Difenacoum (BioDeep_00001873872)

   


代谢物信息卡片


Difenacoum

化学式: C31H24O3 (444.1725)
中文名称: 鼠得克
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(CC2=CC=CC=C2C1C3=C(C4=CC=CC=C4OC3=O)O)C5=CC=C(C=C5)C6=CC=CC=C6
InChI: InChI=1S/C31H24O3/c32-30-26-12-6-7-13-28(26)34-31(33)29(30)27-19-24(18-23-10-4-5-11-25(23)27)22-16-14-21(15-17-22)20-8-2-1-3-9-20/h1-17,24,27,32H,18-19H2

描述信息

D006401 - Hematologic Agents > D000925 - Anticoagulants > D015110 - 4-Hydroxycoumarins
D010575 - Pesticides > D012378 - Rodenticides
D016573 - Agrochemicals

同义名列表

2 个代谢物同义名

Difenacoum; Difenacoum



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Douglas L Feinstein, Daniel G Nosal, Swetha Ramanathan, Jifang Zhou, Luying Chen, Ronald C Hershow, Richard B van Breemen, Erik Wright, John W Hafner, Israel Rubinstein. Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids. Clinical toxicology (Philadelphia, Pa.). 2020 07; 58(7):716-724. doi: 10.1080/15563650.2019.1687903. [PMID: 31736367]
  • Kristin Opdal Seljetun, Vigdis Vindenes, Elisabeth Leere Øiestad, Gerd-Wenche Brochmann, Elin Eliassen, Lars Moe. Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population. Acta veterinaria Scandinavica. 2020 Jun; 62(1):30. doi: 10.1186/s13028-020-00531-5. [PMID: 32546243]
  • Daniel G Nosal, Douglas L Feinstein, Luying Chen, Richard B van Breemen. Separation and Quantification of Superwarfarin Rodenticide Diastereomers-Bromadiolone, Difenacoum, Flocoumafen, Brodifacoum, and Difethialone-in Human Plasma. Journal of AOAC International. 2020 Jun; 103(3):770-778. doi: 10.1093/jaoacint/qsaa007. [PMID: 33241367]
  • Amar H Kelkar, Nichole A Smith, Annia Martial, Harsha Moole, Michael D Tarantino, Jonathan C Roberts. An Outbreak of Synthetic Cannabinoid-Associated Coagulopathy in Illinois. The New England journal of medicine. 2018 09; 379(13):1216-1223. doi: 10.1056/nejmoa1807652. [PMID: 30280655]
  • Anke Geduhn, Jens Jacob, Detlef Schenke, Barbara Keller, Sven Kleinschmidt, Alexandra Esther. Relation between Intensity of Biocide Practice and Residues of Anticoagulant Rodenticides in Red Foxes (Vulpes vulpes). PloS one. 2015; 10(9):e0139191. doi: 10.1371/journal.pone.0139191. [PMID: 26418154]
  • Servet Altay, Huseyin Altug Cakmak, Gulsah Cemiloglu Boz, Sinan Koca, Yalcin Velibey. Prolonged coagulopathy related to coumarin rodenticide in a young patient: superwarfarin poisoning. Cardiovascular journal of Africa. 2012 Oct; 23(9):e9-e11. doi: 10.5830/cvja-2012-051. [PMID: 23108575]
  • Robert A Middleberg, Joseph Homan. Qualitative identification of rodenticide anticoagulants by LC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2012; 902(?):139-48. doi: 10.1007/978-1-61779-934-1_12. [PMID: 22767114]
  • Isabelle Fourel, Christophe Hugnet, Isabelle Goy-Thollot, Philippe Berny. Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products. Journal of analytical toxicology. 2010 Mar; 34(2):95-102. doi: 10.1093/jat/34.2.95. [PMID: 20223102]
  • V Vandenbroucke, A Bousquet-Melou, P De Backer, S Croubels. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. Journal of veterinary pharmacology and therapeutics. 2008 Oct; 31(5):437-45. doi: 10.1111/j.1365-2885.2008.00979.x. [PMID: 19000263]
  • Virginie Vandenbroucke, Noël Desmet, Patrick De Backer, Siska Croubels. Multi-residue analysis of eight anticoagulant rodenticides in animal plasma and liver using liquid chromatography combined with heated electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jun; 869(1-2):101-10. doi: 10.1016/j.jchromb.2008.05.011. [PMID: 18502701]
  • Thomas Grobosch, Boris Angelow, Lena Schönberg, Dagmar Lampe. Acute bromadiolone intoxication. Journal of analytical toxicology. 2006 May; 30(4):281-6. doi: 10.1093/jat/30.4.281. [PMID: 16803669]
  • Barbara E Watt, Alex T Proudfoot, Sally M Bradberry, J Allister Vale. Anticoagulant rodenticides. Toxicological reviews. 2005; 24(4):259-69. doi: 10.2165/00139709-200524040-00005. [PMID: 16499407]
  • S Terneu, D Verhelst, F Thys, E Ketelslegers, P Hantson, X Wittebole. An unusual cause of abdominal pain. Acta clinica Belgica. 2003 Jul; 58(4):241-4. doi: 10.1179/acb.2003.58.4.005. [PMID: 14635532]
  • L Soubiron, P Hantson, I Michaux, M Lambert, P Mahieu, J Pringot. Spontaneous haemoperitoneum from surreptitious ingestion of a rodenticide. European journal of emergency medicine : official journal of the European Society for Emergency Medicine. 2000 Dec; 7(4):305-7. doi: 10.1097/00063110-200012000-00011. [PMID: 11764142]
  • P T McCarthy, A D Cox, D J Harrington, R S Evely, E Hampton, A I al-Sabah, E Massey, H Jackson, T Ferguson. Covert poisoning with difenacoum: clinical and toxicological observations. Human & experimental toxicology. 1997 Mar; 16(3):166-70. doi: 10.1177/096032719701600306. [PMID: 9088970]
  • E A Kuijpers, J den Hartigh, T J Savelkoul, F A de Wolff. A method for the simultaneous identification and quantitation of five superwarfarin rodenticides in human serum. Journal of analytical toxicology. 1995 Nov; 19(7):557-62. doi: 10.1093/jat/19.7.557. [PMID: 8577178]
  • P J Berny, T Buronfosse, G Lorgue. Anticoagulant poisoning in animals: a simple new high-performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of eight anticoagulant rodenticides in liver samples. Journal of analytical toxicology. 1995 Nov; 19(7):576-80. doi: 10.1093/jat/19.7.576. [PMID: 8577181]
  • M J Kelly, J Chambers, A D MacNicoll. Simple and rapid method for the determination of the diastereomers of difenacoum in blood and liver using high-performance liquid chromatography with fluorescence detection. Journal of chromatography. 1993 Oct; 620(1):105-12. doi: 10.1016/0378-4347(93)80057-b. [PMID: 8106576]
  • G P Butcher, M J Shearer, A D MacNicoll, M J Kelly, P W Ind. Difenacoum poisoning as a cause of haematuria. Human & experimental toxicology. 1992 Nov; 11(6):553-4. doi: 10.1177/096032719201100620. [PMID: 1361149]
  • N Nighoghossian, J H Ruel, P Ffrench, J C Froment, P Trouillas. [Cervicodorsal subdural hematoma caused by coumarinic rodenticide poisoning]. Revue neurologique. 1990; 146(3):221-3. doi: . [PMID: 2330467]
  • M J Winn, J A Clegg, B K Park. An investigation of sex-linked differences to the toxic and to the pharmacological actions of difenacoum: studies in mice and rats. The Journal of pharmacy and pharmacology. 1987 Mar; 39(3):219-22. doi: 10.1111/j.2042-7158.1987.tb06252.x. [PMID: 2883288]
  • B K Park, I A Choonara, B P Haynes, A M Breckenridge, R G Malia, F E Preston. Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins. British journal of clinical pharmacology. 1986 Mar; 21(3):289-93. doi: 10.1111/j.1365-2125.1986.tb05192.x. [PMID: 3964529]
  • A M Breckenridge, S Cholerton, J A Hart, B K Park, A K Scott. A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit. British journal of pharmacology. 1985 Jan; 84(1):81-91. doi: . [PMID: 3978316]
  • B K Park, J B Leck. A comparison of vitamin K antagonism by warfarin, difenacoum and brodifacoum in the rabbit. Biochemical pharmacology. 1982 Nov; 31(22):3635-9. doi: 10.1016/0006-2952(82)90587-1. [PMID: 7181945]
  • D E Mundy, A F Machin. The multi-residue determination of coumarin-based anticoagulant rodenticides in animal materials by high-performance liquid chromatography. Journal of chromatography. 1982 Jan; 234(2):427-35. doi: 10.1016/s0021-9673(00)81880-4. [PMID: 7056833]
  • F P Rowe, C J Plant, A Bradfield. Trials of the anticoagulant rodenticides bromadiolone and difenacoum against the house mouse (Mus musculus L.). The Journal of hygiene. 1981 Oct; 87(2):171-7. doi: 10.1017/s0022172400069370. [PMID: 7288171]