Exact Mass: 395.3035426

Exact Mass Matches: 395.3035426

Found 160 metabolites which its exact mass value is equals to given mass value 395.3035426, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Prostaglandin E2 ethanolamide

(5Z)-7-[(1R,2R,3S)-3-Hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]-N-(2-hydroxyethyl)hept-5-enimidate

C22H37NO5 (395.26715920000004)


prostaglandin E2 ethanolamide is the major prostanoid product derived from anandamide. Incubation of anandamide with lysates and the intact cell line expressing COX-2 but not that of COX-1 produced prostaglandin E2 ethanolamide. This reaction demonstrates the existence of a COX-2-mediated pathway for anandamide metabolism, and the metabolites formed represent a novel class of prostaglandins. Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. prostaglandin E2 ethanolamide is the major prostanoid product derived from anandamide. Incubation of anandamide with lysates and the intact cell line expressing COX-2 but not that of COX-1 produced prostaglandin E2 ethanolamide. This reaction demonstrates the existence of a COX-2-mediated pathway for anandamide metabolism, and the metabolites formed represent a novel class of prostaglandins.

   

PGD2 ethanolamide

(5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]-N-(2-hydroxyethyl)hept-5-enamide

C22H37NO5 (395.26715920000004)


PGD2 ethanolamide is a N-acylethanolamine. N-acylethanolamines (NAEs) constitute a class of lipid compounds naturally present in both animal and plant membranes as constituents of the membrane-bound phospholipid, N-acylphosphatidylethanolamine (NAPE). NAPE is composed of a third fatty acid moiety linked to the amino head group of the commonly occurring membrane phospholipid, phosphatidylethanolamine. NAEs are released from NAPE by phospholipase D-type hydrolases in response to a variety of stimuli. Transient NAE release and accumulation has been attributed a variety of biological activities, including neurotransmission, membrane protection, and immunomodulation in animals. N-oleoylethanolamine is an inhibitor of the sphingolipid signaling pathway, via specific ceramidase inhibition (ceramidase converts ceramide to sphingosine). N-oleoylethanolamine blocks the effects of TNF- and arachidonic acid on intracellular Ca concentration. (PMID: 12692337, 12056855, 12560208, 11997249) [HMDB] PGD2 ethanolamide is a N-acylethanolamine. N-acylethanolamines (NAEs) constitute a class of lipid compounds naturally present in both animal and plant membranes as constituents of the membrane-bound phospholipid, N-acylphosphatidylethanolamine (NAPE). NAPE is composed of a third fatty acid moiety linked to the amino head group of the commonly occurring membrane phospholipid, phosphatidylethanolamine. NAEs are released from NAPE by phospholipase D-type hydrolases in response to a variety of stimuli. Transient NAE release and accumulation has been attributed a variety of biological activities, including neurotransmission, membrane protection, and immunomodulation in animals. N-oleoylethanolamine is an inhibitor of the sphingolipid signaling pathway, via specific ceramidase inhibition (ceramidase converts ceramide to sphingosine). N-oleoylethanolamine blocks the effects of TNF- and arachidonic acid on intracellular Ca concentration. (PMID: 12692337, 12056855, 12560208, 11997249)

   

Sphingosine 1-phosphate (d19:1-P)

{[(2S,3R)-2-amino-3-hydroxynonadecyl]oxy}phosphonic acid

C19H42NO5P (395.2800452000001)


Sphingosine 1-phosphate (d19:1-P) is a Sphingosine-1-phosphate. Sphingosine-1-phosphate is a signaling sphingolipid. It is also referred to as a bioactive lipid mediator. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine. (Wikipedia)

   

(7Z,10Z)-Hexadecadienoylcarnitine

3-[(7Z,10Z)-Hexadeca-7,10-dienoyloxy]-4-(trimethylammonio)butanoic acid

C23H41NO4 (395.30354260000007)


(7Z,10Z)-Hexadecadienoylcarnitine is an acylcarnitine. More specifically, it is an (7Z,10Z)-hexadecadienoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. (7Z,10Z)-Hexadecadienoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine (7Z,10Z)-Hexadecadienoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

(3Z,9Z)-Hexadecadienoylcarnitine

3-(hexadeca-3,9-dienoyloxy)-4-(trimethylazaniumyl)butanoate

C23H41NO4 (395.30354260000007)


(3Z,9Z)-Hexadecadienoylcarnitine is an acylcarnitine. More specifically, it is an (3Z,9Z)-hexadeca-3,9-dienoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. (3Z,9Z)-Hexadecadienoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine (3Z,9Z)-Hexadecadienoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

(6Z,9Z)-Hexadecadienoylcarnitine

3-(Hexadeca-6,9-dienoyloxy)-4-(trimethylazaniumyl)butanoic acid

C23H41NO4 (395.30354260000007)


(6Z,9Z)-Hexadecadienoylcarnitine is an acylcarnitine. More specifically, it is an (6Z,9Z)-hexadeca-6,9-dienoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. (6Z,9Z)-Hexadecadienoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine (6Z,9Z)-Hexadecadienoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

(2E,4Z)-Hexadecadienoylcarnitine

3-(hexadeca-2,4-dienoyloxy)-4-(trimethylazaniumyl)butanoate

C23H41NO4 (395.30354260000007)


(2E,4Z)-Hexadecadienoylcarnitine is an acylcarnitine. More specifically, it is an (2E,4Z)-hexadeca-2,4-dienoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. (2E,4Z)-Hexadecadienoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine (2E,4Z)-Hexadecadienoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

(10Z,12E)-Hexadecadienoylcarnitine

3-(hexadeca-10,12-dienoyloxy)-4-(trimethylazaniumyl)butanoate

C23H41NO4 (395.30354260000007)


(10Z,12E)-Hexadecadienoylcarnitine is an acylcarnitine. More specifically, it is an (10Z,12E)-hexadeca-10,12-dienoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. (10Z,12E)-Hexadecadienoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine (10Z,12E)-Hexadecadienoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

(8Z,10Z)-Hexadecadienoylcarnitine

3-(hexadeca-8,10-dienoyloxy)-4-(trimethylazaniumyl)butanoate

C23H41NO4 (395.30354260000007)


(8Z,10Z)-Hexadecadienoylcarnitine is an acylcarnitine. More specifically, it is an (8Z,10Z)-hexadeca-8,10-dienoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. (8Z,10Z)-Hexadecadienoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine (8Z,10Z)-Hexadecadienoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

5-(3-Methyl-5-pentylfuran-2-yl)pentanoylcarnitine

3-{[5-(3-methyl-5-pentylfuran-2-yl)pentanoyl]oxy}-4-(trimethylazaniumyl)butanoate

C22H37NO5 (395.26715920000004)


5-(3-methyl-5-pentylfuran-2-yl)pentanoylcarnitine is an acylcarnitine. More specifically, it is an 5-(3-methyl-5-pentylfuran-2-yl)pentanoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. 5-(3-methyl-5-pentylfuran-2-yl)pentanoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine 5-(3-methyl-5-pentylfuran-2-yl)pentanoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

7-(3-Methyl-5-propylfuran-2-yl)heptanoylcarnitine

3-{[7-(3-methyl-5-propylfuran-2-yl)heptanoyl]oxy}-4-(trimethylazaniumyl)butanoate

C22H37NO5 (395.26715920000004)


7-(3-Methyl-5-propylfuran-2-yl)heptanoylcarnitine is an acylcarnitine. More specifically, it is an 7-(3-methyl-5-propylfuran-2-yl)heptanoic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. 7-(3-Methyl-5-propylfuran-2-yl)heptanoylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine 7-(3-Methyl-5-propylfuran-2-yl)heptanoylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, increased concentrations of insulin effectively inhibits long-chain acylcarnitine production. Several studies have also found increased levels of circulating long-chain acylcarnitines in chronic heart failure patients (PMID: 26796394). The study of acylcarnitines is an active area of research and it is likely that many novel acylcarnitines will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered. An excellent review of the current state of knowledge for acylcarnitines is available at [Dambrova et al. 2021, Physiological Reviews].

   

N-Oleoyl Isoleucine

2-[(1-Hydroxyoctadec-9-en-1-ylidene)amino]-3-methylpentanoate

C24H45NO3 (395.339926)


N-oleoyl isoleucine belongs to the class of compounds known as N-acylamides. These are molecules characterized by a fatty acyl group linked to a primary amine by an amide bond. More specifically, it is an Oleic acid amide of Isoleucine. It is believed that there are more than 800 types of N-acylamides in the human body. N-acylamides fall into several categories: amino acid conjugates (e.g., those acyl amides conjugated with amino acids), neurotransmitter conjugates (e.g., those acylamides conjugated with neurotransmitters), ethanolamine conjugates (e.g., those acylamides conjugated to ethanolamine), and taurine conjugates (e.g., those acyamides conjugated to taurine). N-Oleoyl Isoleucine is an amino acid conjugate. N-acylamides can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain N-acylamides; 2) medium-chain N-acylamides; 3) long-chain N-acylamides; and 4) very long-chain N-acylamides; 5) hydroxy N-acylamides; 6) branched chain N-acylamides; 7) unsaturated N-acylamides; 8) dicarboxylic N-acylamides and 9) miscellaneous N-acylamides. N-Oleoyl Isoleucine is therefore classified as a long chain N-acylamide. N-acyl amides have a variety of signaling functions in physiology, including in cardiovascular activity, metabolic homeostasis, memory, cognition, pain, motor control and others (PMID: 15655504). N-acyl amides have also been shown to play a role in cell migration, inflammation and certain pathological conditions such as diabetes, cancer, neurodegenerative disease, and obesity (PMID: 23144998; PMID: 25136293; PMID: 28854168).N-acyl amides can be synthesized both endogenously and by gut microbiota (PMID: 28854168). N-acylamides can be biosynthesized via different routes, depending on the parent amine group. N-acyl ethanolamines (NAEs) are formed via the hydrolysis of an unusual phospholipid precursor, N-acyl-phosphatidylethanolamine (NAPE), by a specific phospholipase D. N-acyl amino acids are synthesized via a circulating peptidase M20 domain containing 1 (PM20D1), which can catalyze the bidirectional the condensation and hydrolysis of a variety of N-acyl amino acids. The degradation of N-acylamides is largely mediated by an enzyme called fatty acid amide hydrolase (FAAH), which catalyzes the hydrolysis of N-acylamides into fatty acids and the biogenic amines. Many N-acylamides are involved in lipid signaling system through interactions with transient receptor potential channels (TRP). TRP channel proteins interact with N-acyl amides such as N-arachidonoyl ethanolamide (Anandamide), N-arachidonoyl dopamine and others in an opportunistic fashion (PMID: 23178153). This signaling system has been shown to play a role in the physiological processes involved in inflammation (PMID: 25136293). Other N-acyl amides, including N-oleoyl-glutamine, have also been characterized as TRP channel antagonists (PMID: 29967167). N-acylamides have also been shown to have G-protein-coupled receptors (GPCRs) binding activity (PMID: 28854168). The study of N-acylamides is an active area of research and it is likely that many novel N-acylamides will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered for these molecules.

   

N-Oleoyl Leucine

2-[(1-Hydroxyoctadec-9-en-1-ylidene)amino]-4-methylpentanoate

C24H45NO3 (395.339926)


N-oleoyl leucine belongs to the class of compounds known as N-acylamides. These are molecules characterized by a fatty acyl group linked to a primary amine by an amide bond. More specifically, it is an Oleic acid amide of Leucine. It is believed that there are more than 800 types of N-acylamides in the human body. N-acylamides fall into several categories: amino acid conjugates (e.g., those acyl amides conjugated with amino acids), neurotransmitter conjugates (e.g., those acylamides conjugated with neurotransmitters), ethanolamine conjugates (e.g., those acylamides conjugated to ethanolamine), and taurine conjugates (e.g., those acyamides conjugated to taurine). N-Oleoyl Leucine is an amino acid conjugate. N-acylamides can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain N-acylamides; 2) medium-chain N-acylamides; 3) long-chain N-acylamides; and 4) very long-chain N-acylamides; 5) hydroxy N-acylamides; 6) branched chain N-acylamides; 7) unsaturated N-acylamides; 8) dicarboxylic N-acylamides and 9) miscellaneous N-acylamides. N-Oleoyl Leucine is therefore classified as a long chain N-acylamide. N-acyl amides have a variety of signaling functions in physiology, including in cardiovascular activity, metabolic homeostasis, memory, cognition, pain, motor control and others (PMID: 15655504). N-acyl amides have also been shown to play a role in cell migration, inflammation and certain pathological conditions such as diabetes, cancer, neurodegenerative disease, and obesity (PMID: 23144998; PMID: 25136293; PMID: 28854168).N-acyl amides can be synthesized both endogenously and by gut microbiota (PMID: 28854168). N-acylamides can be biosynthesized via different routes, depending on the parent amine group. N-acyl ethanolamines (NAEs) are formed via the hydrolysis of an unusual phospholipid precursor, N-acyl-phosphatidylethanolamine (NAPE), by a specific phospholipase D. N-acyl amino acids are synthesized via a circulating peptidase M20 domain containing 1 (PM20D1), which can catalyze the bidirectional the condensation and hydrolysis of a variety of N-acyl amino acids. The degradation of N-acylamides is largely mediated by an enzyme called fatty acid amide hydrolase (FAAH), which catalyzes the hydrolysis of N-acylamides into fatty acids and the biogenic amines. Many N-acylamides are involved in lipid signaling system through interactions with transient receptor potential channels (TRP). TRP channel proteins interact with N-acyl amides such as N-arachidonoyl ethanolamide (Anandamide), N-arachidonoyl dopamine and others in an opportunistic fashion (PMID: 23178153). This signaling system has been shown to play a role in the physiological processes involved in inflammation (PMID: 25136293). Other N-acyl amides, including N-oleoyl-glutamine, have also been characterized as TRP channel antagonists (PMID: 29967167). N-acylamides have also been shown to have G-protein-coupled receptors (GPCRs) binding activity (PMID: 28854168). The study of N-acylamides is an active area of research and it is likely that many novel N-acylamides will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered for these molecules.

   

N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide

N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide

C26H37NO2 (395.2824142)


   

N-Tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide

N-Tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanimidate

C24H33N3O2 (395.25726380000003)


D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists

   

Solasodiene

5,7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2-piperidine]-16,18-diene

C27H41NO (395.31879760000004)


Solasodiene belongs to spirosolanes and derivatives class of compounds. Those are steroidal alkaloids with a structure containing a spirosolane skeleton. Siporosolane is a polycyclic compound that is characterized by a 1-oxa-6-azaspiro[4.5]decane moiety where the oxolane ring is fused to a docosahydronaphth[2,1:4,5]indene ring system. Spirosolane arises from the conversion of a cholestane side-chain into a bicyclic system containing a piperidine and a tetrahydrofuran ring. Solasodiene is practically insoluble (in water) and a very strong basic compound (based on its pKa). Solasodiene can be found in potato, which makes solasodiene a potential biomarker for the consumption of this food product.

   

Semiplenamide E

[(2S)-2-[[(E)-2-methyloctadec-2-enoyl]amino]propyl] acetate

C24H45NO3 (395.339926)


   
   

N-(4-hydroxyphenyl)eicosa-5,8,11,14-tetraenamide

N-(4-hydroxyphenyl)eicosa-5,8,11,14-tetraenamide

C26H37NO2 (395.2824142)


   

N-oleoyl leucine

N-(9Z-octadecenoyl)-leucine

C24H45NO3 (395.339926)


   

N-Oleyl-Isoleucine

N-Oleyl-Isoleucine

C24H45NO3 (395.339926)


CONFIDENCE standard compound; INTERNAL_ID 298

   
   

20-epi-3-dehydroxy-3-oxo-5,6-dihydro-4,5-dehydroverazine

20-epi-3-dehydroxy-3-oxo-5,6-dihydro-4,5-dehydroverazine

C27H41NO (395.31879760000004)


   

N,N-Diacetyl-N-[3-(azacyclotetradecan-1-yl)propyl]-1,3-propanediamine

N,N-Diacetyl-N-[3-(azacyclotetradecan-1-yl)propyl]-1,3-propanediamine

C23H45N3O2 (395.351159)


   

(22S,25S)-solanid-5,20(21)-dien-3beta-ol

(22S,25S)-solanid-5,20(21)-dien-3beta-ol

C27H41NO (395.31879760000004)


   

N-(4-(3-(3-(3-Aminopropylamino)propylamino)propylamino)butyl)-2,5-dihydroxybenzamide

N-(4-(3-(3-(3-Aminopropylamino)propylamino)propylamino)butyl)-2,5-dihydroxybenzamide

C20H37N5O3 (395.28962520000005)


   

(+)-N-acetyl-N-demethylcyclomicrobuxeine

(+)-N-acetyl-N-demethylcyclomicrobuxeine

C26H37NO2 (395.2824142)


   
   

myceliothermophin E

myceliothermophin E

C26H37NO2 (395.2824142)


   

Stereoisomer, 3, 4-didehydro-Veralinine

Stereoisomer, 3, 4-didehydro-Veralinine

C27H41NO (395.31879760000004)


   
   
   

N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide

N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide

C26H37NO2 (395.2824142)


   
   

N-(4-Hydroxyphenyl)arachidonoyl amide

N-(4-Hydroxyphenyl)arachidonoyl amide

C26H37NO2 (395.2824142)


   

N-Oleyl-Leucine

N-Oleyl-Leucine

C24H45NO3 (395.339926)


CONFIDENCE standard compound; INTERNAL_ID 297

   

Solasodiene (not validated)

Solasodiene (not validated)

C27H41NO (395.31879760000004)


Annotation level-3

   

PGD2-EA

N-(9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoyl)-ethanolamine

C22H37NO5 (395.26715920000004)


   

PGE2-EA

(Z)-N-(2-hydroxyethyl)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enamide

C22H37NO5 (395.26715920000004)


   

N-(3-hydroxyphenyl)-Arachidonoyl amide

N-(3-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

C26H37NO2 (395.2824142)


   

ethyl amide

9,11,15S-trihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid, ethyl amide

C23H41NO4 (395.30354260000007)


   

AM404

(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide

C26H37NO2 (395.2824142)


   

PGI2-EA

N-(6,9S-epoxy-11R,15S-dihydoxy-5Z,13E-prostadienoyl)-ethanolamine

C22H37NO5 (395.26715920000004)


   

N-oleoyl isoleucine

N-(9Z-octadecenoyl)-isoleucine

C24H45NO3 (395.339926)


   

Hexadecadienoylcarnitine

3-[(7Z,10Z)-hexadeca-7,10-dienoyloxy]-4-(trimethylammonio)butanoate;7cis,10cis-hexadecadienoylcarnitine

C23H41NO4 (395.3035426)


   

NA 24:2;O2

N-(9Z-octadecenoyl)-isoleucine

C24H45NO3 (395.339926)


   

C20-HSL

N-(eicosanoyl)-homoserine lactone

C24H45NO3 (395.339926)


   

hexadecyltrimethylammonium methyl sulphate

hexadecyltrimethylammonium methyl sulphate

C20H45NO4S (395.30691300000007)


   

2,6-BIS((DI-TERT-BUTYLPHOSPHINO)METHYL)PYRIDINE

2,6-BIS((DI-TERT-BUTYLPHOSPHINO)METHYL)PYRIDINE

C23H43NP2 (395.2870578)


   

3-Amino-4-chlorobenzoic acid hexadecyl ester

3-Amino-4-chlorobenzoic acid hexadecyl ester

C23H38ClNO2 (395.2590918)


   

5,5-dimethyl-8-(3-methyloctan-2-yl)-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-ol

5,5-dimethyl-8-(3-methyloctan-2-yl)-2-prop-2-ynyl-3,4-dihydro-1H-chromeno[4,3-c]pyridin-10-ol

C26H37NO2 (395.2824142)


   

Tetradecyldimethyl(ethylbenzyl)ammonium chloride

Tetradecyldimethyl(ethylbenzyl)ammonium chloride

C25H46ClN (395.33185860000003)


   
   

Quaternary ammonium compounds, C12-18-alkyl[(ethylphenyl)methyl]dimethyl, chlorides

Quaternary ammonium compounds, C12-18-alkyl[(ethylphenyl)methyl]dimethyl, chlorides

C25H46ClN (395.33185860000003)


   
   

8-(Diethylamino)octyl 3,4,5-trimethoxybenzoate

8-(Diethylamino)octyl 3,4,5-trimethoxybenzoate

C22H37NO5 (395.26715920000004)


D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators

   

1-[2-Hydroxy-3-(4-cyclohexyl-phenoxy)-propyl]-4-(2-pyridyl)-piperazine

1-[2-Hydroxy-3-(4-cyclohexyl-phenoxy)-propyl]-4-(2-pyridyl)-piperazine

C24H33N3O2 (395.25726380000003)


   

(2Z,4E,6S,7S,8R,9R,10R)-10-[(1S,3S,4R,5S)-1,4-Dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl]-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienamide

(2Z,4E,6S,7S,8R,9R,10R)-10-[(1S,3S,4R,5S)-1,4-Dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl]-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienamide

C22H37NO5 (395.26715920000004)


   
   

(1S,2S,10R,11S,14S,15R,16S,17R,20S,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-5-en-7-one

(1S,2S,10R,11S,14S,15R,16S,17R,20S,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-5-en-7-one

C27H41NO (395.31879760000004)


   

N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide

N-(4-Hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide

C26H37NO2 (395.2824142)


   

5-(3-Methyl-5-pentylfuran-2-yl)pentanoylcarnitine

5-(3-Methyl-5-pentylfuran-2-yl)pentanoylcarnitine

C22H37NO5 (395.26715920000004)


   

7-(3-Methyl-5-propylfuran-2-yl)heptanoylcarnitine

7-(3-Methyl-5-propylfuran-2-yl)heptanoylcarnitine

C22H37NO5 (395.26715920000004)


   
   
   
   
   

(8Z,10Z)-Hexadecadienoylcarnitine

(8Z,10Z)-Hexadecadienoylcarnitine

C23H41NO4 (395.30354260000007)


   

(10Z,12E)-Hexadecadienoylcarnitine

(10Z,12E)-Hexadecadienoylcarnitine

C23H41NO4 (395.30354260000007)


   

3-methyl-2-[[(E)-octadec-9-enoyl]amino]pentanoic acid

3-methyl-2-[[(E)-octadec-9-enoyl]amino]pentanoic acid

C24H45NO3 (395.339926)


   

4-methyl-2-[[(E)-octadec-9-enoyl]amino]pentanoic acid

4-methyl-2-[[(E)-octadec-9-enoyl]amino]pentanoic acid

C24H45NO3 (395.339926)


   

(4S)-4-[(9Z,12Z)-hexadeca-9,12-dienoyl]oxy-4-(trimethylazaniumyl)butanoate

(4S)-4-[(9Z,12Z)-hexadeca-9,12-dienoyl]oxy-4-(trimethylazaniumyl)butanoate

C23H41NO4 (395.30354260000007)


   

1-(4-Cyclohexylphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol

1-(4-Cyclohexylphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol

C24H33N3O2 (395.25726380000003)


   

N-(9Z-octadecenoyl)-L-asparagine

N-(9Z-octadecenoyl)-L-asparagine

C22H39N2O4- (395.2909674)


   

N-hexanoyl-sphinga-4E,14Z-dienine

N-hexanoyl-sphinga-4E,14Z-dienine

C24H45NO3 (395.339926)


   

(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one

(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one

C26H37NO2 (395.2824142)


   

cyclopropyl-[(8R,9S,10R)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

cyclopropyl-[(8R,9S,10R)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

C24H33N3O2 (395.25726380000003)


   

cyclopropyl-[(8S,9S,10S)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

cyclopropyl-[(8S,9S,10S)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

C24H33N3O2 (395.25726380000003)


   

cyclopropyl-[(8S,9R,10R)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

cyclopropyl-[(8S,9R,10R)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

C24H33N3O2 (395.25726380000003)


   

cyclopropyl-[(8R,9R,10R)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

cyclopropyl-[(8R,9R,10R)-9-[4-[3-(dimethylamino)prop-1-ynyl]phenyl]-10-(hydroxymethyl)-1,6-diazabicyclo[6.2.0]decan-6-yl]methanone

C24H33N3O2 (395.25726380000003)


   

15(S)-15-methyl Prostaglandin F2alpha ethyl amide

15(S)-15-methyl Prostaglandin F2alpha ethyl amide

C23H41NO4 (395.30354260000007)


   

[(2R)-2-amino-3-hexadecoxypropyl] dihydrogen phosphate

[(2R)-2-amino-3-hexadecoxypropyl] dihydrogen phosphate

C19H42NO5P (395.2800452000001)


   

5-[[(2E,14E,17R)-17-hydroxyoctadeca-2,14-dienoyl]amino]pentanoic acid

5-[[(2E,14E,17R)-17-hydroxyoctadeca-2,14-dienoyl]amino]pentanoic acid

C23H41NO4 (395.30354260000007)


   

(9Z,12Z)-N-(1,3-dihydroxyoctan-2-yl)hexadeca-9,12-dienamide

(9Z,12Z)-N-(1,3-dihydroxyoctan-2-yl)hexadeca-9,12-dienamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxyicosa-4,8-dien-2-yl]butanamide

N-[(4E,8E)-1,3-dihydroxyicosa-4,8-dien-2-yl]butanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxypentadeca-4,8-dien-2-yl]nonanamide

N-[(4E,8E)-1,3-dihydroxypentadeca-4,8-dien-2-yl]nonanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxynonadeca-4,8-dien-2-yl]pentanamide

N-[(4E,8E)-1,3-dihydroxynonadeca-4,8-dien-2-yl]pentanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxyheptadeca-4,8-dien-2-yl]heptanamide

N-[(4E,8E)-1,3-dihydroxyheptadeca-4,8-dien-2-yl]heptanamide

C24H45NO3 (395.339926)


   

(Z)-N-[(E)-1,3-dihydroxyoct-4-en-2-yl]hexadec-9-enamide

(Z)-N-[(E)-1,3-dihydroxyoct-4-en-2-yl]hexadec-9-enamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxyoctadeca-4,8-dien-2-yl]hexanamide

N-[(4E,8E)-1,3-dihydroxyoctadeca-4,8-dien-2-yl]hexanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxyhexadeca-4,8-dien-2-yl]octanamide

N-[(4E,8E)-1,3-dihydroxyhexadeca-4,8-dien-2-yl]octanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxydocosa-4,8-dien-2-yl]acetamide

N-[(4E,8E)-1,3-dihydroxydocosa-4,8-dien-2-yl]acetamide

C24H45NO3 (395.339926)


   

(Z)-N-[(E)-1,3-dihydroxynon-4-en-2-yl]pentadec-9-enamide

(Z)-N-[(E)-1,3-dihydroxynon-4-en-2-yl]pentadec-9-enamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxyhenicosa-4,8-dien-2-yl]propanamide

N-[(4E,8E)-1,3-dihydroxyhenicosa-4,8-dien-2-yl]propanamide

C24H45NO3 (395.339926)


   

(Z)-N-[(E)-1,3-dihydroxyundec-4-en-2-yl]tridec-9-enamide

(Z)-N-[(E)-1,3-dihydroxyundec-4-en-2-yl]tridec-9-enamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxytetradeca-4,8-dien-2-yl]decanamide

N-[(4E,8E)-1,3-dihydroxytetradeca-4,8-dien-2-yl]decanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxydodeca-4,8-dien-2-yl]dodecanamide

N-[(4E,8E)-1,3-dihydroxydodeca-4,8-dien-2-yl]dodecanamide

C24H45NO3 (395.339926)


   

N-[(4E,8E)-1,3-dihydroxytrideca-4,8-dien-2-yl]undecanamide

N-[(4E,8E)-1,3-dihydroxytrideca-4,8-dien-2-yl]undecanamide

C24H45NO3 (395.339926)


   

(Z)-N-[(E)-1,3-dihydroxydec-4-en-2-yl]tetradec-9-enamide

(Z)-N-[(E)-1,3-dihydroxydec-4-en-2-yl]tetradec-9-enamide

C24H45NO3 (395.339926)


   

alpha-(4-Dimethylaminophenyl)-omega-(9-phenanthryl)heptane

alpha-(4-Dimethylaminophenyl)-omega-(9-phenanthryl)heptane

C29H33N (395.26128580000005)


   

N-[(2S,3R,4E,8E)-1,3-dihydroxytetradeca-4,8-dien-2-yl]decanamide

N-[(2S,3R,4E,8E)-1,3-dihydroxytetradeca-4,8-dien-2-yl]decanamide

C24H45NO3 (395.339926)


   

N-[(2S,3R,4E,6E)-1,3-dihydroxytetradeca-4,6-dien-2-yl]decanamide

N-[(2S,3R,4E,6E)-1,3-dihydroxytetradeca-4,6-dien-2-yl]decanamide

C24H45NO3 (395.339926)


   
   

N-Tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide

N-Tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide

C24H33N3O2 (395.25726380000003)


D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists

   

(5Z)-7-[(1R,2R,3S)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]-N-(2-hydroxyethyl)hept-5-enamide

(5Z)-7-[(1R,2R,3S)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]-N-(2-hydroxyethyl)hept-5-enamide

C22H37NO5 (395.26715920000004)


   

(7Z,10Z)-hexadecadienoylcarnitine

(7Z,10Z)-hexadecadienoylcarnitine

C23H41NO4 (395.30354260000007)


An O-hexadecadienoylcarnitine having (7Z,10Z)-hexadecadienoyl as the acyl substituent.

   

Sphingosine 1-phosphate (d19:1-P)

Sphingosine 1-phosphate (d19:1-P)

C19H42NO5P (395.2800452000001)


   
   

O-hexadecadienoylcarnitine

O-hexadecadienoylcarnitine

C23H41NO4 (395.30354260000007)


An O-acylcarnitine having a hexadecadienoyl group as acyl substituent in which the positions of the two double bonds are unspecified.

   

O-hexadecadienoyl-L-carnitine

O-hexadecadienoyl-L-carnitine

C23H41NO4 (395.30354260000007)


An O-acyl-L-carnitine that is L-carnitine having a hexadecadienoyl group as the acyl substituent in which the positions of the two double bonds are unspecified.

   
   
   
   
   

NA-Histamine 20:5(5Z,8Z,11Z,14Z,17Z)

NA-Histamine 20:5(5Z,8Z,11Z,14Z,17Z)

C25H37N3O (395.2936472)


   
   
   
   
   
   
   
   

n-(3-{[3-({3-[(4-aminobutyl)amino]propyl}amino)propyl](hydroxy)amino}propyl)-4-hydroxybenzamide

n-(3-{[3-({3-[(4-aminobutyl)amino]propyl}amino)propyl](hydroxy)amino}propyl)-4-hydroxybenzamide

C20H37N5O3 (395.28962520000005)


   

n-{15-acetyl-12,16-dimethyl-7-methylidenepentacyclo[9.7.0.0¹,³.0³,⁸.0¹²,¹⁶]octadec-14-en-6-yl}-n-methylacetamide

n-{15-acetyl-12,16-dimethyl-7-methylidenepentacyclo[9.7.0.0¹,³.0³,⁸.0¹²,¹⁶]octadec-14-en-6-yl}-n-methylacetamide

C26H37NO2 (395.2824142)


   

9a,11a-dimethyl-1-[1-(5-methyl-3,4,5,6-tetrahydropyridin-2-yl)ethyl]-1h,2h,3h,3ah,3bh,4h,5h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one

9a,11a-dimethyl-1-[1-(5-methyl-3,4,5,6-tetrahydropyridin-2-yl)ethyl]-1h,2h,3h,3ah,3bh,4h,5h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one

C27H41NO (395.31879760000004)


   

1-benzoyl-2-methyl-3-[(7z)-pentadec-7-en-1-yl]-4,5-dihydropyrrole

1-benzoyl-2-methyl-3-[(7z)-pentadec-7-en-1-yl]-4,5-dihydropyrrole

C27H41NO (395.31879760000004)


   

n-(4-{[3-({3-[(3-aminopropyl)amino]propyl}amino)propyl]amino}butyl)-2,5-dihydroxybenzenecarboximidic acid

n-(4-{[3-({3-[(3-aminopropyl)amino]propyl}amino)propyl]amino}butyl)-2,5-dihydroxybenzenecarboximidic acid

C20H37N5O3 (395.28962520000005)


   

(1s,2s,7s,10r,11s,14s,15s,17s,20s,23s)-10,14,20-trimethyl-16-methylidene-22-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁵,²³.0¹⁷,²²]tetracos-4-en-7-ol

(1s,2s,7s,10r,11s,14s,15s,17s,20s,23s)-10,14,20-trimethyl-16-methylidene-22-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁵,²³.0¹⁷,²²]tetracos-4-en-7-ol

C27H41NO (395.31879760000004)


   

20-epi-3-dehydroxy-3-oxo-5,6-dihydro-4,5-dehydroverazine

NA

C27H41NO (395.31879760000004)


{"Ingredient_id": "HBIN003400","Ingredient_name": "20-epi-3-dehydroxy-3-oxo-5,6-dihydro-4,5-dehydroverazine","Alias": "NA","Ingredient_formula": "C27H41NO","Ingredient_Smile": "CC1CCC(=NC1)C(C)C2CCC3C2(CCC4C3CCC5=CC(=O)CCC45C)C","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "41878","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}

   

8-ethoxysachaconitine

NA

C23H41NO4 (395.30354260000007)


{"Ingredient_id": "HBIN013727","Ingredient_name": "8-ethoxysachaconitine","Alias": "NA","Ingredient_formula": "C23H41NO4","Ingredient_Smile": "Not Available","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "7414","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}

   

10-{1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl}-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienimidic acid

10-{1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl}-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienimidic acid

C22H37NO5 (395.26715920000004)


   

(4e)-n-[(3r,11e,13z)-14-chloro-3-methyl-5-oxotetradeca-11,13-dien-1-yl]oct-4-enimidic acid

(4e)-n-[(3r,11e,13z)-14-chloro-3-methyl-5-oxotetradeca-11,13-dien-1-yl]oct-4-enimidic acid

C23H38ClNO2 (395.2590918)


   

(5z)-3-[(1r,2s,4as,6s,8ar)-2-[(2e)-but-2-en-2-yl]-3,4a,6-trimethyl-2,5,6,7,8,8a-hexahydro-1h-naphthalene-1-carbonyl]-5-(2-methylpropylidene)pyrrol-2-ol

(5z)-3-[(1r,2s,4as,6s,8ar)-2-[(2e)-but-2-en-2-yl]-3,4a,6-trimethyl-2,5,6,7,8,8a-hexahydro-1h-naphthalene-1-carbonyl]-5-(2-methylpropylidene)pyrrol-2-ol

C26H37NO2 (395.2824142)


   

(4e)-n-[(3r,11e,13e)-14-chloro-3-methyl-5-oxotetradeca-11,13-dien-1-yl]oct-4-enimidic acid

(4e)-n-[(3r,11e,13e)-14-chloro-3-methyl-5-oxotetradeca-11,13-dien-1-yl]oct-4-enimidic acid

C23H38ClNO2 (395.2590918)


   

5-(4-aminobutyl)-1,5-diazacyclohenicosane-6,14-dione

5-(4-aminobutyl)-1,5-diazacyclohenicosane-6,14-dione

C23H45N3O2 (395.351159)


   

(2s)-2-[(2s)-n,3-dimethyl-2-(methylamino)butanamido]-3-phenyl-n-(2-phenylethyl)propanimidic acid

(2s)-2-[(2s)-n,3-dimethyl-2-(methylamino)butanamido]-3-phenyl-n-(2-phenylethyl)propanimidic acid

C24H33N3O2 (395.25726380000003)


   

n-(3-{[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl](hydroxy)amino}propyl)-4-hydroxybenzamide

n-(3-{[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl](hydroxy)amino}propyl)-4-hydroxybenzamide

C20H37N5O3 (395.28962520000005)


   

10,14,20-trimethyl-16-methylidene-22-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁵,²³.0¹⁷,²²]tetracos-4-en-7-ol

10,14,20-trimethyl-16-methylidene-22-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁵,²³.0¹⁷,²²]tetracos-4-en-7-ol

C27H41NO (395.31879760000004)


   

n-(3-{[3-({3-[(4-aminobutyl)amino]propyl}amino)propyl]amino}propyl)-2,5-dihydroxybenzenecarboximidic acid

n-(3-{[3-({3-[(4-aminobutyl)amino]propyl}amino)propyl]amino}propyl)-2,5-dihydroxybenzenecarboximidic acid

C20H37N5O3 (395.28962520000005)


   

(1s,4s,5'r,6r,7s,8r,9s,12s,13r)-5',7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2'-piperidine]-16,18-diene

(1s,4s,5'r,6r,7s,8r,9s,12s,13r)-5',7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2'-piperidine]-16,18-diene

C27H41NO (395.31879760000004)


   

n-[(1s,3r,6s,8r,11s,12s,16s)-15-acetyl-12,16-dimethyl-7-methylidenepentacyclo[9.7.0.0¹,³.0³,⁸.0¹²,¹⁶]octadec-14-en-6-yl]-n-methylacetamide

n-[(1s,3r,6s,8r,11s,12s,16s)-15-acetyl-12,16-dimethyl-7-methylidenepentacyclo[9.7.0.0¹,³.0³,⁸.0¹²,¹⁶]octadec-14-en-6-yl]-n-methylacetamide

C26H37NO2 (395.2824142)


   

5-{[(17r)-1,17-dihydroxyoctadeca-2,14-dien-1-ylidene]amino}pentanoic acid

5-{[(17r)-1,17-dihydroxyoctadeca-2,14-dien-1-ylidene]amino}pentanoic acid

C23H41NO4 (395.30354260000007)


   

3-[2-(but-2-en-2-yl)-3,4a,6-trimethyl-2,5,6,7,8,8a-hexahydro-1h-naphthalene-1-carbonyl]-5-(2-methylpropylidene)pyrrol-2-ol

3-[2-(but-2-en-2-yl)-3,4a,6-trimethyl-2,5,6,7,8,8a-hexahydro-1h-naphthalene-1-carbonyl]-5-(2-methylpropylidene)pyrrol-2-ol

C26H37NO2 (395.2824142)


   

5-(4-aminobutyl)-1,5-diazacyclohenicosane-6,15-dione

5-(4-aminobutyl)-1,5-diazacyclohenicosane-6,15-dione

C23H45N3O2 (395.351159)


   

n-(3-{n-[3-(1-azacyclotetradecan-1-yl)propyl]acetamido}propyl)ethanimidic acid

n-(3-{n-[3-(1-azacyclotetradecan-1-yl)propyl]acetamido}propyl)ethanimidic acid

C23H45N3O2 (395.351159)


   

(2z,4e,6s,7s,8r,9r,10r)-10-[(1s,3s,4r,5s)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl]-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienimidic acid

(2z,4e,6s,7s,8r,9r,10r)-10-[(1s,3s,4r,5s)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl]-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienimidic acid

C22H37NO5 (395.26715920000004)


   

5',7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2'-piperidine]-16,18-diene

5',7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2'-piperidine]-16,18-diene

C27H41NO (395.31879760000004)


   

(1r,3as,3bs,9ar,9bs,11as)-9a,11a-dimethyl-1-[(1r)-1-[(5s)-5-methyl-3,4,5,6-tetrahydropyridin-2-yl]ethyl]-1h,2h,3h,3ah,3bh,4h,5h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one

(1r,3as,3bs,9ar,9bs,11as)-9a,11a-dimethyl-1-[(1r)-1-[(5s)-5-methyl-3,4,5,6-tetrahydropyridin-2-yl]ethyl]-1h,2h,3h,3ah,3bh,4h,5h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one

C27H41NO (395.31879760000004)


   

(2e)-n-[(2s)-1-(acetyloxy)propan-2-yl]-2-methyloctadec-2-enimidic acid

(2e)-n-[(2s)-1-(acetyloxy)propan-2-yl]-2-methyloctadec-2-enimidic acid

C24H45NO3 (395.339926)


   

(1s,2s,4s,5'r,6r,7s,8r,9s,12s,13r)-5',7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2'-piperidine]-16,18-diene

(1s,2s,4s,5'r,6r,7s,8r,9s,12s,13r)-5',7,9,13-tetramethyl-5-oxaspiro[pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane-6,2'-piperidine]-16,18-diene

C27H41NO (395.31879760000004)


   

1-benzoyl-2-methyl-3-(pentadec-7-en-1-yl)-4,5-dihydropyrrole

1-benzoyl-2-methyl-3-(pentadec-7-en-1-yl)-4,5-dihydropyrrole

C27H41NO (395.31879760000004)


   

3-[(1r,2s,4as,6s,8ar)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-2,5,6,7,8,8a-hexahydro-1h-naphthalene-1-carbonyl]-5-(2-methylpropylidene)pyrrol-2-ol

3-[(1r,2s,4as,6s,8ar)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-2,5,6,7,8,8a-hexahydro-1h-naphthalene-1-carbonyl]-5-(2-methylpropylidene)pyrrol-2-ol

C26H37NO2 (395.2824142)


   

n-[1-(acetyloxy)propan-2-yl]-2-methyloctadec-2-enimidic acid

n-[1-(acetyloxy)propan-2-yl]-2-methyloctadec-2-enimidic acid

C24H45NO3 (395.339926)


   

(4e)-n-[(11e,13e)-14-chloro-3-methyl-5-oxotetradeca-11,13-dien-1-yl]oct-4-enimidic acid

(4e)-n-[(11e,13e)-14-chloro-3-methyl-5-oxotetradeca-11,13-dien-1-yl]oct-4-enimidic acid

C23H38ClNO2 (395.2590918)


   

(2z,4e,6s,7s,8r,9r,10r)-10-[(1s,3s,4r,5r)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl]-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienimidic acid

(2z,4e,6s,7s,8r,9r,10r)-10-[(1s,3s,4r,5r)-1,4-dimethyl-2,8-dioxabicyclo[3.2.1]octan-3-yl]-7,9-dihydroxy-2,6,8-trimethylundeca-2,4-dienimidic acid

C22H37NO5 (395.26715920000004)