Procyanidin A1 (BioDeep_00000621340)

Main id: BioDeep_00000004330

 

PANOMIX_OTCML-2023 PANOMIX-Anthocyanidin natural product


代谢物信息卡片


(1R,5R,6S,13S,21R)-5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0^{2,11}.0^{3,8}.0^{15,20}]henicosa-2,8,10,15,17,19-hexaene-6,9,17,19,21-pentol

化学式: C30H24O12 (576.1267703999999)
中文名称: 原花青素A1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC2=C1C(=CC3=C2C4C(C(O3)(OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC(=C(C=C7)O)O)O
InChI: InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26+,27+,29+,30-/m0/s1

描述信息

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects[1].
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects[1].

同义名列表

5 个代谢物同义名

(1R,5R,6S,13S,21R)-5,13-bis(3,4-dihydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0^{2,11}.0^{3,8}.0^{15,20}]henicosa-2,8,10,15,17,19-hexaene-6,9,17,19,21-pentol; Epicatechin-(2b->7,4b->8)-catechin; Proanthocyanidin A1; EC-(4b,8)(2b,7)-C; Procyanidin A1



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

101 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rong Wang, Xiaolong Hu, Jingjin Wang, Lina Zhou, Yu Hong, Yuanhao Zhang, Fei Xiong, Xiaoqi Zhang, Wen-Cai Ye, Hao Wang. Proanthocyanidin A1 promotes the production of platelets to ameliorate chemotherapy-induced thrombocytopenia through activating JAK2/STAT3 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153880. doi: 10.1016/j.phymed.2021.153880. [PMID: 34906892]
  • Shan Han, Hongwei Gao, Shaoru Chen, Qinqin Wang, Xinxing Li, Li-Jun Du, Jun Li, Ying-Ying Luo, Jun-Xiu Li, Li-Chun Zhao, Jianfang Feng, Shilin Yang. Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264.7 cells. Scientific reports. 2019 10; 9(1):15087. doi: 10.1038/s41598-019-51614-x. [PMID: 31636354]
  • Yong Sui, Yan Zheng, Xiaopeng Li, Shuyi Li, Bijun Xie, Zhida Sun. Characterization and preparation of oligomeric procyanidins from Litchi chinensis pericarp. Fitoterapia. 2016 Jul; 112(?):168-74. doi: 10.1016/j.fitote.2016.06.001. [PMID: 27282208]
  • Tatiane L C Oldoni, Priscilla S Melo, Adna P Massarioli, Ivani A M Moreno, Rosângela M N Bezerra, Pedro L Rosalen, Gil V J da Silva, Andréa M Nascimento, Severino M Alencar. Bioassay-guided isolation of proanthocyanidins with antioxidant activity from peanut (Arachis hypogaea) skin by combination of chromatography techniques. Food chemistry. 2016 Feb; 192(?):306-12. doi: 10.1016/j.foodchem.2015.07.004. [PMID: 26304352]
  • Silvia C Heredia-Vieira, Ana M Simonet, Wagner Vilegas, Francisco A Macías. Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. Journal of natural products. 2015 Jan; 78(1):77-84. doi: 10.1021/np500715x. [PMID: 25517504]
  • Maria S Pesca, Fabrizio Dal Piaz, Rokia Sanogo, Antonio Vassallo, Maryan Bruzual de Abreu, Antonio Rapisarda, Maria P Germanò, Giovanna Certo, Sandro De Falco, Nunziatina De Tommasi, Alessandra Braca. Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities. Journal of natural products. 2013 Jan; 76(1):29-35. doi: 10.1021/np300614u. [PMID: 23268742]
  • Keisuke Tomochika, Akiko Shimizu-Ibuka, Tomoko Tamura, Kiyoshi Mura, Naoki Abe, Jun-Ichi Onose, Soichi Arai. Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells. Bioscience, biotechnology, and biochemistry. 2011; 75(9):1644-8. doi: 10.1271/bbb.110085. [PMID: 21897038]
  • Ying Zi Liu, Yong Guo Cao, Jun Qing Ye, Wei Guang Wang, Ke Ji Song, Xiao Liang Wang, Chun Hua Wang, Rong Tao Li, Xu Ming Deng. Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum. Fitoterapia. 2010 Mar; 81(2):108-14. doi: 10.1016/j.fitote.2009.08.005. [PMID: 19686816]
  • Fumihide Takano, Takanobu Takata, Akio Yoshihara, Yuka Nakamura, Yukiko Arima, Tomihisa Ohta. Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biological & pharmaceutical bulletin. 2007 May; 30(5):922-7. doi: 10.1248/bpb.30.922. [PMID: 17473436]
  • Lie-Chwen Lin, Yuh-Chi Kuo, Cheng-Jen Chou. Immunomodulatory proanthocyanidins from Ecdysanthera utilis. Journal of natural products. 2002 Apr; 65(4):505-8. doi: 10.1021/np010414l. [PMID: 11975489]