Exact Mass: 451.2125

Exact Mass Matches: 451.2125

Found 500 metabolites which its exact mass value is equals to given mass value 451.2125, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Doxazosin

1 (4-amino-6,7-Dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)piperazine

C23H25N5O5 (451.1856)

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α₁-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH). α₁-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland. C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

Piscerythramine

4-Amino-5,7,3-trihydroxy-5-methoxy-2,6-diprenylisoflavone

C26H29NO6 (451.1995)

A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5, 7 and 3, prenyl groups at positions 2 and 6, a methoxy group at position 5 and an amino group at position 4.

FMLP OMe

Formylmethionyl-leucyl-phenylalanine methyl ester

C22H33N3O5S (451.2141)

14alpha-Hydroxypaxilline

5,11-dihydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁶,²⁴.0¹⁷,²²]tetracosa-9,16(24),17(22),18,20-pentaen-8-one

C27H33NO5 (451.2359)

14alpha-Hydroxypaxilline is a metabolite from Penicillium paxilli. Also identified chromatographically in Acremonium lolii. Metabolite from Penicillium paxilliand is) also identified chromatographically in Acremonium lolii

4-Hydroxyvalsartan

(2S)-2-(4-Hydroxy-N-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}pentanamido)-3-methylbutanoate

C24H29N5O4 (451.2219)

4-Hydroxyvalsartan is only found in individuals that have used or taken Valsartan. 4-Hydroxyvalsartan is a metabolite of Valsartan. 4-hydroxyvalsartan belongs to the family of Biphenyltetrazoles and Derivatives. These are organic compounds containing a biphenyl attached to a tetrazole. A carbon atom of the biphenyl moiety is boned to a carbon or the nitrogen atom of the tetrazole moiety.

1-Hydroxytrimazosin

2-Hydroxy-2-hydroxymethylpropyl-4(4-amino-6,7,8-trimethoxy-2-quinazolinyl)-1-piperazine carboxylic acid

C20H29N5O7 (451.2067)

4-Hydroxypropranolol glucuronide

3,4,5-trihydroxy-6-[(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}naphthalen-1-yl)oxy]oxane-2-carboxylic acid

C22H29NO9 (451.1842)

Cenisertib

3-[(5-fluoro-2-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide

C24H30FN7O (451.2496)

(2S)-2-((3-((4-(4-Fluorophenoxy)phenyl)methylcarbamoyl)-4-methoxy-phenyl)methyl)butanoic acid

2-{[3-({[4-(4-fluorophenoxy)phenyl]methyl}-C-hydroxycarbonimidoyl)-4-methoxyphenyl]methyl}butanoate

C26H26FNO5 (451.1795)

tetrahydrogeranylgeranyl-PP

3,7,11,15-Tetramethylhexadeca-2,14-dien-1-yl (phosphonatooxy)phosphonic acid

C20H37O7P2 (451.2014)

Tetrahydrogeranylgeranyl-pp is practically insoluble (in water) and a moderately acidic compound (based on its pKa). Tetrahydrogeranylgeranyl-pp can be found in a number of food items such as muskmelon, wax gourd, deerberry, and pineapple, which makes tetrahydrogeranylgeranyl-pp a potential biomarker for the consumption of these food products.

Isopiscerythramine

4-Amino-5,7,3-trihydroxy-5-methoxy-8,2-diprenylisoflavone

C26H29NO6 (451.1995)

Terpendole H

C27H33NO5 (451.2359)

Pseudolycorine-1-O-beta-D-glucoside

C22H29NO9 (451.1842)

O-Methylsakerinol A

C23H33NO6S (451.2028)

dysidine

(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-4-carbamoylbutanoyl]pyrrolidin-2-yl]formamido}propanoic acid

C19H29N7O6 (451.2179)

C15H29N7O7S (451.1849)

(2S)-2-[4-hydroxy-N-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]-3-methylbutanoic acid

C24H29N5O4 (451.2219)

7-Hydroxypaxilline

5,11-dihydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0^{2,11}.0^{5,10}.0^{16,24}.0^{17,22}]tetracosa-9,16(24),17,19,21-pentaen-8-one

C27H33NO5 (451.2359)

Levofloxacin hydrate

C18H20FN3O4.0.5H2O (451.1966)

H-Gly-Gly-Tyr-Arg-OH

C19H29N7O6 (451.2179)

Z-Leu-Trp-OH

C25H29N3O5 (451.2107)

Fmoc-glu(ochx)-oh

C26H29NO6 (451.1995)

Lavofloxacin Lactate

C21H26FN3O7 (451.1755)

4-(2,2-diphenylvinyl)-N,N-di-p-tolylaniline

C34H29N (451.23)

Fmoc-(R)-3-Amino-4-(1-naphthyl)-butyric acid

C29H25NO4 (451.1783)

4-methylumbelliferyl a-l-idopyranosiduronic acid, cyclohexylammonium salt

C22H29NO9 (451.1842)

fmoc-(s)-3-amino-4-(2-naphthyl)-butyric acid

C29H25NO4 (451.1783)

AZ 628

3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide

C27H25N5O2 (451.2008)

AZ 628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively.

4-Hydroxy Valsartan

Valeryl-4-hydroxyvalsartan

C24H29N5O4 (451.2219)

Fmoc-(S)-3-Amino-4-(1-naphthyl)-butyric acid

C29H25NO4 (451.1783)

Fmoc-(R)-3-Amino-4-(2-naphthyl)-butyric acid

C29H25NO4 (451.1783)

Tetrazolast meglumine [usan]

C17H25N9O6 (451.1928)

Cenisertib

C24H30FN7O (451.2496)

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia[1][2][3].

(1r)-1-[(4-{[(6,7-Dihydro[1,4]dioxino[2,3-C]pyridazin-3-Yl)methyl]amino}piperidin-1-Yl)methyl]-9-Fluoro-1,2-Dihydro-4h-Pyrrolo[3,2,1-Ij]quinolin-4-One

C24H26FN5O3 (451.202)

2-(4-Dimethylaminophenyl)-5-(4-methyl-1-piperazinyl)-2,5-BI-benzimidazole

C27H29N7 (451.2484)

Dihydrocodeine bitartrate

C22H29NO9 (451.1842)

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist D002491 - Central Nervous System Agents > D000700 - Analgesics

Sanfetrinem cilexetil

C23H33NO8 (451.2206)

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

Homofenazine

C23H28F3N3OS (451.1905)

C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic

4-[4-(1-Amino-1-methylethyl)phenyl]-5-chloro-N-[4-(2-morpholin-4-ylethyl)phenyl]pyrimidin-2-amine

C25H30ClN5O (451.2139)

2-[[5-[(1,2,4a,5-Tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl)methyl]-6-hydroxy-3,4-dioxocyclohexa-1,5-dien-1-yl]amino]ethanesulfonic acid

C23H33NO6S (451.2028)

(2S)-2-((3-((4-(4-Fluorophenoxy)phenyl)methylcarbamoyl)-4-methoxy-phenyl)methyl)butanoic acid

2-{[3-({[4-(4-fluorophenoxy)phenyl]methyl}-C-hydroxycarbonimidoyl)-4-methoxyphenyl]methyl}butanoate

PE(15:1)

ST 22:3;O2;Tau

C24H37NO5S (451.2392)

AZ304

C27H25N5O2 (451.2008)

AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity[1].

PRGL493

C25H21N7O2 (451.1757)

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research[1].

9,20-dihydroxy-4,5-dimethoxy-16-oxa-24-azapentacyclo[15.7.1.1⁸,¹².0²,⁷.0¹⁹,²⁴]hexacosa-2(7),3,5,8(26),9,11,13-heptaen-15-one

C26H29NO6 (451.1995)

5-{[(10s)-11-chloro-10-hydroxy-3,7,11-trimethyldodeca-2,6-dien-1-yl]oxy}-6-methoxy-3h-isoindole-1,4-diol

C24H34ClNO5 (451.2125)

(2r,3s,4s,5r,6s)-2-{[(1r,14s,15s,16s)-4,14-dihydroxy-5-methoxy-9-azatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-2(7),3,5,12-tetraen-15-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C22H29NO9 (451.1842)

(1s,2r,5s,7r,11s,14s)-5,11-dihydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁶,²⁴.0¹⁷,²²]tetracosa-9,16(24),17,19,21-pentaen-8-one

C27H33NO5 (451.2359)

(1s,2r,5s,7s,8r,9r,11s,16r)-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6,10,13-trioxa-25-azaoctacyclo[14.10.0.0²,¹².0⁵,¹¹.0⁹,¹¹.0¹²,¹⁴.0¹⁸,²⁶.0¹⁹,²⁴]hexacosa-18(26),19,21,23-tetraen-8-ol

24,25-dihydroxy-15,16,23,23-tetramethyl-22,26-dioxa-13-azaheptacyclo[14.10.0.0¹,²⁰.0⁴,¹⁵.0⁶,¹⁴.0⁷,¹².0²¹,²⁵]hexacosa-6(14),7,9,11-tetraen-19-one

C27H33NO5 (451.2359)

17-[(4-hydroxy-2,2-dimethyl-5-oxooxolan-3-yl)oxy]-1,20-dimethyl-3-azapentacyclo[10.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]icosa-2(10),4,6,8-tetraen-16-one

C27H33NO5 (451.2359)

(1s,2r,5s,7s,8r,9r,11s,12r,14s,16r)-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6,10,13-trioxa-25-azaoctacyclo[14.10.0.0²,¹².0⁵,¹¹.0⁹,¹¹.0¹²,¹⁴.0¹⁸,²⁶.0¹⁹,²⁴]hexacosa-18(26),19,21,23-tetraen-8-ol

(1s,2r,5s,7s,8r,9r,11s,12r,14s,16r)-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6,10,13-trioxa-25-azaoctacyclo[14.10.0.0²,¹².0⁵,¹¹.0⁹,¹¹.0¹²,¹⁴.0¹⁸,²⁶.0¹⁹,²⁴]hexacosa-18(26),19,21,23-tetraen-8-ol

7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6,10,13-trioxa-25-azaoctacyclo[14.10.0.0²,¹².0⁵,¹¹.0⁹,¹¹.0¹²,¹⁴.0¹⁸,²⁶.0¹⁹,²⁴]hexacosa-18(26),19,21,23-tetraen-8-ol

C27H33NO5 (451.2359)

2-[(1-hydroxy-2,6,10,12-tetramethyl-3-oxotetradeca-4,6,8,10,12-pentaen-1-ylidene)amino]-3-(4-hydroxyphenyl)propanoic acid

C27H33NO5 (451.2359)

5-{[(2e,6e,10s)-11-chloro-10-hydroxy-3,7,11-trimethyldodeca-2,6-dien-1-yl]oxy}-6-methoxy-3h-isoindole-1,4-diol

C24H34ClNO5 (451.2125)

2-[(5-{[(2r,4s,4as,8as)-2,4,8,8a-tetramethyl-1,3,4,4a,5,6-hexahydronaphthalen-2-yl]methyl}-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)amino]ethanesulfonic acid

C23H33NO6S (451.2028)

(1r,4z,8z,10s,13r,15r)-15-butoxy-15-[(4r)-2-hydroxy-4,5-dihydro-1,3-thiazol-4-yl]-5,10-dimethyl-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-3-one

C24H37NO5S (451.2392)

(1s,2e,16e,23r,25s)-4,25-dihydroxy-22-oxa-5,10,14-triazapentacyclo[16.9.2.1¹⁰,¹⁴.0¹,²³.0²¹,²⁸]triaconta-2,4,16,18,20,28-hexaen-15-one

C26H33N3O4 (451.2471)

12-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6,8-dioxa-24-azahexacyclo[13.10.0.0²,¹².0⁵,¹¹.0¹⁷,²⁵.0¹⁸,²³]pentacosa-10,17(25),18,20,22-pentaen-9-one

C27H33NO5 (451.2359)