L-glutamate(1-) (BioDeep_00000897955)

   


代谢物信息卡片


L-glutamate(1-)

化学式: C5H8NO4- (146.0453308)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 19%

分子结构信息

SMILES: C(CC(=O)[O-])C(C(=O)[O-])[NH3+]
InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1

描述信息

An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group

同义名列表

1 个代谢物同义名

L-glutamate(1-)



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(70)

BioCyc(194)

PlantCyc(33)

代谢反应

8296 个相关的代谢反应过程信息。

Reactome(948)

BioCyc(781)

WikiPathways(0)

Plant Reactome(3322)

INOH(0)

PlantCyc(3245)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Minako Oda, Kousuke Fujibayashi, Minoru Wakasa, Shintaro Takano, Wataru Fujita, Michihiko Kitayama, Hiroaki Nakanishi, Kazuyuki Saito, Yasuyuki Kawai, Kouji Kajinami. Increased plasma glutamate in non-smokers with vasospastic angina pectoris is associated with plasma cystine and antioxidant capacity. Scandinavian cardiovascular journal : SCJ. 2022 12; 56(1):180-186. doi: 10.1080/14017431.2022.2085884. [PMID: 35695518]
  • Laura M McNair, Graeme F Mason, Golam Mi Chowdhury, Lihong Jiang, Xiaoxian Ma, Douglas L Rothman, Helle S Waagepetersen, Kevin L Behar. Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022 08; 42(8):1507-1523. doi: 10.1177/0271678x221074211. [PMID: 35048735]
  • Domenica Donatella Li Puma, Cristian Ripoli, Giulia Puliatti, Francesco Pastore, Giacomo Lazzarino, Barbara Tavazzi, Ottavio Arancio, Roberto Piacentini, Claudio Grassi. Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT-1 expression and impairment of NKA1A2 function. Neuropathology and applied neurobiology. 2022 08; 48(5):e12811. doi: 10.1111/nan.12811. [PMID: 35274343]
  • Yanhua Chen, Qianlun Pu, Fengting Yu, Xian Ding, Yu Sun, Qinglan Guo, Jiangong Shi, Jianjun Zhang, Zeper Abliz. Comprehensive quantitative method for neurotransmitters to study the activity of a sedative-hypnotic candidate using microdialysis and LC×LC-MS/MS. Talanta. 2022 Aug; 245(?):123418. doi: 10.1016/j.talanta.2022.123418. [PMID: 35472683]
  • Marzieh Jafari Fakharbad, Mohammad Moshiri, Mohammad Mehdi Ommati, Mehdi Talebi, Leila Etemad. A review of basic to clinical studies of the association between hyperammonemia, methamphetamine. Naunyn-Schmiedeberg's archives of pharmacology. 2022 08; 395(8):921-931. doi: 10.1007/s00210-022-02248-w. [PMID: 35604430]
  • Santi Devi Upadhaya, Sang Seon Lee, Young Hwa Kim, Zhenlong Wu, In Ho Kim. Effects of supplementation of graded level of glutamic acid to crude protein reduced diets on the performance of growing pigs. Journal of animal physiology and animal nutrition. 2022 Jul; 106(4):825-831. doi: 10.1111/jpn.13625. [PMID: 34423869]
  • Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Fabio Fumagalli, Judith R Homberg. Responsivity of serotonin transporter knockout rats to short and long access to cocaine: Modulation of the glutamate signalling in the nucleus accumbens shell. British journal of pharmacology. 2022 07; 179(14):3727-3739. doi: 10.1111/bph.15823. [PMID: 35174489]
  • María Paz Guerrero-Molina, Montserrat Morales-Conejo, Aitor Delmiro, María Morán, Cristina Domínguez-González, Elena Arranz-Canales, Ana Ramos-González, Joaquín Arenas, Miguel A Martín, Jesús González de la Aleja. Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. Journal of neurology. 2022 Jun; 269(6):3238-3248. doi: 10.1007/s00415-021-10942-7. [PMID: 35088140]
  • Yue Yang, Pingya He, Yuhao Hou, Zhicheng Liu, Xiaoping Zhang, Ning Li. Osmundacetone modulates mitochondrial metabolism in non-small cell lung cancer cells by hijacking the glutamine/glutamate/α-KG metabolic axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):154075. doi: 10.1016/j.phymed.2022.154075. [PMID: 35413646]
  • Harald John, Philipp Hörmann, Michael Schrader, Horst Thiermann. Alkylated glutamic acid and histidine derived from protein-adducts indicate exposure to sulfur mustard in avian serum. Drug testing and analysis. 2022 Jun; 14(6):1140-1148. doi: 10.1002/dta.3236. [PMID: 35137544]
  • Wanting Chen, Qian Li, Ranran Hou, Huaguo Liang, Yongli Zhang, Yongxia Yang. An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer. Journal of pharmaceutical and biomedical analysis. 2022 May; 214(?):114711. doi: 10.1016/j.jpba.2022.114711. [PMID: 35306435]
  • Yanru Zhu, Feng Wang, Yunli Zhao, Miao Yu, Mingyan Ma, Zhiguo Yu. A sensitive HILIC-MS/MS method for quantification of theanine in rat plasma and tissues: Application to preclinical pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 May; 1198(?):123248. doi: 10.1016/j.jchromb.2022.123248. [PMID: 35428008]
  • S Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem M Mohammed, Dennis R Phillips, James C Whisstock, Adam J Quek, Edward P Feener, Ruby H P Law, David Gailani. A mechanism for hereditary angioedema caused by a lysine 311-to-glutamic acid substitution in plasminogen. Blood. 2022 05; 139(18):2816-2829. doi: 10.1182/blood.2021012945. [PMID: 35100351]
  • Gergely Pallag, Sara Nazarian, Dora Ravasz, David Bui, Timea Komlódi, Carolina Doerrier, Erich Gnaiger, Thomas N Seyfried, Christos Chinopoulos. Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited. International journal of molecular sciences. 2022 May; 23(9):. doi: 10.3390/ijms23095111. [PMID: 35563503]
  • Jonas Holm, Gabriele Ferrari, Anders Holmgren, Farkas Vanky, Örjan Friberg, Mårten Vidlund, Rolf Svedjeholm. Effect of glutamate infusion on NT-proBNP after coronary artery bypass grafting in high-risk patients (GLUTAMICS II): A randomized controlled trial. PLoS medicine. 2022 05; 19(5):e1003997. doi: 10.1371/journal.pmed.1003997. [PMID: 35533197]
  • Shuo Gu, Tingting Mou, Jian Chen, Jing Wang, Ying Zhang, Meirong Cui, Wenqian Hao, Yue Sun, Chengqin Zhang, Tiantian Zhao, Binbin Wei. Develop a stepwise integrated method to screen biomarkers of Baihe-Dihuang Tang on the treatment of depression in rats applying with composition screened, untargeted, and targeted metabolomics analysis. Journal of separation science. 2022 May; 45(10):1656-1671. doi: 10.1002/jssc.202100841. [PMID: 35234356]
  • Chae Gyu Park, Min Kyung Chu. Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine. Scientific reports. 2022 04; 12(1):6921. doi: 10.1038/s41598-022-10883-9. [PMID: 35484312]
  • Kouji Fukuyama, Motohiro Okada. Brivaracetam and Levetiracetam Suppress Astroglial L-Glutamate Release through Hemichannel via Inhibition of Synaptic Vesicle Protein. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094473. [PMID: 35562864]
  • Yinan Chen, Lei Hu, Hexin Lin, Huangdao Yu, Jun You. Serum metabolomic profiling for patients with adenocarcinoma of the esophagogastric junction. Metabolomics : Official journal of the Metabolomic Society. 2022 04; 18(5):26. doi: 10.1007/s11306-022-01883-x. [PMID: 35441991]
  • S Hisadomi, A Haruno, T Fujieda, T Sugino, M Oba. Effects of rumen-protected glutamate supplementation during the periparturient period on digestibility, inflammation, metabolic responses, and performance in dairy cows. Journal of dairy science. 2022 Apr; 105(4):3129-3141. doi: 10.3168/jds.2021-21357. [PMID: 35086702]
  • Lise Verbruggen, Gamze Ates, Olaya Lara, Jolien De Munck, Agnès Villers, Laura De Pauw, Sigrid Ottestad-Hansen, Sho Kobayashi, Pauline Beckers, Pauline Janssen, Hideyo Sato, Yun Zhou, Emmanuel Hermans, Rose Njemini, Lutgarde Arckens, Niels C Danbolt, Dimitri De Bundel, Joeri L Aerts, Kurt Barbé, Benoit Guillaume, Laurence Ris, Eduard Bentea, Ann Massie. Lifespan extension with preservation of hippocampal function in aged system xc--deficient male mice. Molecular psychiatry. 2022 Apr; 27(4):2355-2368. doi: 10.1038/s41380-022-01470-5. [PMID: 35181756]
  • Claudia Sikorski, Sandi Azab, Russell J de Souza, Meera Shanmuganathan, Dipika Desai, Koon Teo, Stephanie A Atkinson, Katherine Morrison, Milan Gupta, Philip Britz-McKibbin, Sonia S Anand. Serum metabolomic signatures of gestational diabetes in South Asian and white European women. BMJ open diabetes research & care. 2022 04; 10(2):. doi: 10.1136/bmjdrc-2021-002733. [PMID: 35450870]
  • Remy Verhaeghe, Vance Gao, Sara Morley-Fletcher, Hammou Bouwalerh, Gilles Van Camp, Francesca Cisani, Ferdinando Nicoletti, Stefania Maccari. Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats. GeroScience. 2022 04; 44(2):1047-1069. doi: 10.1007/s11357-021-00375-5. [PMID: 33983623]
  • Kouji Fukuyama, Eishi Motomura, Takashi Shiroyama, Motohiro Okada. Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Apr; 148(?):112750. doi: 10.1016/j.biopha.2022.112750. [PMID: 35219120]
  • Sudhish Gupta, Rajesh Chetiwal, Amit Kumar, Priyank Rastogi, Saurabh Gupta, Pradeep Tomar. Serum Glutamic Oxaloacetic Transaminase - Predictor in Detection of Early Neurological Deterioration in Acute Ischemic Stroke. The Journal of the Association of Physicians of India. 2022 Apr; 70(4):11-12. doi: NULL. [PMID: 35443420]
  • Jefrin Sultana, Dibya Jyoti Sharma. Evaluation of Serum Ferritin as a Prognostic Marker in Acute Ischemic Stroke Patients-A Prospective Cohort Study. The Journal of the Association of Physicians of India. 2022 Apr; 70(4):11-12. doi: NULL. [PMID: 35443413]
  • Yindan Lin, Ze Yang, Jingjia Li, Yandi Sun, Xueyun Zhang, Zihao Qu, Yan Luo, Lihong Zhang. Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study. BMC genomics. 2022 Mar; 23(1):213. doi: 10.1186/s12864-022-08442-7. [PMID: 35296245]
  • Laura Sánchez-Marín, Maria Flores-López, Antoni Pastor, Ana Luisa Gavito, Juan Suárez, Rafael de la Torre, Francisco Javier Pavón, Fernando Rodríguez de Fonseca, Antonia Serrano. Acute stress and alcohol exposure during adolescence result in an anxious phenotype in adulthood: Role of altered glutamate/endocannabinoid transmission mechanisms. Progress in neuro-psychopharmacology & biological psychiatry. 2022 03; 113(?):110460. doi: 10.1016/j.pnpbp.2021.110460. [PMID: 34695542]
  • Anna Szeliga, Ewa Rudnicka, Marzena Maciejewska-Jeske, Marek Kucharski, Anna Kostrzak, Marta Hajbos, Olga Niwczyk, Roman Smolarczyk, Blazej Meczekalski. Neuroendocrine Determinants of Polycystic Ovary Syndrome. International journal of environmental research and public health. 2022 03; 19(5):. doi: 10.3390/ijerph19053089. [PMID: 35270780]
  • Thaysa Mara Gazzotto Neves, Estefania Simoes, Maria Concepcíon García Otaduy, Elie Leal de Barros Calfat, Pâmela Bertolazzi, Naomi Antunes da Costa, Fábio Luís de Souza Duran, Joanna Correia-Lima, Maria da Graça Morais Martin, Marília Cerqueira Leite Seelander, Victor Henrique Oyamada Otani, Thais Zélia Dos Santos Otani, Daniel Augusto Corrêa Vasques, Geraldo Busatto Filho, Cristiane Kochi, Ricardo Riyoiti Uchida. Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity. The Journal of nutrition. 2022 03; 152(3):663-670. doi: 10.1093/jn/nxab415. [PMID: 34888674]
  • Carla Perego, Eliana S Di Cairano, Alessandra Galli, Stefania Moretti, Elena Bazzigaluppi, Victoria Frolich Centonze, Amalia Gastaldelli, Emma Assi, Paolo Fiorina, Massimo Federici, Ottavia Porzio, Federico Bertuzzi, Alberto M Davalli, Franco Folli. Autoantibodies against the glial glutamate transporter GLT1/EAAT2 in Type 1 diabetes mellitus-Clues to novel immunological and non-immunological therapies. Pharmacological research. 2022 03; 177(?):106130. doi: 10.1016/j.phrs.2022.106130. [PMID: 35151858]
  • Dilşad Yıldız Miniksar, Mehmet Akif Cansız, Mahmut Kılıç, Ayşe Yeşim Göçmen. Relationship between sleep problems and chronotypes of children and adolescents with attention deficit and hyperactivity disorder and serum GABA, glutamate and homocysteine levels. Chronobiology international. 2022 03; 39(3):386-397. doi: 10.1080/07420528.2021.2018452. [PMID: 34961406]
  • Thitigun Jaimipuk, Saranya Sachdev, Sutee Yoksan, Chutima Thepparit. A Small-Plaque Isolate of the Zika Virus with Envelope Domain III Mutations Affect Viral Entry and Replication in Mammalian but Not Mosquito Cells. Viruses. 2022 02; 14(3):. doi: 10.3390/v14030480. [PMID: 35336887]
  • Wei-Hao Peng, Hung-Wei Kan, Yu-Cheng Ho. Periaqueductal gray is required for controlling chronic stress-induced depression-like behavior. Biochemical and biophysical research communications. 2022 02; 593(?):28-34. doi: 10.1016/j.bbrc.2022.01.025. [PMID: 35051779]
  • Waleed A El-Said, Ramy M Qaisi, Virginie Placide, Jeong-Woo Choi. A stable naked-eye colorimetric sensor for monitoring release of extracellular gamma-aminobutyric acid (GABA) neurotransmitter from SH-SY5Y cells. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Feb; 267(Pt 2):120517. doi: 10.1016/j.saa.2021.120517. [PMID: 34739892]
  • Mengge Bai, Heming Yu, Chong Chen, Xingzhe Xu, Yong He, Yue Wang, Yu Tian, Zhonghao Wu, Tianlan Lan, Yan Li, Xiangyu Chen, Zhi Chen, Libo Zhao, Liang Fang, Deyu Yang, Ke Cheng, Peng Xie. Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex. Neuroscience letters. 2022 02; 771(?):136423. doi: 10.1016/j.neulet.2021.136423. [PMID: 34965441]
  • Vanessa Castro-Rodríguez, Thomas J Kleist, Nicoline M Gappel, Fatiha Atanjaoui, Sakiko Okumoto, Mackenzie Machado, Tom Denyer, Marja C P Timmermans, Wolf B Frommer, Michael M Wudick. Sponging of glutamate at the outer plasma membrane surface reveals roles for glutamate in development. The Plant journal : for cell and molecular biology. 2022 02; 109(3):664-674. doi: 10.1111/tpj.15585. [PMID: 34783104]
  • Lin Wang, Xi Xing, Xianfeng Zeng, S RaElle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z Samarah, Katharine Goodwin, Lifeng Yang, Melanie R McReynolds, Xiaoxuan Li, Jeremy J Wolff, Joshua D Rabinowitz, Shawn M Davidson. Spatially resolved isotope tracing reveals tissue metabolic activity. Nature methods. 2022 02; 19(2):223-230. doi: 10.1038/s41592-021-01378-y. [PMID: 35132243]
  • Mingyan Cao, Niluka De Mel, Jihong Wang, Conner Parthemore, Yang Jiao, Weimin Chen, Shihua Lin, Dengfeng Liu, Greg Kilby, Xiaoyu Chen. Characterization of N-Terminal Glutamate Cyclization in Monoclonal Antibody and Bispecific Antibody Using Charge Heterogeneity Assays and Hydrophobic Interaction Chromatography. Journal of pharmaceutical sciences. 2022 02; 111(2):335-344. doi: 10.1016/j.xphs.2021.09.006. [PMID: 34516988]
  • Gavin Boerboom, Javier Martín-Tereso, Teun Veldkamp, Jan van Harn, Paul Bikker, Ronald Busink. Tolerance and safety evaluation of L-glutamic acid, N,N-diacetic acid as a feed additive in broiler diets. Poultry science. 2022 Feb; 101(2):101623. doi: 10.1016/j.psj.2021.101623. [PMID: 34936962]
  • Wei Shi, Yajie Deng, Chenyang Zhao, Wei Xiao, Zhenzhong Wang, Zhili Xiong, Longshan Zhao. Integrative serum metabolomic analysis for preventive effects of Yaobitong capsule in adjuvant-induced rheumatoid arthritis rat based on RP/HILIC-UHPLC-Q-TOF MS. Analytical biochemistry. 2022 01; 637(?):114474. doi: 10.1016/j.ab.2021.114474. [PMID: 34801482]
  • Hannah E Greenwood, Richard Edwards, Norman Koglin, Mathias Berndt, Friedrich Baark, Jana Kim, George Firth, Eman Khalil, Andre Mueller, Timothy H Witney. Radiotracer stereochemistry affects substrate affinity and kinetics for improved imaging of system xC - in tumors. Theranostics. 2022; 12(4):1921-1936. doi: 10.7150/thno.63237. [PMID: 35198080]
  • Laia Reverté, Elena Yeregui, Montserrat Olona, Alicia Gutiérrez-Valencia, Maria José Buzón, Anna Martí, Frederic Gómez-Bertomeu, Teresa Auguet, Luis F López-Cortés, Joaquin Burgos, Clara Benavent-Bofill, Carme Boqué, Graciano García-Pardo, Ezequiel Ruiz-Mateos, Maria Teresa Mestre, Francesc Vidal, Consuelo Viladés, Joaquim Peraire, Anna Rull. Fetuin-A, inter-α-trypsin inhibitor, glutamic acid and ChoE (18:0) are key biomarkers in a panel distinguishing mild from critical coronavirus disease 2019 outcomes. Clinical and translational medicine. 2022 01; 12(1):e704. doi: 10.1002/ctm2.704. [PMID: 35075803]
  • Claudia Alleva, Jan-Philipp Machtens, Daniel Kortzak, Ingo Weyand, Christoph Fahlke. Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters. Neurochemical research. 2022 Jan; 47(1):9-22. doi: 10.1007/s11064-021-03252-x. [PMID: 33587237]
  • Xiaomin Liu, Xin Tong, Yuanqiang Zou, Xiaoqian Lin, Hui Zhao, Liu Tian, Zhuye Jie, Qi Wang, Zhe Zhang, Haorong Lu, Liang Xiao, Xuemei Qiu, Jin Zi, Rong Wang, Xun Xu, Huanming Yang, Jian Wang, Yang Zong, Weibin Liu, Yong Hou, Shida Zhu, Huijue Jia, Tao Zhang. Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome. Nature genetics. 2022 01; 54(1):52-61. doi: 10.1038/s41588-021-00968-y. [PMID: 34980918]
  • Kehinde S Olaniyi, Isaiah W Sabinari, Adesola A Oniyide, Nifesimi T Akinnagbe, Toluwani B Agunbiade, Oluwole O Alese. Aqueous Extract of Cola nitida and Garcinia kola Synergistically Enhances Hippocampal-hypothalamic Glutamate and Na+ /K+ -ATPase Activity in Male Wistar Rats. Current drug discovery technologies. 2022; 19(1):e290321192495. doi: 10.2174/1570163818666210329102207. [PMID: 33781191]
  • Sharlene D Newman, Ashley M Schnakenberg Martin, David Raymond, Hu Cheng, Landon Wilson, Stephen Barnes, Brian F O'Donnell. The relationship between cannabis use and taurine: A MRS and metabolomics study. PloS one. 2022; 17(6):e0269280. doi: 10.1371/journal.pone.0269280. [PMID: 35653401]
  • Jiali Wang, Laura Zielewicz, Yang Dong, Christof Grewer. Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain. Neurochemical research. 2022 Jan; 47(1):148-162. doi: 10.1007/s11064-021-03247-8. [PMID: 33550531]
  • Cécile Loï, Luc Cynober. Glutamate: A Safe Nutrient, Not Just a Simple Additive. Annals of nutrition & metabolism. 2022; 78(3):133-146. doi: 10.1159/000522482. [PMID: 35172302]
  • Xinyue Wang, Ruiyue Yang, Wenduo Zhang, Siming Wang, Hongna Mu, Hongxia Li, Jun Dong, Wenxiang Chen, Xue Yu, Fusui Ji. Serum glutamate and glutamine-to-glutamate ratio are associated with coronary angiography defined coronary artery disease. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2022 01; 32(1):186-194. doi: 10.1016/j.numecd.2021.09.021. [PMID: 34906414]
  • Penghao Sun, Mengli Wang, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao. Eucommiae cortex polysaccharides mitigate obesogenic diet-induced cognitive and social dysfunction via modulation of gut microbiota and tryptophan metabolism. Theranostics. 2022; 12(8):3637-3655. doi: 10.7150/thno.72756. [PMID: 35664075]
  • Keming Yang, Xin Li, Oana A Zeleznik, A Heather Eliassen, Clary B Clish, Eunyoung Cho, Ally-Khan B Somani, Abrar A Qureshi, Edward L Giovannucci, Hongmei Nan. Higher susceptibility to sunburn is associated with decreased plasma glutamine and increased plasma glutamate levels among US women: An analysis of the Nurses' Health Study I and II. Journal of the American Academy of Dermatology. 2022 01; 86(1):169-172. doi: 10.1016/j.jaad.2020.12.081. [PMID: 33444667]
  • Rafael Paez, Chirayu Shah, Angelina J Cords, Anel Muterspaugh, John E Helton, Sanja Antic, Rosana Eisenberg, Heidi Chen, Eric L Grogan, Henry C Manning, Ronald C Walker, Pierre P Massion. 18F-FSPG PET imaging for the evaluation of indeterminate pulmonary nodules. PloS one. 2022; 17(3):e0265427. doi: 10.1371/journal.pone.0265427. [PMID: 35294486]
  • Touhid Feghhi, Roberto X Hernandez, Michal Stawarski, Connon I Thomas, Naomi Kamasawa, A W C Lau, Gregory T Macleod. Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft. Biophysical journal. 2021 12; 120(24):5575-5591. doi: 10.1016/j.bpj.2021.11.011. [PMID: 34774503]
  • Sylvain Perriot, Mathieu Canales, Amandine Mathias, Renaud Du Pasquier. Differentiation of functional astrocytes from human-induced pluripotent stem cells in chemically defined media. STAR protocols. 2021 12; 2(4):100902. doi: 10.1016/j.xpro.2021.100902. [PMID: 34746863]
  • Kiran Sapkota, Erica S Burnell, Mark W Irvine, Guangyu Fang, Dinesh Y Gawande, Shashank M Dravid, David E Jane, Daniel T Monaghan. Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792. Neuropharmacology. 2021 12; 201(?):108818. doi: 10.1016/j.neuropharm.2021.108818. [PMID: 34610288]
  • Hassan Nasrollahpour, Abdolhossein Naseri, Mohammad-Reza Rashidi, Balal Khalilzadeh. Application of green synthesized WO3-poly glutamic acid nanobiocomposite for early stage biosensing of breast cancer using electrochemical approach. Scientific reports. 2021 12; 11(1):23994. doi: 10.1038/s41598-021-03209-8. [PMID: 34907220]
  • Venkatesh Gunasekaran, Anitta Augustine, Jinu Avarachan, Abdul Khayum, Arivukkarasu Ramasamy. 3-O-Acetyl-11-keto-β-boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate/GABA aberration in depressive rats. Clinical and experimental pharmacology & physiology. 2021 12; 48(12):1633-1641. doi: 10.1111/1440-1681.13567. [PMID: 34343356]
  • Mohamed S Abdel-Bakky, Elham Amin, Tarek M Faris, Ahmed A H Abdellatif. Mental depression: Relation to different disease status, newer treatments and its association with COVID-19 pandemic (Review). Molecular medicine reports. 2021 Dec; 24(6):. doi: 10.3892/mmr.2021.12479. [PMID: 34633054]
  • Abhilasha Tripathi, Jayantee Kalita, Usha K Misra. A study of glutamate excitotoxicity in seizures related to tuberculous meningitis. Epilepsy research. 2021 12; 178(?):106789. doi: 10.1016/j.eplepsyres.2021.106789. [PMID: 34800755]
  • Jingtong Zhao, Meng Liu, Tongfei Shi, Mohan Gao, Yuqian Lv, Yawei Zhao, Jing Li, Ming Zhang, Hansi Zhang, Fengying Guan, Kan He, Li Chen. Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237181. [PMID: 34885759]
  • Ludi Zhang, Jing Wang, Chenxu Niu, Yu Zhang, Tiantian Zhu, Dongyang Huang, Jing Ma, Hui Sun, Nikita Gamper, Xiaona Du, Hailin Zhang. Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice. Cell reports. 2021 11; 37(5):109936. doi: 10.1016/j.celrep.2021.109936. [PMID: 34731609]
  • Zhijun Diao, Li Yao, Qiangqiang Cheng, Meilin Wu, Yuanyuan Di, Zhaoqiang Qian, Chunling Wei, Yingxun Liu, Yingfang Tian, Wei Ren. Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice. Molecular neurobiology. 2021 Nov; 58(11):5667-5681. doi: 10.1007/s12035-021-02515-6. [PMID: 34387814]
  • Jayantee Kalita, Vijay Kumar, Vasudev Parashar, Usha K Misra. Neuropsychiatric Manifestations of Wilson Disease: Correlation with MRI and Glutamate Excitotoxicity. Molecular neurobiology. 2021 Nov; 58(11):6020-6031. doi: 10.1007/s12035-021-02525-4. [PMID: 34435331]
  • Manabu Kubota, Yasuyuki Kimura, Masafumi Shimojo, Yuhei Takado, Joao Mn Duarte, Hiroyuki Takuwa, Chie Seki, Hitoshi Shimada, Hitoshi Shinotoh, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Kenji Tagai, Takayuki Obata, Jin Nakahara, Yutaka Tomita, Masaki Tokunaga, Jun Maeda, Kazunori Kawamura, Ming-Rong Zhang, Masanori Ichise, Tetsuya Suhara, Makoto Higuchi. Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 11; 41(11):2928-2943. doi: 10.1177/0271678x211004150. [PMID: 34039039]
  • Deepak Kumar, Navneeta Bansal, Ashish Gupta, Anil Mandhani, Hira Lal, Manoj Kumar, Satya Narain Sankhwar. Metabolomics of prostate cancer: Knock-in versus knock-out prostate. Journal of pharmaceutical and biomedical analysis. 2021 Oct; 205(?):114333. doi: 10.1016/j.jpba.2021.114333. [PMID: 34461489]
  • Jialiang Shao, Tiezhu Shi, Hua Yu, Yufeng Ding, Liping Li, Xiang Wang, Xiongjun Wang. Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation. The EMBO journal. 2021 10; 40(20):e107480. doi: 10.15252/embj.2020107480. [PMID: 34269483]
  • Suk-Yun Kang, Su Yeon Seo, Se Kyun Bang, Seong Jin Cho, Kwang-Ho Choi, Yeonhee Ryu. Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011177. [PMID: 34681836]
  • Marco Gelpi, Flora Mikaeloff, Andreas D Knudsen, Rui Benfeitas, Shuba Krishnan, Sara Svenssson Akusjärvi, Julie Høgh, Daniel D Murray, Henrik Ullum, Ujjwal Neogi, Susanne D Nielsen. The central role of the glutamate metabolism in long-term antiretroviral treated HIV-infected individuals with metabolic syndrome. Aging. 2021 10; 13(19):22732-22751. doi: 10.18632/aging.203622. [PMID: 34635603]
  • Li-Ching Lee, Ming-Tsan Su, Hsing-Ying Huang, Ying-Chun Cho, Ting-Kuang Yeh, Chun-Yen Chang. Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents. Molecular brain. 2021 10; 14(1):152. doi: 10.1186/s13041-021-00858-8. [PMID: 34607601]
  • T V Davydova, T I Nevidimova, L A Vetrile, I A Zakharova, D N Savochkina, S A Galkin, N A Bokhan. Correlation of Antibodies to Neurotransmitters in the Sera of Women with Alcohol Dependence and Depressive Disorders. Bulletin of experimental biology and medicine. 2021 Oct; 171(6):704-706. doi: 10.1007/s10517-021-05299-w. [PMID: 34705169]
  • Claudia Salcedo, Antonie Wagner, Jens V Andersen, Kasper Tore Vinten, Helle S Waagepetersen, Arne Schousboe, Kristine K Freude, Blanca I Aldana. Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease. Neurochemical research. 2021 Oct; 46(10):2676-2686. doi: 10.1007/s11064-021-03276-3. [PMID: 33710537]
  • Wei Wang, Yanchuan Wu, Xiaoling Li, Lin Li, Ke Sun, Suying Yan. Altered plasma glutamate and glutamine levels in patients with drug-resistant and drug-responsive symptomatic focal epilepsy. Neurosciences (Riyadh, Saudi Arabia). 2021 Oct; 26(4):315-322. doi: 10.17712/nsj.2021.4.20210041. [PMID: 34663703]
  • Patricia Martínez-Miguel, Marta Albalate, Violeta Durán-Laforet, Carolina Peña-Martínez, Patricia de Sequera, Hanane Bouarich, Korina Peña-Esparragoza, Susana López-Ongil, Ignacio Lizasoain, José Sánchez-Prieto, Magdalena Torres, María Ángeles Moro, Diego Rodríguez-Puyol. Effective glutamate clearance from the systemic circulation by hemodialysis: Potential relevance for cerebral ischemia management. Artificial organs. 2021 Oct; 45(10):1183-1188. doi: 10.1111/aor.13933. [PMID: 33560549]
  • Vedrana Montana, Daniel Flint, Helle S Waagepetersen, Arne Schousboe, Vladimir Parpura. Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes. Neurochemical research. 2021 Oct; 46(10):2551-2579. doi: 10.1007/s11064-021-03340-y. [PMID: 34057673]
  • Anna Kamynina, Noemi Esteras, Dmitry O Koroev, Plamena R Angelova, Olga M Volpina, Andrey Y Abramov. Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons. Journal of cellular physiology. 2021 09; 236(9):6496-6506. doi: 10.1002/jcp.30324. [PMID: 33570767]
  • Kathleen F Holton, Shalini S Ramachandra, Sidney L Murray, Michael Baron, James N Baraniuk. Effect of the low glutamate diet on inflammatory cytokines in veterans with Gulf War Illness (GWI): A pilot study. Life sciences. 2021 Sep; 280(?):119637. doi: 10.1016/j.lfs.2021.119637. [PMID: 34015284]
  • Lisa Felix, Jonathan Stephan, Christine R Rose. Astrocytes of the early postnatal brain. The European journal of neuroscience. 2021 09; 54(5):5649-5672. doi: 10.1111/ejn.14780. [PMID: 32406559]
  • Yaqing Yang, Encheng Xie, Lingyu Du, Yu Yang, Bin Wu, Liming Sun, Shuqing Wang, Bo OuYang. Positive Charges in the Brace Region Facilitate the Membrane Disruption of MLKL-NTR in Necroptosis. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175194. [PMID: 34500630]
  • Valentina Medici, Anna Czlonkowska, Tomasz Litwin, Cecilia Giulivi. Diagnosis of Wilson Disease and Its Phenotypes by Using Artificial Intelligence. Biomolecules. 2021 08; 11(8):. doi: 10.3390/biom11081243. [PMID: 34439909]
  • Yuwei Zhao, Lei Liang, Guanghui Liu, Yongqing Liu, Hong Zheng, Liying Dai. The effects of short time hyperoxia on glutamate concentration and glutamate transporters expressions in brain of neonatal rats. Neuroscience letters. 2021 07; 758(?):136013. doi: 10.1016/j.neulet.2021.136013. [PMID: 34111510]
  • Yona Goldshmit, Rita Perelroizen, Alex Yakovchuk, Evgeni Banyas, Lior Mayo, Sari David, Amit Benbenishty, Pablo Blinder, Moshe Shalom, Angela Ruban. Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo. Scientific reports. 2021 07; 11(1):14644. doi: 10.1038/s41598-021-94183-8. [PMID: 34282238]
  • Jae Hyun Yoo, Ji-Won Chun, Mi Ran Choi, Hyun Cho, Jin-Young Kim, Jihye Choi, Dai-Jin Kim. Caudate nucleus volume mediates the link between glutamatergic neurotransmission and problematic smartphone use in youth. Journal of behavioral addictions. 2021 Jul; 10(2):338-346. doi: 10.1556/2006.2021.00024. [PMID: 33905351]
  • A A Savchenko, A G Borisov, V D Belenyuk, A V Moshev. Changes in the Subpopulation Composition and Phagocytic Activity of Monocytes in Patients with Kidney Cancer under the Influence of Metabolites In Vitro. Bulletin of experimental biology and medicine. 2021 Jul; 171(3):362-366. doi: 10.1007/s10517-021-05228-x. [PMID: 34297298]
  • Jennifer M Coughlin, Kun Yang, Anouk Marsman, Subechhya Pradhan, Min Wang, Rebecca E Ward, Susanne Bonekamp, Emily B Ambinder, Cecilia P Higgs, Pearl K Kim, Jamie A Edwards, Mark Varvaris, Hongxing Wang, Sotirios Posporelis, Shuangchao Ma, Tsuyoshi Tsujimura, Richard A E Edden, Martin G Pomper, Thomas W Sedlak, Margot Fournier, David J Schretlen, Nicola G Cascella, Peter B Barker, Akira Sawa. A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia. Molecular psychiatry. 2021 07; 26(7):3502-3511. doi: 10.1038/s41380-020-00901-5. [PMID: 33077854]
  • Navatha Alugubelly, Afzaal N Mohammed, Russell L Carr. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. 2021 07; 85(?):234-244. doi: 10.1016/j.neuro.2021.05.012. [PMID: 34058248]
  • Guozhi Bi, Min Su, Nan Li, Yu Liang, Song Dang, Jiachao Xu, Meijuan Hu, Jizong Wang, Minxia Zou, Yanan Deng, Qiyu Li, Shijia Huang, Jiejie Li, Jijie Chai, Kangmin He, Yu-Hang Chen, Jian-Min Zhou. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Cell. 2021 06; 184(13):3528-3541.e12. doi: 10.1016/j.cell.2021.05.003. [PMID: 33984278]
  • Lingling Mao, Shuhong Fang, Meirong Zhao, Weiping Liu, Hangbiao Jin. Effects of Bisphenol A and Bisphenol S Exposure at Low Doses on the Metabolome of Adolescent Male Sprague-Dawley Rats. Chemical research in toxicology. 2021 06; 34(6):1578-1587. doi: 10.1021/acs.chemrestox.1c00018. [PMID: 34019419]
  • Motohiro Okada, Kouji Fukuyama, Takashi Shiroyama, Yuto Ueda. Brivaracetam prevents astroglial l-glutamate release associated with hemichannel through modulation of synaptic vesicle protein. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111462. doi: 10.1016/j.biopha.2021.111462. [PMID: 33706129]
  • Shi-Feng Chu, Zhao Zhang, Xin Zhou, Wen-Bin He, Bo Yang, Li-Yuan Cui, Hong-Yuan He, Zhen-Zhen Wang, Nai-Hong Chen. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Acta pharmacologica Sinica. 2021 Jun; 42(6):848-860. doi: 10.1038/s41401-020-00536-w. [PMID: 33028984]
  • Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wang. Typhaneoside Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals. Chemical research in toxicology. 2021 05; 34(5):1286-1295. doi: 10.1021/acs.chemrestox.0c00446. [PMID: 33621091]
  • H-Y Wang, C-H Zhu, D-S Liu, Y Wang, J-B Zhang, S-P Wang, Y-N Song. Rehabilitation training improves cognitive disorder after cerebrovascular accident by improving BDNF Bcl-2 and Bax expressions in regulating the JMK pathway. European review for medical and pharmacological sciences. 2021 05; 25(10):3807-3821. doi: 10.26355/eurrev_202105_25949. [PMID: 34109590]
  • Umit Haluk Yesilkaya, Meltem Sen, Yasin Hasan Balcioglu. COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2021 May; 87(?):153-155. doi: 10.1016/j.jocn.2021.03.007. [PMID: 33863524]
  • Imène Sakhi, Yohan Bignon, Nadia Frachon, Marguerite Hureaux, Bárbara Arévalo, Wendy González, Rosa Vargas-Poussou, Stéphane Lourdel. Diversity of functional alterations of the ClC-5 exchanger in the region of the proton glutamate in patients with Dent disease 1. Human mutation. 2021 05; 42(5):537-550. doi: 10.1002/humu.24184. [PMID: 33600050]
  • Meng-Ting Zuo, Yong Wu, Zi-Yuan Wang, Na Wang, Si-Juan Huang, Hui Yu, Xue-Jiao Zhao, Chong-Yin Huang, Zhao-Ying Liu. A comprehensive toxicity evaluation in rats after long-term oral Gelsemium elegans exposure. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111284. doi: 10.1016/j.biopha.2021.111284. [PMID: 33561641]
  • Aven Lee, Buddhika Jayakody Arachchige, Robert Henderson, David Pow, Sarah Reed, James Aylward, Pamela Ann McCombe. Elevated plasma levels of D-serine in some patients with amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration. 2021 05; 22(3-4):206-210. doi: 10.1080/21678421.2020.1832120. [PMID: 33908331]
  • Ching-On Wong, Nicholas E Karagas, Jewon Jung, Qiaochu Wang, Morgan A Rousseau, Yufang Chao, Ryan Insolera, Pushpanjali Soppina, Catherine A Collins, Yong Zhou, John F Hancock, Michael X Zhu, Kartik Venkatachalam. Regulation of longevity by depolarization-induced activation of PLC-β-IP3R signaling in neurons. Proceedings of the National Academy of Sciences of the United States of America. 2021 04; 118(16):. doi: 10.1073/pnas.2004253118. [PMID: 33859040]
  • Kouji Fukuyama, Tomosuke Nakano, Takashi Shiroyama, Motohiro Okada. Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084122. [PMID: 33923533]
  • Clemens L Schöpf, Cornelia Ablinger, Stefanie M Geisler, Ruslan I Stanika, Marta Campiglio, Walter A Kaufmann, Benedikt Nimmervoll, Bettina Schlick, Johannes Brockhaus, Markus Missler, Ryuichi Shigemoto, Gerald J Obermair. Presynaptic α2δ subunits are key organizers of glutamatergic synapses. Proceedings of the National Academy of Sciences of the United States of America. 2021 04; 118(14):. doi: 10.1073/pnas.1920827118. [PMID: 33782113]