Vinorine (BioDeep_00000008887)
Secondary id: BioDeep_00000900385
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C21H22N2O2 (334.1681)
中文名称: 维诺任碱
谱图信息:
最多检出来源 Viridiplantae(plant) 77.66%
分子结构信息
SMILES: CC=C1CN2C3CC1C1C2CC2(C3=Nc3ccccc32)C1OC(C)=O
InChI: InChI=1S/C21H22N2O2/c1-3-12-10-23-16-8-13(12)18-17(23)9-21(20(18)25-11(2)24)14-6-4-5-7-15(14)22-19(16)21/h3-7,13,16-18,20H,8-10H2,1-2H3/b12-3-/t13-,16-,17-,18?,20+,21+/m0/s1
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:16791
- KEGG: C11807
- PubChem: 5281974
- PubChem: 6442672
- PubChem: 4491168
- Metlin: METLIN64345
- Wikipedia: Vinorine
- MeSH: vinorine
- ChemIDplus: 0034020070
- MetaCyc: VINORINE
- KNApSAcK: C00024291
- KNApSAcK: C00024313
- CAS: 34020-07-0
- medchemexpress: HY-N1086
- PMhub: MS000022591
- MetaboLights: MTBLC16791
- PubChem: 13971
- 3DMET: B04316
- NIKKAJI: J696.386B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
代谢反应
3 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(3)
- ajmaline and sarpagine biosynthesis:
3-α(S)-strictosidine + H2O ⟶ D-glucopyranose + strictosidine aglycone - ajmaline and sarpagine biosynthesis:
3-α(S)-strictosidine + H2O ⟶ D-glucopyranose + strictosidine aglycone - ajmaline and sarpagine biosynthesis:
H2O + polyneuridine aldehyde ⟶ 16-epivellosimine + CO2 + MeOH
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 947874 - Rauvolfia bahiensis: 10.1021/NP0200919
- 141607 - Rauvolfia balansae:
- 947877 - Rauvolfia caffra:
- 2508340 - Rauvolfia perakensis:
- 4060 - Rauvolfia serpentina:
- 4060 - Rauvolfia serpentina: 10.1016/S0031-9422(02)00122-X
- 329875 - Rauvolfia verticillata:
- 60093 - Vinca minor: 10.1007/SPRINGERREFERENCE_37170
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuriy V Sheludko, Jascha Volk, Wolfgang Brandt, Heribert Warzecha. Expanding the Diversity of Plant Monoterpenoid Indole Alkaloids Employing Human Cytochrome P450 3A4.
Chembiochem : a European journal of chemical biology.
2020 07; 21(14):1976-1980. doi:
10.1002/cbic.202000020. [PMID: 32181956] - Dongdong Guo, Xingang Lu, Xiaoli Xu, Haixin Gou, Zhiqian Wang, Yi Cao, Xingjing Luo. Therapeutic Effect of Vinorine on Sciatic Nerve Injured Rat.
Neurochemical research.
2018 Feb; 43(2):375-386. doi:
10.1007/s11064-017-2432-4. [PMID: 29119332] - Xueyan Ma, Juergen Koepke, Anja Bayer, Günter Fritzsch, Hartmut Michel, Joachim Stöckigt. Crystallization and preliminary X-ray analysis of native and selenomethionyl vinorine synthase from Rauvolfia serpentina.
Acta crystallographica. Section D, Biological crystallography.
2005 Jun; 61(Pt 6):694-6. doi:
10.1107/s0907444904028756. [PMID: 15930622] - Xueyan Ma, Juergen Koepke, Santosh Panjikar, Günter Fritzsch, Joachim Stöckigt. Crystal structure of vinorine synthase, the first representative of the BAHD superfamily.
The Journal of biological chemistry.
2005 Apr; 280(14):13576-83. doi:
10.1074/jbc.m414508200. [PMID: 15665331] - Irina Gerasimenko, Xueyan Ma, Yuri Sheludko, Reinhard Mentele, Friedrich Lottspeich, Joachim Stöckigt. Purification and partial amino acid sequences of the enzyme vinorine synthase involved in a crucial step of ajmaline biosynthesis.
Bioorganic & medicinal chemistry.
2004 May; 12(10):2781-6. doi:
10.1016/j.bmc.2004.02.028. [PMID: 15110859] - . .
.
. doi:
. [PMID: 15110860]
