Glucuronate (BioDeep_00000265136)

描述信息

A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.

Glucuronic acid, an important derivative of glucose, serves several key biological functions:

Detoxification: Glucuronic acid plays a crucial role in the detoxification process within the liver. It conjugates with various toxins, drugs, and bilirubin (a breakdown product of heme) to form water-soluble glucuronides. This conjugation process enhances the elimination of these substances from the body.
Glycosaminoglycan Synthesis: It is a precursor for the synthesis of glycosaminoglycans (GAGs), such as hyaluronic acid, chondroitin sulfate, and dermatan sulfate. These GAGs are important components of connective tissues, providing structural support and contributing to tissue hydration and lubrication.
Ascorbic Acid (Vitamin C) Synthesis: In some animals, glucuronic acid is involved in the synthesis of ascorbic acid, an essential vitamin.
Bile Acid Synthesis: Glucuronic acid is also involved in the synthesis of certain bile acids, which are crucial for the digestion and absorption of dietary fats.
Metabolism of Steroids and Xenobiotics: It participates in the metabolism of steroids and various xenobiotics (foreign substances), aiding in their elimination from the body.
Cell Signaling: Glucuronic acid-containing compounds, like GAGs, can interact with cell surface receptors and influence cell signaling pathways, impacting processes like cell growth, adhesion, and migration.

DL-Glucuronic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=576-37-4 (retrieved 2024-07-01) (CAS RN: 576-37-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

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