Ribose 1,5-bisphosphate (BioDeep_00000004595)

 

Secondary id: BioDeep_00001869429

human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


{[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}phosphonic acid

化学式: C5H12O11P2 (309.9855)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 15.34%

分子结构信息

SMILES: C(C1C(C(C(O1)OP(=O)(O)O)O)O)OP(=O)(O)O
InChI: InChI=1S/C5H12O11P2/c6-3-2(1-14-17(8,9)10)15-5(4(3)7)16-18(11,12)13/h2-7H,1H2,(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1

描述信息

Ribose 1,5-bisphosphate (Rib-1,5-P2), a newly discovered activator of phosphofructokinase. It forms rapidly during the initiation of glycolytic flux and disappears within 20 s/ Ribose 1,5-bisphosphate is a potent regulator of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in the liver. Ribose 1,5-bisphosphate is a substrate for Ribose 1,5-bisphosphate phosphokinase (EC 2.7.4.23), an enzyme that catalyzes the chemical reaction. ATP + ribose 1,5-bisphosphate <-> ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
Ribose 1,5-bisphosphate (Rib-1,5-P2), a newly discovered activator of phosphofructokinase. It forms rapidly during the initiation of glycolytic flux and disappears within 20 s/ Ribose 1,5-bisphosphate is a potent regulator of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in the liver. Ribose 1,5-bisphosphate is a substrate for Ribose 1,5-bisphosphate phosphokinase (EC 2.7.4.23), an enzyme that catalyzes the chemical reaction

同义名列表

19 个代谢物同义名

{[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}phosphonic acid; [(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxyphosphonic acid; 1,5-Di-O-Phosphono-Alpha-D-Ribofuranose; alpha-D-Ribose 1,5-bisphosphoric acid; alpha-D-Ribose 1,5-diphosphoric acid; Α-D-ribose 1,5-bisphosphoric acid; a-D-Ribose 1,5-bisphosphoric acid; a-D-Ribose 1,5-diphosphoric acid; Α-D-ribose 1,5-diphosphoric acid; alpha-D-Ribose 1,5-bisphosphate; alpha-D-Ribose 1,5-diphosphate; Ribose 1,5-bisphosphoric acid; Α-D-ribose 1,5-bisphosphate; a-D-Ribose 1,5-bisphosphate; Α-D-ribose 1,5-diphosphate; a-D-Ribose 1,5-diphosphate; D-Ribose 1,5-diphosphate; Ribose 1,5-bisphosphate; Rib-1,5-P2



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

  • Methylphosphonate Degradation I: Adenosine triphosphate + Methylphosphonate ⟶ -D-Ribose 1-methylphosphonate 5-triphosphate + Adenine
  • PRPP Biosynthesis: Adenosine triphosphate + D-Ribose 5-phosphate ⟶ Adenosine monophosphate + Hydrogen Ion + Phosphoribosyl pyrophosphate

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hairong Huang, Stefan Berg, John S Spencer, Danny Vereecke, Wim D'Haeze, Marcelle Holsters, Michael R McNeil. Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis. Microbiology (Reading, England). 2008 Mar; 154(Pt 3):736-743. doi: 10.1099/mic.0.2007/013532-0. [PMID: 18310020]
  • I Ozaki, Y Mitsui, H Sugiya, S Furuyama. Ribose 1,5-bisphosphate inhibits fructose-1,6-bisphosphatase in rat kidney cortex. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2000 Jan; 125(1):97-102. doi: 10.1016/s0305-0491(99)00156-x. [PMID: 10840645]
  • T Ozeki, Y Mitsui, H Sugiya, S Furuyama. Ribose 1,5-bisphosphate regulates rat kidney cortex phosphofructokinase. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 1999 Nov; 124(3):327-32. doi: 10.1016/s0305-0491(99)00127-3. [PMID: 10631808]
  • E Ishikawa, S Ogushi, T Ishikawa, K Uyeda. Activation of mammalian phosphofructokinases by ribose 1,5-bisphosphate. The Journal of biological chemistry. 1990 Nov; 265(31):18875-8. doi: . [PMID: 2146265]