DEGA (BioDeep_00000008405)

   


代谢物信息卡片


N-(2,6-Dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide

化学式: C21H27N3O2 (353.2103)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 85.71%

分子结构信息

SMILES: CCN(CC)CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=CC=C2C)C
InChI: InChI=1S/C21H27N3O2/c1-5-24(6-2)14-19(25)22-18-12-10-17(11-13-18)21(26)23-20-15(3)8-7-9-16(20)4/h7-13H,5-6,14H2,1-4H3,(H,22,25)(H,23,26)



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ALB, ARHGAP45, ITPR3, RPS6KA6
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 4 ALB, AMIGO2, DNMT3B, RPS6KA6
cytosol 5 ALB, ARHGAP45, GPT, PPAT, RPS6KA6
dendrite 1 AMIGO1
centrosome 1 ALB
nucleoplasm 3 DNMT3B, ITPR3, RPS6KA6
Cell membrane 2 AMIGO1, AMIGO2
ruffle membrane 1 ARHGAP45
Cell projection, axon 1 AMIGO1
Multi-pass membrane protein 1 ITPR3
Golgi apparatus 1 ALB
neuronal cell body 1 ITPR3
Cytoplasm, cytosol 1 RPS6KA6
plasma membrane 3 AMIGO2, ARHGAP45, ITPR3
Membrane 4 AMIGO1, AMIGO2, ARHGAP45, ITPR3
brush border 1 ITPR3
extracellular exosome 2 ALB, GPT
endoplasmic reticulum 2 ALB, ITPR3
extracellular space 1 ALB
mitochondrion 1 RPS6KA6
protein-containing complex 1 ALB
Single-pass type I membrane protein 2 AMIGO1, AMIGO2
Secreted 1 ALB
extracellular region 2 ALB, ARHGAP45
neuronal cell body membrane 1 AMIGO1
anchoring junction 1 ALB
perikaryon 1 AMIGO1
nucleolus 2 ITPR3, RPS6KA6
apical part of cell 1 ITPR3
Cell projection, ruffle membrane 1 ARHGAP45
sarcoplasmic reticulum 1 ITPR3
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
fibrillar center 1 RPS6KA6
Cell projection, dendrite 1 AMIGO1
voltage-gated potassium channel complex 1 AMIGO1
secretory granule lumen 1 ARHGAP45
secretory granule membrane 1 ITPR3
endoplasmic reticulum lumen 1 ALB
platelet alpha granule lumen 1 ALB
azurophil granule lumen 1 ARHGAP45
platelet dense tubular network membrane 1 ITPR3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
transport vesicle membrane 1 ITPR3
catalytic complex 1 DNMT3B
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
ciliary transition fiber 1 ALB
pericellular basket 1 AMIGO1


文献列表

  • Karen E Rabenau, Jennifer M O'Toole, Rajiv Bassi, Helen Kotanides, Larry Witte, Dale L Ludwig, Daniel S Pereira. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Oncogene. 2004 Jun; 23(29):5056-67. doi: 10.1038/sj.onc.1207681. [PMID: 15107827]
  • C J Parli, E Evenson, B D Potts, E Beedle, R Lawson, D W Robertson, J D Leander. Metabolism of the prodrug DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide) to the potent anticonvulsant LY201116 in mice. Effect of bis-(p-nitrophenyl)phosphate. Drug metabolism and disposition: the biological fate of chemicals. 1988 Sep; 16(5):707-11. doi: . [PMID: 2906594]