O-(4-Hydroxy-3,5-diiodophenyl)-L-tyrosine (BioDeep_00000841283)
代谢物信息卡片
O-(4-Hydroxy-3,5-diiodophenyl)-L-tyrosine
化学式: C15H13I2NO4 (524.8934)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OC2=CC(=C(C(=C2)I)O)I
InChI: InChI=1S/C15H13I2NO4/c16-11-6-10(7-12(17)14(11)19)22-9-3-1-8(2-4-9)5-13(18)15(20)21/h1-4,6-7,13,19H,5,18H2,(H,20,21)/t13-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lili Shao, Xi Chen, Jinxiu Lyu, Meng Zhao, Qing Li, Shuai Ji, Qiang Sun, Daoquan Tang, Houfa Geng, Mengzhe Guo. Enrichment and Quantitative Determination of Free 3,5- Diiodothyronine, 3',5'-Diiodothyronine, and 3,5-Diiodothyronamine in Human Serum of Thyroid Cancer by Covalent Organic Hyper Cross-linked Poly-ionic Liquid.
Journal of chromatography. A.
2021 Jan; 1637(?):461821. doi:
10.1016/j.chroma.2020.461821. [PMID: 33360433] - Elena Grasselli, Laura Canesi, Piero Portincasa, Adriana Voci, Laura Vergani, Ilaria Demori. Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine.
Annals of hepatology.
2017 Sep; 16(5):707-719. doi:
10.5604/01.3001.0010.2713. [PMID: 28809727] - Sergio Scapin, Silvia Leoni, Silvana Spagnuolo, Anna Maria Fiore, Sandra Incerpi. Short-term effects of thyroid hormones on Na+-K+-ATPase activity of chick embryo hepatocytes during development: focus on signal transduction.
American journal of physiology. Cell physiology.
2009 Jan; 296(1):C4-12. doi:
10.1152/ajpcell.90604.2007. [PMID: 18829895] - B Shameena, S Varghese, S Leena, O V Oommen. 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyrone (T2) have short-term effects on lipid metabolism in a teleost Anabas testudineus (Bloch): evidence from enzyme activities.
Endocrine research.
2000 Aug; 26(3):431-44. doi:
10.3109/07435800009066178. [PMID: 11019906] - M Cimmino, F Mion, F Goglia, Y Minaire, A Géloën. Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine.
The Journal of endocrinology.
1996 May; 149(2):319-25. doi:
10.1677/joe.0.1490319. [PMID: 8708544] - E Krysin, E Brzezińska-Slebodzińska. Ontogeny of the generation of diiodothyronines (3,3'-T2 and 3',5'-T2) from triiodothyronines in the liver and kidney during the fetal life of the pig.
Acta veterinaria Hungarica.
1996; 44(2):203-12. doi:
NULL. [PMID: 8908744] - C Horst, A Harneit, H J Seitz, H Rokos. 3,5-Di-iodo-L-thyronine suppresses TSH in rats in vivo and in rat pituitary fragments in vitro.
The Journal of endocrinology.
1995 May; 145(2):291-7. doi:
10.1677/joe.0.1450291. [PMID: 7616162] - U Piran, W J Riordan, D R Silbert. Effect of hapten heterology on thyroid hormone immunoassays.
Journal of immunological methods.
1990 Oct; 133(2):207-14. doi:
10.1016/0022-1759(90)90361-x. [PMID: 2230139] - C Bregengaard, C Kirkegaard, J Faber, S Poulsen, K Siersbaek-Nielsen, T Friis. Concentrations of thyroxine, 3,5,3'-triiodothyronine, 3,3',5'-triiodothyronine, 3,3'-diiodothyronine, and 3',5'-diiodothyronine in human red blood cells.
Scandinavian journal of clinical and laboratory investigation.
1989 Jun; 49(4):329-36. doi:
10.3109/00365518909089105. [PMID: 2740826] - J J DiStefano, D Feng. Comparative aspects of the distribution, metabolism, and excretion of six iodothyronines in the rat.
Endocrinology.
1988 Nov; 123(5):2514-25. doi:
10.1210/endo-123-5-2514. [PMID: 3168932] - J Faber, K Siersbaek-Nielsen, C Kirkegaard. Renal handling of thyroxine, 3,5,3'- and 3,3',5'-triiodothyronine, 3,3'- and 3',5'-diiodothyronine in man.
Acta endocrinologica.
1987 May; 115(1):144-8. doi:
10.1530/acta.0.1150144. [PMID: 3591221] - J Faber, I B Lumholtz, C Kirkegaard, S Poulsen, P H Jørgensen, K Siersbaek-Nielsen, T Friis. The effects of phenytoin (diphenylhydantoin) on the extrathyroidal turnover of thyroxine, 3,5,3'-triiodothyronine, 3,3',5'-triiodothyronine, and 3',5'-diiodothyronine in man.
The Journal of clinical endocrinology and metabolism.
1985 Dec; 61(6):1093-9. doi:
10.1210/jcem-61-6-1093. [PMID: 4055984] - R A Peterfreund, P E Sawchenko, W Vale. Thyroid hormones reversibly suppress somatostatin secretion and immunoreactivity in cultured neocortical cells.
Brain research.
1985 Mar; 328(2):259-70. doi:
10.1016/0006-8993(85)91037-6. [PMID: 2859080] - J Faber, P Rogowski, C Kirkegaard, K Siersbaek-Nielsen, T Friis. Serum free T4, T3, rT3, 3,3'-diiodothyronine and 3',5'-diiodothyronine measured by ultrafiltration.
Acta endocrinologica.
1984 Nov; 107(3):357-65. doi:
10.1530/acta.0.1070357. [PMID: 6507005] - J Faber, O Faber, A Wennlund, J Wahren. Splanchnic extraction of 3,3'-diiodothyronine and 3',5'-diiodothyronine in hyperthyroidism.
The Journal of clinical endocrinology and metabolism.
1984 Jul; 59(1):147-50. doi:
10.1210/jcem-59-1-147. [PMID: 6725519] - I J Chopra, T S Huang, R E Hurd, D H Solomon. Thyromimetic effects of 3,5-dimethyl,3'-isopropyl thyronine (DIMIT) and 3,5-diethyl,3'-isopropyl thyronine (DIET) in various tissues of the rat.
Metabolism: clinical and experimental.
1984 Jul; 33(7):622-8. doi:
10.1016/0026-0495(84)90060-x. [PMID: 6738362] - D Engler, U Merkelbach, G Steiger, A G Burger. The monodeiodination of triiodothyronine and reverse triiodothyronine in man: a quantitative evaluation of the pathway by the use of turnover rate techniques.
The Journal of clinical endocrinology and metabolism.
1984 Jan; 58(1):49-61. doi:
10.1210/jcem-58-1-49. [PMID: 6689682] - J Faber, C Kirkegaard, H F Thomsen, I B Lumholtz, K Siersbaek-Nielsen, T Friis. The extrathyroidal conversion of 3,5,3'-triiodothyronine to 3,5-diiodothyronine in patients with liver cirrhosis.
The Journal of clinical endocrinology and metabolism.
1983 Aug; 57(2):428-31. doi:
10.1210/jcem-57-2-428. [PMID: 6863483] - M Nishikawa, M Inada, K Naito, H Ishii, K Tanaka, Y Mashio, H Imura. Serum concentrations of 3, 3'-diiodothyronine, 3', 5'-diiodothyronine, and 3, 5-diiodothyronine in altered thyroid states.
Endocrinologia japonica.
1983 Apr; 30(2):167-72. doi:
10.1507/endocrj1954.30.167. [PMID: 6641638] - J Faber, M Busch-Sørensen, P Rogowski, C Kirkegaard, K Siersbaek-Nielsen, T Friis. Urinary excretion of free and conjugated 3',5'-diiodothyronine and 3,3'-diiodothyronine.
The Journal of clinical endocrinology and metabolism.
1981 Sep; 53(3):587-93. doi:
10.1210/jcem-53-3-587. [PMID: 7263841] - R C Smallridge, K D Burman, K E Ward, L Wartofsky, R C Dimond, F D Wright, K R Latham. 3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat: enzyme characteristics and evidence for two distinct 5'-deiodinases.
Endocrinology.
1981 Jun; 108(6):2336-45. doi:
10.1210/endo-108-6-2336. [PMID: 7227308] - I J Chopra, F Geola, D H Solomon, R M Maciel. 3'-5'-Diiodothyronine in health and disease: studies by a radioimmunoassay.
The Journal of clinical endocrinology and metabolism.
1978 Dec; 47(6):1198-207. doi:
10.1210/jcem-47-6-1198. [PMID: 263734] - K D Burman, F D Wright, R C Smallridge, B J Green, L P Georges, L Wartofsky. A radioimmunoassay for 3',5'-diiodothyronine.
The Journal of clinical endocrinology and metabolism.
1978 Nov; 47(5):1059-64. doi:
10.1210/jcem-47-5-1059. [PMID: 263335]
