Reaction Process: BioCyc:ECO_TRNA-CHARGING-PWY

tRNA charging related metabolites

find 9 related metabolites which is associated with chemical reaction(pathway) tRNA charging

ATP + ala ⟶ AMP + diphosphate

View the spectrum consensus network of the metabolites related with current reaction.

Pyrophosphate

phosphono dihydrogen phosphate

H4O7P2 (177.9432)


The anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. The pyrophosphate anion is abbreviated PPi and is formed by the hydrolysis of ATP into AMP in cells. This hydrolysis is called pyrophosphorolysis. The pyrophosphate anion has the structure P2O74-, and is an acid anhydride of phosphate. It is unstable in aqueous solution and rapidly hydrolyzes into inorganic phosphate. Pyrophosphate is an osteotoxin (arrests bone development) and an arthritogen (promotes arthritis). It is also a metabotoxin (an endogenously produced metabolite that causes adverse health affects at chronically high levels). Chronically high levels of pyrophosphate are associated with hypophosphatasia. Hypophosphatasia (also called deficiency of alkaline phosphatase or phosphoethanolaminuria) is a rare, and sometimes fatal, metabolic bone disease. Hypophosphatasia is associated with a molecular defect in the gene encoding tissue non-specific alkaline phosphatase (TNSALP). TNSALP is an enzyme that is tethered to the outer surface of osteoblasts and chondrocytes. TNSALP hydrolyzes several substances, including inorganic pyrophosphate (PPi) and pyridoxal 5-phosphate (PLP), a major form of vitamin B6. When TSNALP is low, inorganic pyrophosphate (PPi) accumulates outside of cells and inhibits the formation of hydroxyapatite, one of the main components of bone, causing rickets in infants and children and osteomalacia (soft bones) in adults. Vitamin B6 must be dephosphorylated by TNSALP before it can cross the cell membrane. Vitamin B6 deficiency in the brain impairs synthesis of neurotransmitters which can cause seizures. In some cases, a build-up of calcium pyrophosphate dihydrate crystals in the joints can cause pseudogout. COVID info from WikiPathways Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

(2S,3R)-2-azaniumyl-3-hydroxybutanoate

(2S,3R)-2-azaniumyl-3-hydroxybutanoate

C4H9NO3 (119.0582)


   

(2S)-2-azaniumylpropanoate

(2S)-2-azaniumylpropanoate

C3H7NO2 (89.0477)


   

(2S,3S)-2-ammonio-3-methylpentanoate

(2S,3S)-2-ammonio-3-methylpentanoate

C6H13NO2 (131.0946)


   

(2S)-2-ammonio-4-(methylsulfanyl)butanoate

(2S)-2-ammonio-4-(methylsulfanyl)butanoate

C5H11NO2S (149.051)


   

D,L-Cysteine

(2R)-2-ammonio-3-mercaptopropanoate

C3H7NO2S (121.0197)


   

[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate

[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate

C10H12N5O13P3-4 (502.9644)


COVID info from COVID-19 Disease Map, WikiPathways Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

Adenosine-5-monophosphate(2-)

Adenosine-5-monophosphate(2-)

C10H12N5O7P-2 (345.0474)


   

L-glutamate(1-)

L-glutamate(1-)

C5H8NO4- (146.0453)


An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group