Squalen (BioDeep_00000175549)

human metabolite blood metabolite

代谢物信息卡片

2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene

化学式: C30H50 (410.39123)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C
InChI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3

描述信息

同义名列表

3 个代谢物同义名

2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene; Squalene; Squalen

数据库引用编号

4 个数据库交叉引用编号

PubChem: 1105
HMDB: HMDB0247780
KNApSAcK: C00043452
chemspider: 1074

分类词条

Triterpenoids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

114 个相关的物种来源信息

3816 - Abrus precatorius: 10.1002/JPS.2600570840
746491 - Achyrocline alata: 10.1016/S0031-9422(00)91058-6
414589 - Aleuritopteris farinosa:
204585 - Alsophila podophylla: 10.1248/CPB.51.1311
3567 - Amaranthus caudatus: 10.1007/BF02249626
2306982 - Antidesma pentandrum var. barbatum: 10.1002/JCCS.200700187
59523 - Antidorcas marsupialis: 10.1016/S0040-4039(01)85855-X
4220 - Artemisia vulgaris: 10.1007/S11418-008-0253-0
3489 - Artocarpus heterophyllus: 10.1007/S10600-010-9698-Y
947972 - Aster koraiensis:
385370 - Aster scaber:
988334 - Athrixia elata: 10.1016/S0031-9422(82)85073-5
336974 - Azolla nilotica: 10.1016/S0031-9422(97)01126-6
79557 - Barringtonia asiatica: 10.1248/CPB.59.778
3806 - Bauhinia purpurea: 10.1002/JCCS.200200042
1603694 - Beilschmiedia tsangii: 10.1055/S-2007-967195
191885 - Biancaea decapetala: 10.1248/CPB.53.428
42337 - Bidens pilosa: 10.1002/JCCS.200000152
2712134 - Bidens rubifolia: 10.1016/0031-9422(83)80242-8
172644 - Broussonetia papyrifera: 10.1016/0031-9422(94)00594-J
2813830 - Callicarpa pilosissima: 10.1021/NP800721F
1609857 - Casearia membranacea: 10.1055/S-2003-41120
1284881 - Cassinia subtropica: 10.1016/0031-9422(88)83027-9
317272 - Cineraria parvifolia: 10.1016/0031-9422(82)85251-5
1132458 - Cinnamomum kotoense: 10.1021/NP0580210
337469 - Cinnamomum philippinense: 10.1007/S10600-011-9788-5
977953 - Cinnamomum subavenium: 10.1248/CPB.56.97
41139 - Coccinella septempunctata: 10.1007/BF00574376
34329 - Corymbia citriodora: 10.1002/JCCS.200000074
1475389 - Croton cortesianus: 10.1016/0031-9422(92)80479-X
128609 - Cryptocarya chinensis: 10.1021/NP100014J
3656 - Cucumis melo: 10.1021/NP800692T
328070 - Dactylanthus taylorii: 10.1016/0031-9422(95)00403-T
170817 - Dalatias licha: 10.1042/BJ0220077
2876 - Dictyota dichotoma: 10.1071/CH08343
1932074 - Diospyros blancoi: 10.1080/14786410902951054
268838 - Diospyros discolor: 10.1080/14786410902951054
413758 - Diospyros maritima: 10.3390/MOLECULES14125281
1745051 - Disynaphia multicrenulata: 10.1016/S0031-9422(00)80481-1
313931 - Duhaldea cappa: 10.1016/0031-9422(82)83188-9
124949 - Ekebergia capensis: 10.1016/0031-9422(96)00004-0
72930 - Erigeron philadelphicus: 10.1016/S0031-9422(00)81585-X
568080 - Erythrophleum fordii: 10.1016/J.BMC.2008.09.021
100573 - Ficus septica:
572113 - Galeopsis bifida: 10.1007/BF00568505
1009474 - Garcinia multiflora: 10.1021/NP8006364
1548571 - Geigeria brevifolia: 10.1016/S0031-9422(82)85040-1
1548572 - Geigeria burkei: 10.1016/S0031-9422(82)85040-1
1169730 - Gentiana arisanensis: 10.1248/CPB.51.885
38851 - Gentiana lutea: 10.1248/CPB.51.885
183032 - Greenmaniella resinosa: 10.1016/S0031-9422(00)81746-X
1224798 - Gymnanthemum corymbosum: 10.1016/0031-9422(83)80212-X
1775740 - Hedlundia hybrida: 10.1016/S0031-9422(00)81059-6
379243 - Helichrysum cymosum: 10.1016/S0031-9422(00)91472-9
630321 - Helichrysum mimetes: 10.1016/S0031-9422(00)81569-1
630325 - Helichrysum nudifolium: 10.1016/S0031-9422(00)81569-1
185653 - Heliopsis longipes: 10.1016/J.PHYTOL.2011.04.014
9606 - Homo sapiens: -
498914 - Hydrangea chinensis: 10.1021/NP0302394
557660 - Inula salsoloides: 10.1016/0031-9422(95)00807-1
317279 - Kleinia galpinii: 10.1016/0031-9422(82)85252-7
1745096 - Lasiolaena morii: 10.1016/0031-9422(82)80035-6
55740 - Liabum solidagineum: 10.1016/S0031-9422(00)83499-8
186954 - Ligularia fischeri: 10.1016/S0031-9422(00)91056-2
332435 - Lindera glauca: 10.1002/JCCS.200000050
344083 - Litsea acutivena: 10.1002/JCCS.200700071
3670 - Luffa aegyptiaca: 10.1021/NP800692T
37501 - Maackia amurensis: 10.1007/BF00576208
164936 - Melaleuca leucadendra: 10.1021/NP9606052
29719 - Mentha spicata: 10.1080/00021369.1980.10864214
183052 - Milleria quinqueflora: 10.1016/S0031-9422(00)81748-3
244352 - Mondia whitei: 10.1016/J.PHYTOCHEM.2004.11.012
460332 - Moscharia pinnatifida: 10.1016/S0031-9422(00)81059-6
316725 - Neoboutonia mannii: 10.1016/S0031-9422(03)00158-4
1136774 - Neomirandea angularis: 10.1016/0031-9422(89)80149-9
4097 - Nicotiana tabacum: 10.1016/0031-9422(82)83143-9
1932738 - Nidorella auriculata: 10.1016/S0031-9422(00)88691-4
41618 - Osteospermum muricatum: 10.1016/0031-9422(83)80102-2
84099 - Paleosuchus palpebrosus: 10.1021/NP0600797
38658 - Paleosuchus trigonatus: 10.1021/NP0600797
136774 - Phoradendron reichenbachianum: 10.1055/S-2001-15823
1514139 - Pleurosigma strigosum: 10.1016/J.PHYTOCHEM.2004.09.002
90468 - Polemannia montana: 10.1016/S0031-9422(00)84743-3
82751 - Polydora poskeana: 10.1016/0031-9422(83)80212-X
1477715 - Porophyllum angustissimum: 10.1016/0031-9422(83)85053-5
1754171 - Pseudognaphalium gaudichaudianum: 10.1016/S0031-9422(02)00611-8
2906642 - Pteris pulchra:
141212 - Rhododendron formosanum: 10.1002/MRC.1844
1608497 - Rosa transmorrisonensis: 10.1002/JCCS.199300096
1650721 - Rubia yunnanensis: 10.1021/NP2002918
52304 - Rudbeckia mollis: 10.1016/0031-9422(92)80361-H
54447 - Sabal palmetto: 10.1016/J.PHYTOCHEM.2004.02.026
1009589 - Salacia chinensis:
268906 - Salvia fruticosa: 10.1016/S0367-326X(01)00327-6
457732 - Schistostephium crataegifolium: 10.1016/0031-9422(83)80100-9
1383557 - Scutellaria discolor: 10.1248/CPB.44.1540
155236 - Sideritis candicans: 10.1016/0031-9422(73)85087-3
403019 - Sideritis discolor: 10.1016/J.PHYTOCHEM.2009.05.011
403024 - Sideritis lotsyi: 10.1016/J.PHYTOCHEM.2009.05.011
155263 - Sideritis soluta: 10.1016/J.PHYTOCHEM.2009.05.011
176613 - Smallanthus uvedalia: 10.1016/0031-9422(88)80463-1
471149 - Solidago nemoralis: 10.1016/S0031-9422(00)83939-4
2067377 - Stilpnopappus glomeratus: 10.1016/S0031-9422(00)82414-0
547782 - Symphyotrichum undulatum:
118510 - Tanacetum cinerariifolium: 10.1016/S0031-9422(00)94177-3
41396 - Tectona grandis:
354522 - Tetradium glabrifolium: 10.1002/JCCS.199500128
1209860 - Teucrium heterophyllum: 10.1016/S0031-9422(00)90719-2
161594 - Trachyrhamphus serratus: 10.1007/S10600-011-9966-5
1640458 - Trichilia claussenii: 10.1016/0031-9422(95)00969-8
458696 - Tripterygium wilfordii: 10.1002/RECL.19961150115
329212 - Turnera diffusa: 10.1021/NP060253R
138038 - Vachellia pennatula: 10.1007/S10600-005-0133-8
159071 - Zanthoxylum ailanthoides:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
I Lacatusu, N Badea, R Stan, A Meghea. Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol. Nanotechnology. 2012 Nov; 23(45):455702. doi: 10.1088/0957-4484/23/45/455702. [PMID: 23064178]
Minh T Ta, Tamar S Kapterian, Weihua Fei, Ximing Du, Andrew J Brown, Ian W Dawes, Hongyuan Yang. Accumulation of squalene is associated with the clustering of lipid droplets. The FEBS journal. 2012 Nov; 279(22):4231-44. doi: 10.1111/febs.12015. [PMID: 23013491]
Zhubo Dai, Yi Liu, Luqi Huang, Xueli Zhang. Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae. Biotechnology and bioengineering. 2012 Nov; 109(11):2845-53. doi: 10.1002/bit.24547. [PMID: 22566191]
Michael R Rasch, Christian A Bosoy, Yixuan Yu, Brian A Korgel. Chains, sheets, and droplets: assemblies of hydrophobic gold nanocrystals with saturated phosphatidylcholine lipid and squalene. Langmuir : the ACS journal of surfaces and colloids. 2012 Oct; 28(43):15160-7. doi: 10.1021/la302734r. [PMID: 23033891]
Eleni Naziri, Fani Mantzouridou, Maria Z Tsimidou. Recovery of squalene from wine lees using ultrasound assisted extraction-a feasibility study. Journal of agricultural and food chemistry. 2012 Sep; 60(36):9195-201. doi: 10.1021/jf301059y. [PMID: 22888984]
Ga-Hee Shin, Markus Veen, Ulf Stahl, Christine Lang. Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. Yeast (Chichester, England). 2012 Sep; 29(9):371-83. doi: 10.1002/yea.2916. [PMID: 22926964]
G Niculae, I Lacatusu, N Badea, A Meghea. Lipid nanoparticles based on butyl-methoxydibenzoylmethane: in vitro UVA blocking effect. Nanotechnology. 2012 Aug; 23(31):315704. doi: 10.1088/0957-4484/23/31/315704. [PMID: 22797534]
Gero P Hooff, W Gibson Wood, Ji-Hyun Kim, Urule Igbavboa, Wei-Yi Ong, Walter E Muller, Gunter P Eckert. Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. Molecular neurobiology. 2012 Aug; 46(1):179-85. doi: 10.1007/s12035-012-8285-6. [PMID: 22692983]
Zhidong Xu, Kevin A Harvey, Thomas Pavlina, Guy Dutot, Mary Hise, Gary P Zaloga, Rafat A Siddiqui. Steroidal compounds in commercial parenteral lipid emulsions. Nutrients. 2012 08; 4(8):904-21. doi: 10.3390/nu4080904. [PMID: 23016123]
Didier Desmaële, Ruxandra Gref, Patrick Couvreur. Squalenoylation: a generic platform for nanoparticular drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2012 Jul; 161(2):609-18. doi: 10.1016/j.jconrel.2011.07.038. [PMID: 21840355]
José M Lou-Bonafonte, Carmen Arnal, María A Navarro, Jesús Osada. Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development. Molecular nutrition & food research. 2012 Jul; 56(7):1043-57. doi: 10.1002/mnfr.201100668. [PMID: 22760979]
Masumi Kamiyama, Takayuki Shibamoto. Flavonoids with potent antioxidant activity found in young green barley leaves. Journal of agricultural and food chemistry. 2012 Jun; 60(25):6260-7. doi: 10.1021/jf301700j. [PMID: 22681491]
John Lokvam, Paul V A Fine. An oxidized squalene derivative from Protium subserratum Engl. (Engl.) growing in Peru. Molecules (Basel, Switzerland). 2012 Jun; 17(6):7451-7. doi: 10.3390/molecules17067451. [PMID: 22706374]
Markus Schröder, Walter Vetter. Investigation of unsaponifiable matter of plant oils and isolation of eight phytosterols by means of high-speed counter-current chromatography. Journal of chromatography. A. 2012 May; 1237(?):96-105. doi: 10.1016/j.chroma.2012.03.033. [PMID: 22481107]
Wajid Waheed Bhat, Surrinder K Lattoo, Sumeer Razdan, Niha Dhar, Satiander Rana, Rekha S Dhar, Shabnam Khan, Ram A Vishwakarma. Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal. Gene. 2012 May; 499(1):25-36. doi: 10.1016/j.gene.2012.03.004. [PMID: 22425978]
Björn Pasternak, Henrik Svanström, Ditte Mølgaard-Nielsen, Tyra G Krause, Hanne-Dorthe Emborg, Mads Melbye, Anders Hviid. Vaccination against pandemic A/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark. BMJ (Clinical research ed.). 2012 May; 344(?):e2794. doi: 10.1136/bmj.e2794. [PMID: 22551713]
Hisashi Omura, Nanako Yanai, Keiichi Honda. Sexual dimorphism in scent substances and cuticular lipids of adult Papilio protenor butterflies. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2012 May; 67(5-6):331-41. doi: 10.1515/znc-2012-5-614. [PMID: 22888540]
Gadham Setty Saayi Krushna, Mohammed Abdul Kareem, Vaddi Damodara Reddy, Pannuru Padmavathi, Shaik Althaf Hussain, Lakshmi Devi Kodidhela. Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats. Journal of clinical biochemistry and nutrition. 2012 May; 50(3):199-204. doi: 10.3164/jcbn.11-69. [PMID: 22573921]
Carmen Cabrera-Vique, Rocío Marfil, Rafael Giménez, Olga Martínez-Augustin. Bioactive compounds and nutritional significance of virgin argan oil--an edible oil with potential as a functional food. Nutrition reviews. 2012 May; 70(5):266-79. doi: 10.1111/j.1753-4887.2012.00478.x. [PMID: 22537213]
Sergio Granados-Principal, Jose L Quiles, Cesar L Ramirez-Tortosa, Julio Ochoa-Herrera, Patricia Perez-Lopez, Mario Pulido-Moran, M Carmen Ramirez-Tortosa. Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages. Molecular nutrition & food research. 2012 May; 56(5):733-40. doi: 10.1002/mnfr.201100703. [PMID: 22648620]
Jordi Tronchoni, Nicolas Rozès, Amparo Querol, José Manuel Guillamón. Lipid composition of wine strains of Saccharomyces kudriavzevii and Saccharomyces cerevisiae grown at low temperature. International journal of food microbiology. 2012 Apr; 155(3):191-8. doi: 10.1016/j.ijfoodmicro.2012.02.004. [PMID: 22405355]
Komar Ruslan, Anggrahaeni Dewi Selfitri, Shella A Bulan, Yaya Rukayadi, Elfahmi. Effect of Agrobacterium rhizogenes and elicitation on the asiaticoside production in cell cultures of Centella asiatica. Pharmacognosy magazine. 2012 Apr; 8(30):111-5. doi: 10.4103/0973-1296.96552. [PMID: 22701283]
A Calmy, M Bel, A Nguyen, C Combescure, C Delhumeau, S Meier, S Yerly, L Kaiser, B Hirschel, C-A Siegrist. Strong serological responses and HIV RNA increase following AS03-adjuvanted pandemic immunization in HIV-infected patients. HIV medicine. 2012 Apr; 13(4):207-18. doi: 10.1111/j.1468-1293.2011.00961.x. [PMID: 22093373]
Miroslava Spanova, Dagmar Zweytick, Karl Lohner, Lisa Klug, Erich Leitner, Albin Hermetter, Günther Daum. Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae. Biochimica et biophysica acta. 2012 Apr; 1821(4):647-53. doi: 10.1016/j.bbalip.2012.01.015. [PMID: 22342273]
Raveen Parboosing, Glenn E M Maguire, Patrick Govender, Hendrik G Kruger. Nanotechnology and the treatment of HIV infection. Viruses. 2012 04; 4(4):488-520. doi: 10.3390/v4040488. [PMID: 22590683]
Ebru Oral, Bassem W Ghali, Andrew Neils, Orhun K Muratoglu. A new mechanism of oxidation in ultrahigh molecular weight polyethylene caused by squalene absorption. Journal of biomedical materials research. Part B, Applied biomaterials. 2012 Apr; 100(3):742-51. doi: 10.1002/jbm.b.32507. [PMID: 22190411]
Minu Joseph, M Dolors Ludevid, Margarita Torrent, Valérie Rofidal, Marc Tauzin, Michel Rossignol, Jean-Benoit Peltier. Proteomic characterisation of endoplasmic reticulum-derived protein bodies in tobacco leaves. BMC plant biology. 2012 Mar; 12(?):36. doi: 10.1186/1471-2229-12-36. [PMID: 22424442]
Tom D Niehaus, Scott Kinison, Shigeru Okada, Yun-soo Yeo, Stephen A Bell, Ping Cui, Timothy P Devarenne, Joe Chappell. Functional identification of triterpene methyltransferases from Botryococcus braunii race B. The Journal of biological chemistry. 2012 Mar; 287(11):8163-73. doi: 10.1074/jbc.m111.316059. [PMID: 22241476]
Zheyong Xue, Lixin Duan, Dan Liu, Jie Guo, Song Ge, Jo Dicks, Paul ÓMáille, Anne Osbourn, Xiaoquan Qi. Divergent evolution of oxidosqualene cyclases in plants. The New phytologist. 2012 Mar; 193(4):1022-1038. doi: 10.1111/j.1469-8137.2011.03997.x. [PMID: 22150097]
Bernd Genser, Günther Silbernagel, Guy De Backer, Eric Bruckert, Rafael Carmena, M John Chapman, John Deanfield, Olivier S Descamps, Ernst R Rietzschel, Karen C Dias, Winfried März. Plant sterols and cardiovascular disease: a systematic review and meta-analysis. European heart journal. 2012 Feb; 33(4):444-51. doi: 10.1093/eurheartj/ehr441. [PMID: 22334625]
Anastasia C Weeks, Charles L Balzli, Armando Caballero, Aihua Tang, Richard O'Callaghan. Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin. Current eye research. 2012 Feb; 37(2):87-93. doi: 10.3109/02713683.2011.624669. [PMID: 22050601]
Nobutaka Hanagata. Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. International journal of nanomedicine. 2012; 7(?):2181-95. doi: 10.2147/ijn.s30197. [PMID: 22619554]
Victor J Valdes, Alejandro Athie, Laura S Salinas, Rosa E Navarro, Luis Vaca. CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. PloS one. 2012; 7(3):e33962. doi: 10.1371/journal.pone.0033962. [PMID: 22479487]
Consolacion Y Ragasa, Dinah L Espineli, Chien-Chang Shen. A new triterpene from Barringtonia asiatica. Natural product research. 2012; 26(20):1869-75. doi: 10.1080/14786419.2011.619187. [PMID: 21929282]
Rahele Ghanbari, Farooq Anwar, Khalid M Alkharfy, Anwarul-Hassan Gilani, Nazamid Saari. Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review. International journal of molecular sciences. 2012; 13(3):3291-3340. doi: 10.3390/ijms13033291. [PMID: 22489153]
Mariarosaria Marinaro, Giovanni Rezza, Giuseppe Del Giudice, Valeriana Colao, Elvira Tarsitano, Michele Camero, Michele Losurdo, Canio Buonavoglia, Maria Tempesta. A caprine herpesvirus 1 vaccine adjuvanted with MF59™ protects against vaginal infection and interferes with the establishment of latency in goats. PloS one. 2012; 7(4):e34913. doi: 10.1371/journal.pone.0034913. [PMID: 22511971]
Ji-Ho Lim, Sung-Kyun You, Jong-Suep Baek, Chan-Ju Hwang, Young-Guk Na, Sang-Chul Shin, Cheong-Weon Cho. Preparation and evaluation of polymeric microparticulates for improving cellular uptake of gemcitabine. International journal of nanomedicine. 2012; 7(?):2307-14. doi: 10.2147/ijn.s30465. [PMID: 22661887]
Iti Som, Kashish Bhatia, Mohd Yasir. Status of surfactants as penetration enhancers in transdermal drug delivery. Journal of pharmacy & bioallied sciences. 2012 Jan; 4(1):2-9. doi: 10.4103/0975-7406.92724. [PMID: 22368393]
Tomoko Toyama, Michiru Tahara, Kisaburo Nagamune, Kenji Arimitsu, Yoshio Hamashima, Nirianne M Q Palacpac, Hiroshi Kawaide, Toshihiro Horii, Kazuyuki Tanabe. Gibberellin biosynthetic inhibitors make human malaria parasite Plasmodium falciparum cells swell and rupture to death. PloS one. 2012; 7(3):e32246. doi: 10.1371/journal.pone.0032246. [PMID: 22412858]
Vladimir Kostyuk, Alla Potapovich, Andrea Stancato, Chiara De Luca, Daniela Lulli, Saveria Pastore, Liudmila Korkina. Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes. PloS one. 2012; 7(8):e44472. doi: 10.1371/journal.pone.0044472. [PMID: 22952984]
Jacqueline Surls, Cristina Nazarov-Stoica, Margaret Kehl, Cara Olsen, Sofia Casares, Teodor-D Brumeanu. Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. PloS one. 2012; 7(6):e38733. doi: 10.1371/journal.pone.0038733. [PMID: 22723880]
Sherif Hanafy, Ayman O S El-Kadi, Fakhreddin Jamali. Effect of inflammation on molecular targets and drug transporters. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2012; 15(3):361-75. doi: 10.18433/j30300. [PMID: 22974786]
Tokuma Fukuoka, Takashi Yanagihara, Seya Ito, Tomohiro Imura, Tomotake Morita, Hideki Sakai, Masahiko Abe, Dai Kitamoto. Reverse vesicle formation from the yeast glycolipid biosurfactant mannosylerythritol lipid-D. Journal of oleo science. 2012; 61(5):285-9. doi: 10.5650/jos.61.285. [PMID: 22531056]
Shashi Kumar, Frederick M Hahn, Edward Baidoo, Talwinder S Kahlon, Delilah F Wood, Colleen M McMahan, Katrina Cornish, Jay D Keasling, Henry Daniell, Maureen C Whalen. Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. Metabolic engineering. 2012 Jan; 14(1):19-28. doi: 10.1016/j.ymben.2011.11.005. [PMID: 22123257]
Bagavathi Perumal Ezhilan, Ramasamy Neelamegam. GC-MS analysis of phytocomponents in the ethanol extract of Polygonum chinense L. Pharmacognosy research. 2012 Jan; 4(1):11-4. doi: 10.4103/0974-8490.91028. [PMID: 22224055]
Melisa Gualdron-López, Miia H Vapola, Ilkka J Miinalainen, J Kalervo Hiltunen, Paul A M Michels, Vasily D Antonenkov. Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PloS one. 2012; 7(4):e34530. doi: 10.1371/journal.pone.0034530. [PMID: 22506025]
Gero Steinberg. Cytoplasmic fungal lipases release fungicides from ultra-deformable vesicular drug carriers. PloS one. 2012; 7(5):e38181. doi: 10.1371/journal.pone.0038181. [PMID: 22666476]
Gonzalo Obal, Ana Lía Ramos, Valeria Silva, Analía Lima, Carlos Batthyany, María Inés Bessio, Fernando Ferreira, Gustavo Salinas, Ana María Ferreira. Characterisation of the native lipid moiety of Echinococcus granulosus antigen B. PLoS neglected tropical diseases. 2012; 6(5):e1642. doi: 10.1371/journal.pntd.0001642. [PMID: 22616019]
Xin Hua Zhang, Jaime A Teixeira da Silva, Yong Xia Jia, Jie Tang Zhao, Guo Hua Ma. Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods. Natural product communications. 2012 Jan; 7(1):93-6. doi: ". [PMID: 22428257]
Jittra Suthiwong, Kitisak Poopasit, Chavi Yenjai. A new phenolic compound from the stem of Hymenocardia wallichii. Journal of Asian natural products research. 2012; 14(5):482-5. doi: 10.1080/10286020.2012.669377. [PMID: 22423644]
Manoj Kumar, Ravinder Nagpal, Rajesh Kumar, R Hemalatha, Vinod Verma, Ashok Kumar, Chaitali Chakraborty, Birbal Singh, Francesco Marotta, Shalini Jain, Hariom Yadav. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Experimental diabetes research. 2012; 2012(?):902917. doi: 10.1155/2012/902917. [PMID: 22611376]
Lakshmi P Manavalan, Xi Chen, Joseph Clarke, John Salmeron, Henry T Nguyen. RNAi-mediated disruption of squalene synthase improves drought tolerance and yield in rice. Journal of experimental botany. 2012 Jan; 63(1):163-75. doi: 10.1093/jxb/err258. [PMID: 21926092]
Thi Nga Vo, Phi Linh Nguyen, Lam Truong Tuong, Lawrence Michael Pratt, Phung Nguyen Vo, Kim Phi Phung Nguyen, Ngoc Suong Nguyen. Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum. Chemical & pharmaceutical bulletin. 2012; 60(9):1125-33. doi: 10.1248/cpb.c12-00222. [PMID: 22976320]
Hongmei Luo, Chao Sun, Yongzhen Sun, Qiong Wu, Ying Li, Jingyuan Song, Yunyun Niu, Xianglin Cheng, Hongxi Xu, Chuyuan Li, Juyan Liu, André Steinmetz, Shilin Chen. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. BMC genomics. 2011 Dec; 12 Suppl 5(?):S5. doi: 10.1186/1471-2164-12-s5-s5. [PMID: 22369100]
Jesper S Hansen, Ardcharaporn Vararattanavech, Thomas Vissing, Jaume Torres, Jenny Emnéus, Claus Hélix-Nielsen. Formation of giant protein vesicles by a lipid cosolvent method. Chembiochem : a European journal of chemical biology. 2011 Dec; 12(18):2856-62. doi: 10.1002/cbic.201100537. [PMID: 22069223]
Tânia R Cabrito, Miguel C Teixeira, Ashutosh Singh, Rajendra Prasad, Isabel Sá-Correia. The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. The Biochemical journal. 2011 Dec; 440(2):195-202. doi: 10.1042/bj20110876. [PMID: 21831043]
Sherif Hanafy, Mahtab Tavasoli, Fakhreddin Jamali. Inflammation alters angiotensin converting enzymes (ACE and ACE-2) balance in rat heart. Inflammation. 2011 Dec; 34(6):609-13. doi: 10.1007/s10753-010-9269-1. [PMID: 21053061]
M Vyssotski, K C-Y Lee, K Lagutin, J Ryan, X C Morgan, M B Stott. Fatty Acids of Chthonomonas calidirosea, of a novel class Chthonomonadetes from a recently described phylum Armatimonadetes. Lipids. 2011 Dec; 46(12):1155-61. doi: 10.1007/s11745-011-3597-2. [PMID: 21805326]
Christopher B Fox, Susan L Baldwin, Malcolm S Duthie, Steven G Reed, Thomas S Vedvick. Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. Vaccine. 2011 Nov; 29(51):9563-72. doi: 10.1016/j.vaccine.2011.08.089. [PMID: 21906648]
Alon Ben-Gal, Arnon Dag, Loai Basheer, Uri Yermiyahu, Isaac Zipori, Zohar Kerem. The influence of bearing cycles on olive oil quality response to irrigation. Journal of agricultural and food chemistry. 2011 Nov; 59(21):11667-75. doi: 10.1021/jf202324x. [PMID: 21950468]
Alexander R Precioso, João L Miraglia, Lúcia Maria A Campos, Alessandra C Goulart, Maria do Carmo S T Timenetsky, Maria Regina A Cardoso, Expedito Luna, Gabriella Mondini, José da S Guedes, Isaias Raw. A phase I randomized, double-blind, controlled trial of 2009 influenza A (H1N1) inactivated monovalent vaccines with different adjuvant systems. Vaccine. 2011 Nov; 29(48):8974-81. doi: 10.1016/j.vaccine.2011.09.040. [PMID: 21945258]
Kristin Baumann, Núria Adelantado, Christine Lang, Diethard Mattanovich, Pau Ferrer. Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. Microbial cell factories. 2011 Nov; 10(?):93. doi: 10.1186/1475-2859-10-93. [PMID: 22050768]
Chih-Jen Wen, Tzu-Chen Yen, Saleh A Al-Suwayeh, Hui-Wen Chang, Jia-You Fang. In vivo real-time fluorescence visualization and brain-targeting mechanisms of lipid nanocarriers with different fatty ester:oil ratios. Nanomedicine (London, England). 2011 Nov; 6(9):1545-59. doi: 10.2217/nnm.11.46. [PMID: 22077462]
Gabriela Soto, Margarita Stritzler, Christian Lisi, Karina Alleva, María Elba Pagano, Fernando Ardila, Matteo Mozzicafreddo, Massimiliano Cuccioloni, Mauro Angeletti, Nicolás Daniel Ayub. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. Journal of experimental botany. 2011 Nov; 62(15):5699-711. doi: 10.1093/jxb/err287. [PMID: 21908473]
Nilufer E Broeders, Anneleen Hombrouck, Anne Lemy, Karl Martin Wissing, Judith Racapé, Karine Gastaldello, Annick Massart, Steven Van Gucht, Laura Weichselbaum, Aurelie De Mul, Bernard Brochier, Isabelle Thomas, Daniel Abramowicz. Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis: a cohort study. Clinical journal of the American Society of Nephrology : CJASN. 2011 Nov; 6(11):2573-8. doi: 10.2215/cjn.04670511. [PMID: 21921153]
Bingji Ma, Wei Ren, Yan Zhou, Jinchuan Ma, Yuan Ruan, Chun-Nan Wen. Triterpenoids from the spores of Ganoderma lucidum. North American journal of medical sciences. 2011 Nov; 3(11):495-8. doi: 10.4297/najms.2011.3495. [PMID: 22361494]
Farid Khallouki, Roswitha Haubner, Cornelia M Ulrich, Robert W Owen. Ethnobotanical survey, chemical composition, and antioxidant capacity of methanolic extract of the root bark of Annona cuneata Oliv. Journal of medicinal food. 2011 Nov; 14(11):1397-402. doi: 10.1089/jmf.2010.0228. [PMID: 21870939]
Jennifer M Friederichs, Suman Ghosh, Christine J Smoyer, Scott McCroskey, Brandon D Miller, Kyle J Weaver, Kym M Delventhal, Jay Unruh, Brian D Slaughter, Sue L Jaspersen. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. PLoS genetics. 2011 Nov; 7(11):e1002365. doi: 10.1371/journal.pgen.1002365. [PMID: 22125491]
Karin Athenstaedt. YALI0E32769g (DGA1) and YALI0E16797g (LRO1) encode major triacylglycerol synthases of the oleaginous yeast Yarrowia lipolytica. Biochimica et biophysica acta. 2011 Oct; 1811(10):587-96. doi: 10.1016/j.bbalip.2011.07.004. [PMID: 21782973]
Fatima Zohra Mharti, Badiaa Lyoussi, Abdelfattah Abdellaoui. Antibacterial activity of the essential oils of Pistacia lentiscus used in Moroccan folkloric medicine. Natural product communications. 2011 Oct; 6(10):1505-6. doi: . [PMID: 22164794]
Dennis D Raga, Glorina N Pocsidio, Annabelle A Herrera. Effects of the oral administration of nonpolar extract from Ardisia squamulosa Presl (Myrsinaceae) leaves on spermatogenesis in rats. Pharmacognosy research. 2011 Oct; 3(4):260-5. doi: 10.4103/0974-8490.89747. [PMID: 22224050]
Dylan Mackay, Peter J H Jones. Evaluation of methods for the determination of cholesterol absorption and synthesis in humans. Atherosclerosis. 2011 Oct; 218(2):253-62. doi: 10.1016/j.atherosclerosis.2010.04.022. [PMID: 21763652]
Fernando Warleta, Cristina Sánchez Quesada, María Campos, Yosra Allouche, Gabriel Beltrán, José J Gaforio. Hydroxytyrosol protects against oxidative DNA damage in human breast cells. Nutrients. 2011 10; 3(10):839-57. doi: 10.3390/nu3100839. [PMID: 22254082]
Eleni Naziri, Fani Mantzouridou, Maria Z Tsimidou. Enhanced squalene production by wild-type Saccharomyces cerevisiae strains using safe chemical means. Journal of agricultural and food chemistry. 2011 Sep; 59(18):9980-9. doi: 10.1021/jf201328a. [PMID: 21806066]
Ignacio Párraga, Jesús López-Torres, Fernando Andrés, Beatriz Navarro, José M del Campo, Mercedes García-Reyes, María P Galdón, Angeles Lloret, Juan C Precioso, Joseba Rabanales. Effect of plant sterols on the lipid profile of patients with hypercholesterolaemia. Randomised, experimental study. BMC complementary and alternative medicine. 2011 Sep; 11(?):73. doi: 10.1186/1472-6882-11-73. [PMID: 21910898]
Ifeanyichukwu O Okike, Chee Yung, Shamez Ladhani, Clarissa Oeser, Aisleen Bennett, Katja Doerholt, Sharon Storey, Sheila Donaghy, Nigel Butter, Katja Hoschler, Liz Sheasby, Paul T Heath, Elizabeth Miller. The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children. Vaccine. 2011 Sep; 29(38):6636-40. doi: 10.1016/j.vaccine.2011.06.103. [PMID: 21742005]
Madhesh Murugesan, Ramalingam Revathi, Vaiyapuri Manju. Cardioprotective effect of fenugreek on isoproterenol-induced myocardial infarction in rats. Indian journal of pharmacology. 2011 Sep; 43(5):516-9. doi: 10.4103/0253-7613.84957. [PMID: 22021992]
G Lupattelli, S De Vuono, E Mannarino. Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2011 Sep; 21(9):620-7. doi: 10.1016/j.numecd.2011.04.010. [PMID: 21855307]
Luis A Brito, Michelle Chan, Barbara Baudner, Simona Gallorini, George Santos, Derek T O'Hagan, Manmohan Singh. An alternative renewable source of squalene for use in emulsion adjuvants. Vaccine. 2011 Aug; 29(37):6262-8. doi: 10.1016/j.vaccine.2011.06.067. [PMID: 21723355]
Nadia Alam, Monzur Hossain, Md Ibrahim Khalil, Mohammed Moniruzzaman, Siti Amrah Sulaiman, Siew Hua Gan. High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis. BMC complementary and alternative medicine. 2011 Aug; 11(?):65. doi: 10.1186/1472-6882-11-65. [PMID: 21854608]
Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young-Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi, Teruo Kawada. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. The Biochemical journal. 2011 Aug; 438(1):111-9. doi: 10.1042/bj20101939. [PMID: 21605082]
Christine Dawczynski, Ursula Hackermeier, Martin Viehweger, Rainer Stange, Monika Springer, Gerhard Jahreis. Incorporation of n-3 PUFA and γ-linolenic acid in blood lipids and red blood cell lipids together with their influence on disease activity in patients with chronic inflammatory arthritis--a randomized controlled human intervention trial. Lipids in health and disease. 2011 Aug; 10(?):130. doi: 10.1186/1476-511x-10-130. [PMID: 21816071]
Karel Stránský, Irena Valterová, Edita Kofroňová, Klára Urbanová, Marie Zarevúcka, Zdeněk Wimmer. Non-polar lipid components of human cerumen. Lipids. 2011 Aug; 46(8):781-8. doi: 10.1007/s11745-011-3564-y. [PMID: 21547555]
Francisco Cen-Pacheco, Janny A Villa-Pulgarin, Faustino Mollinedo, Manuel Norte, Antonio H Daranas, José J Fernández. Cytotoxic oxasqualenoids from the red alga Laurencia viridis. European journal of medicinal chemistry. 2011 Aug; 46(8):3302-8. doi: 10.1016/j.ejmech.2011.04.051. [PMID: 21616566]
Kelly Ishida, Gonzalo Visbal, Juliany Cola Fernandes Rodrigues, Julio A Urbina, Wanderley de Souza, Sonia Rozental. Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2011 Aug; 17(4):563-70. doi: 10.1007/s10156-010-0190-1. [PMID: 21264486]
Maria Carelli, Elisa Biazzi, Francesco Panara, Aldo Tava, Laura Scaramelli, Andrea Porceddu, Neil Graham, Miriam Odoardi, Efisio Piano, Sergio Arcioni, Sean May, Carla Scotti, Ornella Calderini. Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins. The Plant cell. 2011 Aug; 23(8):3070-81. doi: 10.1105/tpc.111.087312. [PMID: 21821776]
Theodora Psaltopoulou, Rena I Kosti, Dimitrios Haidopoulos, Meletios Dimopoulos, Demosthenes B Panagiotakos. Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies. Lipids in health and disease. 2011 Jul; 10(?):127. doi: 10.1186/1476-511x-10-127. [PMID: 21801436]
Zhi-Hong Yang, Hiroko Miyahara, Akimasa Hatanaka. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids in health and disease. 2011 Jul; 10(?):120. doi: 10.1186/1476-511x-10-120. [PMID: 21774832]
Qi Tang, Xiaojun Ma, Changming Mo, Iain W Wilson, Cai Song, Huan Zhao, Yanfang Yang, Wei Fu, Deyou Qiu. An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis. BMC genomics. 2011 Jul; 12(?):343. doi: 10.1186/1471-2164-12-343. [PMID: 21729270]
Wei Wu, Man Yuan, Qing Zhang, Yanming Zhu, Li Yong, Wei Wang, Yan Qi, Dianjing Guo. Chemotype-dependent metabolic response to methyl jasmonate elicitation in Artemisia annua. Planta medica. 2011 Jul; 77(10):1048-53. doi: 10.1055/s-0030-1250744. [PMID: 21267809]
Cyril Brendolise, Yar-Khing Yauk, Ellen D Eberhard, Mindy Wang, David Chagne, Christelle Andre, David R Greenwood, Lesley L Beuning. An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. The FEBS journal. 2011 Jul; 278(14):2485-99. doi: 10.1111/j.1742-4658.2011.08175.x. [PMID: 21575133]
Radava R Korać, Kapil M Khambholja. Potential of herbs in skin protection from ultraviolet radiation. Pharmacognosy reviews. 2011 Jul; 5(10):164-73. doi: 10.4103/0973-7847.91114. [PMID: 22279374]
Mouna Raouane, Didier Desmaele, Marie Gilbert-Sirieix, Claire Gueutin, Fatima Zouhiri, Claudie Bourgaux, Elise Lepeltier, Ruxandra Gref, Ridha Ben Salah, Gary Clayman, Liliane Massaad-Massade, Patrick Couvreur. Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma. Journal of medicinal chemistry. 2011 Jun; 54(12):4067-76. doi: 10.1021/jm2000272. [PMID: 21561161]
Joanne M Langley, George Risi, Michael Caldwell, Larry Gilderman, Bruce Berwald, Charles Fogarty, Terry Poling, Dennis Riff, Mira Baron, Louise Frenette, Eric Sheldon, Harry Collins, Marc Shepard, Marc Dionne, Daniel Brune, Linda Ferguson, David Vaughn, Ping Li, Louis Fries. Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized study. The Journal of infectious diseases. 2011 Jun; 203(12):1729-38. doi: 10.1093/infdis/jir172. [PMID: 21606531]
Li Zhang, Wen-Hwa Li, Michael Anthonavage, Apostolos Pappas, Dianne Rossetti, Druie Cavender, Miri Seiberg, Magdalena Eisinger. Melanocortin-5 receptor and sebogenesis. European journal of pharmacology. 2011 Jun; 660(1):202-6. doi: 10.1016/j.ejphar.2010.10.100. [PMID: 21215742]
Mohammad Othman, Didier Desmaële, Patrick Couvreur, Luce Vander Elst, Sophie Laurent, Robert N Muller, Claudie Bourgaux, Estelle Morvan, Thierry Pouget, Sinda Lepêtre-Mouelhi, Philippe Durand, Ruxandra Gref. Synthesis and physicochemical characterization of new squalenoyl amphiphilic gadolinium complexes as nanoparticle contrast agents. Organic & biomolecular chemistry. 2011 Jun; 9(11):4367-86. doi: 10.1039/c1ob00015b. [PMID: 21487599]
Andrew J Brasser, Christopher A Barwacz, Deborah V Dawson, Kim A Brogden, David R Drake, Philip W Wertz. Presence of wax esters and squalene in human saliva. Archives of oral biology. 2011 Jun; 56(6):588-91. doi: 10.1016/j.archoralbio.2010.12.002. [PMID: 21247555]
Tim Vanmierlo, Kris Rutten, Leonie C van Vark-van der Zee, Silvia Friedrichs, Vincent W Bloks, Arjan Blokland, Frans C Ramaekers, Eric Sijbrands, Harry Steinbusch, Jos Prickaerts, Folkert Kuipers, Dieter Lütjohann, Monique Mulder. Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. Plant foods for human nutrition (Dordrecht, Netherlands). 2011 Jun; 66(2):149-56. doi: 10.1007/s11130-011-0219-3. [PMID: 21431910]