Salvigenin (BioDeep_00000017527)
Secondary id: BioDeep_00000270172
human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs
代谢物信息卡片
4H-1-Bbenzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-
化学式: C18H16O6 (328.0946836)
中文名称: 三裂鼠尾草素, 三裂鼠尾草素
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 0.06%
分子结构信息
SMILES: C1(OC)=CC2OC(C3C=CC(OC)=CC=3)=CC(=O)C=2C(O)=C1OC
InChI: InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)13-8-12(19)16-14(24-13)9-15(22-2)18(23-3)17(16)20/h4-9,20H,1-3H3
描述信息
Salvigenin, also known as psathyrotin or 7-O-methylpectolinarigenin, is a member of the class of compounds known as 7-O-methylated flavonoids. 7-O-Methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, salvigenin is considered to be a flavonoid lipid molecule. Salvigenin is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Salvigenin has been detected, but not quantified in, several different foods, such as rosemaries, mandarin orange (clementine, tangerine), common sages, sweet basils, and peppermints. This could make salvigenin a potential biomarker for the consumption of these foods. BioTransformer predicts that salvigenin is a product of tetramethylscutellarein metabolism via an O-dealkylation reaction catalyzed by CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 enzymes (PMID: 30612223).
Salvigenin, also known as 5-hydroxy-6,7,4-trimethoxyflavone or 7-O-methylpectolinarigenin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, salvigenin is considered to be a flavonoid lipid molecule. Salvigenin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Salvigenin can be found in a number of food items such as sweet basil, mandarin orange (clementine, tangerine), common sage, and peppermint, which makes salvigenin a potential biomarker for the consumption of these food products.
Salvigenin is a trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4, 6, and 7 are replaced by methoxy groups. It has a role as an autophagy inducer, an apoptosis inhibitor, an antilipemic drug, an immunomodulator, an antineoplastic agent, a neuroprotective agent, a hypoglycemic agent and a plant metabolite. It is a trimethoxyflavone and a monohydroxyflavone. It is functionally related to a scutellarein.
Salvigenin is a natural product found in Liatris elegans, Achillea santolina, and other organisms with data available.
See also: Tangerine peel (part of).
A trimethoxyflavone that is scutellarein in which the hydroxy groups at positions 4, 6, and 7 are replaced by methoxy groups.
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis[1][2].
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis[1][2].
同义名列表
18 个代谢物同义名
4H-1-Bbenzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-; 5-Hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 5-Hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one; flavone, 5-hydroxy-4,6,7-trimethoxy-; 5-Desmethyltetraraethylscutellarein; 5-hydroxy-6,7,4-trimethoxy-flavone; 5-Hydroxy-6,7,4’-trimethoxyflavone; 5-Hydroxy-4’,6,7-trimethoxyflavone; 5-hydroxy-4,6,7-trimethoxyflavone; 5-hydroxy-6,7,4-trimethoxyflavone; QCDYOIZVELGOLZ-UHFFFAOYSA-N; 7-O-methylpectolinarigenin; Salvigenin-d9; Salvesigenine; psathyrotin; Salvigenin
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:192703
- PubChem: 161271
- HMDB: HMDB0128577
- ChEMBL: CHEMBL376644
- LipidMAPS: LMPK12111166
- MeSH: salvigenin
- ChemIDplus: 0019103549
- MetaCyc: CPD-15477
- KNApSAcK: C00003840
- foodb: FDB006184
- chemspider: 141666
- CAS: 19103-54-9
- medchemexpress: HY-N1318
- PMhub: MS000221284
- MetaboLights: MTBLC192703
分类词条
相关代谢途径
Reactome(0)
代谢反应
84 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(3)
- salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - nevadensin biosynthesis:
2-oxoglutarate + O2 + gardenin B ⟶ CO2 + formaldehyde + nevadensin + succinate - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(81)
- salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
H+ + NADPH + O2 + genkwanin ⟶ H2O + NADP+ + scutellarein 7-methyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
H+ + NADPH + O2 + apigenin-7,4'-dimethyl ether ⟶ H2O + NADP+ + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - nevadensin biosynthesis:
2-oxoglutarate + O2 + gardenin B ⟶ CO2 + formaldehyde + nevadensin + succinate - salvigenin biosynthesis:
SAM + apigenin ⟶ SAH + genkwanin - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
H+ + NADPH + O2 + apigenin-7,4'-dimethyl ether ⟶ H2O + NADP+ + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + apigenin-7,4'-dimethyl ether ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + ladanein - salvigenin biosynthesis:
SAM + genkwanin ⟶ H+ + SAH + apigenin-7,4'-dimethyl ether - salvigenin biosynthesis:
SAM + scutellarein 7-methyl ether ⟶ H+ + SAH + cirsimaritin
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
218 个相关的物种来源信息
- 496633 Jungia polita: 10.1016/0031-9422(92)83741-G
- 1933725 Salvia heldreichiana:
- 1294397 Salvia hypoleuca:
- 1571167 Salvia mirzayanii:
- 1933769 Salvia yosgadensis:
- 49207 Salvia aethiopis:
- 1520031 Salvia lanigera:
- 268896 Salvia candidissima:
- 1571166 Salvia macrosiphon:
- 1298553 Salvia virgata:
- 1685717 Salvia syriaca:
- 1933716 Salvia cyanescens:
- 268912 Salvia verbenaca:
- 49214 Salvia lavandulifolia:
- 268920 Salvia palaestina:
- 95165 Salvia columbariae:
- 1048535 Centaurea cuneifolia:
- 350585 Osyris alba: 10.1080/10286020.2010.502892
- 166995 Montanoa leucantha: 10.1016/S0031-9422(00)89739-3
- 714449 Artemisia anomala:
- 1473222 Artemisia cina: 10.1007/BF00595086
- 401898 Artemisia gmelinii: 10.1007/BF00595086
- 109063 Alnus japonica: 10.1016/0031-9422(74)85049-1
- 3508 Betula nigra: 10.1016/S0031-9422(00)86815-6
- 1685713 Salvia limbata:
- 201290 Trichostema lanatum: 10.1515/ZNC-1992-9-1025
- 207754 Salvia dorrii: 10.1515/ZNC-1992-9-1025
- 149410 Arnica longifolia: 10.1016/S0031-9422(00)89581-3
- 168499 Buddleja macrostachya: 10.1016/0378-8741(84)90075-8
- 1241420 Lantana fucata: 10.1021/NP9002383
- 457732 Schistostephium crataegifolium: 10.1016/0031-9422(83)80100-9
- 1209860 Teucrium heterophyllum: 10.1016/S0031-9422(00)90719-2
- 1123534 Baccharis pedunculata: 10.1016/0031-9422(91)85145-P
- 1227617 Artemisia assoana: 10.1016/S0031-9422(00)83891-1
- 282760 Achillea pseudopectinata: 10.1055/S-2007-969447
- 282770 Achillea virescens:
- 65409 Scutellaria baicalensis: 10.1248/YAKUSHI1947.104.5_529
- 85571 Citrus reticulata: 10.1248/CPB.41.714
- 558547 Citrus deliciosa: 10.1248/CPB.41.714
- 363453 Centaurea spinosa:
- 102784 Liatris elegans: 10.1080/14786410903027789
- 301866 Achillea tenuifolia: 10.1016/S0031-9422(99)00054-0
- 1028379 Achillea santolina: 10.1016/S0031-9422(99)00054-0
- 204151 Orthosiphon aristatus:
- 1585254 Salvia moorcroftiana: 10.1078/094471102321621386
- 124926 Centaurea cineraria: 10.1016/0031-9422(88)80467-9
- 49215 Salvia nemorosa: 10.1016/S0031-9422(00)90672-1
- 282767 Achillea setacea: 10.1016/0305-1978(88)90071-3
- 542674 Phyla dulcis:
- 359922 Achillea formosa: 10.1515/ZNC-1989-3-423
- 301871 Leucocyclus formosus: 10.1515/ZNC-1989-3-423
- 312798 Ferula aucheri: 10.1016/0031-9422(94)00840-P
- 306376 Plectranthus fruticosus: 10.1021/NP030490J
- 2485406 Coleus sylvestris: 10.1021/NP030490J
- 39350 Ocimum basilicum:
- 1550803 Brickellia baccharidea: 10.1016/S0031-9422(00)98581-9
- 983213 Liatris aspera: 10.1016/0031-9422(83)83036-2
- 1933756 Salvia sahendica:
- 403027 Sideritis nutans: 10.1021/NP50057A027
- 925377 Aloysia citrodora: 10.1055/S-2006-962505
- 1550814 Brickellia dentata: 10.1016/0031-9422(80)85136-3
- 2291707 Marrubium velutinum: 10.1016/J.PHYTOCHEM.2005.02.029
- 650269 Mentha aquatica var. citrata:
- 41657 Ursinia nana: 10.1016/0031-9422(82)80131-3
- 1933767 Salvia wiedemannii: 10.1016/0031-9422(91)83665-8
- 268899 Salvia chionopeplica:
- 268888 Salvia amplexicaulis:
- 268906 Salvia fruticosa:
- 38868 Salvia officinalis:
- 588964 Salvia prionitis:
- 226208 Salvia miltiorrhiza:
- 1933710 Salvia caespitosa: 10.1080/10575630108041297
- 282771 Achillea wilhelmsii: 10.4268/CJCMM20150722
- 301867 Achillea vermicularis: 10.1016/0305-1978(91)90061-4
- 13329 Achillea millefolium: 10.1016/0031-9422(90)85371-L
- 482483 Achillea millefolium var. millefolium: 10.1016/0031-9422(90)85371-L
- 282720 Achillea aspleniifolia: 10.1016/0031-9422(90)85371-L
- 980664 Lepechinia caulescens: 10.1016/0031-9422(92)83466-C
- 204211 Callicarpa americana: 10.1021/NP060534Z
- 38869 Salvia sclarea: 10.1016/S0031-9422(00)90474-6
- 211591 Iphiona scabra: 10.1016/S0031-9422(00)81848-8
- 392666 Salvia hydrangea: 10.1021/NP200559C
- 28940 Nothofagus dombeyi: 10.1016/J.PHYTOCHEM.2004.04.002
- 145513 Centaurea raphanina: 10.1021/NP50021A025
- 1209871 Teucrium massiliense: 10.1016/S0031-9422(00)85040-2
- 1117157 Teucrium polium:
- 1854018 Teucrium alyssifolium:
- 2072395 Centaurea scoparia: 10.1055/S-2006-959378
- 49994 Volkameria inermis:
- 190902 Mentha aquatica: 10.1016/S0031-9422(98)00672-4
- 315439 Bellardia trixago: 10.3109/13880209009082777
- 2029211 Achillea sibirica: 10.1016/S0305-1978(98)00112-4
- 282741 Achillea impatiens: 10.1016/S0305-1978(98)00112-4
- 1685712 Salvia ceratophylla: 10.1016/0031-9422(95)00416-5
- 145508 Centaurea ornata: 10.1021/NP50069A006
- 167007 Montanoa tomentosa: 10.1016/0031-9422(91)85045-2
- 204141 Ocimum americanum:
- 1224218 Ocimum kilimandscharicum: 10.1016/S0031-9422(00)00439-8
- 1933761 Salvia tchihatcheffii:
- 1281416 Coleus hadiensis: 10.1002/HLCA.200490210
- 436459 Arnica acaulis: 10.1016/0031-9422(88)80605-8
- 53177 Teucrium flavum: 10.1016/S0031-9422(00)85039-6
- 986249 Mesosphaerum urticoides: 10.1016/0031-9422(91)83668-B
- 1423403 Teucrium leucocladum: 10.1016/J.BSE.2003.12.009
- 1138119 Pseudodictamnus hirsutus: 10.1021/NP50045A043
- 1115765 Tanacetum aucherianum: 10.1016/S0031-9422(96)00373-1
- 2291699 Marrubium cylleneum: 10.1076/PHBI.40.4.245.8472
- 1209892 Teucrium stocksianum: 10.1300/J044V03N01_03
- 496633 Jungia polita: 10.1016/0031-9422(92)83741-G
- 1933725 Salvia heldreichiana:
- 1294397 Salvia hypoleuca:
- 1571167 Salvia mirzayanii:
- 1933769 Salvia yosgadensis:
- 49207 Salvia aethiopis:
- 1520031 Salvia lanigera:
- 268896 Salvia candidissima:
- 1571166 Salvia macrosiphon:
- 1298553 Salvia virgata:
- 1685717 Salvia syriaca:
- 1933716 Salvia cyanescens:
- 268912 Salvia verbenaca:
- 49214 Salvia lavandulifolia:
- 268920 Salvia palaestina:
- 95165 Salvia columbariae:
- 1048535 Centaurea cuneifolia:
- 350585 Osyris alba: 10.1080/10286020.2010.502892
- 166995 Montanoa leucantha: 10.1016/S0031-9422(00)89739-3
- 714449 Artemisia anomala:
- 1473222 Artemisia cina: 10.1007/BF00595086
- 401898 Artemisia gmelinii: 10.1007/BF00595086
- 109063 Alnus japonica: 10.1016/0031-9422(74)85049-1
- 3508 Betula nigra: 10.1016/S0031-9422(00)86815-6
- 1685713 Salvia limbata:
- 201290 Trichostema lanatum: 10.1515/ZNC-1992-9-1025
- 207754 Salvia dorrii: 10.1515/ZNC-1992-9-1025
- 149410 Arnica longifolia: 10.1016/S0031-9422(00)89581-3
- 168499 Buddleja macrostachya: 10.1016/0378-8741(84)90075-8
- 1241420 Lantana fucata: 10.1021/NP9002383
- 457732 Schistostephium crataegifolium: 10.1016/0031-9422(83)80100-9
- 1209860 Teucrium heterophyllum: 10.1016/S0031-9422(00)90719-2
- 1123534 Baccharis pedunculata: 10.1016/0031-9422(91)85145-P
- 1227617 Artemisia assoana: 10.1016/S0031-9422(00)83891-1
- 282760 Achillea pseudopectinata: 10.1055/S-2007-969447
- 282770 Achillea virescens:
- 65409 Scutellaria baicalensis: 10.1248/YAKUSHI1947.104.5_529
- 85571 Citrus reticulata: 10.1248/CPB.41.714
- 558547 Citrus deliciosa: 10.1248/CPB.41.714
- 363453 Centaurea spinosa:
- 102784 Liatris elegans: 10.1080/14786410903027789
- 301866 Achillea tenuifolia: 10.1016/S0031-9422(99)00054-0
- 1028379 Achillea santolina: 10.1016/S0031-9422(99)00054-0
- 204151 Orthosiphon aristatus:
- 1585254 Salvia moorcroftiana: 10.1078/094471102321621386
- 124926 Centaurea cineraria: 10.1016/0031-9422(88)80467-9
- 49215 Salvia nemorosa: 10.1016/S0031-9422(00)90672-1
- 282767 Achillea setacea: 10.1016/0305-1978(88)90071-3
- 542674 Phyla dulcis:
- 359922 Achillea formosa: 10.1515/ZNC-1989-3-423
- 301871 Leucocyclus formosus: 10.1515/ZNC-1989-3-423
- 312798 Ferula aucheri: 10.1016/0031-9422(94)00840-P
- 306376 Plectranthus fruticosus: 10.1021/NP030490J
- 2485406 Coleus sylvestris: 10.1021/NP030490J
- 39350 Ocimum basilicum:
- 1550803 Brickellia baccharidea: 10.1016/S0031-9422(00)98581-9
- 983213 Liatris aspera: 10.1016/0031-9422(83)83036-2
- 1933756 Salvia sahendica:
- 403027 Sideritis nutans: 10.1021/NP50057A027
- 925377 Aloysia citrodora: 10.1055/S-2006-962505
- 1550814 Brickellia dentata: 10.1016/0031-9422(80)85136-3
- 2291707 Marrubium velutinum: 10.1016/J.PHYTOCHEM.2005.02.029
- 650269 Mentha aquatica var. citrata:
- 41657 Ursinia nana: 10.1016/0031-9422(82)80131-3
- 1933767 Salvia wiedemannii: 10.1016/0031-9422(91)83665-8
- 268899 Salvia chionopeplica:
- 268888 Salvia amplexicaulis:
- 268906 Salvia fruticosa:
- 38868 Salvia officinalis:
- 588964 Salvia prionitis:
- 226208 Salvia miltiorrhiza:
- 1933710 Salvia caespitosa: 10.1080/10575630108041297
- 282771 Achillea wilhelmsii: 10.4268/CJCMM20150722
- 301867 Achillea vermicularis: 10.1016/0305-1978(91)90061-4
- 13329 Achillea millefolium: 10.1016/0031-9422(90)85371-L
- 482483 Achillea millefolium var. millefolium: 10.1016/0031-9422(90)85371-L
- 282720 Achillea aspleniifolia: 10.1016/0031-9422(90)85371-L
- 980664 Lepechinia caulescens: 10.1016/0031-9422(92)83466-C
- 204211 Callicarpa americana: 10.1021/NP060534Z
- 38869 Salvia sclarea: 10.1016/S0031-9422(00)90474-6
- 211591 Iphiona scabra: 10.1016/S0031-9422(00)81848-8
- 392666 Salvia hydrangea: 10.1021/NP200559C
- 28940 Nothofagus dombeyi: 10.1016/J.PHYTOCHEM.2004.04.002
- 145513 Centaurea raphanina: 10.1021/NP50021A025
- 1209871 Teucrium massiliense: 10.1016/S0031-9422(00)85040-2
- 1117157 Teucrium polium:
- 1854018 Teucrium alyssifolium:
- 2072395 Centaurea scoparia: 10.1055/S-2006-959378
- 49994 Volkameria inermis:
- 190902 Mentha aquatica: 10.1016/S0031-9422(98)00672-4
- 315439 Bellardia trixago: 10.3109/13880209009082777
- 2029211 Achillea sibirica: 10.1016/S0305-1978(98)00112-4
- 282741 Achillea impatiens: 10.1016/S0305-1978(98)00112-4
- 1685712 Salvia ceratophylla: 10.1016/0031-9422(95)00416-5
- 145508 Centaurea ornata: 10.1021/NP50069A006
- 167007 Montanoa tomentosa: 10.1016/0031-9422(91)85045-2
- 204141 Ocimum americanum:
- 1224218 Ocimum kilimandscharicum: 10.1016/S0031-9422(00)00439-8
- 1933761 Salvia tchihatcheffii:
- 1281416 Coleus hadiensis: 10.1002/HLCA.200490210
- 436459 Arnica acaulis: 10.1016/0031-9422(88)80605-8
- 53177 Teucrium flavum: 10.1016/S0031-9422(00)85039-6
- 986249 Mesosphaerum urticoides: 10.1016/0031-9422(91)83668-B
- 1423403 Teucrium leucocladum: 10.1016/J.BSE.2003.12.009
- 1138119 Pseudodictamnus hirsutus: 10.1021/NP50045A043
- 1115765 Tanacetum aucherianum: 10.1016/S0031-9422(96)00373-1
- 2291699 Marrubium cylleneum: 10.1076/PHBI.40.4.245.8472
- 1209892 Teucrium stocksianum: 10.1300/J044V03N01_03
- 9606 Homo sapiens: -
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
Journal of natural products.
2021 01; 84(1):1-10. doi:
10.1021/acs.jnatprod.0c00589. [PMID: 33393294] - Mahmoud A Al-Qudah, Hasan I Tashtoush, Ethar F Khlaifat, Sahar O Ibrahim, Ayman M Saleh, Hala I Al-Jaber, Musa H Abu Zarga, Sultan T Abu Orabi. Chemical constituents of the aerial parts of Salvia judaica Boiss. from Jordan.
Natural product research.
2020 Oct; 34(20):2981-2985. doi:
10.1080/14786419.2019.1597349. [PMID: 31161797] - Melanie Deipenbrock, Andreas Hensel. Polymethoxylated flavones from Orthosiphon stamineus leaves as antiadhesive compounds against uropathogenic E. coli.
Fitoterapia.
2019 Nov; 139(?):104387. doi:
10.1016/j.fitote.2019.104387. [PMID: 31678632] - Radhakrishnan Srivedavyasasri, Taylor Hayes, Samir A Ross. Phytochemical and biological evaluation of Salvia apiana.
Natural product research.
2017 Sep; 31(17):2058-2061. doi:
10.1080/14786419.2016.1269096. [PMID: 28025900] - Sahar Mofidi Tabatabaei, Peyman Salehi, Mahdi Moridi Farimani, Markus Neuburger, Maria De Mieri, Matthias Hamburger, Samad Nejad-Ebrahimi. A nor-diterpene from Salvia sahendica leaves.
Natural product research.
2017 Aug; 31(15):1758-1765. doi:
10.1080/14786419.2017.1290619. [PMID: 28278660] - Amer Tarawneh, Francisco León, Sara Pettaway, Khaled M Elokely, Michael L Klein, Janet Lambert, Arsala Mansoor, Stephen J Cutler. Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
Journal of natural products.
2015 Jun; 78(6):1461-5. doi:
10.1021/acs.jnatprod.5b00218. [PMID: 26035635] - Fatma Pinar Turkmenoglu, İpek Baysal, Samiye Ciftci-Yabanoglu, Kemal Yelekci, Hamdi Temel, Salih Paşa, Nurten Ezer, İhsan Çalış, Gulberk Ucar. Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol.
Molecules (Basel, Switzerland).
2015 Apr; 20(5):7454-73. doi:
10.3390/molecules20057454. [PMID: 25915461] - Anna Berim, Jeong-Jin Park, David R Gang. Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase.
The Plant journal : for cell and molecular biology.
2014 Nov; 80(3):385-95. doi:
10.1111/tpj.12642. [PMID: 25139498] - Elke H Heiss, Thi Van Anh Tran, Kristin Zimmermann, Stefan Schwaiger, Corina Vouk, Barbara Mayerhofer, Clemens Malainer, Atanas G Atanasov, Hermann Stuppner, Verena M Dirsch. Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata.
Journal of natural products.
2014 Mar; 77(3):503-8. doi:
10.1021/np400778m. [PMID: 24476568] - Burcu Çulhaoğlu, Gönül Yapar, Tuncay Dirmenci, Gülaçtı Topçu. Bioactive constituents of Salvia chrysophylla Stapf.
Natural product research.
2013 Mar; 27(4-5):438-47. doi:
10.1080/14786419.2012.734820. [PMID: 23126495] - Z Habibi, Z Cheraghi, S Ghasemi, M Yousefi. A new highly hydroxylated triterpene from Salvia atropatana Bunge.
Natural product research.
2012; 26(20):1910-3. doi:
10.1080/14786419.2011.628668. [PMID: 22017660] - Somayyeh Gandomkar, Maryam Yousefi, Zohreh Habibi, Mohammad Ali As'habi. A new triterpene from Salvia xanthocheila Boiss.
Natural product research.
2012; 26(7):648-53. doi:
10.1080/14786419.2010.541884. [PMID: 21848491] - Megumi Furukawa, Mitsuko Makino, Emika Ohkoshi, Taketo Uchiyama, Yasuo Fujimoto. Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae).
Phytochemistry.
2011 Dec; 72(17):2244-52. doi:
10.1016/j.phytochem.2011.07.008. [PMID: 21893325] - Catherine Argyropoulou, Anastasia Karioti, Helen Skaltsa. Minor labdane diterpenes from Marrubium thessalum.
Chemistry & biodiversity.
2011 Oct; 8(10):1880-90. doi:
10.1002/cbdv.201000215. [PMID: 22006716] - Seed Niazmand, Maryam Esparham, Tahereh Hassannia, Mohammad Derakhshan. Cardiovascular effects of Teucrium polium L. extract in rabbit.
Pharmacognosy magazine.
2011 Jul; 7(27):260-4. doi:
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Journal of agricultural and food chemistry.
2011 Apr; 59(8):3674-85. doi:
10.1021/jf104837w. [PMID: 21375325] - Naisheng Bai, Kan He, Marc Roller, Ching-Shu Lai, Xi Shao, Min-Hsiung Pan, Antoine Bily, Chi-Tang Ho. Flavonoid glycosides from Microtea debilis and their cytotoxic and anti-inflammatory effects.
Fitoterapia.
2011 Mar; 82(2):168-72. doi:
10.1016/j.fitote.2010.08.014. [PMID: 20804824] - Ahmad R Gohari, Soodabeh Saeidnia, Maryam Malmir, Abbass Hadjiakhoondi, Yousef Ajani. Flavones and rosmarinic acid from Salvia limbata.
Natural product research.
2010 Dec; 24(20):1902-6. doi:
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Natural product communications.
2010 Jun; 5(6):889-92. doi:
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Chemical & pharmaceutical bulletin.
2010 Apr; 58(4):546-8. doi:
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Pharmacognosy research.
2010 Mar; 2(2):86-8. doi:
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Journal of chromatography. A.
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Zeitschrift fur Naturforschung. C, Journal of biosciences.
2009 Nov; 64(11-12):831-9. doi:
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Phytochemistry.
2009 Jul; 70(11-12):1435-41. doi:
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Journal of natural products.
2007 Mar; 70(3):372-7. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2005 Sep; 30(17):1335-8. doi:
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2005 Sep; 53(9):1175-7. doi:
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2003 Jul; 63(5):555-67. doi:
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