Methylisocitric acid (BioDeep_00000005584)
Secondary id: BioDeep_00000629073, BioDeep_00001869592
human metabolite
代谢物信息卡片
1-hydroxy-1-methylpropane-1,2,3-tricarboxylic acid
化学式: C7H10O7 (206.042651)
中文名称:
谱图信息:
最多检出来源 Macaca mulatta(otcml) 0.93%
分子结构信息
SMILES: CC(C(CC(=O)O)C(=O)O)(C(=O)O)O
InChI: InChI=1S/C7H10O7/c1-7(14,6(12)13)3(5(10)11)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)
描述信息
Methylisocitric acid is a product of bacterial metabolism in the gut. It can be produced by 2-methylisocitrate lyase and by 2-methylisocitrate dehydratase. Methylisocitric acid has also been found to be a metabolite of Candida (https://www.tandfonline.com/doi/pdf/10.1080/00021369.1974.10861293).
Methylisocitric acid is a product of bacterial metabolism in the gut. It can be produced by 2-methylisocitrate lyase and by 2-methylisocitrate dehydratase. [HMDB]
同义名列表
22 个代谢物同义名
1-hydroxy-1-methylpropane-1,2,3-tricarboxylic acid; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylic acid; 3-Carboxy-2,3-dideoxy-4-C-methylpentaric acid; (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate; Threo-alpha-methylisocitrate, (3)H-labeled; 3-Carboxy-2,3-dideoxy-4-C-methylpentarate; 3-Hydroxybutane-1,2,3-tricarboxylic acid; 3-Hydroxy-1,2,3-butanetricarboxylic acid; 3-Hydroxy-1,2,3-butanetricarboxylate; DL-Threo-alpha-methylisocitrate; threo-alpha-Methylisocitrate; alpha-Methylisocitric acid; (2R,3S)2-Methylisocitrate; DL-Methylisocitric acid; Α-methylisocitric acid; a-Methylisocitric acid; alpha-Methylisocitrate; Methylisocitric acid; D.L-methylisocitrate; Α-methylisocitrate; a-Methylisocitrate; Methylisocitrate
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:142525
- ChEBI: CHEBI:15607
- KEGG: C04593
- PubChem: 5459784
- PubChem: 513
- HMDB: HMDB0006471
- Metlin: METLIN58419
- DrugBank: DB04072
- MetaCyc: CPD-618
- foodb: FDB023929
- chemspider: 498
- CAS: 6061-95-6
- PMhub: MS000018418
- PubChem: 7191
- LipidMAPS: LMFA01050444
- PDB-CCD: MIC
- 3DMET: B01764
- NIKKAJI: J1.534.785F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Propanoate Metabolism:
2-iminobutanoate + Hydrogen Ion + Water ⟶ 2-Ketobutyric acid + Ammonium - Propanoate Metabolism:
2-Ketobutyric acid + Coenzyme A ⟶ Formic acid + Propionyl-CoA
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Japanese journal of antibiotics.
1984 Jun; 37(6):1058-69. doi:
. [PMID: 6092738] - T Miyano, H Shimomura, T Arai, K Sasaki, T Ogawa, E Deguchi, K Suruga. [Postoperative evaluation of renal function from the aspect of urinary concentration of cefmetazole in infants and children with vesicoureteral reflux and hydronephrosis. I].
The Japanese journal of antibiotics.
1984 Feb; 37(2):237-42. doi:
NULL. [PMID: 6588212] - T Miyano, T Arai, H Shimomura, T Ogawa, K Sasaki, E Deguchi, K Suruga, H Nittono. [The correlation between the biliary excretion of cefmetazole and the bile acid metabolism in postoperative patients with biliary atresia].
The Japanese journal of antibiotics.
1984 Feb; 37(2):243-6. doi:
NULL. [PMID: 6588213] - T Nishihata, H Takahagi, M Yamamoto, H Tomida, J H Rytting, T Higuchi. Enhanced rectal absorption of cefmetazole and cefoxitin in the presence of epinephrine metabolites in rats and a high-performance liquid chromatographic assay for cephamycin antibiotics.
Journal of pharmaceutical sciences.
1984 Jan; 73(1):109-12. doi:
10.1002/jps.2600730129. [PMID: 6582265] - H Mitsuya, Y Naide, K Ohtaguro, A Segawa. [Clinical evaluation of cefmetazole in urological infections].
Hinyokika kiyo. Acta urologica Japonica.
1984 Jan; 30(1):87-95. doi:
. [PMID: 6587764] - H Takeuchi, T Tomoyoshi. [Treatment of infection stones. I. Dissolution of experimental infection stones in rats].
Hinyokika kiyo. Acta urologica Japonica.
1983 Mar; 29(3):293-6. doi:
NULL. [PMID: 6375314] - T Miwatani, Y Takeda, K Kotera, T Nishimura, T Takashima, K Hiromatsu, K Tabuki, S Fujimoto, T Kamiki, E Yoshizaki, E Yabuuchi, Y Shimizu, K Matsunaga, K Yamanaka, I Furuta, M Iimori, J Kodama, M Tanaka, K Maejima, M Nukina, E Takashima, M Takahashi, O Harikane, T Masutani. [The antibacterial activity of new cephem antibiotics against clinical isolates. A comparison of the antibacterial activity of cefotaxime with 6 other antibiotics].
The Japanese journal of antibiotics.
1983 Feb; 36(2):260-76. doi:
NULL. [PMID: 6304368] - T Nagao, M Komatsuda, K Yamauchi, H Nozaki. Clinical evaluation of combination of cefmetazole and piperacillin in the treatment of infections in patients with acute leukemia.
Chemotherapy.
1983; 29(3):230-5. doi:
10.1159/000238202. [PMID: 6223792] - M Suwaki, N Kashiwa, N Nohara. [Experimental studies of cefmetazole in the field of dermatology].
The Japanese journal of antibiotics.
1982 Aug; 35(8):1957-60. doi:
NULL. [PMID: 6961240] - F Doko. [Preliminary and clinical investigations of cefmetazole in the obstetric and gynecological field].
The Japanese journal of antibiotics.
1982 Aug; 35(8):1951-6. doi:
NULL. [PMID: 6961239] - E Konaga, Y Orita, T Kawamura, T Mannami, K Orita, K Mano, K Kataoka, H Kimura, J Shimizu, T Kanbayashi, H Fujii, Y Okada, O Kondo, N Miyata, K Ohmori, N Chikazawa, K Kondo, H Sakai, S Kayata, K Nakajima, Y Ide, J Nakagawa, J Kotani, M Yumura, T Hatayama, N Kobayashi, T Souji, T Ohta, K Sakai, J Kasahara, Y Kuwata, E Kashihara, M Sakamoto, M Narusue, T Yagi, M Inoue. [Basic and clinical evaluations of cefmetazole in postoperative wound infections].
The Japanese journal of antibiotics.
1982 Jul; 35(7):1690-8. doi:
. [PMID: 6757470] - H Shindo, K Kawai, T Ikeda, I Igarashi, S Sugawara. Absorption, distribution, excretion and metabolism of cefmetazole in cynomolgus monkeys.
The Journal of antibiotics.
1982 Jun; 35(6):742-54. doi:
10.7164/antibiotics.35.742. [PMID: 6956564] - Y Minami, M Taguchi, R Nanba, H Tsuto, T Yamamoto, K Ueda, T Tsushima, T Morihana, K Nagata, K Nakao, K Shimada. [Experimental and clinical studies of cefmetazole in the field of oral surgery].
The Japanese journal of antibiotics.
1982 May; 35(5):1308-21. doi:
NULL. [PMID: 6957626] - K Wada, S Baba, T Hatano, K Murai, H Kinoshita, I Takimoto, T Nomura, M Naito, S Iwata, T Nishimura, A Takasu, T Sekiya, K Miyagawa, M Tsukiyama, H Ito, Y Suzuki, J Hondoh, M Noda, K Umeda, T Maruo. [Pharmacokinetics and clinical studies of cefmetazole in the otorhinolaryngological field].
The Japanese journal of antibiotics.
1982 May; 35(5):1261-90. doi:
NULL. [PMID: 6752461] - M Sekine, K Sasahara, T Kojima, T Morioka. High-performance liquid chromatographic method for determination of cefmetazole in human serum.
Antimicrobial agents and chemotherapy.
1982 May; 21(5):740-3. doi:
10.1128/aac.21.5.740. [PMID: 6954877] - T Motohiro, Y Sakata, T Fujimoto, T Nishiyama, K Ishimoto, K Tominaga, F Yamashita, Y Onoda, T Kusayanagi, M Tsuboi, Y Toubo, M Yamamoto, R Komatsu, C Tanaka, Y Baba. [Laboratory and clinical studies of cefmetazole in serious infection by Staphylococcus (author's transl)].
The Japanese journal of antibiotics.
1982 Mar; 35(3):821-34. doi:
. [PMID: 6954289] - M Kawashima, H Tamura, Y Kitahara, K Jinyama. [Basic study on efficacy of cefmetazole against osseous and articular infections (author's transl)].
The Japanese journal of antibiotics.
1982 Mar; 35(3):835-9. doi:
NULL. [PMID: 6954290] - S Goto, H Sakamoto, M Ogawa, A Tsuji, S Kuwahara. Bactericidal activity of cefazolin, cefoxitin, and cefmetazole against Escherichia coli and Klebsiella pneumoniae.
Chemotherapy.
1982; 28(1):18-25. doi:
10.1159/000238056. [PMID: 7035088] - T Nagao, M Komatsuda, K Yamauchi, H Nozaki, S Arimori. Evaluation of cefmetazole and piperacillin with or without tobramycin for infections in patients with hematological disorders.
The Tokai journal of experimental and clinical medicine.
1981 Oct; 6(4):415-20. doi:
. [PMID: 6459664] - N Iwai, A Sasaki, Y Taneda, K Inokuma. [A study on cefmetazole in the neonatal period (author's transl)].
The Japanese journal of antibiotics.
1981 Jun; 34(6):881-92. doi:
NULL. [PMID: 6945448] - J Yura, N Tsuruga, S Hayashi. [Studies on absorption and excretion of cefmetazole in neonates and excretion into the bile of infants with congenital biliary atresia (author's transl)].
The Japanese journal of antibiotics.
1981 Jun; 34(6):903-6. doi:
NULL. [PMID: 6945450] - NULL. [Cefmetazole preparations].
The Japanese journal of antibiotics.
1981 Jun; 34(6):925-8. doi:
NULL. [PMID: 6945453] - S Nanri, K Sunakawa, N Yamashita, H Akita, M Hotta, Y Ichihashi, K Ishikawa, K Okazaki, T Kanemitsu, S Ri. [Examination of blood levels and urinary excretion of cefmetazole in the mature and immature neonates (author's transl)].
The Japanese journal of antibiotics.
1981 Jun; 34(6):874-9. doi:
NULL. [PMID: 6945447] - N Cho, K Fukunaga, K Kunii. [A study of clinical application of cefmetazole in perinatal period (author's transl)].
The Japanese journal of antibiotics.
1981 Jun; 34(6):915-24. doi:
. [PMID: 6945452] - M Ohkawa, M Orito, T Sugata, M Shimamura, M Sawaki, E Nakashita, K Kuroda, K Sasahara. Pharmacokinetics of cefmetazole in normal subjects and in patients with impaired renal function.
Antimicrobial agents and chemotherapy.
1980 Sep; 18(3):386-9. doi:
10.1128/aac.18.3.386. [PMID: 6932824] - M Minamitani, H Hayashi, T Tohma, T Kojima, Y Sahashi, T Terao. [Studies on the shift of cefmetazole into the gastrointestinal tract (author's transl)].
The Japanese journal of antibiotics.
1980 Jan; 33(1):10-7. doi:
NULL. [PMID: 6929355]