3,3'-Diiodo-L-thyronine (BioDeep_00000174018)

   

human metabolite blood metabolite natural product


代谢物信息卡片


2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid

化学式: C15H13I2NO4 (524.8934)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C=C2)O)I
InChI: InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

9 个代谢物同义名

2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid; 2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoate; 3,3-Diiodothyronine, (L)-isomer, 125I-labeled; O-(4-Hydroxy-3-iodophenyl)-3-iodotyrosine; 3,3-Diiodothyronine, (DL)-isomer; 3,3-Diiodothyronine, (L)-isomer; 3,3-diiodo-L-thyronine; 3,3-Diiodothyronine; 3,3-T2



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • S da Silva Teixeira, C Filgueira, D H Sieglaff, C Benod, R Villagomez, L J Minze, A Zhang, P Webb, M T Nunes. 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. Acta physiologica (Oxford, England). 2017 06; 220(2):238-250. doi: 10.1111/apha.12821. [PMID: 27770485]
  • Jesper Svanfelt, Johan Eriksson, Leif Kronberg. Analysis of thyroid hormones in raw and treated waste water. Journal of chromatography. A. 2010 Oct; 1217(42):6469-74. doi: 10.1016/j.chroma.2010.08.032. [PMID: 20850122]
  • Dongli Wang, Heather M Stapleton. Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2010 Jul; 397(5):1831-9. doi: 10.1007/s00216-010-3705-9. [PMID: 20437035]
  • Yves Debaveye, Björn Ellger, Liese Mebis, Theo J Visser, Veerle M Darras, Greet Van den Berghe. Effects of substitution and high-dose thyroid hormone therapy on deiodination, sulfoconjugation, and tissue thyroid hormone levels in prolonged critically ill rabbits. Endocrinology. 2008 Aug; 149(8):4218-28. doi: 10.1210/en.2007-1566. [PMID: 18450965]
  • Maria Moreno, Pieter de Lange, Assunta Lombardi, Elena Silvestri, Antonia Lanni, Fernando Goglia. Metabolic effects of thyroid hormone derivatives. Thyroid : official journal of the American Thyroid Association. 2008 Feb; 18(2):239-53. doi: 10.1089/thy.2007.0248. [PMID: 18279024]
  • Edith C H Friesema, George G J M Kuiper, Jurgen Jansen, Theo J Visser, Monique H A Kester. Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Molecular endocrinology (Baltimore, Md.). 2006 Nov; 20(11):2761-72. doi: 10.1210/me.2005-0256. [PMID: 16887882]
  • Robin P Peeters, Monique H A Kester, Pieter J Wouters, Ellen Kaptein, Hans van Toor, Theo J Visser, Greet Van den Berghe. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity. The Journal of clinical endocrinology and metabolism. 2005 Dec; 90(12):6460-5. doi: 10.1210/jc.2005-0866. [PMID: 16189257]
  • Frank W J S Wassen, Willem Klootwijk, Ellen Kaptein, Dirk J Duncker, Theo J Visser, George G J M Kuiper. Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs. Endocrinology. 2004 Sep; 145(9):4251-63. doi: 10.1210/en.2004-0356. [PMID: 15192045]
  • Inder J Chopra. A radioimmunoassay for measurement of 3,3'-diiodothyronine sulfate: Studies in thyroidal and nonthyroidal diseases, pregnancy, and fetal/neonatal life. Metabolism: clinical and experimental. 2004 Apr; 53(4):538-43. doi: 10.1016/j.metabol.2003.10.023. [PMID: 15045705]
  • Edith C H Friesema, Sumita Ganguly, Amal Abdalla, Jocelyn E Manning Fox, Andrew P Halestrap, Theo J Visser. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. The Journal of biological chemistry. 2003 Oct; 278(41):40128-35. doi: 10.1074/jbc.m300909200. [PMID: 12871948]
  • F A Verhoeven, H H A G M Van der Putten, G Hennemann, J M J Lamers, T J Visser, M E Everts. Uptake of triiodothyronine and triiodothyroacetic acid in neonatal rat cardiomyocytes: effects of metabolites and analogs. The Journal of endocrinology. 2002 May; 173(2):247-55. doi: 10.1677/joe.0.1730247. [PMID: 12010632]
  • C Tsoi, C N Falany, R Morgenstern, S Swedmark. Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog. Archives of biochemistry and biophysics. 2001 Jun; 390(1):87-92. doi: 10.1006/abbi.2001.2373. [PMID: 11368519]
  • R Rajatanavin, D A Fisher, L Chailurkit, W S Huang, S Srisupandit, S Y Wu. A T2S cross-reactive material (compound W) in hyperthyroid patients with trophoblastic disease. Thyroid : official journal of the American Thyroid Association. 1999 Oct; 9(10):989-94. doi: 10.1089/thy.1999.9.989. [PMID: 10560952]
  • E C Friesema, R Docter, E P Moerings, B Stieger, B Hagenbuch, P J Meier, E P Krenning, G Hennemann, T J Visser. Identification of thyroid hormone transporters. Biochemical and biophysical research communications. 1999 Jan; 254(2):497-501. doi: 10.1006/bbrc.1998.9974. [PMID: 9918867]
  • G Pinna, L Hiedra, H Meinhold, M Eravci, H Prengel, O Brödel, K J Gräf, G Stoltenburg-Didinger, M Bauer, A Baumgartner. 3,3'-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress. The Journal of clinical endocrinology and metabolism. 1998 Sep; 83(9):3071-7. doi: 10.1210/jcem.83.9.5080. [PMID: 9745405]
  • E C Friesema, R Docter, E P Krenning, M E Everts, G Hennemann, T J Visser. Rapid sulfation of 3,3',5'-triiodothyronine in native Xenopus laevis oocytes. Endocrinology. 1998 Feb; 139(2):596-600. doi: 10.1210/endo.139.2.5743. [PMID: 9449630]
  • M Moreno, A Lombardi, P Lombardi, F Goglia, A Lanni. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life sciences. 1998; 62(26):2369-77. doi: 10.1016/s0024-3205(98)00219-7. [PMID: 9651103]
  • S Y Wu, M Jordan, J H Nguyen. Compound W: a potential marker in maternal serum for assessing fetal thyroid function. Comprehensive therapy. 1995 Oct; 21(10):594-6. doi: NULL. [PMID: 8565429]
  • A Wojtczak, J Luft, V Cody. Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin. The Journal of biological chemistry. 1992 Jan; 267(1):353-7. doi: NULL. [PMID: 1730601]
  • M Rutgers, F A Heusdens, F Bonthuis, T J Visser. Metabolism of triiodothyroacetic acid (TA3) in rat liver. II. Deiodination and conjugation of TA3 by rat hepatocytes and in rats in vivo. Endocrinology. 1989 Jul; 125(1):433-43. doi: 10.1210/endo-125-1-433. [PMID: 2737157]
  • C Bregengaard, C Kirkegaard, J Faber, S Poulsen, K Siersbaek-Nielsen, T Friis. Concentrations of thyroxine, 3,5,3'-triiodothyronine, 3,3',5'-triiodothyronine, 3,3'-diiodothyronine, and 3',5'-diiodothyronine in human red blood cells. Scandinavian journal of clinical and laboratory investigation. 1989 Jun; 49(4):329-36. doi: 10.3109/00365518909089105. [PMID: 2740826]
  • J J DiStefano, D Feng. Comparative aspects of the distribution, metabolism, and excretion of six iodothyronines in the rat. Endocrinology. 1988 Nov; 123(5):2514-25. doi: 10.1210/endo-123-5-2514. [PMID: 3168932]
  • A G Bauer, J H Wilson, S W Lamberts, R Docter, G Hennemann, T J Visser. Handling of iodothyronines by the liver and kidney in patients with chronic liver disease. Acta endocrinologica. 1987 Nov; 116(3):339-46. doi: 10.1530/acta.0.1160339. [PMID: 3120447]
  • J Faber, K Siersbaek-Nielsen, C Kirkegaard. Renal handling of thyroxine, 3,5,3'- and 3,3',5'-triiodothyronine, 3,3'- and 3',5'-diiodothyronine in man. Acta endocrinologica. 1987 May; 115(1):144-8. doi: 10.1530/acta.0.1150144. [PMID: 3591221]
  • S Y Wu, R Reggio, W H Florsheim. Characterization of thyrotropin-induced increase in iodothyronine monodeiodinating activity in mice. Endocrinology. 1985 Mar; 116(3):901-8. doi: 10.1210/endo-116-3-901. [PMID: 3971910]
  • G Benker, C Splittstösser, H Meinhold, T Olbricht, D Reinwein. Effects of small doses of bovine TSH on serum levels of free and total thyroid hormones, their degradation products, and diiodotyrosine. Acta endocrinologica. 1985 Feb; 108(2):211-6. doi: 10.1530/acta.0.1080211. [PMID: 3969815]
  • J Faber, P Rogowski, C Kirkegaard, K Siersbaek-Nielsen, T Friis. Serum free T4, T3, rT3, 3,3'-diiodothyronine and 3',5'-diiodothyronine measured by ultrafiltration. Acta endocrinologica. 1984 Nov; 107(3):357-65. doi: 10.1530/acta.0.1070357. [PMID: 6507005]
  • M H Otten, G Hennemann, R Docter, T J Visser. Metabolism of 3,3'-diiodothyronine in rat hepatocytes: interaction of sulfation with deiodination. Endocrinology. 1984 Sep; 115(3):887-94. doi: 10.1210/endo-115-3-887. [PMID: 6745193]
  • J Faber, O Faber, A Wennlund, J Wahren. Splanchnic extraction of 3,3'-diiodothyronine and 3',5'-diiodothyronine in hyperthyroidism. The Journal of clinical endocrinology and metabolism. 1984 Jul; 59(1):147-50. doi: 10.1210/jcem-59-1-147. [PMID: 6725519]
  • J M Corcoran, C J Eastman. Radioimmunoassay of 3-L-monoiodothyronine: application in normal human physiology and thyroid disease. The Journal of clinical endocrinology and metabolism. 1983 Jul; 57(1):66-70. doi: 10.1210/jcem-57-1-66. [PMID: 6853682]
  • M Nishikawa, M Inada, K Naito, H Ishii, K Tanaka, Y Mashio, H Imura. Serum concentrations of 3, 3'-diiodothyronine, 3', 5'-diiodothyronine, and 3, 5-diiodothyronine in altered thyroid states. Endocrinologia japonica. 1983 Apr; 30(2):167-72. doi: 10.1507/endocrj1954.30.167. [PMID: 6641638]
  • J Faber, J Heaf, C Kirkegaard, I B Lumholtz, K Siersbaek-Nielsen, K Kølendorf, T Friis. Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure. The Journal of clinical endocrinology and metabolism. 1983 Feb; 56(2):211-7. doi: 10.1210/jcem-56-2-211. [PMID: 6401746]
  • S Jaedig, J Faber. The effect of starvation and refeeding with oral versus intravenous glucose on serum 3,5-,3,3'-and 3'-5'-diiodothyronine and 3'-monoiodothyronine. Acta endocrinologica. 1982 Jul; 100(3):388-92. doi: 10.1530/acta.0.1000388. [PMID: 7113605]
  • J Faber, M Busch-Sørensen, P Rogowski, C Kirkegaard, K Siersbaek-Nielsen, T Friis. Urinary excretion of free and conjugated 3',5'-diiodothyronine and 3,3'-diiodothyronine. The Journal of clinical endocrinology and metabolism. 1981 Sep; 53(3):587-93. doi: 10.1210/jcem-53-3-587. [PMID: 7263841]
  • J M Corcoran, C J Eastman. Measurement of 3'-monoiodothyronine in human serum. Clinical endocrinology. 1981 Jul; 15(1):11-8. doi: 10.1111/j.1365-2265.1981.tb02742.x. [PMID: 7307281]
  • S W Dietrich, M B Bolger, P A Kollman, E C Jorgensen. Thyroxine analogues. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities. Journal of medicinal chemistry. 1977 Jul; 20(7):863-80. doi: 10.1021/jm00217a001. [PMID: 195056]
  • E V FLOCK, C DAVID, G H STOBIE, C A OWEN. 3,3',5'-TRIIODOTHYRONINE AND 3,3'-DIIODOTHYRONINE: PARTIALLY DEIODINATED INTERMEDIATES IN THE METABOLISM OF THE THYROID HORMONES. Endocrinology. 1963 Oct; 73(?):442-55. doi: 10.1210/endo-73-4-442. [PMID: 14068831]