Exact Mass: 347.2824142

Exact Mass Matches: 347.2824142

Found 65 metabolites which its exact mass value is equals to given mass value 347.2824142, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Anandamide

(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide

C22H37NO2 (347.2824142)


Anandamide, also known as arachidonoylethanolamide (AEA), is a highly potent endogenous agonist of the cannabinoid CB1 and CB2 receptors. CB1 receptors are predominantly found in the central nervous system (CNS) where they mainly mediate the psychotropic effects of tetrahydrocannabinol (THC) and endocannabinoids, whereas the expression of the CB2 receptor is thought to be restricted to cells of the immune system. It was suggested that AEA might inhibit tumour cell proliferation or induce apoptosis independently of CB1 and CB2 receptors, via interaction with the type 1 vanilloid receptor (VR1). VR1 is an ion channel expressed almost exclusively by sensory neurons, activated by pH, noxious heat (> 48-degree centigrade), and plant toxins and is thought to play an important role in nociception. Cervical cancer cells are sensitive to AEA-induced apoptosis via VR1 that is aberrantly expressed in vitro and in vivo while CB1 and CB2 receptors play a protective role. (PMID: 15047233). Novel prostaglandins (prostaglandin glycerol esters and prostaglandin ethanolamides) are COX-2 oxidative metabolites of endogenous cannabinoids (such as anandamide). Recent evidence suggests that these new types of prostaglandins are likely novel signalling mediators involved in synaptic transmission and plasticity (PMID: 16957004). Anandamide is a highly potent endogenous agonist of the cannabinoid CB1 and CB2 receptors. CB1 receptors are predominantly found in the central nervous system (CNS) where they mainly mediate the psychotropic effects of Tetrahydrocannabinol (THC) and endocannabinoids, whereas the expression of the CB2 receptor is thought to be restricted to cells of the immune system. It was suggested that AEA might inhibit tumor cell proliferation or induce apoptosis independently of CB1 and CB2 receptors, via interaction with the type 1 vanilloid receptor (VR1). VR1 is an ion channel expressed almost exclusively by sensory neurons, activated by pH, noxious heat (>48 degree centigrade) and plant toxins and is thought to play an important role in nociception. Cervical cancer cells are sensitive to AEA-induced apoptosis via VR1 that is aberrantly expressed in vitro and in vivo while CB1 and CB2 receptors play a protective role. (PMID 15047233) D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D000077264 - Calcium-Regulating Hormones and Agents CONFIDENCE standard compound; INTERNAL_ID 41 D049990 - Membrane Transport Modulators

   

Stearyltrimethylammonium chloride

1-Octadecanaminium, N,N,N-trimethyl-, chloride

C21H46ClN (347.33185860000003)


   

O-Arachidonoyl Ethanolamine

2-aminoethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate

C22H37NO2 (347.2824142)


Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as tetrahydrocannabinols (THC). Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG).O-Arachidonoyl ethanolamine hydrochloride (O-AEA) is a recently isolated constituent of human and rat brain wherein the ethanolamine moiety is attached ?backwards?, as an ester instead of an amide, as in AEA.1,2,4 O-AEA has mixed agonist/antagonist activity at the CB1 receptor and does not appear to be the native endogenous cannabinoid agonist at this receptor. This is in keeping with other observations that 2-AG is the primary endogenous CB1 receptor ligand [HMDB] Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as tetrahydrocannabinols (THC). Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (2-AG).O-Arachidonoyl ethanolamine hydrochloride (O-AEA) is a recently isolated constituent of human and rat brain wherein the ethanolamine moiety is attached "backwards", as an ester instead of an amide, as in AEA.1,2,4 O-AEA has mixed agonist/antagonist activity at the CB1 receptor and does not appear to be the native endogenous cannabinoid agonist at this receptor. This is in keeping with other observations that 2-AG is the primary endogenous CB1 receptor ligand. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators D018377 - Neurotransmitter Agents

   

N-Lauroyl Phenylalanine

2-dodecanamido-3-phenylpropanoic acid

C21H33NO3 (347.2460308000001)


N-lauroyl phenylalanine belongs to the class of compounds known as N-acylamides. These are molecules characterized by a fatty acyl group linked to a primary amine by an amide bond. More specifically, it is a Lauric acid amide of Phenylalanine. It is believed that there are more than 800 types of N-acylamides in the human body. N-acylamides fall into several categories: amino acid conjugates (e.g., those acyl amides conjugated with amino acids), neurotransmitter conjugates (e.g., those acylamides conjugated with neurotransmitters), ethanolamine conjugates (e.g., those acylamides conjugated to ethanolamine), and taurine conjugates (e.g., those acyamides conjugated to taurine). N-Lauroyl Phenylalanine is an amino acid conjugate. N-acylamides can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain N-acylamides; 2) medium-chain N-acylamides; 3) long-chain N-acylamides; and 4) very long-chain N-acylamides; 5) hydroxy N-acylamides; 6) branched chain N-acylamides; 7) unsaturated N-acylamides; 8) dicarboxylic N-acylamides and 9) miscellaneous N-acylamides. N-Lauroyl Phenylalanine is therefore classified as a long chain N-acylamide. N-acyl amides have a variety of signaling functions in physiology, including in cardiovascular activity, metabolic homeostasis, memory, cognition, pain, motor control and others (PMID: 15655504). N-acyl amides have also been shown to play a role in cell migration, inflammation and certain pathological conditions such as diabetes, cancer, neurodegenerative disease, and obesity (PMID: 23144998; PMID: 25136293; PMID: 28854168).N-acyl amides can be synthesized both endogenously and by gut microbiota (PMID: 28854168). N-acylamides can be biosynthesized via different routes, depending on the parent amine group. N-acyl ethanolamines (NAEs) are formed via the hydrolysis of an unusual phospholipid precursor, N-acyl-phosphatidylethanolamine (NAPE), by a specific phospholipase D. N-acyl amino acids are synthesized via a circulating peptidase M20 domain containing 1 (PM20D1), which can catalyze the bidirectional the condensation and hydrolysis of a variety of N-acyl amino acids. The degradation of N-acylamides is largely mediated by an enzyme called fatty acid amide hydrolase (FAAH), which catalyzes the hydrolysis of N-acylamides into fatty acids and the biogenic amines. Many N-acylamides are involved in lipid signaling system through interactions with transient receptor potential channels (TRP). TRP channel proteins interact with N-acyl amides such as N-arachidonoyl ethanolamide (Anandamide), N-arachidonoyl dopamine and others in an opportunistic fashion (PMID: 23178153). This signaling system has been shown to play a role in the physiological processes involved in inflammation (PMID: 25136293). Other N-acyl amides, including N-oleoyl-glutamine, have also been characterized as TRP channel antagonists (PMID: 29967167). N-acylamides have also been shown to have G-protein-coupled receptors (GPCRs) binding activity (PMID: 28854168). The study of N-acylamides is an active area of research and it is likely that many novel N-acylamides will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered for these molecules.

   

O-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoate

O-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoic acid

C22H37NO2 (347.2824142)


   

N-(2-Hydroxyethyl)eicosa-5,8,11,14-tetraenamide

N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenimidic acid

C22H37NO2 (347.2824142)


   

arachidonoylethanolamine

1-amino-2-hydroxydocosa-7,10,13,16-tetraen-3-one

C22H37NO2 (347.2824142)


   

2-(Icosa-5,8,11,14-tetraenylamino)acetic acid

2-[(icosa-5,8,11,14-tetraen-1-yl)amino]acetic acid

C22H37NO2 (347.2824142)


   

2H-Benzo(a)quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-

2-ethyl-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol

C21H33NO3 (347.2460308000001)


   

Carrageenan, potassium salt of

(2S,3R)-2-{[(2S)-2-amino-1-hydroxy-3-methylbutylidene]amino}-N-[(2S)-1,1-diamino-1-hydroxy-4-methylpentan-2-yl]-3-hydroxybutanimidate

C15H33N5O4 (347.2532418)


It is used as a food additive .

   
   
   

(-)-clavepictine A|(3R,4S,6S,9aS)-6-((1E,3E)-deca-1,3-dienyl)-4-methyl-octahydro-quinolizin-3-yl acetate|Clavepictine A

(-)-clavepictine A|(3R,4S,6S,9aS)-6-((1E,3E)-deca-1,3-dienyl)-4-methyl-octahydro-quinolizin-3-yl acetate|Clavepictine A

C22H37NO2 (347.2824142)


   

1-[(2E,4E,12Z)-octadecatrienoyl]-N-isobutylamide

1-[(2E,4E,12Z)-octadecatrienoyl]-N-isobutylamide

C23H41NO (347.31879760000004)


   
   

3beta-Hydroxy-20alpha-dimethylamino-5alpha-pregnan; Funtuphyllamin C|Funtuphyllamin C

3beta-Hydroxy-20alpha-dimethylamino-5alpha-pregnan; Funtuphyllamin C|Funtuphyllamin C

C23H41NO (347.31879760000004)


   
   

16beta-acetoxy-1alpha,4alpha-epoxy-(5beta)-3-aza-4a-homo-androstane|O-Acetyl-samandarin|O-acetyl-samandarine

16beta-acetoxy-1alpha,4alpha-epoxy-(5beta)-3-aza-4a-homo-androstane|O-Acetyl-samandarin|O-acetyl-samandarine

C21H33NO3 (347.2460308000001)


   
   

Manzamin C|Manzamine C

Manzamin C|Manzamine C

C23H29N3 (347.2361354)


   

Piperidine, 1-[(2E,4E)-1-oxo-2,4-octadecadienyl]-

Piperidine, 1-[(2E,4E)-1-oxo-2,4-octadecadienyl]-

C23H41NO (347.31879760000004)


   

Oxime-3beta-3,21-Dihydroxypregn-5-en-20-one

Oxime-3beta-3,21-Dihydroxypregn-5-en-20-one

C21H33NO3 (347.2460308000001)


   

N-allylisonitrarine

N-allylisonitrarine

C23H29N3 (347.2361354)


   
   

(2E,9Z)-octadeca-2,9-dienoic acid piperidine

(2E,9Z)-octadeca-2,9-dienoic acid piperidine

C23H41NO (347.31879760000004)


   

N-methyltyroscherin

N-methyltyroscherin

C22H37NO2 (347.2824142)


   

N-Me-(3beta,16alpha,20S)-20-Aminopregn-5-ene-3,16-diol

N-Me-(3beta,16alpha,20S)-20-Aminopregn-5-ene-3,16-diol

C22H37NO2 (347.2824142)


   

5-octadecylpyrrole-2-carboxaldehyde

5-octadecylpyrrole-2-carboxaldehyde

C23H41NO (347.31879760000004)


   
   

CAY10590

4-[(1-oxo-7-phenylheptyl)amino]-(4R)-octanoic acid

C21H33NO3 (347.2460308000001)


   
   

N-(7Z,10Z,13Z,16Z-Docosatetraenoyl)-ethanolamide

N-(7Z,10Z,13Z,16Z-Docosatetraenoyl)-ethanolamide

C22H37NO2 (347.2824142)


   

Virodhamine

O-(2-aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenester

C22H37NO2 (347.2824142)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators D018377 - Neurotransmitter Agents

   

Arachidonoyl-EA(d8)

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine(d8)

C22H37NO2 (347.2824142)


   

NAE 20:4

N-(8Z,11Z,14,17ZZ-eicoscatetraenoyl)- ethanolamine

C22H37NO2 (347.2824142)


   

4-cholesten-3-one-2,2,4,6,6-d5

4-cholesten-3-one-2,2,4,6,6-d5

C24H33D5O (347.32363569)


   
   

2,3,4,5-Tetrahydro-2-butyl-5-(2-(6-methyl-3-pyridyl)ethyl)-1H-pyrido(4 ,3-b)indole

2,3,4,5-Tetrahydro-2-butyl-5-(2-(6-methyl-3-pyridyl)ethyl)-1H-pyrido(4 ,3-b)indole

C23H29N3 (347.2361354)


   

2-Hydroxypropanoic acid - 2-(tetradecylamino)ethanol (1:1)

2-Hydroxypropanoic acid - 2-(tetradecylamino)ethanol (1:1)

C19H41NO4 (347.30354260000007)


   
   

13-[(E)-2-methylcrotonoyl]oxylupanine

13-[(E)-2-methylcrotonoyl]oxylupanine

C20H31N2O3+ (347.23345559999996)


   

N-(2-Hydroxyethyl)eicosa-5,8,11,14-tetraenamide

N-(2-Hydroxyethyl)eicosa-5,8,11,14-tetraenamide

C22H37NO2 (347.2824142)


   

arachidonoylethanolamine

arachidonoylethanolamine

C22H37NO2 (347.2824142)


   

2-(Icosa-5,8,11,14-tetraenylamino)acetic acid

2-(Icosa-5,8,11,14-tetraenylamino)acetic acid

C22H37NO2 (347.2824142)


   

2-aminoethyl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate

2-aminoethyl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate

C22H37NO2 (347.2824142)


   
   
   

N-[3-(dimethylamino)-2,2-dimethylpropyl]-1-[(2-hydroxyphenyl)methyl]-4-piperidinecarboxamide

N-[3-(dimethylamino)-2,2-dimethylpropyl]-1-[(2-hydroxyphenyl)methyl]-4-piperidinecarboxamide

C20H33N3O2 (347.25726380000003)


   

(1S,5R)-6-(cyclohexylmethyl)-7-(4-pyridin-4-ylphenyl)-3,6-diazabicyclo[3.1.1]heptane

(1S,5R)-6-(cyclohexylmethyl)-7-(4-pyridin-4-ylphenyl)-3,6-diazabicyclo[3.1.1]heptane

C23H29N3 (347.2361354)


   

(8Z,11Z,14Z,17Z)-N-(2-hydroxyethyl)icosa-8,11,14,17-tetraenamide

(8Z,11Z,14Z,17Z)-N-(2-hydroxyethyl)icosa-8,11,14,17-tetraenamide

C22H37NO2 (347.2824142)


   

Picolinyl hexadecanoate

Picolinyl hexadecanoate

C22H37NO2 (347.2824142)


   

3-(Benzylamino)pentadecanoic acid

3-(Benzylamino)pentadecanoic acid

C22H37NO2 (347.2824142)


   

Trimethylstearylammonium Chloride

1-Octadecanaminium, N,N,N-trimethyl-, chloride

C21H46ClN (347.33185860000003)


   

Anandamide

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine

C22H37NO2 (347.2824142)


An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators

   
   
   
   

NA-Histamine 16:1(9Z)

NA-Histamine 16:1(9Z)

C21H37N3O (347.2936472)


   
   
   

2-(10,13-dihydroxytridecyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

2-(10,13-dihydroxytridecyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

C18H37NO5 (347.26715920000004)


   

4-[(2s,3r,8r,10r)-2-(dimethylamino)-3-hydroxy-8,10-dimethyldodec-6-en-1-yl]phenol

4-[(2s,3r,8r,10r)-2-(dimethylamino)-3-hydroxy-8,10-dimethyldodec-6-en-1-yl]phenol

C22H37NO2 (347.2824142)


   

(1s,5r,8r,9r,10r,11s,12r,13s,15s,16r)-12-(hydroxymethyl)-5,7-dimethyl-7-azahexacyclo[7.6.2.2¹⁰,¹³.0¹,⁸.0⁵,¹⁶.0¹⁰,¹⁵]nonadecane-11,12-diol

(1s,5r,8r,9r,10r,11s,12r,13s,15s,16r)-12-(hydroxymethyl)-5,7-dimethyl-7-azahexacyclo[7.6.2.2¹⁰,¹³.0¹,⁸.0⁵,¹⁶.0¹⁰,¹⁵]nonadecane-11,12-diol

C21H33NO3 (347.2460308000001)