Exact Mass: 524.8934
Exact Mass Matches: 524.8934
Found 22 metabolites which its exact mass value is equals to given mass value 524.8934,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
3,5-Diiodothyronine
3,5-Diiodothyronine, also known as 3,5-T2, belongs to the class of organic compounds known as phenylalanines and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. It is also a member of the class of compounds known as iodothyronines. Iodothyronines are phenolic amino acids with iodine substituents. 3,5-Diiodothyronine is a metabolite of the two main thyroid hormones T3 and T4 (thyroxine and triiodo-L-thyronine). It is a biologically active iodothyronine with mitochondria and bioenergetic mechanisms being the major targets of 3,5-T2. Nanomolar concentrations of 3,5-T2 significantly increases cytochrome oxidase (COX) activity (PMID: 30090086). It increases COX activity by preventing the interaction of adenosine triphosphate (ATP) as an allosteric inhibitor. At 1 pM concentration, 3,5-T2 stimulates oxygen consumption more rapidly than thyroxine (T3). A case report involving two human participants revealed that administration of 3,5-T2 to humans (1–5 ug/kg BW) rapidly (after 4–6 h) increased resting metabolic rate. Chronic 3,5-T2 administration (28 days, approximately 5 ug/kg BW) increased resting metabolic rate by approximately 15\\% and decreased body weight by approximately 4 kg in both participants (PMID: 22217997). 3,5-T2 stimulates the thyroid receptor (TR)-beta receptor for thyroid hormones and thus increases energy expenditure. It has agonistic (thyromimetic) effects on myocardial tissue and on the pituitary, which results in 3,5-T2 suppressing thyroid stimulating hormone release. 3,5-Diiodothyronine is a metabolite of thyroid hormones (thyroxine and triiodo-L-thyronine). It has specific actions and those actions do not involve thyroid hormone receptors. (PMID 15807655) [HMDB] D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
3,3'-Diiodothyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones 3,3-Diiodothyronine is a precursor of thyroid hormone. [HMDB] 3,3-Diiodothyronine is a precursor of thyroid hormone.
3,3'-Diiodo-L-thyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(2S)-2-(Diiodoamino)-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid
3,5-Diiodothyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
3,5-Diiodo-L-thyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones NSC 90469 is an endogenous metabolite.
3,5-T2
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
3,3-diiodo-L-thyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid
O-(4-Hydroxy-3,5-diiodophenyl)-L-tyrosine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(2S)-2-(Diiodoamino)-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid
3,5-diiodo-L-thyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]propanoate
3,3-Diiodothyronine
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
