Phendimetrazine (BioDeep_00000002087)

 

Secondary id: BioDeep_00000405984

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


Phendimetrazine tartrate, (2S-trans(R-(r*,r*)))-isomer

化学式: C12H17NO (191.1310072)
中文名称: 苯二甲嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 0.66%

分子结构信息

SMILES: CC1C(c2ccccc2)OCCN1C
InChI: InChI=1S/C12H17NO/c1-10-12(14-9-8-13(10)2)11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3

描述信息

Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, phendimetrazine is a Schedule III controlled substance under the Uniform Controlled Substances Act of 1970.
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

29 个代谢物同义名

Phendimetrazine tartrate, (2S-trans(R-(r*,r*)))-isomer; Phendimetrazine hydrochloride, (2S-trans)-isomer; Phendimetrazine tartrate, (R-(r*,r*))-isomer; (2S,3S)-3,4-Dimethyl-2-phenylmorpholine; (+)-3,4-Dimethyl-2-phenylmorpholine; Phendimetrazine, (2S-trans)-isomer; D-2-Phenyl-3,4-dimethylmorpholine; Phendimetrazine, trans(+-)-isomer; Phendimetrazine, (2R-cis)-isomer; 3,4-Dimethyl-2-phenylmorpholine; Phendimetrazine hydrochloride; 3-Phenyl-2-methylmorpholine; Phendimetrazine tartrate; (+)-Phendimetrazine; phendimetrazine; Di-ap-trol; X-Trozine; Weightrol; Trimstat; Melfiat; Bontril; Obezine; Adipost; Wehless; Dyrexan; Prelu-2; Hyrex; Phendimetrazine; Phendimetrazine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ernesto Solis, Julie A Suyama, Matthew F Lazenka, Louis J DeFelice, S Stevens Negus, Bruce E Blough, Matthew L Banks. Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters. Scientific reports. 2016 08; 6(?):31385. doi: 10.1038/srep31385. [PMID: 27514281]
  • Matthew L Banks, Bruce E Blough, Timothy R Fennell, Rodney W Snyder, S Stevens Negus. Effects of phendimetrazine treatment on cocaine vs food choice and extended-access cocaine consumption in rhesus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013 Dec; 38(13):2698-707. doi: 10.1038/npp.2013.180. [PMID: 23893022]
  • Matthew L Banks, Bruce E Blough, Timothy R Fennell, Rodney W Snyder, S Stevens Negus. Role of phenmetrazine as an active metabolite of phendimetrazine: evidence from studies of drug discrimination and pharmacokinetics in rhesus monkeys. Drug and alcohol dependence. 2013 Jun; 130(1-3):158-66. doi: 10.1016/j.drugalcdep.2012.10.026. [PMID: 23211394]
  • Kelly E Steidl, William Darko, Luke A Probst, John A Noviasky, Samer Nasser. Rhabdomyolysis associated with phentermine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2010 Nov; 67(22):1929-32. doi: 10.2146/ajhp090395. [PMID: 21048209]
  • Patrick J Phillips, Steven G Smith, D W Kolpin, Steven D Zaugg, Herbert T Buxton, Edward T Furlong, Kathleen Esposito, Beverley Stinson. Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents. Environmental science & technology. 2010 Jul; 44(13):4910-6. doi: 10.1021/es100356f. [PMID: 20521847]
  • D Kwiker, D Godkar, N Lokhandwala, M Yakoby. Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate. American journal of therapeutics. 2006 Mar; 13(2):175-6. doi: 10.1097/00045391-200603000-00015. [PMID: 16645436]
  • Richard B Rothman, Marina Katsnelson, Nga Vu, John S Partilla, Christina M Dersch, Bruce E Blough, Michael H Baumann. Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. European journal of pharmacology. 2002 Jun; 447(1):51-7. doi: 10.1016/s0014-2999(02)01830-7. [PMID: 12106802]
  • G S Markowitz, A Tartini, V D D'Agati. Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. Clinical nephrology. 1998 Oct; 50(4):252-4. doi: . [PMID: 9799071]
  • J F Cui, Y Zhou, K R Cui, L Li, T H Zhou. [Study on metabolism of phenmetrazine-like drugs and their metabolites]. Yao xue xue bao = Acta pharmaceutica Sinica. 1990; 25(8):632-6. doi: . [PMID: 1982038]
  • P Kintz, A Tracqui, P Mangin, A A Lugnier, A J Chaumont. A simple gas chromatographic identification and determination of 11 CNS stimulants in biological samples. Application on a fatality involving phendimetrazine. Forensic science international. 1989 Feb; 40(2):153-9. doi: 10.1016/0379-0738(89)90142-4. [PMID: 2564835]
  • I Hood, J Monforte, R Gault, H Mirchandani. Fatality from illicit phendimetrazine use. Journal of toxicology. Clinical toxicology. 1988; 26(3-4):249-55. doi: 10.3109/15563658809000351. [PMID: 2901497]
  • G R Rudolph, J R Miksic, M J Levitt. GLC determination of phendimetrazine in human plasma, serum, or urine. Journal of pharmaceutical sciences. 1983 May; 72(5):519-21. doi: 10.1002/jps.2600720510. [PMID: 6688092]
  • B HELLMAN, S LARSSON, S WESTMAN. Acetate metabolism in isolated epididymal adipost tissue from obese-hyperglycemic mice of different ages. Acta physiologica Scandinavica. 1962 Oct; 56(?):189-98. doi: 10.1111/j.1748-1716.1962.tb02495.x. [PMID: 13953610]