3,5-Diiodothyronine (BioDeep_00000405306)

   


代谢物信息卡片


3,5-diiodo-dl-thyronine

化学式: C15H13I2NO4 (524.8934)
中文名称: 3,5-二碘甲腺氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OC2=CC(=C(C(=C2)I)O)I
InChI: InChI=1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

2 个代谢物同义名

3,5-diiodo-dl-thyronine; 3,5-Diiodothyronine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ruy Andrade Louzada, Alvaro Souto Padron, Silvio Rodrigues Marques-Neto, Leonardo Maciel, João Pedro Werneck-de-Castro, Andrea Claudia Freitas Ferreira, Jose Hamilton Matheus Nascimento, Denise Pires Carvalho. 3,5-Diiodothyronine protects against cardiac ischaemia-reperfusion injury in male rats. Experimental physiology. 2021 11; 106(11):2185-2197. doi: 10.1113/ep089589. [PMID: 34605090]
  • Julika Lietzow, Janine Golchert, Maik Pietzner, Uwe Völker, Matti Poutanen, Claes Ohlsson, Georg Homuth, Josef Köhrle. Comparative Analysis of the Effects of Long-Term 3,5-diiodothyronine Treatment on the Murine Hepatic Proteome and Transcriptome Under Conditions of Normal Diet and High-Fat Diet. Thyroid : official journal of the American Thyroid Association. 2021 07; 31(7):1135-1146. doi: 10.1089/thy.2020.0160. [PMID: 33637021]
  • Lili Shao, Xi Chen, Jinxiu Lyu, Meng Zhao, Qing Li, Shuai Ji, Qiang Sun, Daoquan Tang, Houfa Geng, Mengzhe Guo. Enrichment and Quantitative Determination of Free 3,5- Diiodothyronine, 3',5'-Diiodothyronine, and 3,5-Diiodothyronamine in Human Serum of Thyroid Cancer by Covalent Organic Hyper Cross-linked Poly-ionic Liquid. Journal of chromatography. A. 2021 Jan; 1637(?):461821. doi: 10.1016/j.chroma.2020.461821. [PMID: 33360433]
  • Eleonore Fröhlich, Richard Wahl. Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients. Frontiers in endocrinology. 2021; 12(?):587518. doi: 10.3389/fendo.2021.587518. [PMID: 33981284]
  • Riccardo Zucchi. Thyroid Hormone Analogues: An Update. Thyroid : official journal of the American Thyroid Association. 2020 08; 30(8):1099-1105. doi: 10.1089/thy.2020.0071. [PMID: 32098589]
  • Marco Giammanco, Carlo Maria Di Liegro, Gabriella Schiera, Italia Di Liegro. Genomic and Non-Genomic Mechanisms of Action of Thyroid Hormones and Their Catabolite 3,5-Diiodo-L-Thyronine in Mammals. International journal of molecular sciences. 2020 Jun; 21(11):. doi: 10.3390/ijms21114140. [PMID: 32532017]
  • Davide Gnocchi, Ewa C S Ellis, Helene Johansson, Mats Eriksson, Giovannella Bruscalupi, Knut R Steffensen, Paolo Parini. Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity. Molecular and cellular endocrinology. 2020 01; 499(?):110604. doi: 10.1016/j.mce.2019.110604. [PMID: 31580898]
  • Maik Pietzner, Josef Köhrle, Ina Lehmphul, Kathrin Budde, Gabi Kastenmüller, Georg Brabant, Henry Völzke, Anna Artati, Jerzy Adamski, Uwe Völker, Matthias Nauck, Nele Friedrich, Georg Homuth. A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans. Thyroid : official journal of the American Thyroid Association. 2019 12; 29(12):1743-1754. doi: 10.1089/thy.2018.0549. [PMID: 31571530]
  • Antonio Gnoni, Luisa Siculella, Giuseppina Paglialonga, Fabrizio Damiano, Anna Maria Giudetti. 3,5-diiodo-L-thyronine increases de novo lipogenesis in liver from hypothyroid rats by SREBP-1 and ChREBP-mediated transcriptional mechanisms. IUBMB life. 2019 07; 71(7):863-872. doi: 10.1002/iub.2014. [PMID: 30707786]
  • Elena Silvestri, Rosalba Senese, Federica Cioffi, Rita De Matteis, Davide Lattanzi, Assunta Lombardi, Antonia Giacco, Anna Maria Salzano, Andrea Scaloni, Michele Ceccarelli, Maria Moreno, Fernando Goglia, Antonia Lanni, Pieter de Lange. 3,5-Diiodo-L-Thyronine Exerts Metabolically Favorable Effects on Visceral Adipose Tissue of Rats Receiving a High-Fat Diet. Nutrients. 2019 Jan; 11(2):. doi: 10.3390/nu11020278. [PMID: 30691227]
  • A Olvera, C J Martyniuk, N Buisine, V Jiménez-Jacinto, A Sanchez-Flores, L M Sachs, A Orozco. Differential transcriptome regulation by 3,5-T2 and 3',3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia. Scientific reports. 2017 11; 7(1):15043. doi: 10.1038/s41598-017-14913-9. [PMID: 29118400]
  • Elena Grasselli, Laura Canesi, Piero Portincasa, Adriana Voci, Laura Vergani, Ilaria Demori. Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine. Annals of hepatology. 2017 Sep; 16(5):707-719. doi: 10.5604/01.3001.0010.2713. [PMID: 28809727]
  • S da Silva Teixeira, C Filgueira, D H Sieglaff, C Benod, R Villagomez, L J Minze, A Zhang, P Webb, M T Nunes. 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. Acta physiologica (Oxford, England). 2017 06; 220(2):238-250. doi: 10.1111/apha.12821. [PMID: 27770485]
  • Fabrizio Damiano, Alessio Rochira, Antonio Gnoni, Luisa Siculella. Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms. International journal of molecular sciences. 2017 Mar; 18(4):. doi: 10.3390/ijms18040744. [PMID: 28362337]
  • Lies Langouche, Ina Lehmphul, Sarah Vander Perre, Josef Köhrle, Greet Van den Berghe. Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study. Thyroid : official journal of the American Thyroid Association. 2016 12; 26(12):1674-1680. doi: 10.1089/thy.2016.0214. [PMID: 27676423]
  • Till Ittermann, Roberto Lorbeer, Marcus Dörr, Tobias Schneider, Alexander Quadrat, Lydia Heßelbarth, Michael Wenzel, Ina Lehmphul, Josef Köhrle, Birger Mensel, Henry Völzke. High levels of thyroid-stimulating hormone are associated with aortic wall thickness in the general population. European radiology. 2016 Dec; 26(12):4490-4496. doi: 10.1007/s00330-016-4316-4. [PMID: 26973144]
  • Alessandro Cavallo, Federica Taurino, Fabrizio Damiano, Luisa Siculella, Anna Maria Sardanelli, Antonio Gnoni. Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats stimulates bioenergetic parameters in liver mitochondria. Journal of bioenergetics and biomembranes. 2016 10; 48(5):521-529. doi: 10.1007/s10863-016-9686-4. [PMID: 27854029]
  • Julika Lietzow, Janine Golchert, Georg Homuth, Uwe Völker, Wenke Jonas, Josef Köhrle. 3,5-T2 alters murine genes relevant for xenobiotic, steroid, and thyroid hormone metabolism. Journal of molecular endocrinology. 2016 05; 56(4):311-23. doi: 10.1530/jme-15-0159. [PMID: 26903510]
  • Maria Coppola, Federica Cioffi, Maria Moreno, Fernando Goglia, Elena Silvestri. 3,5-diiodo-L-thyronine: A Possible Pharmacological Agent?. Current drug delivery. 2016; 13(3):330-8. doi: 10.2174/1567201813666151123124340. [PMID: 26593437]
  • Maik Pietzner, Ina Lehmphul, Nele Friedrich, Claudia Schurmann, Till Ittermann, Marcus Dörr, Matthias Nauck, René Laqua, Uwe Völker, Georg Brabant, Henry Völzke, Josef Köhrle, Georg Homuth, Henri Wallaschofski. Translating pharmacological findings from hypothyroid rodents to euthyroid humans: is there a functional role of endogenous 3,5-T2?. Thyroid : official journal of the American Thyroid Association. 2015 Feb; 25(2):188-97. doi: 10.1089/thy.2014.0262. [PMID: 25343227]
  • Assunta Lombardi, Rosalba Senese, Rita De Matteis, Rosa Anna Busiello, Federica Cioffi, Fernando Goglia, Antonia Lanni. 3,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats. PloS one. 2015; 10(2):e0116498. doi: 10.1371/journal.pone.0116498. [PMID: 25658324]
  • Daniel F Vatner, Jaclyn Snikeris, Violeta Popov, Rachel J Perry, Yasmeen Rahimi, Varman T Samuel. 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. PloS one. 2015; 10(10):e0140837. doi: 10.1371/journal.pone.0140837. [PMID: 26485433]
  • Wenke Jonas, Julika Lietzow, Franziska Wohlgemuth, Carolin S Hoefig, Petra Wiedmer, Ulrich Schweizer, Josef Köhrle, Annette Schürmann. 3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. Endocrinology. 2015 Jan; 156(1):389-99. doi: 10.1210/en.2014-1604. [PMID: 25322465]
  • Ina Lehmphul, Georg Brabant, Henri Wallaschofski, Marek Ruchala, Christian J Strasburger, Josef Köhrle, Zida Wu. Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody-based chemiluminescence immunoassay. Thyroid : official journal of the American Thyroid Association. 2014 Sep; 24(9):1350-60. doi: 10.1089/thy.2013.0688. [PMID: 24967815]
  • Alvaro Souto Padron, Ruy Andrade Louzada Neto, Thiago Urgal Pantaleão, Maria Carolina de Souza dos Santos, Renata Lopes Araujo, Bruno Moulin de Andrade, Monique da Silva Leandro, João Pedro Saar Werneck de Castro, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho. Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues. The Journal of endocrinology. 2014 Jun; 221(3):415-27. doi: 10.1530/joe-13-0502. [PMID: 24692290]
  • D Gnocchi, M Massimi, A Alisi, S Incerpi, G Bruscalupi. Effect of fructose and 3,5-diiodothyronine (3,5-T(2)) on lipid accumulation and insulin signalling in non-alcoholic fatty liver disease (NAFLD)-like rat primary hepatocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2014 May; 46(5):333-40. doi: 10.1055/s-0034-1371858. [PMID: 24816759]
  • Rosalba Senese, Federica Cioffi, Pieter de Lange, Fernando Goglia, Antonia Lanni. Thyroid: biological actions of 'nonclassical' thyroid hormones. The Journal of endocrinology. 2014 May; 221(2):R1-12. doi: 10.1530/joe-13-0573. [PMID: 24464019]
  • Elena Grasselli, Adriana Voci, Laura Canesi, Annalisa Salis, Gianluca Damonte, Andrea D Compalati, Fernando Goglia, Gabriella Gallo, Laura Vergani. 3,5-diiodo-L-thyronine modifies the lipid droplet composition in a model of hepatosteatosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2014; 33(2):344-56. doi: 10.1159/000356674. [PMID: 24525903]
  • Guoguo Shang, Pan Gao, Zhonghua Zhao, Qi Chen, Tao Jiang, Nong Zhang, Hui Li. 3,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats. Biochimica et biophysica acta. 2013 May; 1832(5):674-84. doi: 10.1016/j.bbadis.2013.01.023. [PMID: 23416120]
  • Assunta Lombardi, Rita De Matteis, Maria Moreno, Laura Napolitano, Rosa Anna Busiello, Rosalba Senese, Pieter de Lange, Antonia Lanni, Fernando Goglia. Responses of skeletal muscle lipid metabolism in rat gastrocnemius to hypothyroidism and iodothyronine administration: a putative role for FAT/CD36. American journal of physiology. Endocrinology and metabolism. 2012 Nov; 303(10):E1222-33. doi: 10.1152/ajpendo.00037.2012. [PMID: 22967501]
  • Ira J Goldberg, Li-Shin Huang, Lesley A Huggins, Shuiqing Yu, Prabhakara R Nagareddy, Thomas S Scanlan, Joel R Ehrenkranz. Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology. 2012 Nov; 153(11):5143-9. doi: 10.1210/en.2012-1572. [PMID: 22948212]
  • Adelaide Del Viscovo, Agnese Secondo, Alba Esposito, Fernando Goglia, Maria Moreno, Lorella M T Canzoniero. Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells. American journal of physiology. Endocrinology and metabolism. 2012 Jun; 302(11):E1419-30. doi: 10.1152/ajpendo.00389.2011. [PMID: 22414808]
  • Elena Grasselli, Adriana Voci, Ilaria Demori, Laura Canesi, Rita De Matteis, Fernando Goglia, Antonia Lanni, Gabriella Gallo, Laura Vergani. 3,5-Diiodo-L-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver. The Journal of endocrinology. 2012 Feb; 212(2):149-58. doi: 10.1530/joe-11-0288. [PMID: 22107956]
  • Pieter de Lange, Federica Cioffi, Rosalba Senese, Maria Moreno, Assunta Lombardi, Elena Silvestri, Rita De Matteis, Lillà Lionetti, Maria Pina Mollica, Fernando Goglia, Antonia Lanni. Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats. Diabetes. 2011 Nov; 60(11):2730-9. doi: 10.2337/db11-0207. [PMID: 21926273]
  • Alessandro Cavallo, Antonio Gnoni, Elena Conte, Luisa Siculella, Franco Zanotti, Sergio Papa, Gabriele Vincenzo Gnoni. 3,5-diiodo-L-thyronine increases FoF1-ATP synthase activity and cardiolipin level in liver mitochondria of hypothyroid rats. Journal of bioenergetics and biomembranes. 2011 Aug; 43(4):349-57. doi: 10.1007/s10863-011-9366-3. [PMID: 21739248]
  • Elena Grasselli, Adriana Voci, Laura Canesi, Rita De Matteis, Fernando Goglia, Federica Cioffi, Emilia Fugassa, Gabriella Gallo, Laura Vergani. Direct effects of iodothyronines on excess fat storage in rat hepatocytes. Journal of hepatology. 2011 Jun; 54(6):1230-6. doi: 10.1016/j.jhep.2010.09.027. [PMID: 21145833]
  • Elena Silvestri, Federica Cioffi, Daniela Glinni, Michele Ceccarelli, Assunta Lombardi, Pieter de Lange, Angela Chambery, Valeria Severino, Antonia Lanni, Fernando Goglia, Maria Moreno. Pathways affected by 3,5-diiodo-l-thyronine in liver of high fat-fed rats: evidence from two-dimensional electrophoresis, blue-native PAGE, and mass spectrometry. Molecular bioSystems. 2010 Nov; 6(11):2256-71. doi: 10.1039/c0mb00040j. [PMID: 20844788]
  • Federica Cioffi, Antonia Lanni, Fernando Goglia. Thyroid hormones, mitochondrial bioenergetics and lipid handling. Current opinion in endocrinology, diabetes, and obesity. 2010 Oct; 17(5):402-7. doi: 10.1097/med.0b013e32833cf354. [PMID: 20625286]
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  • Maria Pina Mollica, Lillà Lionetti, Maria Moreno, Assunta Lombardi, Pieter De Lange, Alessandro Antonelli, Antonia Lanni, Gina Cavaliere, Antonio Barletta, Fernando Goglia. 3,5-diiodo-l-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet. Journal of hepatology. 2009 Aug; 51(2):363-70. doi: 10.1016/j.jhep.2009.03.023. [PMID: 19464748]
  • A Lombardi, P de Lange, E Silvestri, R A Busiello, A Lanni, F Goglia, M Moreno. 3,5-Diiodo-L-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement. American journal of physiology. Endocrinology and metabolism. 2009 Mar; 296(3):E497-502. doi: 10.1152/ajpendo.90642.2008. [PMID: 19116374]
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  • Antonia Lanni, Maria Moreno, Assunta Lombardi, Pieter de Lange, Elena Silvestri, Maurizio Ragni, Paola Farina, Gabriella Chieffi Baccari, Pupah Fallahi, Alessandro Antonelli, Fernando Goglia. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Sep; 19(11):1552-4. doi: 10.1096/fj.05-3977fje. [PMID: 16014396]
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