Exact Mass: 304.0098858
Exact Mass Matches: 304.0098858
Found 313 metabolites which its exact mass value is equals to given mass value 304.0098858,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
(+)-taxifolin
Taxifolin, also known as dihydroquercetin or (+)-taxifolin, is a member of the class of compounds known as flavanonols. Flavanonols are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a hydroxyl group and a ketone at the carbon C2 and C3, respectively. Taxifolin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Taxifolin can be found in a number of food items such as sweet rowanberry, arrowroot, evening primrose, and walnut, which makes taxifolin a potential biomarker for the consumption of these food products. Taxifolin is a flavanonol, a type of flavonoid . D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2]. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
Taxifolin
(+)-taxifolin is a taxifolin that has (2R,3R)-configuration. It has a role as a metabolite. It is a conjugate acid of a (+)-taxifolin(1-). It is an enantiomer of a (-)-taxifolin. Taxifolin is a natural product found in Austrocedrus chilensis, Smilax corbularia, and other organisms with data available. See also: Milk Thistle (part of); Maritime Pine (part of). D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics A taxifolin that has (2R,3R)-configuration. D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2]. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
Thymidine 3',5'-cyclic monophosphate
Thymidine 3,5-cyclic monophosphate is an intermediate in the Pyrimidine metabolism. Is the product or substrate of the enzymes Thymidylate synthase (EC 2.1.1.45), Thymidylate synthase (FAD) (EC 2.1.1.148), Thymidine kinase (EC 2.7.1.21), AMP-thymidine kinase (EC 2.7.1.114), ADP-thymidine kinase (EC 2.7.1.118), dTMP kinase (EC 2.7.4.9), T2-induced deoxynucleotide kinase (EC 2.7.4.12), 5-nucleotidase (EC 3.1.3.5), Thymidylate 5-phosphatase (EC 3.1.3.35), and ATP-diphosphatase (EC 3.6.1.5). (KEGG) [HMDB] Thymidine 3,5-cyclic monophosphate is an intermediate in the pyrimidine metabolism. It is the product or substrate of the enzymes thymidylate synthase (EC 2.1.1.45), thymidylate synthase (FAD) (EC 2.1.1.148), thymidine kinase (EC 2.7.1.21), AMP-thymidine kinase (EC 2.7.1.114), ADP-thymidine kinase (EC 2.7.1.118), dTMP kinase (EC 2.7.4.9), T2-induced deoxynucleotide kinase (EC 2.7.4.12), 5-nucleotidase (EC 3.1.3.5), Thymidylate 5-phosphatase (EC 3.1.3.35), and ATP-diphosphatase (EC 3.6.1.5).
Taxifolin
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2]. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
3-(3,4-dihydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propane-1,2-dione
Pratenol B
Pratenol B is found in herbs and spices. Pratenol B is a constituent of Trifolium pratense (red clover). Constituent of Trifolium pratense (red clover). Pratenol B is found in tea and herbs and spices.
5-(3',4',5'-Trihydroxyphenyl)-gamma-valerolactone-3'-O-sulphate
C11H12O8S (304.02528720000004)
5-(3,4,5-Trihydroxyphenyl)-gamma-valerolactone-3-O-sulphate belongs to the family of Catechols. These are compounds containing a 1,2-benzenediol moiety.
5-(3',4',5'-Trihydroxyphenyl)-gamma-valerolactone-4'-O-sulphate
C11H12O8S (304.02528720000004)
5-(3,4,5-Trihydroxyphenyl)-gamma-valerolactone-4-O-sulphate belongs to the family of Resorcinols. These are compounds containing a resorcinol moiety, which is a benzene ring bearing two hydrocyl groups at positions 1 and 3.
Sinapic acid 4-O-sulfate
C11H12O8S (304.02528720000004)
Sinapic acid 4-O-sulfate is an endogenous phenolic acid metabolite. Sinapic acid 4-O-sulfate was found to be elevated in rat urine after whole rye consumption which makes this compound a potential urinary biomarker of whole grain intake (PMID: 26862900).
(2R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2]. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one
Arctinone A acetate
Arctinone a acetate is a member of the class of compounds known as bi- and oligothiophenes. Bi- and oligothiophenes are organic compounds containing two or more linked thiophene rings. Thiophene is a five-member aromatic ring with one sulfur and four carbon atoms. Arctinone a acetate is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Arctinone a acetate can be found in burdock, which makes arctinone a acetate a potential biomarker for the consumption of this food product.
Dihydrorobinetin
Dihydrorobinetin is a natural product found in Robinia pseudoacacia and Adenanthera pavonina Dihydrorobinetin is a naturally occurring organic compound, classified as a flavanonol, which is a type of flavonoid. It is the dihydro derivative of robinetin, meaning it has two additional hydrogen atoms compared to robinetin. The chemical formula of dihydrorobinetin is C15H14O6. This compound is found in various plants and has been studied for its potential biological activities, including antioxidant and anti-inflammatory properties. Dihydrorobinetin, like other flavonoids, is known for its ability to scavenge free radicals and modulate cellular processes, which may contribute to its health benefits. (+)-Dihydrorobinetin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=4382-33-6 (retrieved 2024-07-12) (CAS RN: 4382-33-6). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Alphitonin
A hydroxyaurone that is aurone substituted by hydroxy groups at positions 2, 4, 6, 3 and 4 respectively. It has been isolated from Alphitonia excelsa.
Dihydromorin
Dihydromorin is a natural product found in Broussonetia papyrifera, Artocarpus altilis, and other organisms with data available.
1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide
C11H8ClF3N4O (304.03387039999996)
Delorazepam
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
8-Chloro-3-(4-hydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
C15H9ClO5 (304.01384939999997)
4-Chlorophenol glucuronide|O1-(4-Chlor-phenyl)-beta-D-glucopyranuronsaeure|O1-(4-chloro-phenyl)-beta-D-glucopyranuronic acid|p-Chlor-phenyl-beta-D-glucopyranosiduronsaeure|p-chlorophenyl glucuronide
2鈥樎封€樎?Acetoxy-5-Acetyl-5?脣-(1-propynyl)-2,2?脣-bithiophene
2-(cis-1,2-dihydroxy-4-oxo-cyclohex-5-enyl)-5,7-dihydroxychromone
2,3,7,8-tetrahydroxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione|ellagic acid
1,7-Dimethoxy-2,3,8-trihydroxyxanthon|2,3,8-trihydroxy-1,7-dimethoxy-xanthen-9-one
Corymbiferin
Corymbiferin is a natural product found in Gentiana orbicularis, Gentianopsis barbata, and other organisms with data available.
2-(3,4-Dihydroxy-phenyl)-2,5,7-trihydroxy-chroman-3-on|2-(3,4-dihydroxy-phenyl)-2,5,7-trihydroxy-chroman-3-one
3-Methyl-5,10-dihydroxy-7-methoxy-3,4-dihydro-1H-naphtho[2,3-c]pyran-1,6,9-trione
2-O-(4-hydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid
globosuxanthone A
A member of the class of xanthones that is methyl 9-oxo-2,9-dihydro-1H-xanthene-1-carboxylate substituted by hydroxy groups at positions 1, 2 and 8 (the 1R,2R stereoisomer). Isolated from Chaetomium globosum, it exhibits cytotoxicity towards human tumour cell lines.
1-(3,4-dihydro xyphenyl)-3-(2,4,6-trihydroxyphenyl)-1,3-propanedione
(-)-Taxifolin
(-)-taxifolin is the (2S,3S)-stereoisomer of taxifolin. It is an enantiomer of a (+)-taxifolin. (-)-Taxifolin is a natural product found in Acer mandshuricum, Artabotrys hexapetalus, and Bauhinia purpurea with data available. The (2S,3S)-stereoisomer of taxifolin.
2,3-Dihydro-2-hydroxyprotoapigenone
Thymidine-3,5-cyclic monophosphate
Acquisition and generation of the data is financially supported in part by CREST/JST.
Taxifolin
A pentahydroxyflavanone that is the 2,3-dihydro derivative of quercetin. D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents Origin: Plant; Formula(Parent): C15H12O7; Bottle Name:(+-)-Taxifolin; PRIME Parent Name:Dihydroquercetin; PRIME in-house No.:S0088, Pyrans relative retention time with respect to 9-anthracene Carboxylic Acid is 0.594 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.596 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.590 Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2]. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
(2R,3R)-2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
(2R,3R)-3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
8-hydroxy-7-methoxy-3-methyl-10-oxo-1H-pyrano[4,3-b]chromene-9-carboxylic acid
1,3,8-trihydroxy-4,5-dimethoxyxanthen-9-one
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
(2R,3R)-2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
(2R,3R)-2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one_major
1,4-Pentadien-3-one, 1,5-bis(5-nitro-2-furanyl)- (9CI)
N-(5-bromo-3-methylpyridin-2-yl)-N-methylbenzamide
Disodium 6-O-phosphonato-D-glucose
C6H11Na2O9P (303.9936086000001)
D-Glucose-6-phosphate disodium salt is a glucose sugar phosphorylated at the hydroxy group on carbon 6[1].
2,6-Dichloropurine-2-deoxyriboside
C10H10Cl2N4O3 (304.01299300000005)
Methyl 2-(bromomethyl)-[1,1-biphenyl]-2-carboxylate
d-mannose 6-phosphate disodium salt
C6H11Na2O9P (303.9936086000001)
(N-PHENYLAMINOMETHYL)TRIMETHOXYSILANE
C14H10F5P (304.04402500000003)
2-ethylcyclopenta-1,3-diene,titanium(4+),dichloride
1-CHLORO-4-PROPOXY-9H-THIOXANTHEN-9-ONE
C16H13ClO2S (304.03247480000005)
5-(2-bromophenyl)-1-methyl-3-(trifluoromethyl)pyrazole
Disodium 1-O-phosphonato-β-D-glucopyranose
C6H11Na2O9P (303.9936086000001)
1-(4-CHLORO-2,5-DIMETHOXYPHENYL)-2-AMINOPROPANEHCL
7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
C15H10ClFN2O2 (304.04148019999997)
n-benzyl-4-nitro-2,1,3-benzoxadiazol-5-amine
C13H9ClN4O3 (304.03631540000003)
2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridine monohydrobromine
4-[2-(Dimethylamino)ethylaminosulfonyl]-7-chloro-2,1,3-benzoxadiazole
C10H13ClN4O3S (304.03968580000003)
METHYL 3-(BROMOMETHYL)-[1,1-BIPHENYL]-4-CARBOXYLATE
6-Hydroxy-benzo[h]chromeno[5,4,3-cde]chromene-5,12-dione
Phosphoric acid, 2-ethylhexyl ester, potassium salt
2-(METHACRYLOYLOXY)ETHYL 1,3-DIOXO-1,3-DIHYDROISOBENZOFURAN-5-CARBOXYLATE
Disodium 6-O-phosphonato-D-fructose
C6H11Na2O9P (303.9936086000001)
D-Fructose-6-phosphate disodium is an endogenous metabolite.
4-Chloro-3-cyano-N,N-dimethyl-6-nitro-8-quinolinecarboxamide
C13H9ClN4O3 (304.03631540000003)
2-(1-Benzyl-1H-pyrrol-2-yl)-4,6-dichloro-1,3,5-triazine
ETHYL 2,2-DIMETHYL-3-(4-CHLOROSULFONYLPHENYL)PROPIONATE
C13H17ClO4S (304.05360320000005)
7-(2,6-DICHLOROPHENYL)-5-METHYLBENZO[E][1,2,4]TRIAZIN-3-AMINE
2,5-Cyclohexadien-1-one,2,6-dichloro-4-[(4-hydroxy-3-methylphenyl)imino]-, sodium salt (1:1)
C13H9Cl2NNaO2+ (303.99080139999995)
5-Bromo-3-(phenylsulfanyl)-1H-pyrrolo[2,3-b]pyridine
1-(3-bromophenyl)-2-(3-hydroxyphenyl)ethane-1,2-dione
C14H9BrO3 (303.97350240000003)
2-bromo-2-methyl-1-(4-(methylsulfonyl)phenyl)propan-1-one
2-(4-Chlorophenyl)-3-(trifluoromethyl)pyrazole-4-carboxylic acid hydrazide
C11H8ClF3N4O (304.03387039999996)
2-bromo-5-((3,3-difluorocyclobutyl)methoxy)-1,3-dimethylbenzene
C13H15BrF2O (304.02742639999997)
[6-Chloro-4-(2-chlorophenyl)-2-quinazolinyl]methanol
(E)-4-nitro-N-(1-phenyl ethylidene)benzenesulfonaMide
(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride
C9H14F2N2O3S*ClH (304.04599340000004)
1-methyl-5-phenoxy-3-(trifluoromethyl)pyrazole-4-carbonyl chloride
C12H8ClF3N2O2 (304.02263739999995)
2-AMINO-3-(1, 2-DIHYDRO-2-OXO-4-QUINOLYL)PROPIONIC ACID DIHYDROCHLORIDE
C12H14Cl2N2O3 (304.03814339999997)
Ethyl 8-bromoimidazo[1,2-a]pyridine-6-carboxylate, HCl
3,6-BIS(2-CHLOROPHENYL)-1,2-DIHYDRO-1,2,4,5-TETRAZINE
2-(3-CHLORO-PHENYL)-5-THIOPHEN-2-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID
methyl (2Z,4Z)-5-chloro-2-(chloromethyl)-5-(4-chlorophenyl)penta-2,4-dienoate
C13H11Cl3O2 (303.98245959999997)
methyl (2Z,4Z)-5-chloro-2-(chloromethyl)-5-(3-chlorophenyl)penta-2,4-dienoate
C13H11Cl3O2 (303.98245959999997)
2,2,3,3,4,4,5,5-octafluoropentyl 2-fluoroprop-2-enoate
2-((2-BROMO-5-CHLOROPHENOXY)METHYL)TETRAHYDRO-2H-PYRAN
3-Methyl-7-[(3-methylphenyl)methylthio]-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
4H-1-Benzopyran-4-one, 2-(2,6-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one
5-(3',4',5'-Trihydroxyphenyl)-gamma-valerolactone-3'-O-sulphate
C11H12O8S (304.02528720000004)
5-(3,4,5-Trihydroxyphenyl)-gamma-valerolactone-3-O-sulphate belongs to the family of Catechols. These are compounds containing a 1,2-benzenediol moiety.
5-(3',4',5'-Trihydroxyphenyl)-gamma-valerolactone-4'-O-sulphate
C11H12O8S (304.02528720000004)
5-(3,4,5-Trihydroxyphenyl)-gamma-valerolactone-4-O-sulphate belongs to the family of Resorcinols. These are compounds containing a resorcinol moiety, which is a benzene ring bearing two hydrocyl groups at positions 1 and 3.
(R)-5-Diphosphomevalonate
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3,5-cyclic CMP(1-)
The conjugate base of 3,5-cyclic CMP; major species at pH 7.3.
4-(5-O-phosphonato-beta-D-ribofuranosyl)phenol(2-)
N-(4-oxoglutaryl)-L-cysteinylglycine
C10H12N2O7S-2 (304.03652020000004)
(3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
(4S)-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-3,4,5,7-tetrol
4-Chloro-5-(2,3-dihydro-1,4-benzodioxin-3-yl)thieno[2,3-d]pyrimidine
N-[(E)-furan-2-ylmethylideneamino]-3,5-dinitrobenzamide
1-(4-Methylphenyl)sulfonyl-3-methylsulfonylimidazolidine
2-[5-Bromo-2-ethoxy-4-(hydroxymethyl)phenoxy]acetic acid
C11H13BrO5 (303.99463080000004)
2-(2,4-dioxo-3-thiazolidinyl)-N-(2,3,4-trifluorophenyl)acetamide
N-(1,3-benzothiazol-2-yl)-2-[(1-methyl-2-imidazolyl)thio]acetamide
4-Carboxylato-4-sulfonatoazobenzene
C13H8N2O5S-2 (304.01539180000003)
1-(2,3-Dihydroxy-5-methylphenyl)-2-(2,4,6-trihydroxyphenyl)ethane-1,2-dione
(2R)-2-(3,4-dihydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
5,7-Dihydroxy-2-(2,3,4-trihydroxyphenyl)-2,3-dihydrochromen-4-one
8-hydroxy-7-methoxy-3-methyl-10-oxo-1H-pyrano[4,3-b]chromene-9-carboxylic acid
4-(5-O-phosphonato-beta-D-ribofuranosyl)phenol(2-)
An organophosphate oxoanion obtained by deprotonation of the phosphate OH groups of 4-(5-O-phospho-beta-D-ribofuranosyl)phenol; major species at pH 7.3.
Dihydrotricetin
A pentahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3, 4 and 5.
5-(3,4,5-Trihydroxyphenyl)-gamma-valerolactone-4-O-sulphate
C11H12O8S (304.02528720000004)
5-(3,4,5-Trihydroxyphenyl)-gamma-valerolactone-3-O-sulphate
C11H12O8S (304.02528720000004)
2,3-cyclic CMP(1-)
A 2,3-cyclic nucleotide(1-) which is obtained from 2,3-cyclic CMP by removal of a proton from the cyclic phosphate group.
3,5-Cyclic dTMP
A 3,5-cyclic pyrimidine nucleotide derived from thymidine monophosphate.
(R)-5-diphosphonatomevalonate(4-)
An organophosphate oxoanion arising from deprotonation of carboxylic acid and phosphate functions of (R)-5-diphosphomevalonic acid.
α-D-Glucose-1-phosphate (disodium)
C6H11Na2O9P (303.9936086000001)
α-D-Glucose-1-phosphate disodium is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiotic, as an immunosuppressive agent, and as a circulatory system therapy element[1].