Tyrphostin AG 1024 (BioDeep_00000017105)
代谢物信息卡片
化学式: C14H13BrN2O (304.0211188)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O
InChI: InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Xiangxiang Zhou, Na Chen, Hongzhi Xu, Xiaoming Zhou, Jianhong Wang, Xiaosheng Fang, Ya Zhang, Ying Li, Juan Yang, Xin Wang. Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma.
Journal of hematology & oncology.
2020 06; 13(1):77. doi:
10.1186/s13045-020-00906-1
. [PMID: 32546241] - Chum-Liang Tung, Dennis Jine-Yuan Hsieh, Rathinasamy Baskaran, Bo Ban, Tran Duc Dung, Da-Tong Ju, Vijaya Padma Viswanadha, Cecilia Hsuan Day, Yu-Lan Yeh, Chih-Yang Huang. LPS-enhanced IGF-IIR pathway to induce H9c2 cardiomyoblast cell hypertrophy was attenuated by Carthamus tinctorius extract via IGF-IR activation.
Environmental toxicology.
2020 Feb; 35(2):145-151. doi:
10.1002/tox.22850
. [PMID: 31714667] - Chun-Liang Tung, Da-Tong Ju, Bharath Kumar Velmurugan, Bo Ban, Tran D Dung, Dennis J-Y Hsieh, Vijaya P Viswanadha, Cecilia H Day, Yueh-Min Lin, Chih-Yang Huang. Carthamus tinctorius L. extract activates insulin-like growth factor-I receptor signaling to inhibit FAS-death receptor pathway and suppress lipopolysaccharides-induced H9c2 cardiomyoblast cell apoptosis.
Environmental toxicology.
2019 Dec; 34(12):1320-1328. doi:
10.1002/tox.22833
. [PMID: 31486215] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Yan He, Xiaoming Yuan, Hao Zuo, Xiangwei Li, Ying Sun, Aiwen Feng. Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis.
Life sciences.
2019 Sep; 233(?):116697. doi:
10.1016/j.lfs.2019.116697
. [PMID: 31351968] - Abeer A Elhenawy, Rehab H Ashour, Nairmen Nabih, Naglaa M Shalaby, Amr A El-Karef, Hala S Abou-El-Wafa. Insulin growth factor inhibitor as a potential new anti-schistosoma drug: An in vivo experimental study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Nov; 95(?):1346-1358. doi:
10.1016/j.biopha.2017.09.015
. [PMID: 28946182] - Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhang. Prostaglandin E(2) and insulin-like growth factor I interact to enhance proliferation of theca externa cells from chicken prehierarchical follicles.
Prostaglandins & other lipid mediators.
2013 Oct; 106(?):91-8. doi:
10.1016/j.prostaglandins.2013.05.007
. [PMID: 23810989] - Hui-Ping Lin, Li-Kuo Kuo, Chih-Pin Chuu. Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
Phytotherapy research : PTR.
2012 Jan; 26(1):122-6. doi:
10.1002/ptr.3523
. [PMID: 21567511] - Heng-Chih Chang, Yea-Ru Yang, Paulus S Wang, Chia-Hua Kuo, Ray-Yau Wang. Insulin-like growth factor I signaling for brain recovery and exercise ability in brain ischemic rats.
Medicine and science in sports and exercise.
2011 Dec; 43(12):2274-80. doi:
10.1249/mss.0b013e318223b5d9
. [PMID: 21606872] - Robert X-D Song, Yuchai Chen, Zhenguo Zhang, Yongde Bao, Wei Yue, Ji-Ping Wang, Ping Fan, Richard J Santen. Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells.
The Journal of steroid biochemistry and molecular biology.
2010 Feb; 118(4-5):219-30. doi:
10.1016/j.jsbmb.2009.09.018
. [PMID: 19815064] - Peter Zahradka, Benjamin Storie, Brenda Wright. IGF-1 receptor transactivation mediates Src-dependent cortactin phosphorylation in response to angiotensin II.
Canadian journal of physiology and pharmacology.
2009 Oct; 87(10):805-12. doi:
10.1139/y09-052
. [PMID: 19898563] - Huiyan Pan, Mustafa B A Djamgoz. Biochemical constitution of extracellular medium is critical for control of human breast cancer MDA-MB-231 cell motility.
The Journal of membrane biology.
2008 May; 223(1):27-36. doi:
10.1007/s00232-008-9110-z
. [PMID: 18575796] - V E MacRae, T Burdon, S F Ahmed, C Farquharson. Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.
The Journal of endocrinology.
2006 Nov; 191(2):369-77. doi:
10.1677/joe.1.06958
. [PMID: 17088406] - Amandine Hurbin, Laurence Dubrez, Jean-Luc Coll, Marie C Favrot. Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.
Annals of the New York Academy of Sciences.
2003 Dec; 1010(?):354-7. doi:
10.1196/annals.1299.065
. [PMID: 15033751] - Jenny E Gunton, Patric J D Delhanty, Shin-Ichiro Takahashi, Robert C Baxter. Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.
The Journal of clinical endocrinology and metabolism.
2003 Mar; 88(3):1323-32. doi:
10.1210/jc.2002-021394
. [PMID: 12629126] - Amandine Hurbin, Laurence Dubrez, Jean-Luc Coll, Marie-Christine Favrot. Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.
The Journal of biological chemistry.
2002 Dec; 277(51):49127-33. doi:
10.1074/jbc.m207584200
. [PMID: 12356750] - M Párrizas, A Gazit, A Levitzki, E Wertheimer, D LeRoith. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins.
Endocrinology.
1997 Apr; 138(4):1427-33. doi:
10.1210/endo.138.4.5092
. [PMID: 9075698]