Dipivefrin (BioDeep_00000006387)
Secondary id: BioDeep_00001868553
human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds
代谢物信息卡片
化学式: C19H29NO5 (351.20456240000004)
中文名称: 地匹福林
谱图信息:
最多检出来源 Homo sapiens(blood) 18.18%
分子结构信息
SMILES: CC(C)(C)C(=O)OC1=C(C=C(C=C1)C(CNC)O)OC(=O)C(C)(C)C
InChI: InChI=1S/C19H29NO5/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6/h8-10,13,20-21H,11H2,1-7H3
描述信息
Dipivefrin is only found in individuals that have used or taken this drug. It is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologically activity until it is hydrolyzed into epinephrine inside the human eye. The liberated epinephrine, an adrenergic agonist, appears to exert its action by stimulating α- and/or β2-adrenergic receptors, leading to a decrease in aqueous production and an enhancement of outflow facility. The dipivefrin prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EA - Sympathomimetics in glaucoma therapy
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78283 - Agent Affecting Organs of Special Senses > C29705 - Anti-glaucoma Agent
同义名列表
42 个代谢物同义名
2-[(2,2-dimethylpropanoyl)oxy]-5-[1-hydroxy-2-(methylamino)ethyl]phenyl 2,2-dimethylpropanoate; (+-)-4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalic acid; (+-)-4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate; 4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalic acid; 4-[1-Hydroxy-2-(methylamino)ethyl]-O-phenylene divavalate; 1-(3,4-Dipivaloyloxyphenyl)-2-methylamino-1-ethanol; Dipivefrin tartrate (1:1), (+-)-(R-(r*,r*))-isomer; Dipivefrin tartrate (1:1), (R)-(R-(r*,r*))-isomer; Pharm-allergan brand OF dipivefrin hydrochloride; Pharmascience brand OF dipivefrin hydrochloride; Ratiopharm brand OF dipivefrin hydrochloride; Allergan brand OF dipivefrin hydrochloride; Apotex brand OF dipivefrin hydrochloride; Ioquin brand OF dipivefrin hydrochloride; Alcon brand OF dipivefrin hydrochloride; Dipivefrin monophosphate, (+-)-isomer; Dipivefrin citrate (1:1), (+-)-isomer; Dipivefrin hydrochloride, (+-)-isomer; Dipivefrin monosulfate, (+-)-isomer; Dipivefrin propanoate, (+-)-isomer; Dipivefrin nitrate, (+-)-isomer; Dipivefrin acetate, (+-)-isomer; Dipivefrin hydrochloride; Dipivefrin, (R)-isomer; Dipivefrin perchlorate; Adrenaline dipivalate; Dipivalyl epinephrine; Dipivaloylepinephrine; Ratio-dipivefrin; PMS-Dipivefrin; Apo-dipivefrin; Dipivefrinum; Dipivefrina; Dipivefrine; dipivefrin; Glaucothil; D Epifrin; Glaudrops; Dipoquin; Diopine; Propine; Dipivefrin
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:4646
- KEGG: C06963
- KEGGdrug: D02349
- PubChem: 3105
- HMDB: HMDB0014592
- Metlin: METLIN3987
- DrugBank: DB00449
- ChEMBL: CHEMBL1201262
- Wikipedia: Dipivefrin
- chemspider: 2994
- CAS: 52365-63-6
- PMhub: MS000019420
- PubChem: 9177
- NIKKAJI: J244.400C
- RefMet: Dipivefrin
- KNApSAcK: 4646
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- John D Mahan, Mahmoud Kallash, William E Smoyer. Results of the PROPINE randomized controlled trial: determining the ever-elusive target, the optimal plan for relapses of nephrotic syndrome in children.
Kidney international.
2021 02; 99(2):311-313. doi:
10.1016/j.kint.2020.10.034
. [PMID: 33509352] - Antonio Gargiulo, Laura Massella, Barbara Ruggiero, Lucilla Ravà, Marta Ciofi Degli Atti, Marco Materassi, Francesca Lugani, Elisa Benetti, William Morello, Daniela Molino, Francesca Mattozzi, Marco Pennesi, Silvio Maringhini, Andrea Pasini, Bruno Gianoglio, Carmine Pecoraro, Giovanni Montini, Luisa Murer, Gian Marco Ghiggeri, Paola Romagnani, Marina Vivarelli, Francesco Emma. Results of the PROPINE randomized controlled study suggest tapering of prednisone treatment for relapses of steroid sensitive nephrotic syndrome is not necessary in children.
Kidney international.
2021 02; 99(2):475-483. doi:
10.1016/j.kint.2020.09.024
. [PMID: 33152448] - M Kubo, T Sakuraba, Y Arai, M Nakazawa. [A case of suspected drug-induced ocular pemphigoid].
Nippon Ganka Gakkai zasshi.
2001 Mar; 105(3):189-92. doi:
. [PMID: 11280879]
- M J Groh, G Michelson, J Harazny, M Groh, K Koschinsky. [Changes in retinal blood flow by topical administration of 0.1\% dipivefrin].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.
1999 Nov; 96(11):706-10. doi:
10.1007/s003470050481
. [PMID: 10631832] - Y Tamaki, K Tomita, M Araie, A Tomidokoro, M Nagahara. [Effect of topical adrenergic agents on tissue circulation in human optic nerve head evaluated with a laser speckle microcirculation analyser].
Nippon Ganka Gakkai zasshi.
1996 Jan; 100(1):55-62. doi:
. [PMID: 8644530]
- R Garzia. An advance in ophthalmic pharmacology. The use of the epinephrine pro-drug dipivalyl epinephrine in the treatment of glaucoma.
Journal of the American Optometric Association.
1982 Sep; 53(9):727-30. doi:
"
. [PMID: 7130613] - R Eisenburger, H Hampel, G Hofrichter, R Löser. [Comparative pharmacological study of d,1-adrenaline dipivalate hydrochloride and 1-adrenaline hydrochloride after local and oral administration].
Arzneimittel-Forschung.
1981; 31(2):325-34. doi:
"
. [PMID: 7194650]