Delorazepam (BioDeep_00000272589)

   

natural product


代谢物信息卡片


Delorazepam

化学式: C15H10Cl2N2O (304.017015)
中文名称: 地洛西泮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3Cl
InChI: InChI=1S/C15H10Cl2N2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

描述信息

C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

1 个代谢物同义名

Delorazepam



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Claudia Carelli, Francesca Freni, Matteo Moretti, Claudia Vignali, Marco Ballardini, Luca Morini. A case report on fatal intoxication by tapentadol: Study of distribution and metabolism. Forensic science international. 2021 Jul; 324(?):110825. doi: 10.1016/j.forsciint.2021.110825. [PMID: 34000617]
  • Sabrina Lehmann, Alissa Sczyslo, Judith Froch-Cortis, Markus Alexander Rothschild, Mario Thevis, Hilke Andresen-Streichert, Katja Mercer-Chalmers-Bender. Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. Forensic science international. 2019 Oct; 303(?):109959. doi: 10.1016/j.forsciint.2019.109959. [PMID: 31546164]
  • Michele Fabrazzo, Antonietta Fuschillo, Francesco Perris, Francesco Catapano. The unmasking of hidden severe hyponatremia after long-term combination therapy in exacerbated bipolar patients: a case series. International clinical psychopharmacology. 2019 07; 34(4):206-210. doi: 10.1097/yic.0000000000000265. [PMID: 30998596]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Diogo Oliveira-Silva, Celso H Oliveira, Gustavo D Mendes, Paulo Alexandre R Galvinas, Rafael E Barrientos-Astigarraga, Gilberto De Nucci. Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study. Biomedical chromatography : BMC. 2009 Dec; 23(12):1266-75. doi: 10.1002/bmc.1249. [PMID: 19488979]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Pi Cheng, Quan Zhang, Yun-Bao Ma, Zhi-Yong Jiang, Xue-Mei Zhang, Feng-Xue Zhang, Ji-Jun Chen. Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives. Bioorganic & medicinal chemistry letters. 2008 Jul; 18(13):3787-9. doi: 10.1016/j.bmcl.2008.05.065. [PMID: 18524583]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • Carlo G Zambonin, Antonella Aresta. SPME-LC with UV detection to study delorazepam-serum albumin interactions. Journal of pharmaceutical and biomedical analysis. 2002 Jul; 29(5):895-900. doi: 10.1016/s0731-7085(02)00217-0. [PMID: 12093523]
  • Antonella Aresta, Linda Monaci, Carlo Giorgio Zambonin. Determination of delorazepam in urine by solid-phase microextraction coupled to high performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2002 Jun; 28(5):965-72. doi: 10.1016/s0731-7085(02)00012-2. [PMID: 12039639]
  • R Bolognesi, D Tsialtas, P Vasini, M Conti, C Manca. Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. The American journal of cardiology. 1997 Jan; 79(2):242-5. doi: 10.1016/s0002-9149(96)00727-8. [PMID: 9193039]
  • J Sennesael, D Verbeelen, L Vanhaelst, R Pirola, S R Bareggi. Pharmacokinetics of intravenous and oral chlordesmethyldiazepam in patients on regular haemodialysis. European journal of clinical pharmacology. 1991; 41(1):65-8. doi: 10.1007/bf00280109. [PMID: 1782980]
  • C D'Eramo, F Tirelli, D Maestri. [Chlordesmethyldiazepam and prolactinemia during surgical stress]. Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. 1989; 60(5-6):217-22. doi: . [PMID: 2577441]
  • S R Bareggi, G Truci, S Leva, L Zecca, R Pirola, S Smirne. Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans. European journal of clinical pharmacology. 1988; 34(1):109-12. doi: 10.1007/bf01061430. [PMID: 2896126]
  • C D'Eramo, F Tirelli, D Maestri. [Effects of chlordemethyldiazepam on blood cortisol during surgical stress]. Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. 1988; 59(5-6):199-204. doi: NULL. [PMID: 2908216]
  • L Zecca, P Ferrario, R Pirola, S R Bareggi. Analysis of chlorodesmethyldiazepam and its metabolites in plasma and urine. Journal of chromatography. 1987 Sep; 420(2):417-24. doi: 10.1016/0378-4347(87)80199-8. [PMID: 3121659]
  • S R Bareggi, R Pirola, S Leva, L Zecca. Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans. European journal of drug metabolism and pharmacokinetics. 1986 Jul; 11(3):171-4. doi: 10.1007/bf03189844. [PMID: 3102240]
  • S R Bareggi, N P Nielsen, S Leva, R Pirola, L Zecca, M Lorini. Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam). International journal of clinical pharmacology research. 1986; 6(4):309-14. doi: NULL. [PMID: 2875955]
  • S Hashimoto, E Sakurai, M Mizobuchi, S Takahashi, K Yamamoto, T Momose. Determination of peptidoaminobenzophenone (2-o-chlorobenzoyl-4-chloro-N-methyl-N'-glycylglycinanilide) and its metabolites in human plasma by glass capillary gas chromatography negative ion chemical ionization mass spectrometry--1. Biomedical mass spectrometry. 1982 Dec; 9(12):546-51. doi: 10.1002/bms.1200091209. [PMID: 6131705]
  • G B Picotti, O Corli, M D Galva, G P Bondiolotti, M O Carruba. Effects of oral chlordemethyldiazepam on plasma adrenaline and noradrenaline and cardiovascular reactivity in preoperative patients. European journal of clinical pharmacology. 1982; 23(5):383-8. doi: 10.1007/bf00605986. [PMID: 6818039]
  • L Valzelli, W Kostowski, S Bernasconi, A Sala. Effect of chloro-N-desmethyldiazepam on serum and brain tryptophan and serotonin in relation to the activity of central serotonergic neurons. Polish journal of pharmacology and pharmacy. 1981 Jan; 33(1):37-42. doi: NULL. [PMID: 6789314]
  • L Dal Bo, F Marcucci, E Mussini, D Perbellini, A Castellani, P Fresia. Plasma levels of chlorodesmethyldiazepam in humans. Biopharmaceutics & drug disposition. 1980 Jan; 1(3):123-6. doi: 10.1002/bdd.2510010306. [PMID: 6778522]
  • T H Williams, G J Sasso, J J Ryan, M A Schwartz. Novel application of proton nuclear magnetic resonance spectroscopy in the identification of 2'-chloronordiazepam metabolites in the dog. Journal of medicinal chemistry. 1979 Apr; 22(4):436-40. doi: 10.1021/jm00190a016. [PMID: 34722]