, Yulin Dai, Hao Yue. Isoquercitrin Attenuates Osteogenic Injury in MC3T3 Osteoblastic Cells and the Zebrafish Model via the Keap1-Nrf2-ARE Pathway.
Molecules (Basel, Switzerland).
2022 May; 27(11):. doi:
10.3390/molecules27113459. [PMID: 35684398] - Fatma Kübra Ata, Fahriye Ercan, Serap Yalcin Azarkan. In vivo, in vitro and Molecular Modelling Analysis of Isoquercetin, Roseoside, Coreximine, Anonaine, and Arianacin Molecules.
Current computer-aided drug design.
2022; 18(3):168-184. doi:
10.2174/1573409918666220509213313. [PMID: 35538817] - Shi-Chang Cai, Chuan-An Yi, Xiang-Shang Hu, Gen-Yun Tang, Li-Ming Yi, Xiu-Ping Li. Isoquercitrin Upregulates Aldolase C Through Nrf2 to Ameliorate OGD/R-Induced Damage in SH-SY5Y Cells.
Neurotoxicity research.
2021 Dec; 39(6):1959-1969. doi:
10.1007/s12640-021-00430-1. [PMID: 34773594] - John Paul Sese Tosoc, Olga Macas Nuñeza, Thangirala Sudha, Noureldien H E Darwish, Shaker A Mousa. Anticancer Effects of the Corchorus olitorius Aqueous Extract and Its Bioactive Compounds on Human Cancer Cell Lines.
Molecules (Basel, Switzerland).
2021 Oct; 26(19):. doi:
10.3390/molecules26196033. [PMID: 34641577] - Arti Nile, Shivraj Hariram Nile, Juhyun Shin, Gyunseok Park, Jae-Wook Oh. Quercetin-3-Glucoside Extracted from Apple Pomace Induces Cell Cycle Arrest and Apoptosis by Increasing Intracellular ROS Levels.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910749. [PMID: 34639090] - Małgorzata Kikowska, Barbara Thiem, Karolina Jafernik, Marta Klimek-Szczykutowicz, Elżbieta Studzińska-Sroka, Halina Ekiert, Agnieszka Szopa. Effect of Elicitation with (+)-Usnic Acid on Accumulation of Phenolic Acids and Flavonoids in Agitated Microshoots of Eryngium alpinum L.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185532. [PMID: 34577004] - Chan-Su Rha, Cheon-Seok Park, Dae-Ok Kim. Optimized enzymatic synthesis of digestive resistant anomalous isoquercitrin glucosides using amylosucrase and response surface methodology.
Applied microbiology and biotechnology.
2021 Sep; 105(18):6931-6941. doi:
10.1007/s00253-021-11532-3. [PMID: 34477942] - Gabriela Belen Martínez-Hernández, Enrique Jiménez-Ferrer, Rubén Román-Ramos, Alejandro Zamilpa, Manasés González-Cortazar, Ismael León-Rivera, Gabriela Vargas-Villa, Maribel Herrera-Ruiz. A mixture of quercetin 4'-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice.
Journal of ethnopharmacology.
2021 Mar; 267(?):113619. doi:
10.1016/j.jep.2020.113619. [PMID: 33248185] - Lei Peng, Ming Zhao, Huan Li. Method Development and Validation for Simultaneous Determination of Six Flavonoids in Rat Eyes after Oral Administration of Diospyros kaki Leaves Extract by UPLC-MS/MS.
Chemical & pharmaceutical bulletin.
2021 Feb; 69(2):218-221. doi:
10.1248/cpb.c20-00562. [PMID: 33268666] - Liyan Shui, Weina Wang, Mingjie Xie, Bingjue Ye, Xian Li, Yanning Liu, Min Zheng. Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway.
Aging.
2020 11; 12(23):24318-24332. doi:
10.18632/aging.202237. [PMID: 33260158] - Jing Chen, L Lee Hamm, Joshua D Bundy, Damodar R Kumbala, Shirisha Bodana, Sehgal Chandra, Chung-Shiuan Chen, Charlton C Starcke, Yajun Guo, Caroline M Schaefer, Eva Lustigova, Erin Mahone, Aarti M Vadalia, Terra Livingston, Katherine Obst, Jesus Hernandez, Syed Rizwan Bokhari, Myra Kleinpeter, Arnold B Alper, Ivo Lukitsch, Hua He, David C Nieman, Jiang He. Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD: A Randomized Phase 2 Pilot Trial.
Clinical journal of the American Society of Nephrology : CJASN.
2020 11; 15(11):1566-1575. doi:
10.2215/cjn.02020220. [PMID: 33023894] - Fabiana Maia Santos, Camila Adão Malafaia, Daniel Luiz Reis Simas, Aline Barreto Paulino, Michelle F Muzitano, Naomi K Simas, Elaine A Cruz Da-Rocha, Ana Claudia F Amaral, Ivana C R Leal. Phenolic compounds from Tocoyena bullata mart (Rubiaceae) with inhibitory activity in mast cells degranulation.
Natural product research.
2020 Nov; 34(22):3295-3298. doi:
10.1080/14786419.2018.1560281. [PMID: 30663374] - Mariem Haj Romdhane, Hassiba Chahdoura, Lillian Barros, Maria Inês Dias, Rúbia Carvalho Gomes Corrêa, Patricia Morales, Maria Flamini Hatem Ciudad-Mulero, Guido C F R Flamini, Hatem Majdoub, Isabel C F R Ferreira. Chemical Composition, Nutritional Value, and Biological Evaluation of Tunisian Okra Pods (Abelmoschus esculentus L. Moench).
Molecules (Basel, Switzerland).
2020 Oct; 25(20):. doi:
10.3390/molecules25204739. [PMID: 33076530] - Diana Rey, Thaís Alves Fernandes, Paola Miranda Sulis, Renata Gonçalves, Michelle Sepúlveda R, Marisa Jádna Silva Frederico, Marcela Aragon, Luís Fernando Ospina, Geison M Costa, Fátima Regina Mena Barreto Silva. Cellular target of isoquercetin from Passiflora ligularis Juss for glucose uptake in rat soleus muscle.
Chemico-biological interactions.
2020 Oct; 330(?):109198. doi:
10.1016/j.cbi.2020.109198. [PMID: 32692981] - Minsu Kim, Seowoo Im, Yoon Keun Cho, Cheoljun Choi, Yeonho Son, Doyoung Kwon, Young-Suk Jung, Yun-Hee Lee. Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin.
Biomolecules.
2020 09; 10(10):. doi:
10.3390/biom10101394. [PMID: 33008006] - Tlou Grace Manyelo, Nthabiseng Amenda Sebola, Zahra Mohammed Hassan, Monnye Mabelebele. Characterization of the Phenolic Compounds in Different Plant Parts of Amaranthus cruentus Grown under Cultivated Conditions.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184273. [PMID: 32961894] - Lei Chen, Peimin Feng, Anjiao Peng, Xiangmiao Qiu, Wanling Lai, Lin Zhang, Wanling Li. Protective effects of isoquercitrin on streptozotocin-induced neurotoxicity.
Journal of cellular and molecular medicine.
2020 09; 24(18):10458-10467. doi:
10.1111/jcmm.15658. [PMID: 32738031] - Sakina Bouderias, Péter Teszlák, Gábor Jakab, László Kőrösi. Age- and season-dependent pattern of flavonol glycosides in Cabernet Sauvignon grapevine leaves.
Scientific reports.
2020 08; 10(1):14241. doi:
10.1038/s41598-020-70706-7. [PMID: 32859977] - Cezara Zagrean-Tuza, Augustin C Mot, Tomasz Chmiel, Attila Bende, Ioan Turcu. Sugar matters: sugar moieties as reactivity-tuning factors in quercetin O-glycosides.
Food & function.
2020 Jun; 11(6):5293-5307. doi:
10.1039/d0fo00319k. [PMID: 32458896] - Jânio Sousa Santos, Graziela Bragueto Escher, Mariana Vieira do Carmo, Luciana Azevedo, Mariza Boscacci Marques, Heitor Daguer, Luciano Molognoni, Maria Inés Genovese, Mingchun Wen, Liang Zhang, Won Young Oh, Fereidoon Shahidi, Daniel Granato. A new analytical concept based on chemistry and toxicology for herbal extracts analysis: From phenolic composition to bioactivity.
Food research international (Ottawa, Ont.).
2020 06; 132(?):109090. doi:
10.1016/j.foodres.2020.109090. [PMID: 32331681] - Chae Hyun Kim, Jung-Eun Kim, Yoon-Jae Song. Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses.
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102379. [PMID: 32443914] - Ji Hyun Kim, Sanghyun Lee, Eun Ju Cho. The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model.
Nutrients.
2020 May; 12(5):. doi:
10.3390/nu12051353. [PMID: 32397362] - Wei Zhang, Zhi-Tian Fu, Yao Xie, Zhi-Wen Duan, Yu Wang, Rong-Hua Fan. High resolution UPLC-MS/MS method for simultaneous separation and determination of six flavonoids from semen cuscutae extract in rat plasma: application to comparative pharmacokinetic studies in normal and kidney-deficient rats.
Natural product research.
2020 May; 34(10):1446-1451. doi:
10.1080/14786419.2018.1511556. [PMID: 30375249] - Claudio Frezza, Daniela De Vita, Giulia Spinaci, Marco Sarandrea, Alessandro Venditti, Armandodoriano Bianco. Secondary metabolites of Tilia tomentosa Moench inflorescences collected in Central Italy: chemotaxonomy relevance and phytochemical rationale of traditional use.
Natural product research.
2020 Apr; 34(8):1167-1174. doi:
10.1080/14786419.2018.1550487. [PMID: 30638062] - Ding-Tao Wu, Xi-Rui Nie, Dan-Dan Shen, Hong-Yi Li, Li Zhao, Qing Zhang, De-Rong Lin, Wen Qin. Phenolic Compounds, Antioxidant Activities, and Inhibitory Effects on Digestive Enzymes of Different Cultivars of Okra (Abelmoschus esculentus).
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061276. [PMID: 32168896] - Fatma Tuğçe Gürağaç Dereli, Mert Ilhan, Esra Küpeli Akkol. Identification of the main active antidepressant constituents in a traditional Turkish medicinal plant, Centaurea kurdica Reichardt.
Journal of ethnopharmacology.
2020 Mar; 249(?):112373. doi:
10.1016/j.jep.2019.112373. [PMID: 31689479] - Luana Izzo, Luigi Castaldo, Alfonso Narváez, Giulia Graziani, Anna Gaspari, Yelko Rodríguez-Carrasco, Alberto Ritieni. Analysis of Phenolic Compounds in Commercial Cannabis sativa L. Inflorescences Using UHPLC-Q-Orbitrap HRMS.
Molecules (Basel, Switzerland).
2020 Jan; 25(3):. doi:
10.3390/molecules25030631. [PMID: 32024009] - Muthukumaran Jayachandran, Tongze Zhang, Ziyuan Wu, Yinhua Liu, Baojun Xu. Isoquercetin regulates SREBP-1C via AMPK pathway in skeletal muscle to exert antihyperlipidemic and anti-inflammatory effects in STZ induced diabetic rats.
Molecular biology reports.
2020 Jan; 47(1):593-602. doi:
10.1007/s11033-019-05166-y. [PMID: 31677037] - Shivraj Hariram Nile, Doo Hwan Kim, Arti Nile, Gyun Seok Park, Enkhtaivan Gansukh, Guoyin Kai. Probing the effect of quercetin 3-glucoside from Dianthus superbus L against influenza virus infection- In vitro and in silico biochemical and toxicological screening.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Jan; 135(?):110985. doi:
10.1016/j.fct.2019.110985. [PMID: 31765700] - Weijie You, Wei Zheng, Sandra Weiss, Katrin F Chua, Clemens Steegborn. Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Scientific reports.
2019 12; 9(1):19176. doi:
10.1038/s41598-019-55654-1. [PMID: 31844103] - Ahmed Abdelmoniem Mousa, Hala Ali Ibrahim El-Gansh, Mabrouk Attia Abd Eldaim, Mostafa Abd El-Gaber Mohamed, Azza Hassan Morsi, Hesham Saad El Sabagh. Protective effect of Moringa oleifera leaves ethanolic extract against thioacetamide-induced hepatotoxicity in rats via modulation of cellular antioxidant, apoptotic and inflammatory markers.
Environmental science and pollution research international.
2019 Nov; 26(31):32488-32504. doi:
10.1007/s11356-019-06368-4. [PMID: 31617137] - Ji Hyun Kim, Sanghyun Lee, Eun Ju Cho. Acer okamotoanum and isoquercitrin improve cognitive function via attenuation of oxidative stress in high fat diet- and amyloid beta-induced mice.
Food & function.
2019 Oct; 10(10):6803-6814. doi:
10.1039/c9fo01694e. [PMID: 31577306] - Katarzyna Szewczyk, Serhat Sezai Cicek, Christian Zidorn, Sebastian Granica. Phenolic constituents of the aerial parts of Impatiens glandulifera Royle (Balsaminaceae) and their antioxidant activities.
Natural product research.
2019 Oct; 33(19):2851-2855. doi:
10.1080/14786419.2018.1499644. [PMID: 30175924] - Fan Yang, Yingxue Qi, Wei Liu, Jia Li, Daijie Wang, Lei Fang, Yongqing Zhang. Separation of Five Flavonoids from Aerial Parts of Salvia Miltiorrhiza Bunge Using HSCCC and Their Antioxidant Activities.
Molecules (Basel, Switzerland).
2019 Sep; 24(19):. doi:
10.3390/molecules24193448. [PMID: 31547535] - Gokhan Zengin, Mehmet Yavuz Paksoy, Muhammad Zakariyyah Aumeeruddy, Jasmina Glamocilja, Marina Sokovic, Alina Diuzheva, József Jekő, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Mohamad Fawzi Mahomoodally. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species.
Food research international (Ottawa, Ont.).
2019 09; 123(?):414-424. doi:
10.1016/j.foodres.2019.05.013. [PMID: 31284993] - Tizian Klingel, Martina Hadamjetz, Anja Fischer, Daniel Wefers. Glucosylation of flavonoids and flavonoid glycosides by mutant dextransucrase from Lactobacillus reuteri TMW 1.106.
Carbohydrate research.
2019 Sep; 483(?):107741. doi:
10.1016/j.carres.2019.107741. [PMID: 31325545] - Yumi Kitahiro, Hiroshi Ikeda, Hyoung-Tak Im, Eiichi Kodaira, Makio Shibano. Phytochemical characterization of Rosa multiflora Thunb. (Rosaceae) in Japan and South Korea, with a focus on the bioactive flavonol glycoside 'multiflorin A'.
Journal of natural medicines.
2019 Jun; 73(3):555-565. doi:
10.1007/s11418-019-01302-x. [PMID: 30949951] - Fang Dong, Jianhui Hu, Yuanzhi Shi, Meiya Liu, Qunfeng Zhang, Jianyun Ruan. Effects of nitrogen supply on flavonol glycoside biosynthesis and accumulation in tea leaves (Camellia sinensis).
Plant physiology and biochemistry : PPB.
2019 May; 138(?):48-57. doi:
10.1016/j.plaphy.2019.02.017. [PMID: 30849677] - Muthukumaran Jayachandran, Ziyuan Wu, Kumar Ganesan, Sumbul Khalid, S M Chung, Baojun Xu. Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats.
Chemico-biological interactions.
2019 Apr; 303(?):62-69. doi:
10.1016/j.cbi.2019.02.017. [PMID: 30817903] - Magdy Kazzem, Yu-Ting Sun, Mitchell Low, Sai Wang Seto, Dennis Chang, Samiuela Lee, Harsha Suresh, Cheang S Khoo, Alan Bensoussan, Hosen Kiat. Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves.
Molecules (Basel, Switzerland).
2019 Mar; 24(6):. doi:
10.3390/molecules24061101. [PMID: 30897753] - Zhimin Hu, Junbin He, Kuan Chen, Zilong Wang, Jiyang Liu, Xue Qiao, Min Ye. Molecular cloning and biochemical characterization of a new flavonoid glycosyltransferase from the aquatic plant lotus.
Biochemical and biophysical research communications.
2019 03; 510(2):315-321. doi:
10.1016/j.bbrc.2019.01.099. [PMID: 30709586] - Kyung-Chul Shin, Min-Ju Seo, Deok-Kun Oh, Mi-Na Choi, Dae-Wook Kim, Yeong-Su Kim, Chang-Su Park. Cloning and characterization of α-L-rhamnosidase from Chloroflexus aurantiacus and its application in the production of isoquercitrin from rutin.
Biotechnology letters.
2019 Mar; 41(3):419-426. doi:
10.1007/s10529-019-02648-8. [PMID: 30666483] - Guohong Qin, Ji Ma, Qiongshan Huang, Hongli Yin, Jichun Han, Maoru Li, Yang Deng, Bing Wang, Waseem Hassan, Jing Shang. Isoquercetin Improves Hepatic Lipid Accumulation by Activating AMPK Pathway and Suppressing TGF-β Signaling on an HFD-Induced Nonalcoholic Fatty Liver Disease Rat Model.
International journal of molecular sciences.
2018 Dec; 19(12):. doi:
10.3390/ijms19124126. [PMID: 30572631] - Serena Di Francesco, Monica Savio, Nora Bloise, Giovanni Borroni, Lucia Anna Stivala, Riccardo G Borroni. Red grape (Vitis vinifera L.) flavonoids down-regulate collagen type III expression after UV-A in primary human dermal blood endothelial cells.
Experimental dermatology.
2018 09; 27(9):973-980. doi:
10.1111/exd.13682. [PMID: 29742305] - Wei Zhou, Jinjun Shan, Minxin Meng. A two-step ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry with mass defect filtering method for rapid identification of analogues from known components of different chemical structure types in Fructus Gardeniae-Fructus Forsythiae herb pair extract and in rat's blood.
Journal of chromatography. A.
2018 Aug; 1563(?):99-123. doi:
10.1016/j.chroma.2018.05.067. [PMID: 29861306] - Graziela Bragueto Escher, Jânio Sousa Santos, Neiva Deliberali Rosso, Mariza Boscacci Marques, Luciana Azevedo, Mariana Araújo Vieira do Carmo, Heitor Daguer, Luciano Molognoni, Leonardo do Prado-Silva, Anderson S Sant'Ana, Marcia Cristina da Silva, Daniel Granato. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Aug; 118(?):439-453. doi:
10.1016/j.fct.2018.05.046. [PMID: 29787846] - Xiaoyu Zhang, Xueran Mei, Zhanguo Wang, Jing Wu, Gang Liu, Huiling Hu, Qijuan Li. Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Docynia dcne Leaves by High-Performance Liquid Chromatography Coupled with Chemometrics Analysis.
Journal of chromatographic science.
2018 Aug; 56(7):575-581. doi:
10.1093/chromsci/bmy007. [PMID: 29800095] - Da-Wool Jeong, Chi Heung Cho, Jong Suk Lee, Seung Hwan Lee, Taewan Kim, Dae-Ok Kim. Deastringent Peel Extracts of Persimmon (Diospyros kaki Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 and SH-SY5Y Cells against Oxidative Stress.
Journal of microbiology and biotechnology.
2018 Jul; 28(7):1094-1104. doi:
10.4014/jmb.1801.01013. [PMID: 29975999] - Mingya Ding, Zhen Li, Xie-An Yu, Dong Zhang, Jin Li, Hui Wang, Jun He, Xiu-Mei Gao, Yan-Xu Chang. A network pharmacology-integrated metabolomics strategy for clarifying the difference between effective compounds of raw and processed Farfarae flos by ultra high-performance liquid chromatography-quadrupole-time of flight mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2018 Jul; 156(?):349-357. doi:
10.1016/j.jpba.2018.05.003. [PMID: 29753281] - Si Tan, Jose A Caparros-Martin, Vance B Matthews, Henrietta Koch, Fergal O'Gara, Kevin D Croft, Natalie C Ward. Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet.
Scientific reports.
2018 07; 8(1):10100. doi:
10.1038/s41598-018-28521-8. [PMID: 29973701] - Pham Thi Nhat Trinh, Nguyen Huu An, Pham Ngoc An, Mai Dinh Tri, Cao Van Du, Phan Nhat Minh, Nguyen Thi Le Thuy, Nguyen Trong Tuan, Vang Thi Kim Thoa, Nguyen Ngoc Tuan, Le Tien Dung. A new benzofuran derivative from the leaves of Ficus pumila L.
Natural product research.
2018 Jul; 32(14):1648-1652. doi:
10.1080/14786419.2017.1395427. [PMID: 29072969] - Carmen Steinborn, Olivier Potterat, Ulrich Meyer, Rainer Trittler, Sven Stadlbauer, Roman Huber, Carsten Gründemann. In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica.
Planta medica.
2018 May; 84(8):519-526. doi:
10.1055/s-0043-123075. [PMID: 29202511] - Toshiyuki Nakamura, Chinatsu Kinjo, Yoshimasa Nakamura, Yoji Kato, Miyu Nishikawa, Masahiro Hamada, Noriyuki Nakajima, Shinichi Ikushiro, Kaeko Murota. Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats.
Archives of biochemistry and biophysics.
2018 05; 645(?):126-136. doi:
10.1016/j.abb.2018.03.024. [PMID: 29574052] - Majambu Mbikay, Janice Mayne, Francine Sirois, Olesya Fedoryak, Angela Raymond, Jennifer Noad, Michel Chrétien. Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas.
Molecular nutrition & food research.
2018 05; 62(9):e1700729. doi:
10.1002/mnfr.201700729. [PMID: 29396908] - Antonietta Cerulli, Milena Masullo, Angela Mari, Anna Balato, Rosanna Filosa, Serena Lembo, Assunta Napolitano, Sonia Piacente. Phenolics from Castanea sativa leaves and their effects on UVB-induced damage.
Natural product research.
2018 May; 32(10):1170-1175. doi:
10.1080/14786419.2017.1331225. [PMID: 28539059] - Arnaud Gaudry, Sandra Bos, Wildriss Viranaicken, Marjolaine Roche, Pascale Krejbich-Trotot, Gilles Gadea, Philippe Desprès, Chaker El-Kalamouni. The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells.
International journal of molecular sciences.
2018 Apr; 19(4):. doi:
10.3390/ijms19041093. [PMID: 29621184] - A Garbetta, L Nicassio, I D'Antuono, A Cardinali, V Linsalata, G Attolico, F Minervini. Influence of in vitro digestion process on polyphenolic profile of skin grape (cv. Italia) and on antioxidant activity in basal or stressed conditions of human intestinal cell line (HT-29).
Food research international (Ottawa, Ont.).
2018 04; 106(?):878-884. doi:
10.1016/j.foodres.2018.01.072. [PMID: 29579999] - Fangbo Xia, Chenchen Li, Ning Zhao, He Li, Qi Chang, Xinmin Liu, Yonghong Liao, Ruile Pan. Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030550. [PMID: 29498632] - JiEun Yun, Eun-Rhan Woo, Dong Gun Lee. Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli.
Biochimica et biophysica acta. Biomembranes.
2018 Feb; 1860(2):357-363. doi:
10.1016/j.bbamem.2017.11.008. [PMID: 29155212] - Yang Liu, Shengzuo Fang, Wanxia Yang, Xulan Shang, Xiangxiang Fu. Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus.
Journal of photochemistry and photobiology. B, Biology.
2018 Feb; 179(?):66-73. doi:
10.1016/j.jphotobiol.2018.01.002. [PMID: 29334625] - Rana Adhikary, Sahin Sultana, Biswadev Bishayi. Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases.
Journal of ethnopharmacology.
2018 Jan; 210(?):209-222. doi:
10.1016/j.jep.2017.08.017. [PMID: 28826781] - Ilyas Yildiz, Ozkan Sen, Ramazan Erenler, Ibrahim Demirtas, Lutfi Behcet. Bioactivity-guided isolation of flavonoids from Cynanchum acutum L. subsp. sibiricum (willd.) Rech. f. and investigation of their antiproliferative activity.
Natural product research.
2017 Nov; 31(22):2629-2633. doi:
10.1080/14786419.2017.1289201. [PMID: 28278670] - Chang Won Lee, Jeong Yeon Seo, Jisun Lee, Ji Won Choi, Sarang Cho, Jae Youn Bae, Jae Kyung Sohng, Sung Oog Kim, Jihoon Kim, Yong Il Park. 3-O-Glucosylation of quercetin enhances inhibitory effects on the adipocyte differentiation and lipogenesis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Nov; 95(?):589-598. doi:
10.1016/j.biopha.2017.08.002. [PMID: 28869898] - Ping Wu, Siyuan Liu, Jianyu Su, Jianping Chen, Lin Li, Runguang Zhang, Tianfeng Chen. Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway.
Food & function.
2017 Oct; 8(10):3707-3722. doi:
10.1039/c7fo00778g. [PMID: 28948276] - Yifei Wang, Jennifer Johnson-Cicalese, Ajay P Singh, Nicholi Vorsa. Characterization and quantification of flavonoids and organic acids over fruit development in American cranberry (Vaccinium macrocarpon) cultivars using HPLC and APCI-MS/MS.
Plant science : an international journal of experimental plant biology.
2017 Sep; 262(?):91-102. doi:
10.1016/j.plantsci.2017.06.004. [PMID: 28716425] - Pham Thi Nhat Trinh, Ngoc Quoc Luan, Mai Dinh Tri, Vu Duy Khanh, Nguyen Huu An, Phan Nhat Minh, Pham Ngoc An, Nguyen Thi Le Thuy, Nguyen Kim Phi Phung, Le Tien Dung. New naphthalene derivative from the leaves of Cassia grandis L.
Natural product research.
2017 Aug; 31(15):1733-1738. doi:
10.1080/14786419.2017.1290615. [PMID: 28278658] - Sonal Desai, Pratima Tatke, Satish Gabhe. Enhanced HPLC-DAD Method for Fast Determination of Quercetin-3-O-β-d-Glucoside in Extracts and Polyherbal Formulations Containing Azadirachta indica-Optimization and Validation.
Journal of chromatographic science.
2017 Aug; 55(7):706-711. doi:
10.1093/chromsci/bmx024. [PMID: 28334842] - Xiaofeng Yu, Yiling Zhu, Jingyi Fan, Dujun Wang, Xiaohui Gong, Zhen Ouyang. Accumulation of Flavonoid Glycosides and UFGT Gene Expression in Mulberry Leaves (Morus alba L.) before and after Frost.
Chemistry & biodiversity.
2017 Aug; 14(8):. doi:
10.1002/cbdv.201600496. [PMID: 28281324] - Sathishkumar Arumugam, Kapil Bandil, Peter Proksch, Kalaiselvam Murugiyan, Mausumi Bharadwaj. Effects of A.marina-Derived Isoquercitrin on TNF-Related Apoptosis-Inducing Ligand Receptor (TRAIL-R) Expression and Apoptosis Induction in Cervical Cancer Cells.
Applied biochemistry and biotechnology.
2017 Jun; 182(2):697-707. doi:
10.1007/s12010-016-2355-6. [PMID: 28013431] - Eva Heřmánková-Vavříková, Alena Křenková, Lucie Petrásková, Christopher Steven Chambers, Jakub Zápal, Marek Kuzma, Kateřina Valentová, Vladimír Křen. Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues.
International journal of molecular sciences.
2017 May; 18(5):. doi:
10.3390/ijms18051074. [PMID: 28513572] - Lei Wen, Yunliang Lin, Ruimin Lv, Huijiao Yan, Jinqian Yu, Hengqiang Zhao, Xiao Wang, Daijie Wang. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC.
Molecules (Basel, Switzerland).
2017 May; 22(5):. doi:
10.3390/molecules22050767. [PMID: 28486427] - Sam Dawbaa, Önder Aybastıer, Cevdet Demir. Ultrasensitive determination of DNA oxidation products by gas chromatography-tandem mass spectrometry and the role of antioxidants in the prevention of oxidative damage.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Apr; 1051(?):84-91. doi:
10.1016/j.jchromb.2017.03.014. [PMID: 28334650] - Sang Gil Lee, John S Parks, Hye Won Kang. Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes.
The Journal of nutritional biochemistry.
2017 04; 42(?):62-71. doi:
10.1016/j.jnutbio.2016.12.018. [PMID: 28131896] - Hongjuan Li, Ying Liu, Yuetao Yi, Qin Miao, Sujing Liu, Feng Zhao, Wei Cong, Chunhua Wang, Chuanhai Xia. Purification of quercetin-3-O-sophoroside and isoquercitrin from Poacynum hendersonii leaves using macroporous resins followed by Sephadex LH-20 column chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Mar; 1048(?):56-63. doi:
10.1016/j.jchromb.2017.01.041. [PMID: 28213296] - Hong-die Cai, Wei-wei Tao, Shu-lan Su, Sheng Guo, Yue Zhu, Jian-ming Guo, Da-wei Qian, Xu-dong Cong, Ren-mao Tang, Jin-ao Duan. [Antidepressant activity of flavonoid ethanol extract of Abelmoschus manihot corolla with BDNF up-regulation in the hippocampus].
Yao xue xue bao = Acta pharmaceutica Sinica.
2017 Feb; 52(2):222-8. doi:
. [PMID: 29979503] - Yumi Kangawa, Toshinori Yoshida, Kiyoshi Maruyama, Minako Okamoto, Tohru Kihara, Michi Nakamura, Masako Ochiai, Yoshitaka Hippo, Shim-Mo Hayashi, Makoto Shibutani. Cilostazol and enzymatically modified isoquercitrin attenuate experimental colitis and colon cancer in mice by inhibiting cell proliferation and inflammation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Feb; 100(?):103-114. doi:
10.1016/j.fct.2016.12.018. [PMID: 27989839] - N M Kowal, R Eyjolfsson, E S Olafsdottir. Investigations on the constituents of SagaPro tablets, a food supplement manufactured from Angelica archangelica leaf.
Die Pharmazie.
2017 Jan; 72(1):3-4. doi:
10.1691/ph.2017.6807. [PMID: 29441889] - Diana M Cheng, Diana E Roopchand, Alexander Poulev, Peter Kuhn, Isabel Armas, William D Johnson, Andrew Oren, David Ribnicky, Ehud Zelzion, Debashish Bhattacharya, Ilya Raskin. High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet-induced obese mice.
Molecular nutrition & food research.
2016 11; 60(11):2367-2378. doi:
10.1002/mnfr.201600290. [PMID: 27529448] - Simona Scheggi, Aurelio Marandino, Donato Del Monte, Laura De Martino, Teresa Pelliccia, Maria Del Rosario Fusco, Elisa M Petenatti, Carla Gambarana, Vincenzo De Feo. The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content.
Pharmaceutical biology.
2016 Sep; 54(9):1782-92. doi:
10.3109/13880209.2015.1127979. [PMID: 26731632] - Shuang Liu, Fuguo Liu, Yanhui Xue, Yanxiang Gao. Evaluation on oxidative stability of walnut beverage emulsions.
Food chemistry.
2016 Jul; 203(?):409-416. doi:
10.1016/j.foodchem.2016.02.037. [PMID: 26948632] - Nicola P Bondonno, Catherine P Bondonno, Lisa Rich, Emilie Mas, Sujata Shinde, Natalie C Ward, Jonathan M Hodgson, Kevin D Croft. Acute effects of quercetin-3-O-glucoside on endothelial function and blood pressure: a randomized dose-response study.
The American journal of clinical nutrition.
2016 Jul; 104(1):97-103. doi:
10.3945/ajcn.116.131268. [PMID: 27169837] - Francesca Sansone, Tiziana Esposito, Teresa Mencherini, Anna Lisa Piccinelli, Patrizia Gazzerro, Patrizia Picerno, Paola Russo, Pasquale Del Gaudio, Massimilano Essolito, Pietro Campiglia, Rita P Aquino. Annurca peel extract: from the chemical composition, through the functional activity, to the formulation and characterisation of a topical oil-in-water emulsion.
Natural product research.
2016 Jun; 30(12):1398-403. doi:
10.1080/14786419.2015.1062005. [PMID: 26211432] - Li Li, Xiao-Hui Zhang, Guang-Rong Liu, Chang Liu, Yin-Mao Dong. Isoquercitrin suppresses the expression of histamine and pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells.
Chinese journal of natural medicines.
2016 Jun; 14(6):407-12. doi:
10.1016/s1875-5364(16)30036-x. [PMID: 27473957] - Sumudu N Warnakulasuriya, Ziaullah, H P Vasantha Rupasinghe. Long Chain Fatty Acid Esters of Quercetin-3-O-glucoside Attenuate H₂O₂-induced Acute Cytotoxicity in Human Lung Fibroblasts and Primary Hepatocytes.
Molecules (Basel, Switzerland).
2016 Apr; 21(4):452. doi:
10.3390/molecules21040452. [PMID: 27058521] - Meixia Zhu, Jiankuan Li, Ke Wang, Xuliang Hao, Rui Ge, Qingshan Li. Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway.
Molecules (Basel, Switzerland).
2016 Mar; 21(3):356. doi:
10.3390/molecules21030356. [PMID: 27007368] - Kasthuri Bai Magalingam, Ammu Radhakrishnan, Nagaraja Haleagrahara. Protective effects of quercetin glycosides, rutin, and isoquercetrin against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rat pheochromocytoma (PC-12) cells.
International journal of immunopathology and pharmacology.
2016 Mar; 29(1):30-9. doi:
10.1177/0394632015613039. [PMID: 26542606] - Lu Wang, Xiaoyu Li, Zhenyu Wang. Whole body radioprotective effect of phenolic extracts from the fruits of Malus baccata (Linn.) Borkh.
Food & function.
2016 Feb; 7(2):975-81. doi:
10.1039/c5fo01377a. [PMID: 26741951] - Jun Yi, Jian-Guo Wu, Jin-Yu Wu, Yan-Bin Wu. Quality evaluation of the leaves of Magnolia officinalis var. biloba using high-performance liquid chromatography fingerprint analysis of phenolic compounds.
Journal of separation science.
2016 Feb; 39(4):784-92. doi:
10.1002/jssc.201500972. [PMID: 26681396]