Exact Mass: 388.9826218

Exact Mass Matches: 388.9826218

Found 39 metabolites which its exact mass value is equals to given mass value 388.9826218, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Cyclothiazide

3-{bicyclo[2.2.1]hept-5-en-2-yl}-6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide

C14H16ClN3O4S2 (389.0270726)

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D045283 - Natriuretic Agents > D004232 - Diuretics Same as: D01256 Cyclothiazide, a positive allosteric modulator of AMPA receptors, is used frequently to block the desensitization of both native and heterologously expressed AMPA receptors. Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current[1].

phenyl-amidophosphoric acid mono-(4-iodo-benzyl ester)|Phenyl-amidophosphorsaeure-mono-(4-jod-benzylester)

C13H13INO3P (388.9677788000001)

11-N-cyano-11-N-methylmolokaiamine

C13H17Br2N3O (388.9738272)

cyclothiazide

C14H16ClN3O4S2 (389.0270726)

C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D045283 - Natriuretic Agents > D004232 - Diuretics Same as: D01256 Cyclothiazide, a positive allosteric modulator of AMPA receptors, is used frequently to block the desensitization of both native and heterologously expressed AMPA receptors. Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current[1].

3-(4-BROMO-BENZENESULFONYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

C15H20BrNO4S (389.0296340000001)

TERT-BUTYL 5-BROMO-3-(BROMOMETHYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-1-CARBOXYLATE

C12H13Br2N3O2 (388.9374438)

1-(benzenesulfonyl)-3-chloroindole-6-sulfonyl chloride

C14H9Cl2NO4S2 (388.9350054)

2-((tert-Butyldimethylsilyloxy)methyl)-6-iodofuro[3,2-b]pyridine

C14H20INO2Si (389.030801)

3,4-difluoro-2-(4-iodo-2-methylanilino)benzoic acid

C14H10F2INO2 (388.9724334)

Thiazolidine, 2-(2-chlorophenyl)-3-(1-naphthalenylsulfonyl)- (9CI)

C19H16ClNO2S2 (389.0310946)

1-(5-bromofuran-2-yl)ethanone

C15H20BrNO4S (389.0296340000001)

3-(2-BROMO-BENZENESULFONYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

C15H20BrNO4S (389.0296340000001)

3-(3-BROMO-BENZENESULFONYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

C15H20BrNO4S (389.0296340000001)

Manganese disodium EDTA trihydrate

C10H12MnN2Na2O8 (388.9769492)

1-BOC-3-IODO-5-NITRO-1H-INDAZOLE

C12H12IN3O4 (388.98725420000005)

2-[bis(2-phosphonooxyethyl)amino]ethyl dihydrogen phosphate

C6H18NO12P3 (389.0041858)

PIK-93

N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide

C14H16ClN3O4S2 (389.0270726)

3-IODO-6-NITRO-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

C12H12IN3O4 (388.98725420000005)

Thiazolidine, 2-(4-chlorophenyl)-3-(1-naphthalenylsulfonyl)- (9CI)

C19H16ClNO2S2 (389.0310946)

Tungsten(5+) chloride ethanolate (1:2:3)

C6H15Cl2O3W (388.990773)

Benzenebutanoic acid, 2-hydroxy-3,4-dimethoxy-6-methyl-5-(sulfooxy)-, dipotassium salt

C13H18KO9S (389.03085780000004)

DIETHYL2-((2-IODOPHENYLAMINO)METHYLENE)MALONATE

C14H16INO4 (389.0124046)

N-[2,2-dichloro-1-(4-chlorophenyl)sulfonylethenyl]benzamide

C15H10Cl3NO3S (388.94469600000014)

1-[3-(4-Hydroxy-3-iodophenyl)propionyloxy]-2,5-pyrrolidinedione

C13H12INO5 (388.97602120000005)

1-(2-Chloro-10-phenothiazinyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone

C16H12ClN5OS2 (389.0171772)

8-Nitroguanosine 3,5-cyclic monophosphate(1-)

C10H10N6O9P- (389.024688)

5-Nitro-2-thiophenecarboxylic acid [1-[(3,5-dichloro-2-pyridinyl)amino]-1-oxopropan-2-yl] ester

C13H9Cl2N3O5S (388.96399640000004)

2-[[(2,5-dichloro-3-thiophenyl)-oxomethyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide

C14H13Cl2N3O2S2 (388.9826218)

CID 156595911

C18H18ClSn- (389.0118948)

ASM-IN-1

C16H12BrN3O4 (389.0011132)

ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC50 value of 1.5 μM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity[1].