2-(Icosa-5,8,11,14-tetraenylamino)acetic acid (BioDeep_00000181476)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H37NO2 (347.2824142)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CCC=CCC=CCC=CCCCCNCC(O)=O
InChI: InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23-21-22(24)25/h6-7,9-10,12-13,15-16,23H,2-5,8,11,14,17-21H2,1H3,(H,24,25)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Douglas McHugh, Jeremy Page, Emily Dunn, Heather B Bradshaw. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
British journal of pharmacology.
2012 Apr; 165(8):2414-24. doi:
10.1111/j.1476-5381.2011.01497.x. [PMID: 21595653] - Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young-Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi, Teruo Kawada. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.
The Biochemical journal.
2011 Aug; 438(1):111-9. doi:
10.1042/bj20101939. [PMID: 21605082] - Sung Ha Lee, Siham Raboune, J Michael Walker, Heather B Bradshaw. Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain.
International journal of molecular sciences.
2010 Oct; 11(10):3965-76. doi:
10.3390/ijms11103965. [PMID: 21152313] - Hyo-Jin Jeong, Robert J Vandenberg, Christopher W Vaughan. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
British journal of pharmacology.
2010 Oct; 161(4):925-35. doi:
10.1111/j.1476-5381.2010.00935.x. [PMID: 20860669] - Gabor Tigyi. Aiming drug discovery at lysophosphatidic acid targets.
British journal of pharmacology.
2010 Sep; 161(2):241-70. doi:
10.1111/j.1476-5381.2010.00815.x. [PMID: 20735414] - Neelam Parmar, W-S Vanessa Ho. N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels.
British journal of pharmacology.
2010 Jun; 160(3):594-603. doi:
10.1111/j.1476-5381.2009.00622.x. [PMID: 20136843] - Douglas McHugh, Sherry S J Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradshaw. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.
BMC neuroscience.
2010 Mar; 11(?):44. doi:
10.1186/1471-2202-11-44. [PMID: 20346144] - Amelia R Edington, Audra A McKinzie, Aaron J Reynolds, Michael Kassiou, Renae M Ryan, Robert J Vandenberg. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
The Journal of biological chemistry.
2009 Dec; 284(52):36424-36430. doi:
10.1074/jbc.m109.017509. [PMID: 19875446] - Heather B Bradshaw, Neta Rimmerman, Sherry Shu-Jung Hu, Valery M Benton, Jordyn M Stuart, Kim Masuda, Benjamin F Cravatt, David K O'Dell, J Michael Walker. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.
BMC biochemistry.
2009 May; 10(?):14. doi:
10.1186/1471-2091-10-14. [PMID: 19460156] - Sumner H Burstein, Robert B Zurier. Cannabinoids, endocannabinoids, and related analogs in inflammation.
The AAPS journal.
2009 Mar; 11(1):109-19. doi:
10.1208/s12248-009-9084-5. [PMID: 19199042] - Heather B Bradshaw, Neta Rimmerman, Sherry S-J Hu, Sumner Burstein, J Michael Walker. Novel endogenous N-acyl glycines identification and characterization.
Vitamins and hormones.
2009; 81(?):191-205. doi:
10.1016/s0083-6729(09)81008-x. [PMID: 19647113] - Da Young Oh, Jung Min Yoon, Mi Jin Moon, Jong-Ik Hwang, Han Choe, Ju Yeon Lee, Jae Il Kim, Sunoh Kim, Hyewhon Rhim, David K O'Dell, J Michael Walker, Heung Sik Na, Min Goo Lee, Hyuk Bang Kwon, Kyungjin Kim, Jae Young Seong. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
The Journal of biological chemistry.
2008 Jul; 283(30):21054-64. doi:
10.1074/jbc.m708908200. [PMID: 18499677] - Amy L Wiles, Rhonda-Jo Pearlman, Mari Rosvall, Karin R Aubrey, Robert J Vandenberg. N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a.
Journal of neurochemistry.
2006 Nov; 99(3):781-6. doi:
10.1111/j.1471-4159.2006.04107.x. [PMID: 16899062] - Masashi Kohno, Hitoshi Hasegawa, Atsushi Inoue, Masatake Muraoka, Tatsuhiko Miyazaki, Keizo Oka, Masaki Yasukawa. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
Biochemical and biophysical research communications.
2006 Sep; 347(3):827-32. doi:
10.1016/j.bbrc.2006.06.175. [PMID: 16844083]